Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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Pyrimethamine
CAS:Controlled Product<p>Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.<br>References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),<br></p>Formula:C12H13ClN4Color and Shape:White To Off-WhiteMolecular weight:248.71Apatinib
CAS:Controlled Product<p>Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formula:C24H23N5O·CH4O3SColor and Shape:NeatMolecular weight:493.58N-[2-(3,4-Dihydro-1-oxo-2(1H)-isoquinolinyl)-2-oxoethyl]-N-formyl-cyclohexanecarboxamide
CAS:Controlled Product<p>Impurity Praziquantel USP Related Compound C<br>Applications N-[2-(3,4-Dihydro-1-oxo-v2(1H)-isoquinolinyl)-2-oxoethyl]-N-formyl-cyclohexanecarboxamide is a compound related to Praziquantel (P702095),effective against flatworms. Praziquantel USP Related Compound C.<br>References Kuhn, I., et al.: Bioorg. Med. Chem., 18, 7900 (2010), Wang, W., et al.: Parasitol., 137, 1905 (2010),<br></p>Formula:C19H22N2O4Color and Shape:NeatMolecular weight:342.39rac Mirabegron-d5
CAS:Controlled ProductFormula:C21H19D5N4O2SColor and Shape:NeatMolecular weight:401.54Pseudo Vardenafil
CAS:<p>Applications Vardenafil analog.<br>References Blok-Tip, L., et al.: Food Addit. Contam., 21, 737 (2004), Reffelmann, T., et al.: Curr. Pharm. Des., 12, 3485 (2006), Reepmeyer, J., et al.: J. Pharm. Biomed. Anal., 43, 1615 (2007),<br></p>Formula:C22H29N5O4SColor and Shape:NeatMolecular weight:459.56N-Cyano-N’-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea
CAS:Controlled ProductFormula:C10H15N5S2Color and Shape:NeatMolecular weight:269.39Ethyl 2-(2-(4-methoxyphenoxy)acetamido)-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS:Purity:98%Molecular weight:468.5199890136719N-Formyl Apixaban
CAS:Controlled Product<p>Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C26H25N5O5Color and Shape:NeatMolecular weight:487.51Aripiprazole Dimer
CAS:Controlled Product<p>Impurity Aripiprazole EP Impurity G<br>Applications Aripiprazole Dimer is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole EP Impurity G<br>References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998); Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998);<br></p>Formula:C48H56Cl4N6O4Color and Shape:WhiteMolecular weight:922.811,2,4-Triazol-4-amine
CAS:Controlled Product<p>Applications 1,2,4-Triazol-4-amine is an intermediate used to prepare potent, selective, and orally active cyclooxygenase-2 inhibitors. It is also used to synthesize hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.<br>References Song, Y., et al.: J. Med. Chem., 42, 1151 (1999); Emami, S., et al.: Bioorg. Med. Chem. Lett., 18. 141 (2008)<br></p>Formula:C2H4N4Color and Shape:NeatMolecular weight:84.082-Azahypoxanthine Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 2-Azahypoxanthine is a major degradation product of Dacarbazine (D101400). 2-Azahypoxanthine is possibly linked with some adverse effects of Dacarbazine (D101400). AHX is a natural product that is produced by fungi that spurs the growth of grass.<br>References Baird, G., et al.: Lancet, 2, 681 (1978), Horton, J., et al.: J. Pharm. Pharmacol., 33, 808 (1981), Shetty, B., et al.: J. Pharm. Biomed. Anal., 10, 675 (1992); Chem. and Eng. News p.7 Oct.1, (2018)<br></p>Formula:C4H2N5NaOColor and Shape:NeatMolecular weight:159.08Ipragliflozin
CAS:Controlled Product<p>Applications Ipragliflozin is a potent and selective inhibitor of sodium-glucose cotransporter-2 (SGLT2) and can serve as a potential agent for the treatment of type 1 and type 2 diabetes.<br>References Kadokura, T., et al.: Clin. Pharmacokinet., 53, 975 (2014); Kashiwagi, A., et al.: J. Diabetes Investig., 5, 382 (2014); Tahara, A., et al.: J. Pharm. Pharmacol., 66, 975 (2014); Zhang, W., et al.: Clin. Drug Invest., 33, 489 (2013)<br></p>Formula:C21H21FO5SColor and Shape:WhiteMolecular weight:404.45Marbofloxacin-d8
CAS:Controlled Product<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977), Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998),<br></p>Formula:C172H8H11FN4O4Color and Shape:NeatMolecular weight:370.401-Chloro-2-nitrobenzene
CAS:Controlled Product<p>Applications 1-Chloro-2-nitrobenzene is a useful synthetic intermediate. It was used in the synthesis of 1-hydroxybenzotriazole derivatives. Reaction of 1-chloro-2-nitrobenzene with dinitrogen pentoxide in dichloromethane is strongly catalysed by H-Faujasite-720.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fathalla, M., et al.: J. Chem. Soc. Pak., 33, 324 (2011); Claridge, R., et al.: J. Chem. Soc. Perkin Trans. II, 9, 1815, (1999)<br></p>Formula:C6H4ClNO2Color and Shape:NeatMolecular weight:157.55Desmethyl Ofloxacin
CAS:Controlled Product<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>Formula:C17H18FN3O4Color and Shape:White To Light BeigeMolecular weight:347.34[1,1'-Biphenyl]-4-yl(phenyl)methanol
CAS:Controlled Product<p>Impurity Bifonazole EP Impurity A<br>Applications [1,1'-Biphenyl]-4-yl(phenyl)methanol (Bifonazole EP Impurity A) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Formula:C19H16OColor and Shape:NeatMolecular weight:260.33(R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane
CAS:Controlled ProductFormula:C16H17ClOColor and Shape:NeatMolecular weight:260.761-(4-Chlorophenyl)-5-[6-[[4-[(4-chlorophenyl)amino]-6-[(1S,2R,3R,4R)-1,2,3,4,5-pentahydroxypentyl]-1,3,5-triazin-2-yl]amino]hexyl]biguanide D-Gluconic Acid
CAS:Controlled ProductFormula:C28H38Cl2N10O5•C6H12O7Color and Shape:NeatMolecular weight:665.5719616Fluconazole
CAS:<p>Applications Fluconazole is used as an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),<br></p>Formula:C13H12F2N6OColor and Shape:NeatMolecular weight:306.276-(4-AMINO-4-METHYLPIPERIDIN-1-YL)-3-(2,3-DICHLOROPHENYL)PYRAZIN-2-AMINE
CAS:Purity:95.0%Molecular weight:352.260009765625Ref: 10-F544411
1gTo inquire5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquirem-Ranolazine
CAS:Controlled Product<p>Applications m-Ranolazine is an impurity of Ranolazine Ethyl Dimer is an impurity of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. Antianginal.<br>References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004), McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998), Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002),<br></p>Formula:C24H33N3O4Color and Shape:NeatMolecular weight:427.5367-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
CAS:Controlled Product<p>Impurity Aripiprazole Bromobutoxyquinoline Impurity<br>Stability Hygroscopic<br>Applications An impurity in the synthesis of Aripiprazole (A771000). A degradation product in Aripiprazole tablets. Aripiprazole Bromobutoxyquinoline Impurity<br>References Reddy, G.V.R., et al.: Eur. J. Chem., 1, 20 (2010),<br></p>Formula:C13H16BrNO2Color and Shape:White To Off-WhiteMolecular weight:298.18R 84852
CAS:<p>Applications R 84852 is an impurity of paliperidone (P141000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Solanki, P.V., et. al.: ACS Sustainable Chem. Eng., 1, 243 (2013)<br></p>Formula:C23H28FN3O4Color and Shape:NeatMolecular weight:429.48Levosimendan
CAS:<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Formula:C14H12N6OColor and Shape:Yellow To Dark YellowMolecular weight:280.28Tazarotenic Acid
CAS:Controlled Product<p>Applications Tazarotenic acid is the major active metabolite of Tazarotene (T010050).<br>References Nagpal, S., et al.: J. Biol. Chem., 270, 923 (1995), Madhu, C., et al.: J. Pharm. Sci., 86, 972 (1997), Attar, M., et al.: Drug Metab. Dispos., 31, 476 (2003),<br></p>Formula:C19H17NO2SColor and Shape:NeatMolecular weight:323.412-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Montelukast.<br>References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 4, 463 (1994), Roberge, C., et al.: J. Ferment. Bioeng., 81, 530 (1996), Shafiee, A., et al.: App. Microbiol. Biotechnol., 49, 709 (1998),<br></p>Formula:C28H22ClNO3Color and Shape:NeatMolecular weight:455.93Hydrolyzed Pomalidomide M11
CAS:Controlled ProductFormula:C13H13N3O5Color and Shape:NeatMolecular weight:291.26rac-trans-Ketoconazole
CAS:Controlled Product<p>Impurity Ketoconazole EP Impurity C<br>Applications rac-trans-Ketoconazole (Ketoconazole EP Impurity C) is a Ketoconazole (K186000) analog. The trans isomer of Ketoconazole.<br>References Kan, P.B., et al.: J. Steroid Biochem., 23, 1023 (1985),<br></p>Formula:C26H28Cl2N4O4Color and Shape:Off-WhiteMolecular weight:531.43Tadalafil-d3
CAS:Controlled Product<p>Stability Unstable in Methanol<br>Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>Formula:C222H3H16N3O4Color and Shape:White SolidMolecular weight:392.42Tazarotene Thiochromane Dimer
CAS:<p>Applications Tazarotene Thiochromane DImer is an impurity of Tazarotene (T010050), an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>Formula:C26H26S2Color and Shape:NeatMolecular weight:402.6146Valsartan Ethyl Ester
CAS:Controlled Product<p>Applications Valsartan Ethyl Ester is an impurity of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Formula:C26H33N5O3Color and Shape:White To Light BeigeMolecular weight:463.57Cobicistat
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);<br></p>Formula:C40H53N7O5S2Color and Shape:NeatMolecular weight:776.022-Hydroxymethyl Loratadine
CAS:Controlled Product<p>Impurity Loratadine 2-Hydroxymethyl Impurity (USP)<br>Applications A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor. Loratadine 2-Hydroxymethyl Impurity (USP).<br>References Okamoto, T., et al.: Chem. Pharm. Bull ., 7, 130 (1959), Eyjolfsson, R., et al.: Pharmazie, 58, 154 (2003),<br></p>Formula:C23H25ClN2O3Color and Shape:NeatMolecular weight:412.91cis-Tadalafil
CAS:Controlled Product<p>Impurity Tadalafil EP Impurity A<br>Applications The (6R)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6R,12aS)<br>References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),<br></p>Formula:C22H19N3O4Color and Shape:Off-WhiteMolecular weight:389.404-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide
CAS:<p>Impurity Amisulpride EP Impurity C<br>Applications 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide is an impurity of Amisulpride (A633250), an antipsychotic. Amisulpride is a dopamine receptor antagonist. (Amisulpride EP Impurity C). Dopamine imaging agent<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985), Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997),<br></p>Formula:C15H22IN3O2Color and Shape:NeatMolecular weight:403.26(3S,4S,3’S)-Ezetimibe
CAS:<p>Applications (3S,4S,3’S)-Ezetimbe is a 3-epimer impurity of Ezetimibe (E975000), a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C24H21F2NO3Color and Shape:Off-WhiteMolecular weight:409.43(S)-Lisinopril Dimer
CAS:Controlled Product<p>Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)<br></p>Formula:C42H60N6O9Color and Shape:WhiteMolecular weight:792.96Maraviroc-d6
CAS:Controlled Product<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>Formula:C29D6H35F2N5OColor and Shape:NeatMolecular weight:519.70Dechloro-Rivaroxaban
CAS:Controlled Product<p>Applications Dechloro-Rivaroxaban is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H19N3O5SColor and Shape:NeatMolecular weight:401.444-Nitro Lenalidomide
CAS:Controlled Product<p>Impurity Lenalidomide impurity<br>Applications Lenalidomide (L328000) analog. Lenalidomide impurity; Lenalidomide intermediate.<br>References Hashimoto, Y., et al.: Bioorg. Med. Chem., 10, 461 (2002),<br></p>Formula:C13H11N3O5Color and Shape:NeatMolecular weight:289.24Olanzapine LIP 1 Acetyl
CAS:<p>Applications Olanazpine LIP 1 Acetyl is an Olanazpine impurity. Olanazpine is an antipsychotic medicine.<br>References Perera, V., et al.: Br. J. Clin. Pharmacol., 78, 800 (2014); Pratt, N., et al.: Pharmacoepidemiol. Drug Saf., 22, 915 (2013)<br></p>Formula:C18H20N4OSColor and Shape:YellowMolecular weight:340.44Ethyl 4-Acetamidobenzoate
CAS:Controlled Product<p>Applications Ethyl 4-acetamidobenzoate is a reagent that is used in the synthesis of DAMPA-d3, which is a labeleld antitumor agent.<br>References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);<br></p>Formula:C11H13NO3Color and Shape:Off-WhiteMolecular weight:207.235-Nitro-2-furfuraldazine
CAS:Controlled Product<p>Impurity Nitrofurazone USP Related Compound A<br>Applications 5-Nitro-2-furfuraldazine is an impurity in the synthesis of Nitrofurazone (N493880), anti-infective (topical). Antimicrobial. Nitrofurazone USP Related Compound A<br>References Morris, et al.: Cancer Res., 29, 2145 (1969), Sanderson, H., et al.: Toxicol. Lett., 144, 383 (2003),<br></p>Formula:C10H6N4O6Color and Shape:NeatMolecular weight:278.178
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