Benzodiazepine Derivatives
Benzodiazepines are organic compounds with a fused bicyclic benzodiazepine core, widely used in the development of drugs with anxiolytic, sedative, anticonvulsant, and muscle relaxant properties. Their derivatives include modified structures that enhance selectivity and pharmacokinetic profiles, enabling the creation of new molecules with advanced therapeutic applications. These compounds are used in the formulation of APIs for the treatment of sleep disorders, anxiety, epilepsy, and muscle spasms. Additionally, benzodiazepine derivatives are essential in the research of new psychotropic agents and in optimising neurological treatments.
At CymitQuimica, we offer high-purity benzodiazepine derivatives for applications in chemical synthesis, pharmaceutical development, and neuroscience.
Found 332 products of "Benzodiazepine Derivatives"
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Brotizolam
CAS:Controlled Product<p>Applications A hypnotic and a sedative, also used in veterinary medicine as an appetite stimulant<br>References Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Nishino, T., et al.: J. Pharmacol. Sci., 107, 349 (2008), Yamashiro, T., et al.: J. Clin. Pharm, Ther., 33, 273 (2008), Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),<br></p>Formula:C15H10BrClN4SColor and Shape:WhiteMolecular weight:393.69Nitrazepam
CAS:Controlled Product<p>Applications Anticonvulsant; hypnotic.Controlled substance (depressant).<br>References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980).<br></p>Formula:C15H11N3O3Color and Shape:White To Off-WhiteMolecular weight:281.273-Hydroxy Bromazepam 1.0 mg/mL in Methanol
CAS:Controlled ProductFormula:C14H10BrN3O2Color and Shape:ColourlessMolecular weight:332.15Clonazepam
CAS:Controlled Product<p>Applications Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C15H10ClN3O3Color and Shape:WhiteMolecular weight:315.711-Methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:98%Molecular weight:250.30099487304688Deschloro Clobazam
CAS:Controlled Product<p>Applications Deschloro Clobazam is a metabolite of Clobazam (C582500), a benzodiazepine psychotherapeutic agent that has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant.<br>References Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C16H14N2O2Color and Shape:Off WhiteMolecular weight:266.29Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
CAS:Controlled Product<p>Impurity Flumazenil EP Impurity E<br>Applications Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (Flumazenil EP Impurity E) is used in the biological studies and preparation of imidazobenzodiazepines as probes for diazepaminsensitive receptor pharmacophore.<br>References Zhang, P., et al.: J. Med. Chem., 38, 1679 (1995)<br></p>Formula:C15H15N3O3Color and Shape:NeatMolecular weight:285.307-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS:Controlled ProductFormula:C10H9FN2O2Color and Shape:NeatMolecular weight:208.194-(2-Benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde
CAS:Controlled ProductFormula:C17H12ClN3O2Color and Shape:NeatMolecular weight:325.758-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Impurity Flumazenil EP Impurity F<br>Applications 8-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester is an impurity of Flumazenil (F500450), an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines.<br>References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),<br></p>Formula:C15H14ClN3O3Color and Shape:NeatMolecular weight:319.743-AMINO-1-METHYL-5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:265.31600952148442-Bromo-acetamide-2’,5-dichlorobenzophenone
CAS:Controlled Product<p>Stability Unstable in Solution, Moisture Sensitive<br>Applications Used in the synthesis of Cloxazolam and its metabolites.<br>References Ji, M. et al.: Zhongguo Yaoke Daxue Xuebao 24, 180 (1993); Ji, M. et al.: Zhongguo Yaoke Daxue Xuebao 25, 69 (1994).<br></p>Formula:C15H10BrCl2NO2Color and Shape:NeatMolecular weight:387.061-Hydroxy Alprazolam
CAS:Controlled ProductFormula:C17H13ClN4OColor and Shape:NeatMolecular weight:324.767-Amino Nitrazepam
CAS:Controlled Product<p>Applications A metabolite of Nitrazepam (N490140).<br>References Randall, L.O., et al.: Biochem. Pharmacol., 8, 15 (1961),<br></p>Formula:C15H13N3OColor and Shape:Light YellowMolecular weight:251.286-Methyl Bromazepam
CAS:Controlled ProductFormula:C15H12BrN3OColor and Shape:NeatMolecular weight:330.185-Nitro-2-(bromoacetamido)benzophenone
CAS:<p>Applications Nitrazepam derivative.<br>References Hagishita, S., et al.: Bioorg. Med. Chem., 5, 1433 (1997), Amblard, M., et al.: J. Med. Chem., 42, 4185 (1999), Schafferhans, A., et al.: J. Mol. Biol., 307, 407 (2001).<br></p>Formula:C15H11BrN2O4Color and Shape:NeatMolecular weight:363.167-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
CAS:<p>Applications An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay.<br>References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),<br></p>Formula:C17H13ClN4Color and Shape:White To Off-WhiteMolecular weight:308.763-Amino-6-bromo-4-(2-pyridinyl)-2(1H)-quinolinone(>90%)
CAS:Controlled Product<p>Stability Air Sensitive<br>Applications 3-Amino-6-bromo-4-(2-pyridinyl)-2(1H)-quinolinone is an impurity of Bromazepam (B678500); a controlled substance (depressant) and anxiolytic.<br>References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973); Chalmers, P., et al.: Anesthesia, 39, 370 (1984); Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987)<br></p>Formula:C14H10BrN3OPurity:>90%Color and Shape:Light Brown To BrownMolecular weight:316.15(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate
CAS:Purity:97.0%Molecular weight:402.24798583984375Alprazolam 5-Oxide
CAS:Controlled Product<p>Applications A metabolite of Alprazolam (A575650).<br>References Schwartz, M.A., et al.: J. Pharmacol. Exp. Ther., 149, 423 (1965), Childress, S.J., et al.: J. Pharm. Sci., 53, 577 (1964), Gall, M., et al.: J. Med. Chem., 21, 1290 (1978)<br></p>Formula:C17H13ClN4OColor and Shape:NeatMolecular weight:324.767-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione
CAS:Controlled Product<p>Applications 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (cas# 4547-02-8) is a positive allosteric modulator for the muscarinic M1 receptor, which could be a potential treament for the Alzheimer's disease or Schizophrenia.<br>References Flohr, A., et al.: Bioorg. Med. Chem. Lett., 27, 5415 (2017)<br></p>Formula:C15H11ClN2SColor and Shape:BeigeMolecular weight:286.7792Bromazepam-d4
CAS:Controlled Product<p>Applications Controlled substance (depressant). Anxiolytic. Labelled Bromazepam.<br>References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),<br></p>Formula:C142H4H6BrN3OColor and Shape:NeatMolecular weight:320.187-methyl-5-phenyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:95.0%Molecular weight:252.31700134277344Clobazam-13C6 (1 mg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C6C10H13ClN2O2Color and Shape:ColourlessMolecular weight:306.702-Amino-5-nitro-2'-chlorobenzophenone
CAS:<p>Impurity Clonazepam EP Impurity A<br>Applications 2-Amino-5-nitro-2'-chlorobenzophenone (Clonazepam EP Impurity A) is an impurity of Clonazepam (C587080).<br></p>Formula:C13H9ClN2O3Color and Shape:NeatMolecular weight:276.68Defluoro 8-Hydroxy Flumazenil
CAS:Controlled ProductFormula:C15H15N3O4Color and Shape:NeatMolecular weight:301.30Flunitrazepam
CAS:Controlled Product<p>Applications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant).<br>References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),<br></p>Formula:C16H12FN3O3Color and Shape:Off-WhiteMolecular weight:313.283-Amino-4-(2-chlorophenyl)-6-nitro-2(1H)-quinolinone (Clonazepam Impurity)
CAS:<p>Impurity Clonazepam EP Impurity B<br>Applications 3-Amino-4-(2-chlorophenyl)-6-nitro-2(1H)-quinolinone (Clonazepam EP Impurity B) is an impurity of Clonazepam (C587080), antiepileptic agent with anxiolytic and antimanic properties.<br>References Mayer, W., et al.: Pharmazie, 29, 700 (1974), Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C15H10ClN3O3Color and Shape:Yellow BrownMolecular weight:315.711-Hydroxy Alprazolam β-D-Glucuronide (>80%)
CAS:Controlled ProductFormula:C23H21ClN4O7Purity:>80%Color and Shape:White SolidMolecular weight:500.897-Amino Clonazepam
CAS:Controlled Product<p>Applications The major metabolite of Clonazepam (C587080).<br>References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),<br></p>Formula:C15H12ClN3OColor and Shape:YellowMolecular weight:285.73Methyl Clonazepam
CAS:Controlled Product<p>Applications Shows sedative and anxiolytic properties. Impairment of psychomotor performance reported. Activity blocked by flumazenil.<br>References Doumont, A., et al.: Psychopharmacology, 87, 130 (1985), Psychopharmacology, 94(4), 501 (1988)<br></p>Formula:C16H12ClN3O3Color and Shape:YellowMolecular weight:329.74Alprazolam Aminomethyl Ketone Hydrochloride
CAS:Controlled Product<p>Applications Alprazolam (A575650) impurity.<br>References Hirai, K., et al.: J. Med. Chem., 24, 20 (1981),<br></p>Formula:C17H16Cl2N4O·xHClColor and Shape:White To Light YellowMolecular weight:363.24Alprazolam
CAS:Controlled Product<p>Applications Controlled substance (depressant). Anxiolytic.<br>References Sethy, V.H., et al.: Arch. Pharmacol., 301, 157 (1978), Fawcett, J.A., et al.: Pharmacotherapy, 2, 242 (1982),<br></p>Formula:C17H13ClN4Color and Shape:White To Off-WhiteMolecular weight:308.76Bromazepam
CAS:Controlled Product<p>Applications Controlled substance (depressant). Anxiolytic.<br>References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),<br></p>Formula:C14H10BrN3OColor and Shape:WhiteMolecular weight:316.152-Amino-5-chlorobenzophenone
CAS:Controlled Product<p>Applications A metabolite of Diazepam; but has a much weaker anticonvulsant effect.<br>References Hara, T., et al.: J. Med. Chem., 21, 263 (1978),<br></p>Formula:C13H10ClNOColor and Shape:YellowMolecular weight:231.68N-Desmethyl Clobazam
CAS:Controlled Product<p>Applications N-Desmethyl Clobazam is an impurity of Clobazam (C582500), which is a benzodiazepine, psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types and is an anxiolytic, anticonvulsant and controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C15H11ClN2O2Color and Shape:Off-WhiteMolecular weight:286.71Flumazenil Carboxylic Acid
CAS:<p>Applications Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>Formula:C13H10FN3O3Color and Shape:NeatMolecular weight:275.24Clobazam
CAS:Controlled Product<p>Applications Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C16H13ClN2O2Color and Shape:WhiteMolecular weight:300.74Nitrazepam-d5
CAS:Controlled ProductFormula:C152H5H6N3O3Color and Shape:Off-White To Light YellowMolecular weight:286.303-Amino-6-chloro-4-phenylcarbostyril
CAS:<p>Applications Intermediate in the preparation of Alprazolam impurities.<br>References Hanawa, T., et al.: Drug Dev. Ind. Pharm., 26, 1199 (2000), Cheng, P., et al.: Bioorg. Med. Chem. Lett., 18, 3787 (2008),<br></p>Formula:C15H11ClN2OColor and Shape:NeatMolecular weight:270.71(3,4-Dimethoxyphenyl)(2-(2-hydrazonopentan-3-yl)-4,5-dimethoxyphenyl)methanone
CAS:Controlled ProductFormula:C22H28N2O5Color and Shape:Off WhiteMolecular weight:400.477-bromo-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
CAS:Purity:95.0%Molecular weight:315.1700134277344Flumazenil-D5
CAS:Controlled Product<p>Applications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>Formula:C15H9D5FN3O3Color and Shape:NeatMolecular weight:303.295-Chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone
CAS:<p>Applications An impurity of Alprazolam (A575650).<br>References Cho, M., et al.: J. Med. Chem., 29, 1346 (1986), Hall, M., et al.: J. Anal. Toxicol., 19, 511 (1995), Nudelman, N., et al.: J. Pharm. Sci., 84, 998 (1995), Yuan, R., et al.: J. Clin. Pharmacol., 39, 1109 (1999),<br></p>Formula:C16H12ClN3OColor and Shape:NeatMolecular weight:297.74Clonazepam-13C2 ,15N
CAS:Controlled Product<p>Applications Clonazepam-13C2 ,15N, is the labeled analogue of Clonazepam (C587080), an antiepileptic agent with anxiolytic and antimanic properties.<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>Formula:C1313C2H10ClN215NO3Color and Shape:NeatMolecular weight:318.69Nor-Flunitrazepam
CAS:Controlled Product<p>Applications A metabolite of Flunitrazepam (F500700).<br>References Asai, H., et al.: J. Pharmacol. Exp. Ther., 277, 1004 (1996), Kilicarslan, T., et al.: Drug Metab. Dispos., 29, 460 (2001), Tanaka, E., et al.: J. Toxicol. Clin. Toxicol., 40, 69 (2002),<br></p>Formula:C15H10FN3O3Color and Shape:YellowMolecular weight:299.263-Amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS:Purity:95.0%Molecular weight:251.28900146484375N-Desmethyl Clobazam-13C6
CAS:Controlled Product<p>Applications N-Desmethyl Clobazam-13C6 is an isotope labelled metabolite of Clobazam (C582500), a benzodiazepine psychotherapeutic agent that has proven efficacy against multiple seizure types.<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979); Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C913C6H11ClN2O2Color and Shape:Off-WhiteMolecular weight:292.669
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