Steroids and Derivatives

Stability Temperature and Light Sensitive
Applications A metabolite of Vitamin D3.
References Bell, P.A., et al.: Biochem. J., et al.: 115, 663 (1969), Kumar, R.S., et al.: J. Clin. Invest., 65, 277 (1980), Shimada, K., et al.: Biol. Pharm. Bull., 19, 491 (1996),

Applications Max LMG is a progestin derived steroid and not a 17-alpha alkylated steroid. Max LMG is structurally related to RU-486 and acts as an antiprogesterone, decreasing estrogen-like effects.
References Eenoo, P.V., et al.: J. Steroid. Biochem. Molec. Biol., 101, 161 (2006); Kafrouni, M. I., Clinical. Gastroenterol. Hepatol., 5, 805 (2007); Ponsoid, K., et al.: Pharmazie., 33, 729 (1978);

Applications (3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate is an intermediate in the synthesis of Prostaglandin E2 (P838610), the most common and biologically potent of mammalian prostaglandins.
References Radeuchel, B., et al.: Tetrahedron. Lett., 633, 9 (1975);

Applications Lasofoxifene intermediate.
References Rosati, R., et al.: J. Med. Chem., 41, 2928 (1998),

Impurity Levonorgestrel EP Impurity G
Applications 6α-Hydroxy Levonorgestrel (Levonorgestrel EP Impurity G) is a hydroxylated impurity of Norgestrel (N689500).
References Lin, Y., et al.: Biochim. Biophys. Acta, 218, 526 (1970), Smith, K., et al.: J. Steroid Biochem., 32, 445 (1989), Hu, S., et al.: Steroids, 60, 337 (1995),

Applications 6-Ethylchenodeoxycholic-d5 Acid is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis.
References Ali, A. H, et al.: Expert Opin. Orphan Drugs, 4, 1011 (2016)

Stability Light Sensitive, Temperature Sensitive
Applications An Atorvastatin (A791750) derivative which have improved stability.

Applications Norgestrel (N689500) impurity.
References Gorog, S., et al.: J. Chromatogr., 400 177 (1987),

Applications Testosterone Isocaproate, is one of the common anabolic steroid esters. It is a controlled substance in US due to their potential for abuse and misuse. It can be used for the treatment of constitutional delayed puberty (CDP), in combination of other testosterone esters.
References Noggie, F. T., et al.: J. Chromatography. Sci., 28 (5), 263 (1990); Buyukgebiz, A., et al.: Hormone REs., 44 Suppl 3, 32 (1995);

Applications Estradiol 17β-sulfate is a naturally occuring steroid in whihc can be converted into Estradiol(E888000)
References Takanashi, K., et al.: Steroids., 68, 383-392 (2003)

Stability Moisture Sensitive
Applications (11β,16α)-9-Bromo-21-[(ethoxycarbonyl)oxy]-11-(formyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione is an impurity of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.
References Spangler, M., et al.: Chromatographia, 54(5/6), 329-334 (2001);Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995)

Applications (5α)-Pregnane-3,20-dione exerts neuroprotective effects in chronic autoimmune encephalomyelitis (EAE). The neuroactivity of the steroid acts as a therapeutic agent for multiple sclerosis.
References Caruso, D. et al.: J. Neuroendocrinol., 24, 851 (2012);