Flavonoids and Polyphenols

<p>Applications Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),<br></p>

<p>Applications 27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.<br>References Choi, E. et al. J. App. Toxicol., 33, 190 (2010); Findeis, M. et al.: ACS. Chem. Neurosci., 3, 941 (2012); Einbond, L. et al.: Fund. Clin. Pharm., 23, 311 (2009);<br></p>

<p>Applications Methyl trans-Cinnamate is one of the odour active compounds of Tahitian vanilla flavour and basil oil. Methyl trans-Cinnamate is naturally found in Magnolia liliflora oil, which is used to create a variety of nematicides. Methyl trans-Cinnamate also inhibits mushroom tyrosinase and has antimicrobial effects against Escherechia coli in food.<br>References Adams, A., et al.: J. Am. Oil Chem. Soc., 88, 201 (2011); Blank, A., et al.: Ind. Crop. Prod., 38, 93 (2012); Brunschwig, C., et al.: Food Res. Int., 46, 148 (2012); Huang, Q., et al.: J. Agr. Food Chem., 57, 2565 (2009)<br></p>

<p>Applications Secoisolariciresinol diglucoside (SDG) is a lignan found in flaxseed and is an emerging source in the functional food area. Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). SDG metabolites may protect against CVD and the metabolic syndrome by reducing lipid and glucose concentration, lowering blood pressure, and decreasing oxidative stress and inflammation.<br>References Lucas, E., et al.: J. Clin. Endocrinol Metab., 87, 1527 (2002), Choo, W., et al.: J. Food Compost. Anal., 20, 202 (2007), Sicilia, T., et al.: J. Agric. Food Chem., 51, 1181 (2003),<br></p>

Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.

(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian

<p>Pyrogallol triacetate is used as an antiasthmatic.</p>

RS-0406: A β-flake blocker, reverses Aβ toxicity, protects in vitro, and halts behavior decline in vivo.

Leptospermone is an essential oil from Leptospermum scoparium (manuka oil).

5,7-Dihydroxycoumarin is a natural product isolated from the dichloromethane extract of the inflorescences of Macaranga triloba.

Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.

<p>Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation.</p>

<p>Ensaculin, a benzopyrone-piperazine compound, enhances memory, protects neurons, and may treat dementia.</p>

<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>

<p>Malvone A is a compound with antifungal properties found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. It is applicable in research focused on anti-infective solutions.</p>

Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.

<p>Nepetin-7-O-glucoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.</p>

<p>Hispidulin-7-O-glucoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.</p>

<p>Hispidulin analytical standard provided with w/w absolute assay, to be used for quantitative titration.</p>

<p>Dalbergin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.</p>