Organic Phosphates and Phosphonates

Impurity Captopril EP Impurity G
Applications 3-Acetylthio-2-methylpropionic Acid (Captopril EP Impurity G) is a key intermediate for Captopril (C175750) and other hypertension drugs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),

Stability Moisture Sensitive, Temperature Sensitive
Applications A labelled metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent.
References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),

Applications Toldimfos Sodium, is a cattle drug that can be used to investigate the bovine serum paraoxonase 1 (PON1) activity.
References Arslan, M., et al.: J. Enzyme Inhibit. Med. Chem., 27, 722 (2012);

Impurity Captopril EP Impurity C
Applications 3-Mercapto-2-methylpropanoic Acid (Captopril EP Impurity C) is a useful synthetic intermediate.
References Lewis, S.N. et al.: J. Het. Chem., 8, 571-580 (1971)

Applications An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.
References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),

Stability Hygroscopic
Applications Potassium salt of Phosphoric Acid (P359200), used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties. pH buffer.
References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);

Applications A metabolite of Cyclophosphamide (CPA) (C988580).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),

Stability Moisture Sensitive
Applications Fenthion is an organothiophosphate used as an insecticide. Fenthion is also a potent acaricide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);

Stability Hygroscopic
Applications A major biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications Amifostine Trihydrate is a widely used cytoprotective and radio-protective agent.
References Adibhatla K.S., et al. Novel method of manufacture of high purity Amifostine trihydrate. Indian Pat. Appl. IN 2005CH01592 A 20080125. Jan 25, 2008

Applications Alendronic Acid-d6 Sodium Salt is a labelled salt analogue of Alendronic Acid (A521250), a bisphosphonate used as a bone reabsoption inhibitor.
References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000); Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001); Benford, H.L., et al.: Bone, 28, 465 (2001)

Applications Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gorren, A., et al.: Biochem. J., 331, 801 (1998), Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1999), Marchand, C., et al.: Mol. Pharmacol., 64, 600 (2003), Maurin, C., et al.: J. Med. Chem., 47, 5583 (2004),

Stability Hygroscopic
Applications Butafosfan, a component of Catosal, is licensed for the treatment of metabolic disorders or as a tonic in swine. It reduces the stress-induced cortisol (C696302, d4 labelled) response after mixing of unfamiliar pigs. It can also increase milk production in Holstein cows in combination with cyanocobalamin.
References De Groot, J., et al.: J. Vet. Pharmacol. Ther., 26, 222 (2003); Pereira, R., et al.: Animal, 7, 1143 (2013)

Applications (4S)-4-(Phenylthio)-L-proline is an impurity of Zofenopril (Z587000).
References Krapcho, J., et al.: J. Med. Chem., 31, 1148 (1988),

Applications Dichlorvos-d6 is a deuterated analogue of Dichlorvos a Cholinesterase inhibitor. Anthelmintic, insecticide. Used as a standard for Pesticide detection. Also used in Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969), Reuber, M.D., et al.: Clin. Toxicol., 18, 47 (1981),