Nitrosamines and Derivatives
Nitrosamines are chemical compounds that contain a nitroso group (-NO) attached to a nitrogen atom, usually within a heterocyclic structure. These substances commonly form as by-products of chemical reactions, such as the nitrosation of amines in the presence of nitrites. Nitrosamines are known for their high toxicity and carcinogenic properties, especially in living organisms. Due to these effects, their presence in food products, cosmetics, and tobacco is strictly regulated. Nitrosamine derivatives, such as nitrosamides, also exhibit carcinogenic properties and may form in industrial processes, although some derivatives are being investigated for pharmaceutical applications due to their potential in certain biological reactions.
At CymitQuimica, we offer nitrosamines and their derivatives for research in toxicology, analytical chemistry, and pharmacology.
Found 55 products of "Nitrosamines and Derivatives"
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4-(Methylnitrosamino)-1-(3-pyridyl-d4)-1-butanone-d4 (1 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C102H4H9N3O2Color and Shape:ColourlessMolecular weight:211.254-Methylmorpholine
CAS:<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.154-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
CAS:<p>Applications A metabolite of NNK (Cat. #M325750), a tobacco-specific nitrosamine.<br>References Hecht, S.S., et al.: Cancer Res., 40, 4144 (1980), Kutzer, C., et al.: J. Chromatog. Sci., 35, 1 (1997)<br></p>Formula:C10H15N3O2Color and Shape:Colourless To YellowMolecular weight:209.24Rac-N’-Nitroso Nornicotine (1.0 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C9H11N3OColor and Shape:Colourless LiquidMolecular weight:177.20rac-N’-Nitroso Nornicotine
CAS:Controlled Product<p>Applications N'-Nitrosonornicotine (NNN) is a tobacco alkaloid known as esophageal carcinogen. NNN is the cause of esophageal and oral cavity cancer in smokers and snuff dippers. The studies showed that the carcinogenicity of (S)-NNN, the predominant enantiomer in tobacco products, may be greater than that of (R)-NNN or racemic NNN.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anto, R., et al.: Carcinogenesis, 23, 1511 (2002), Pfeifer, G., et al.: Oncogene, 21, 7435 (2002), Shishodia, S., et al.: Cancer Res., 64, 5004 (2004), Jin, Z., et al.: J. Biol. Chem., 279, 23837 (2004),<br></p>Formula:C9H11N3OColor and Shape:Light YellowMolecular weight:177.20Dimethyl (diazomethyl)phosphonate
CAS:Formula:C3H7N2O3PPurity:95.0%Color and Shape:Liquid, OilMolecular weight:150.0744-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (1 mg/mL in Methanol)
CAS:Controlled ProductFormula:C10H13N3O2Color and Shape:ColourlessMolecular weight:207.234-(Methylnitrosamino)-1-(3-pyridyl-d4)-1-butanone-d4 (0.1 mg/mL in Methanol)
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Labelled NNK (M325750). This compound was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. It is likely to be important in the etiology of cancers of the lung, oral cavity, and pancreas in people who use tabacco products. Readily produces cancer in rats and hamsters. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997), Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000), Jalas, J., et al.: Chem. Res. Toxicol., 18, 95 (2005), Zhu, L., et al.: Drug Metab. Dispos., 34, 1672 (2006),<br></p>Formula:C102H4H9N3O2Color and Shape:ColourlessMolecular weight:211.25rac-N’-Nitroso Nornicotine (1 mg/mL in Methanol)
CAS:Controlled ProductFormula:C9H11N3OColor and Shape:ColourlessMolecular weight:177.204-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (10 mg/mL in Methanol)
CAS:Controlled ProductFormula:C10H13N3O2Color and Shape:Single SolutionMolecular weight:207.23Diazoxon
CAS:<p>Diazoxon is the oxidized form of Diazinon -- an organophosphate insecticide. Diazoxon is shown to be a more potent acetylcholinesterase (AChE) inhibitor.</p>Formula:C12H21N2O4PColor and Shape:SolidMolecular weight:288.28
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