Nitrosamines and Derivatives
Nitrosamines are chemical compounds that contain a nitroso group (-NO) attached to a nitrogen atom, usually within a heterocyclic structure. These substances commonly form as by-products of chemical reactions, such as the nitrosation of amines in the presence of nitrites. Nitrosamines are known for their high toxicity and carcinogenic properties, especially in living organisms. Due to these effects, their presence in food products, cosmetics, and tobacco is strictly regulated. Nitrosamine derivatives, such as nitrosamides, also exhibit carcinogenic properties and may form in industrial processes, although some derivatives are being investigated for pharmaceutical applications due to their potential in certain biological reactions.
At CymitQuimica, we offer nitrosamines and their derivatives for research in toxicology, analytical chemistry, and pharmacology.
Found 55 products of "Nitrosamines and Derivatives"
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Molsidomine
CAS:<p>Molsidomine, an oral vasodilator, turns into linsidomine in the liver, releasing NO for prolonged effects.</p>Formula:C9H14N4O4Purity:99.98% - >99.99%Color and Shape:Colorless Or White Crystalline PowderMolecular weight:242.23Molsidomine EP Impurity A HCl (3-(Morpholin-4-yl)-Sydnonimine HCl, Linsidomine HCl)
CAS:Formula:C6H11N4O2·ClColor and Shape:Pale Yellow SolidMolecular weight:171.18 35.45Tenonitrozole
CAS:<p>Tenonitrozole is a biochemical.</p>Formula:C8H5N3O3S2Color and Shape:SolidMolecular weight:255.274-Nitrosomorpholine
CAS:Controlled ProductFormula:C4H8N2O2Color and Shape:YellowMolecular weight:116.124-(Hydroxyacetyl)morpholine
CAS:Controlled ProductFormula:C6H11NO3Color and Shape:NeatMolecular weight:145.16Morpholine-4-carbaldehyde
CAS:Controlled ProductFormula:C5H9NO2Color and Shape:NeatMolecular weight:115.13(2E)-(Morpholin-4-ylimino)acetonitrile
CAS:Controlled ProductFormula:C6H9N3OColor and Shape:Light YellowMolecular weight:139.16Dimethyl (1-diazo-2-oxo-propyl)phosphonate
CAS:Formula:C5H9N2O4PPurity:95.0%Color and Shape:Liquid, ClearMolecular weight:192.111Molsidomine Impurity C ((2E)-(Morpholin-4-ylimino)-Acetonitrile)
CAS:Formula:C6H9N3OMolecular weight:139.16Morpholine
CAS:Controlled Product<p>Applications Morpholine, is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190).<br> E0<br>References Hall, H. K., et al.: J. Am. Chem. Soc., 79 (20), 5441 (1957); Paladini, D., et al.: Biochem., 48, 5760 (2009); Bard, B., et al.: J. Med. Chem., 52, 3416 (2009);<br></p>Formula:C4H9NOColor and Shape:NeatMolecular weight:87.12Ethyl 2-diazoacetate (contains 4-13% Dichloromethane)
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:114.10399627685547Molsidomine
CAS:Controlled Product<p>Applications Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.<br>References Tanayama, S. et al.: Xenobiotica, 4, 175 (1974); Yamada, M. et al.: Chem. Pharmac. Bull., 35, 3390 (1987); Messin, R. et al.: Adv. Ther., 23, 107 (2006);<br></p>Formula:C9H14N4O4Color and Shape:White To Off-WhiteMolecular weight:242.234-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0 mg/mL in Acetonitrile)
CAS:Formula:C10H13N3O2Color and Shape:ColourlessMolecular weight:207.234-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
CAS:Controlled ProductFormula:C10H13N3O2Color and Shape:Off-WhiteMolecular weight:207.234-(Methyl-d3-nitrosamino)-1-(3-pyridyl)-1-butanol
CAS:Controlled Product<p>Applications A deuterated metabolite of NNK (Cat. #M325750), a tobacco-specific nitrosamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hecht, S.S., et al.: Cancer Res., 40, 4144 (1980); Kutzer, C., et al.: J. Chromatog. Sci., 35, 1 (1997)<br></p>Formula:C102H3H12N3O2Color and Shape:NeatMolecular weight:212.264-(Methylnitrosamino)-1-(3-pyridyl-d4)-1-butanone-d4 (1 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C102H4H9N3O2Color and Shape:ColourlessMolecular weight:211.254-Methylmorpholine
CAS:<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.154-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
CAS:<p>Applications A metabolite of NNK (Cat. #M325750), a tobacco-specific nitrosamine.<br>References Hecht, S.S., et al.: Cancer Res., 40, 4144 (1980), Kutzer, C., et al.: J. Chromatog. Sci., 35, 1 (1997)<br></p>Formula:C10H15N3O2Color and Shape:Colourless To YellowMolecular weight:209.24Rac-N’-Nitroso Nornicotine (1.0 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C9H11N3OColor and Shape:Colourless LiquidMolecular weight:177.20rac-N’-Nitroso Nornicotine
CAS:Controlled Product<p>Applications N'-Nitrosonornicotine (NNN) is a tobacco alkaloid known as esophageal carcinogen. NNN is the cause of esophageal and oral cavity cancer in smokers and snuff dippers. The studies showed that the carcinogenicity of (S)-NNN, the predominant enantiomer in tobacco products, may be greater than that of (R)-NNN or racemic NNN.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anto, R., et al.: Carcinogenesis, 23, 1511 (2002), Pfeifer, G., et al.: Oncogene, 21, 7435 (2002), Shishodia, S., et al.: Cancer Res., 64, 5004 (2004), Jin, Z., et al.: J. Biol. Chem., 279, 23837 (2004),<br></p>Formula:C9H11N3OColor and Shape:Light YellowMolecular weight:177.20Dimethyl (diazomethyl)phosphonate
CAS:Formula:C3H7N2O3PPurity:95.0%Color and Shape:Liquid, OilMolecular weight:150.0744-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (1 mg/mL in Methanol)
CAS:Controlled ProductFormula:C10H13N3O2Color and Shape:ColourlessMolecular weight:207.234-(Methylnitrosamino)-1-(3-pyridyl-d4)-1-butanone-d4 (0.1 mg/mL in Methanol)
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Labelled NNK (M325750). This compound was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. It is likely to be important in the etiology of cancers of the lung, oral cavity, and pancreas in people who use tabacco products. Readily produces cancer in rats and hamsters. Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997), Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000), Jalas, J., et al.: Chem. Res. Toxicol., 18, 95 (2005), Zhu, L., et al.: Drug Metab. Dispos., 34, 1672 (2006),<br></p>Formula:C102H4H9N3O2Color and Shape:ColourlessMolecular weight:211.25rac-N’-Nitroso Nornicotine (1 mg/mL in Methanol)
CAS:Controlled ProductFormula:C9H11N3OColor and Shape:ColourlessMolecular weight:177.204-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (10 mg/mL in Methanol)
CAS:Controlled ProductFormula:C10H13N3O2Color and Shape:Single SolutionMolecular weight:207.23Diazoxon
CAS:<p>Diazoxon is the oxidized form of Diazinon -- an organophosphate insecticide. Diazoxon is shown to be a more potent acetylcholinesterase (AChE) inhibitor.</p>Formula:C12H21N2O4PColor and Shape:SolidMolecular weight:288.28
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