Nucleosides and Nucleotides

Entecavir is a drug product that is custom synthesized to order. It has a purity of >98% and is made up of the 1S,3S,4S diastereomer. Entecavir is an antiviral drug that belongs to the nucleoside analog family and inhibits viral replication by inhibiting DNA polymerase α. The metabolism studies for entecavir have been completed and it was found that entecavir undergoes hydrolysis by esterases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Entecavir also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Capecitabine is a prodrug that is converted to 5-fluorouracil in the body. It has been used for many years in the treatment of breast cancer and colorectal cancer. Capecitabine 2',3'-cyclic carbonate is an analytical standard, research and development tool, high purity drug product, and impurity standard for HPLC analysis. This compound is also used as a pharmacopoeia reference material for quality control testing. Capecitabine 2',3'-cyclic carbonate can be custom synthesized or purified from natural or synthetic sources.

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

CNV-2197944 is a novel, small molecule, state-dependent calcium channel blocker, designed to selectively inhibit highly active Cav2.2 channels.

Creatine monohydrate powers ATP for short, high-intensity activities in muscles and brain.

(R)-Oxiracetam is the (R)-enantiomer of the nootropic drug oxiracetam. Oxiracetam is a nootropic drug of the racetam family and stimulant.

Diapocynin (Dehydrodiacetovanillone), a dimer of Apocynin, acts as an orally administered inhibitor of NADPH oxidase.

(S)-AMPA is an active isomer of AMPA and a selective agonist of AMPA.

R306465, a potent HDAC1/8 inhibitor, has broad antitumor effects (IC50: 30-300 nM) on solid and blood cancers.

Galidesivir triphosphate halts viral RNA replication by inhibiting RDRP and NS5B, and combats Ebola in mice; derived from prodrug Galidesivir.

Apadenoson: potent A2 agonist, A3 inhibitor (IC 45 nM), anti-inflammatory, for neurological research.

Adefovir monophosphate: antiviral ANP active against HBV, herpes; ntRTI for hepatitis B, not HIV-1 effective.

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) modulates macrophage G2A for neutrophil inflammation resolution.

S07-2010 is a pan-Aldo-Keto Reductase 1C3 (AKR1C3) inhibitor with potential anti-cancer activity, inducing apoptosis in A549/DDP cells.

Sarcolysine hydrochloride, also known as Melphalan HCl, is a nitrogen mustard and alkylating agent that has been studied for use in multiple myeloma therapy.

Gemcitabine metabolite

Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.

Meropenem EP impurity A is a heterocyclic nitro compound that is used to treat various infectious diseases. Meropenem EP impurity A is an inhibitor of the toll-like receptor, which is a protein that recognizes and binds to bacterial lipopolysaccharide and mediates inflammation. This drug may be effective in treating colorectal carcinoma, autoimmune diseases, chronic bronchitis, cancer, and other inflammatory diseases. Meropenem EP impurity A also has anti-cancer properties due to its structural similarity with the chemotherapeutic agent 5-fluorouracil. Meropenem EP impurity A inhibits the synthesis of proteins by binding to the aminoacyl-tRNA synthetase enzyme and blocking the production of proteins vital for cell division.