Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Found 79171 products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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Ramipril-d5
CAS:Controlled Product<p>Applications A labelled antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite.<br>References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),<br></p>Formula:C23H27D5N2O5Color and Shape:WhiteMolecular weight:421.54Levosimendan Triazene Impurity
CAS:<p>Stability Light Sensitive<br>Applications Levosimendan Triazene is an impurity of Levosimendan (L378000); a positive inotropic agent with vasodilating activity. Also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C22H23N7O2Color and Shape:NeatMolecular weight:417.46trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Formula:C26H40O5Color and Shape:ColourlessMolecular weight:432.594,6-Dihydroxypyrazolo[3,4-d]pyrimidine-13C,15N2
CAS:Controlled Product<p>Applications A labelled metabolite of Allopurinol.<br>References Marro, P., et al.: Brain Res., 650, 9 (1994), Abramov, A., et al.: J. Neurosci., 27, 1129 (2007), Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007),<br></p>Formula:CC4H415N2N2O2Color and Shape:White To BeigeMolecular weight:155.091-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
CAS:Formula:C25H24N4O5Color and Shape:Light Orange ColourMolecular weight:460.48Ramiprilat
CAS:Controlled Product<p>Impurity Ramipril EP Impurity E<br>Stability Hygroscopic<br>Applications Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)<br>References 1. Teetz, V. et al.: Arzneimittelforschung. 1984;34(10B):1399-401.2. Ruggenenti, P. et al.: Lancet. 1998 Oct 17;352(9136):1252-6.3. Badrinath, P. et al.; BMJ. 2002 Aug 24; 325(7361): 439.<br></p>Formula:C21H28N2O5Color and Shape:Light YellowMolecular weight:388.463-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Controlled Product<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Formula:C6H6N6OColor and Shape:Off-WhiteMolecular weight:178.15Bis-[Des(5-Chloro-2-carboxythienyl)] Rivaroxaban Phthalamide
CAS:Controlled ProductFormula:C36H36N6O10Color and Shape:NeatMolecular weight:712.71Ivermectin B1 Aglycon
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Ivermectin B1 Aglycon is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C34H50O8Color and Shape:Off White PowderMolecular weight:586.762-(Cyanomethyl)indole
CAS:Controlled Product<p>Applications Intermediate in the preparation of carcinogenic indole derivatives.<br>References Kato, M., et al.: Chem. Pharm. Bull., 42, 2556 (1994),<br></p>Formula:C10H8N2Color and Shape:NeatMolecular weight:156.183-Descyano Febuxostat
CAS:Controlled Product<p>Applications 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Kadivar, M.H., et. al.: J. Pharmaceut. Biomed. Anal., 56, 749 (2011); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C15H17NO3SColor and Shape:NeatMolecular weight:291.37Diclofenac Acyl-β-D-glucuronide Allyl Ester
CAS:Controlled Product<p>Applications An intermediate for the synthesis of Diclofenac’s glucuronide metaoblite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenny, J.R., et al.: J. Med. Chem., 47, 2816 (2004),<br></p>Formula:C23H23Cl2NO8Color and Shape:NeatMolecular weight:512.341-Chloroethyl Cyclohexyl Carbonate
CAS:<p>Applications 1-Chloroethyl Cyclohexyl Carbonate is a genotoxic impurity used in the synthesis of Candesartan Cilexetil. an angiotensin II receptor antagonist.<br>References Kakasaheb, N. et al.: Int. J. Pharm. Sci., 6, 370 (2014); Mao, Y. et al.: Heterocycles, 81, 1503 (2010);<br></p>Formula:C9H15ClO3Color and Shape:NeatMolecular weight:206.67N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide
CAS:Controlled Product<p>Applications N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C16H19N3O5Color and Shape:NeatMolecular weight:333.34Diclofenac Amide-13C6 (~5% unlabelled)
CAS:Controlled Product<p>Applications Diclofenac Amide-13C6 is a labelled analogue of Diclofenac Amide (D436440), which is a potential prodrug of Diclofenac and possible impurity during its commercial synthesis. Diclofenac Amide-13C6 is also an intermediate in synthesizing Diclofenac-13C6 Sodium Salt (D436453), which is a labelled analogue of Diclofenac Sodium Salt (D436450).<br>References Gaudiano, M.C., et al.: J. Pharm. Biomed. Anal., 32, 151 (2003); De Castro, W.V., et al.: Drug Develop. Ind. Pharm., 32, 1103 (2006); Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>Formula:C813C6H9Cl2NOColor and Shape:White To Light YellowMolecular weight:284.09Oxindole (2-Indolone)
CAS:Controlled Product<p>Applications Indole analogue; shows pharmacological activity.<br>References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),<br></p>Formula:C8H7NOColor and Shape:Light RedMolecular weight:133.15(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS:Controlled Product<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>Formula:C30H42N2O3Color and Shape:NeatMolecular weight:478.67Edoxaban 4-Carboxylic Acid Hydrochloride
CAS:Controlled ProductFormula:C22H25ClN6O5S·xHClColor and Shape:NeatMolecular weight:520.99 + x(36.46)Dehydro Ivabradine
CAS:Controlled ProductFormula:C27H34N2O5Color and Shape:Light Yellow To Dark BrownMolecular weight:466.57FK-506 3’-Methyl Ether
CAS:Controlled Product<p>Applications It is a fermentation process impurity. It is formed during Tacrolimus ((F370000) fermentation using Strain of Streptomyces Tsukubaensis.<br></p>Formula:C45H71NO12Color and Shape:NeatMolecular weight:818.043”-O-Demethyl Ivermectin
CAS:<p>Applications 3”-O-Demethyl Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C47H72O14Color and Shape:NeatMolecular weight:861.072-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide
CAS:Controlled Product<p>Impurity Diclofenac Impurity<br>Applications 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide is used as a reactant in the preparation of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives with in vitro cytotoxic activity on SW620 colon cancer cell lines.<br>References Virsodia, V., et. al.: Eur. J. Med. Chem., 44, 1355 (2009)<br></p>Formula:C14H10Cl3NOColor and Shape:WhiteMolecular weight:314.59Bimatoprost 13,14-Epoxide
<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>Formula:C25H37NO5Color and Shape:ColourlessMolecular weight:431.56(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C12H14N4O4Color and Shape:NeatMolecular weight:278.27(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity (>90%)
CAS:Formula:C44H69NO12Color and Shape:White To Light YellowMolecular weight:804.02S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride
CAS:Controlled Product<p>Applications S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride is an impurity from Clopidogrel (C587250) which acts as an anti-platelet agent.<br>References Zhu, Y. et al.: ACS. Med. Chem. Lett., 4, 349 (2013); Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formula:C15H16ClNO2S·ClHColor and Shape:NeatMolecular weight:346.272-(9H-Carbazol-1-yl)acetic Acid
CAS:Controlled ProductFormula:C14H11NO2Color and Shape:NeatMolecular weight:225.2434-Bromo Riluzole
CAS:Controlled Product<p>Applications 4-Bromo Riluzole is an impurity of Riluzole (R510000); a benzothiazole derivative that is used to treat amyotrophic lateral sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahamed, A., et al.: J. Pharm. Res., 3, 1028 (2010); Satyanarayana, B., et al.: ARKIVOC, no vol., 109 (2008)<br></p>Formula:C8H4BrF3N2OSColor and Shape:NeatMolecular weight:313.09N-Nitroso Propafenone (2,2,3,3,3-Propyl-D5)
Controlled ProductFormula:C21D5H21N2O4Color and Shape:NeatMolecular weight:375.4731,1’-Methylene Bis[Theobromine]
CAS:Controlled ProductFormula:C15H16N8O4Color and Shape:NeatMolecular weight:372.344,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxylic Acid Methyl Ester
CAS:Controlled ProductFormula:C26H26N4O5Color and Shape:NeatMolecular weight:474.5082-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
CAS:Controlled Product<p>Impurity Leflunomide EP Impurity H<br>Stability Hygroscopic<br>Applications 2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.<br>References Nikolakopoulos, G., et al.: Bioorg. Med. Chem., 14, 2358 (2006); Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 19, 1344 (2009)<br></p>Formula:C10H7F3N2OColor and Shape:NeatMolecular weight:228.17Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
CAS:<p>Applications Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.<br>References Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005);<br></p>Formula:C18H21NO4SColor and Shape:NeatMolecular weight:347.43(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS:<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists such as Ticagrelor (T437700)for the prevention of thrombosis.<br>References Springthorpe, B. et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007);<br></p>Formula:C9H9F2N·C8H8O3Color and Shape:NeatMolecular weight:321.325-Chloro-2-Thiophenecarboxylic Acid 4-Nitrophenyl Ester
CAS:Controlled ProductFormula:C11H6ClNO4SColor and Shape:NeatMolecular weight:283.69Febuxostat n-Butyl Isomer
CAS:Controlled Product<p>Applications Febuxostat n-butyl Isomer is an impurity of Febuxostat (F229000) which is a xanthine oxidase/xanthine dehydrogenase inhibitor.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Formula:C16H16N2O3SColor and Shape:NeatMolecular weight:316.372,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
CAS:Controlled Product<p>Impurity Flecainide EP Impurity D<br>Applications Flecainide Acetate Impurity D.<br>References Banitt, E., et al.: J. Med. Chem., 18, 1130 (1975),<br></p>Formula:C11H8F6O4Color and Shape:White To Off-WhiteMolecular weight:318.17(1S,2S,3R,5S)-3-[[3-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]amino]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
CAS:Controlled ProductFormula:C23H28F2N6O4SColor and Shape:NeatMolecular weight:522.57
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