Sulfonamides and Derivatives

<p>Impurity Glipizide EP Impurity G<br>Applications Methyl 4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate (Glipizide EP Impurity G) is an intermediate in the synthesis of Glipizide (G410225).<br>References Bakshi, M., et al.: J. Pharm. Biomed. Anal., 36, 769 (2004), Youssef, N., et al.: Chem. Pharm. Bull., 55, 541 (2007),<br></p>

<p>Applications 2-Methyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxide is an intermediate used in the synthesis of Amido Methyl Meloxicam (A576790), which is an impurity of Meloxicam (M216100).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lazer, E., et al.: J. Med. Chem., 40, 980 (1997),<br></p>

<p>Applications BIS(4-NITROPHENYL) SULFONE (cas# 1156-50-9) is a useful research chemical.<br></p>

<p>Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Impurity Glipizide EP Impurity F<br>Applications [2-[4-(Aminosulfonyl)phenyl]ethyl]carbamic Acid Ethyl Ester (Glipizide EP Impurity F) is a Glipizide (G410225) impurity.<br></p>

<p>Impurity Glipizide EP Impurity E<br>Applications 5-Desmethyl-6-methyl Glipizide (Glipizide EP Impurity E) is a Glipizide (G410225) impurity.<br>References Hoizey, G., et al.: Clin. Chem., 51, 1666 (2005), Singh, S., et al.: J. Pharm. Biomed. Anal., 41, 1037 (2006),<br></p>

<p>Applications Intermediate in the preparation of Indomethacin<br>References Kalgutkar, A.S., et al.: Bioorg. Med. Chem., 13, 6810 (2005),<br></p>

<p>Applications 2-Methyl-4-(1-methylethoxy)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide is an impurity of Piroxicam (P510000), a non-steroidal anti-inflammatory with long half-life.<br>References Carty, T.J., et al.: Prostaglandins, 47, 55 (1980); Brogden, R.N., et al.: Drugs, 22, 165 (1981); Mihalic, M., et al.: Anal. Profiles Drug Subs., 15, 509 (1986); Laneauville., O., et al.: J. Pharmacol. Exp. Ther., 271, 927 (1994)<br></p>

<p>Applications 2-Nitrophenyl Phenyl Sulfide is used in the study of non-nucleoside reverse transcriptase inhibitors of HIV-1.<br>References Chan, J., et al.: J. Med. Chem., 44, 1866 (2001); McMahon, J., et al.: Antimicro. Agents Chemother., 37, 754 (1993)<br></p>

<p>Stability Hygroscopic<br>Applications Mefenamic acid metabolite.<br>References Besunder, J., et al.: Clin. Pharmacokinet., 14, 261 (1988), Smith, P., et al.: Drug Metab. Dipos., 18, 639 (1990), Kraus, D., et al.: Clin. Pharmacol. Ther., 54, 351 (1993), Sato, J., et al.: Biol. Pharm. Bull., 16, 811 (1993),<br></p>

<p>Applications The major hydroxylated metabolite of Gliclazide (G409875).<br>References Miyazaki, H., et al.: Eur. J. Drug Metab. Pharmacokinet., 8, 117 (1983), Rieutord, A., et al.: Xenobiotica, 25, 1345 (1995),<br></p>

<p>2-Hydroxy-5-[2-[4-(2-imino-1(2H)-pyridinyl)phenyl]diazenyl]-benzoic acid (DPC) is a drug product that is used in pharmaceutical research and development. It is an impurity standard for HPLC analysis. DPC has been shown to be a metabolite of the drug product 2,6-dimethoxy-N-(3-methylphenyl)pyrimidine-4,6-diamine (DMX), which is used in the treatment of cancer. Impurities standards are important for ensuring the quality of drugs and ensuring that they are safe for human use. This product can also be synthesized from commercially available amino acids.</p>

<p>N-Acetyl zonisamide is a drug that is used in the treatment of epilepsy. It has a broad spectrum of activity and has been shown to be effective against seizures caused by both genetic and acquired conditions. N-Acetyl zonisamide's mechanism of action is not fully understood, but it may involve inhibition of carbonic anhydrase, modulation of serotonergic systems, and antagonism at adenosine receptors. Zonisamide also binds to glutamate and dopamine receptors in the brain, which may contribute to its clinical effects.</p>

<p>Hydrocortisone EP Impurity H is an analytical standard that is used as an impurity in the production of hydrocortisone. It has been shown to have a purity level of 99.5% and can be used as a reference standard for HPLC analysis. Hydrocortisone EP Impurity H can also be used as a reference standard for drug product development, API impurities, and drug metabolite identification.</p>

<p>Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.</p>