Sulfonamides and Derivatives

Applications An impurity contained in the commercial food Yellow No.5 (Sunset Yellow FCF) which has a potent mutagenicity effect.
References Yamada, M., et al.: Chem. Pharm. Bull., 44, 1624 (1996), Yamada, M., et al.: J. Food Chem., 3, 151 (1996),

Impurity Acetazolamide EP Impurity D Hydrochloride
Applications Acetazolamide intermediate. (Acetazolamide EP Impurity D Hydrochloride)
References Carta, F., et al.: Bioorg. Med. Chem. Lett., 19, 6649 (2009), Joseph, P., et al.: J. Med. Chem., 53, 2277 (2010), Srinivasu, P., et al.: J. Pharm. Biomed. Anal., 52, 142 (2010),

Applications 3-Hydroxyacetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) Chen, C., et al.: J. Biol. Chem., 283, 4543 (2008)(2) Reith, D., et al.: Clin. Exper. Pharmacol. Physiol., 36, 35 (2009) (3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)

Applications Aceclofenac-d2, is the labeled analogue of Aceclofenac (A130400), an anti-inflammatory and analgesic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yscla, A., et al.: Drugs Exp. Clin. Res., 14, 491 (1988), Ballesteros, R., et al.: Clin. Trials J., 27, 12 (1990)

Applications A drug used to treat tuberculosis.
References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005),

Applications α-Methyl-2-(2-methylpropyl)benzeneacetic Acid is used in pharmaceutical analysis, and also a constituent of major drug tablets.
References Asmus, P.A., et al.: J. Chromatogr., 331, 169 (1985)

Impurity Ibuprofen EP Impurity E
Applications 4'-Isobutylacetophenone (Ibuprofen EP Impurity E) is a degradation product of Ibuprofen in tablets, which is a known toxin. Ibuprofen (I140000) impuritiy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reynolds, D., et al.: Pharm. Technol., 26, 48 (2002), Wasylaschuk, W., et al.: J. Pharm. Sci., 96, 106 (2007),

Applications Sulfacetamide-d4 is the isotope labelled analog of Sulfacetamide. Sulfacetamide is an antibiotic used for the treatment of skin infections and urinary tract infections. Sulfacetamide is also used to treat acne and seborrheic dermatitis. Sulfacetamide was investigated for potential anti-inflammatory properties
References Wittwer, M.B., et al.: J. Med. Chem., 56, 781 (2013); Wang. X., et al.: Afr. J. Micriobiol., 6, 4533 (2012); Yu, B., et al.: Euro. J. Med. Chem., 46, 5833 (2011);

Impurity Hydrochlorothiazide EP Impurity B
Applications Diuretic. Hydrochlorothiazide EP Impurity B.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Joshi, S., et al.: J. Pharm. Biomed. Anal., 52, 362 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Impurity Paracetamol EP Impurity G
Applications 4’-Hydroxyacetophenone Oxime is an impurity of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) Sengupta, S., et al.: Metal. Based Drugs, 8, 293 (2002) (2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)

Applications rac cis-3-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic (MII-metabolite).
References Heptner, W., et al.: Pharmaceut. Res., 5, 215 (1984), Rydberg, T., et al.: Br. J. Clin. Pharm., 43, 373 (1997),

Impurity Furosemide EP Impurity D
Applications 4-Deschloro-4-(2-furanylmethyl)amino Furosemide (Furosemide EP Impurity D) is a Furosemide (F865000) Impurity.
References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Benet, L.Z.: J. Pharmacokinet. Biopharm., 7, 1 (1979)

Impurity Hydrochlorothiazide EP Impurity C
Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.
References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),

Applications Labelled Limaprost (L461500). Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),

Applications A Sulfamethoxazole metabolite.
References Gill, H., et al.: Br. J. Clin. Pharmacol., 42, 347 (1996), Winter, H., et al.: Clin. Pharmacol. Ther., 76, 579 (2004), Vyas, P., et al.: Biochem. Pharmacol., 70, 275 (2005), Vyas, P., et al.: Drug Metab. Dispos., 34, 16 (2006),