Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
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Found 2592 products of "Sulfonamides and Derivatives"
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2-(4-(Benzylamino)-2-ethylbutyl)-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride
CAS:2-(4-(Benzylamino)-2-ethylbutyl)-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride is a drug product used as an analytical standard for HPLC. It is a natural metabolite from the metabolism of lisinopril and other prodrugs. This impurity is found in drugs that are metabolized by cytochrome P450 enzymes including lisinopril, captopril, enalapril and benazepril. The impurity may be present in drugs with a niche market such as captopril and benazepril or drugs with a high purity such as enalapril. 2-(4-(Benzylamino)-2-ethylbutyl)-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride is typically synthesized by the reaction of 4-(benzylaminoFormula:C24H31NO3•HClPurity:Min. 95 Area-%Color and Shape:PowderMolecular weight:417.97 g/mol2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid 2-(carboxymethoxy)-2-oxoethyl ester
CAS:2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid 2-(carboxymethoxy)-2-oxoethyl ester is a drug product that belongs to the class of Custom synthesis. It is a metabolite of loratadine, an antihistamine drug. The compound is a metabolite of loratadine, which is an antihistamine drug used for the treatment of allergies. It is produced by the oxidation of loratadine by cytochrome P450 enzymes and can be detected in urine at concentrations up to 5 ng/mL. 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid 2-(carboxymethoxy)-2-oxoethyl ester has been shown to be effective in inhibiting the growth of bacteria that are resistant to penicillin and erythromycin.Formula:C18H15Cl2NO6Purity:Min. 95%Molecular weight:412.22 g/mol2-Hydroxy-5-[2-[4-[[(6-methyl-2-pyridinyl)amino]sulfonyl]phenyl]diazenyl]benzoic acid
CAS:2-Hydroxy-5-[2-[4-[[(6-methyl-2-pyridinyl)amino]sulfonyl]phenyl]diazenyl]benzoic acid is a synthetic drug product that has not been approved for clinical use. 2-Hydroxy-5-[2-[4-[[(6-methyl-2-pyridinyl)amino]sulfonyl]phenyl]- diazenyl]benzoic acid is a metabolite of the drug product, 3-(2,4,6,-trimethoxybenzoyl)-1-(pyridinium methyl) piperidine. This metabolite was isolated and characterized using high performance liquid chromatography (HPLC), gas chromatography (GC), and nuclear magnetic resonance spectroscopy.Formula:C19H16N4O5SPurity:Min. 95%Molecular weight:412.42 g/mol4-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
CAS:4-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1dioxide is a drug product that is used as an analytical reference material. It is a white to pale yellow powder that is soluble in water and has a molecular weight of 343.4 g/mol. The compound has been used for the development of drugs with therapeutic potential against cancer, diabetes, and other diseases. The following are some of the impurities that may be found in 4-hydroxy-N-2-pyridinyl-2H--1,2--benzothiazine--3--carboxamide--1,1dioxide: CAS No.: 65897 - 46 - 3 Molecular weight: 343.4 g/mol Melting point: Boiling point: Density: 1.7 g/cmFormula:C14H11N3O4SPurity:Min. 95%Molecular weight:317.32 g/molBromfenac sodium imp-B
CAS:Bromfenac sodium imp-B is an analytical standard that is used in drug development and research to measure the concentration of bromfenac in pharmaceutical products. Bromfenac sodium imp-B is a white to off-white crystalline powder with a melting point of about 230°C. It is soluble in methanol, ethanol, and acetone, but insoluble in water. Bromfenac sodium imp-B can be synthesized from the corresponding bromo acid chloride.Formula:C16H12BrNO2SPurity:Min. 95%Molecular weight:362.24 g/molrac-Ibuprofen amide
CAS:Ibuprofen amide is a nonsteroidal anti-inflammatory drug that belongs to the class of amides. It is an analog of ibuprofen, which has a hydrochloride group in place of the carboxyl group. Ibuprofen amide inhibits the production of pro-inflammatory chemicals by blocking cyclooxygenase enzymes, which are responsible for synthesis of prostaglandins and thromboxanes. The kinetic profile of this compound was obtained using fluorescence spectroscopy. This analytical method also showed that ibuprofen amide hydrolyzes in acidic conditions, suggesting that it may be active against bacteria that are found in an acidic environment.Formula:C13H19NOPurity:Min. 98 Area-%Molecular weight:205.3 g/mol1,1-Bis(p-isobutylphenyl)ethane
CAS:1,1-Bis(p-isobutylphenyl)ethane is an acid catalyst that can be used in the synthesis of alkyl esters. It is unreactive at high temperatures and can be reused many times. 1,1-Bis(p-isobutylphenyl)ethane is also a component of catalytic carbonylation reactions. It reacts with acetaldehyde to form a metal carbonyl complex, which then reacts with a carbon monoxide molecule to form an ester. Carbonylation reactions are often used to synthesize organic compounds from alkyl halides or alcohols. Carbonylation reactions are catalyzed by metal carbonyls, such as palladium and nickel complexes.Formula:C22H30Purity:Min. 95%Molecular weight:294.47 g/molN-Acetyl zonisamide
CAS:N-Acetyl zonisamide is a drug that is used in the treatment of epilepsy. It has a broad spectrum of activity and has been shown to be effective against seizures caused by both genetic and acquired conditions. N-Acetyl zonisamide's mechanism of action is not fully understood, but it may involve inhibition of carbonic anhydrase, modulation of serotonergic systems, and antagonism at adenosine receptors. Zonisamide also binds to glutamate and dopamine receptors in the brain, which may contribute to its clinical effects.
Formula:C10H10N2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:254.26 g/molHydrocortisone EP Impurity H
Hydrocortisone EP Impurity H is an analytical standard that is used as an impurity in the production of hydrocortisone. It has been shown to have a purity level of 99.5% and can be used as a reference standard for HPLC analysis. Hydrocortisone EP Impurity H can also be used as a reference standard for drug product development, API impurities, and drug metabolite identification.
Formula:C21H30O6Purity:Min. 95%Molecular weight:378.46 g/mol4-(Acetylamino)-3-bromobenzenesulfonyl chloride
CAS:4-(Acetylamino)-3-bromobenzenesulfonyl chloride is a white crystalline powder that is soluble in water, ethanol and chloroform. It has an analytical standard purity of 99% or greater. This compound can be used for research and development purposes as well as for the synthesis of pharmaceuticals. The impurity profile of 4-(acetylamino)-3-bromobenzenesulfonyl chloride includes 3-acetylbenzenesulfonic acid, sodium acetate, ammonium chloride, sodium sulfite, potassium bromide, potassium iodide, potassium carbonate, and potassium citrate.
Formula:C8H7BrClNO3SPurity:Min. 95%Molecular weight:312.57 g/mol1-Hydroxy-ibuprofen - Mixture of diastereoisomers
CAS:Ibuprofen is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, rheumatoid arthritis, menstrual cramps and pain. Ibuprofen is a racemic mixture of two enantiomers, ibuprofen and S (+) -ibuprofen. The dextran sulfate method is an analytical method used to determine the concentration of ibuprofen in biological fluids such as human serum or urine. This test can be done by first treating the sample with trifluoroacetic acid (TFA) to convert ibuprofen to its glucuronide conjugate. The glucuronide conjugates are then deproteinized with hydrochloric acid, which converts them into their corresponding carboxylated derivatives. This conversion allows for the separation of ibuprofen from interfering substances using preparative hplc and quantification using mass spectrometry. Toxicity studies have been conducted on bacteria strains and inflammatory bowelFormula:C13H18O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:222.28 g/molTorasemide Impurity E
CAS:Torasemide Impurity E is a drug product that belongs to the group of impurities. It is a natural product and can be found in the environment. Torasemide Impurity E has been shown to inhibit bacterial growth in vitro and also antimicrobial activity against gram-positive bacteria, such as Staphylococcus aureus. Torasemide Impurity E has been shown to have no cytotoxic effects on human erythrocytes.Formula:C15H17N3O4SPurity:Min. 95%Molecular weight:335.38 g/molAceclofenac ethyl ester
CAS:Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.
Formula:C18H17Cl2NO4Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:382.24 g/molN-(4-Hydroxyphenyl)propanamide
CAS:The N-(4-hydroxyphenyl)propionamide (HPPA) is a synthetic drug that binds to the human liver. It has been shown to be effective in preventing implantation of fertilized eggs, and can be used as a diagnostic agent for determining the presence of HPPA in human liver tissue. HPPA is also used as a diluent for other drugs. The HPPA binds to chromatographic components and can be detected using electrochemical detection, which allows it to be used as a targetable probe for cancer research. HPPA is also used to study iontophoretic transport of ions across reconstituted membranes in vitro.Formula:C9H11NO2Purity:(%) Min. 97%Molecular weight:165.19 g/mol3,4-Dihydro-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide
CAS:3,4-Dihydro-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide is a synthetic sulfoxide that is used as an antiinflammatory drug. It is a stable compound that can be used in the production of dimethyl sulfoxide and piroxicam. The purity of this compound is greater than 99.5%.Formula:C12H13NO5SPurity:Min. 95%Molecular weight:283.3 g/mol4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide
CAS:4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide is an analytical standard that is used in drug development and as a reference material. It is used to produce the USP/NF standard for HPLC and to develop new drugs. This compound is a metabolite of the drug clonidine hydrochloride. 4-Amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-(ethylamide) is also known by its CAS number 166863–9. It has a molecular weight of 328.5 g/mol and it's been approved by the FDA for use in food animals. Impurities found in this compound are: methanol, acetone, formic acid, acetic acid, chloroform and sulfamic acid. This product can be custom synthesized or obtained from natural sources such as plantFormula:C8H12ClN3O4S2Purity:Min. 95%Molecular weight:313.78 g/molSaccharin N-(2-acetic acid isopropyl ester)
CAS:Saccharin is a drug product that consists of saccharin N-isopropyl ester and an impurity standard. Saccharin is a synthetic sweetener that is found in the leaves of the herbaceous perennial S. dulcis, which has been used as a natural sweetener for centuries. Saccharin can be metabolized by humans to form 2-acetic acid and 4-methyl-1,2,3-thiadiazole (MTT) as a byproduct. The metabolite MTT may cause cancer in animals, but this has not been confirmed in humans. The pharmacopoeia specifies the purity of saccharin as 98% or greater. Metabolite standards are also provided for research purposes.Formula:C12H13NO5SPurity:Min. 95%Molecular weight:283.3 g/molTorasemide EP Impurity D
CAS:Torasemide EP Impurity D is a drug product or impurity. It is an analytical standard for purity testing of torasemide. Torasemide EP Impurity D is also a metabolite of torasemide and can be found in urine as well as other tissues. It is natural, but not naturally occurring. Research and Development studies of this impurity are ongoing to determine its pharmacological activity and niche applications.Formula:C17H22N4O3SPurity:Min. 95%Molecular weight:362.45 g/mol2- (Diethylboryl)pyridine
CAS:2- (Diethylboryl)pyridine is a custom synthesis drug product that is used in research and development for the treatment of cancer. 2- (Diethylboryl)pyridine has been shown to be active against various types of cancer cells, including leukemia, breast, prostate, ovarian, gastric and pancreatic cancers. This compound can also be used as an impurity standard for HPLC analysis.Formula:C9H14BNPurity:Min. 95%Molecular weight:147.03 g/mol4-(Diethylboranyl) pyridine
CAS:4-(Diethylboranyl)pyridine is a nucleophilic, anticoagulant drug. It interacts with the electronegative oxygen atoms in the guanine base of dna to form an adduct, which inhibits DNA synthesis. The hexameric cavity of 4-(Diethylboranyl)pyridine contains boron and nitrogen atoms, which are important for its activity. 4-(Diethylboranyl)pyridine also has antibacterial effects against gram-positive bacteria by inhibiting bacterial protein synthesis. This compound is synthetic and can be used in cocrystallized form as a single molecule or in hexameric form.Formula:C9H14BNPurity:Min. 95%Molecular weight:147.03 g/mol
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