Enzyme Activators and Inhibitors

Applications Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
References Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998), Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998), Law, B.K., et al.: J. Biol. Chem., 275, 10796 (2000),

Applications 3-(3-Ethoxy-4-methoxyphenyl)propionic-2,2,3,3-d4 Acid (CAS# 1398065-51-4) is a useful isotopically labeled research compound. This compound can be prepared as an FSH agonist that can be used to treat fertility disorders.
References Yu, H.et.al., U.S. Pat. Appl. Publ., (2015);

Applications 2,6-Dibromophenol-3,4,5-d3 (CAS# 1219803-14-1) is a useful isotopically labeled research compound.

Applications Maintains anti-proliferative activity against human malignant cell strains.
References Pratsinis, H. et al.: J. Med. Food, 13, 286 (2010);