APIs for research and impurities

<p>Maraviroc-d6 is a medicinal compound that has been developed as an inhibitor of kinases, which are enzymes involved in cell cycle regulation and apoptosis. This molecule has been shown to have potent anticancer activity in human cancer cells, including those from Chinese origin. Maraviroc-d6 works by inhibiting the activity of protein kinases, which are involved in the regulation of cell proliferation and survival. This inhibition leads to the induction of apoptosis, or programmed cell death, in cancer cells. Additionally, this compound has been shown to be effective as an inhibitor of tumor growth in animal models. The use of Maraviroc-d6 may represent a promising strategy for the development of novel anticancer therapies.</p>

<p>7-Chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester is a synthetic compound that has not been evaluated in humans. Studies have shown that the drug can be hydrolyzed to 7-chloro-6-fluoroquinoline 1,1′-(ethylenedioxy)bis(ethane), which is an impurity of norfloxacin. The ethyl esters of 7-chloroquinoline are also known to condense with formaldehyde and hydrolyze to 7-chloroquinolinic acid. This product may contain solvents such as acetone, chloroform, and alcohols that are used during the synthesis process. Decarboxylation of the drug occurs when it is heated at high temperatures in the presence of a catalyst, such as pyridine or sodium methoxide. It decarboxyl</p>

<p>Salmeterol dimer impurity is a drug product. It is a custom synthesis with high purity. The metabolite of this compound is salmeterol, which is an active ingredient in the asthma medication Serevent (salmeterol xinafoate). Salmeterol dimer impurity has been shown to be a natural metabolite of salmeterol. Salmeterol dimer impurity has also been shown to have anti-inflammatory properties. This compound can be found as an analytical standard for HPLC and used for research and development purposes.</p>

<p>SLMP53-1 is an anticancer agent that has been shown to induce apoptosis in cancer cells. It works by inhibiting kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. SLMP53-1 has been found to be effective against a variety of tumors, including those of the bladder, breast, and lung. In addition, it has shown promising results as a potential treatment for Chinese hamster ovary (CHO) cells and human cancer cell lines. SLMP53-1 is also an analog of hepcidin, a protein that regulates iron metabolism in the body. Its unique structure allows it to bind specifically to cancer cells without affecting healthy cells, making it a promising candidate for targeted cancer therapy.</p>

<p>Pirtenidine is a potent and selective kinase inhibitor that has been shown to inhibit the activity of cyclin-dependent kinases. It has demonstrated promising results in preclinical studies as an anticancer agent, inducing apoptosis in cancer cells. Pirtenidine is an analog of protein kinase inhibitors, which have been used to treat various types of tumors. It has been found to be effective against human cancer cell lines and has shown significant tumor growth inhibition in animal models. Pirtenidine has also been reported to be a potent urine inhibitor of Chinese hamster ovary cells, making it a promising candidate for the treatment of urinary tract cancers.</p>

<p>Fonofos is a potent inhibitor that has been shown to induce apoptosis in Chinese hamster ovary cells. It is also known to inhibit chitin kinase, a protein that plays an important role in the biosynthesis of chitin, which is essential for the formation of cell walls in fungi and insects. Fonofos has medicinal properties and has been studied as a potential anticancer agent due to its ability to inhibit tumor growth. In vitro studies have shown that Fonofos can inhibit the growth of human cancer cells by inhibiting heparin-binding proteins. Additionally, it has been found to have inhibitory effects on several other enzymes involved in cancer development and progression. Although not approved for use in humans, Fonofos may hold promise as a therapeutic agent for the treatment of certain cancers.</p>

<p>Miproxifene is a potent anticancer drug that has been shown to induce apoptosis and inhibit cell cycle progression in human cancer cells. This drug has been extensively studied in Chinese hamster ovary (CHO) cells and has demonstrated significant activity against various types of cancer, including leukemia. Miproxifene acts as a protein inhibitor and has been found to be effective against several tumor cell lines. It is a promising medicinal compound for the treatment of cancer, with potential applications in both chemotherapy and radiation therapy. Miproxifene is excreted primarily through urine and is well-tolerated by patients. Its use as an anticancer agent holds great promise for the future of cancer treatment.</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(1-Ethyl-1-methylpropyl)benzene is an impurity of some drugs. It is a metabolite of the drug, and can be found in urine or blood samples as a result of its excretion from the body. (1-Ethyl-1-methylpropyl)benzene is used as an analytical standard for HPLC analysis. This chemical is not on the USP list of impurities, but it is listed on the pharmacopoeia. The CAS number for (1-Ethyl-1-methylpropyl)benzene is 1985-97-3.</p>

<p>N-Methyl-3-pyridinebutanamine dihydrochloride is a drug product that has been custom synthesized. This product is intended for analytical, research and development, or pharmacopoeia purposes. The CAS number of this substance is 3000-74-6. This product includes impurities at levels below 1% (w/w). The purity level of this product is &gt;98% (w/w).</p>

<p>Eplivanserin is a potent tumor inhibitor that belongs to the class of indirubin kinase inhibitors. It has shown great promise as an anticancer agent due to its ability to induce apoptosis in cancer cells and inhibit their growth cycle. Eplivanserin has been found to be effective against a variety of cancers, including breast, lung, and prostate cancer. This medicinal compound is derived from Chinese herbs and has been extensively studied for its potential in cancer treatment. In addition, eplivanserin has been found in urine samples from humans, indicating that it may have potential as a diagnostic tool for cancer detection. Its protein targets are still being investigated, but it is believed that eplivanserin works by inhibiting key enzymes involved in cell signaling pathways that promote cancer cell growth and survival.</p>

<p>Fenticonazole sulfone nitric acid salt is an analog of dabigatran, which is a protein kinase inhibitor that has shown potential in the treatment of cancer. It induces apoptosis in human cancer cells and inhibits the activity of various kinases involved in tumor growth and proliferation. Fenticonazole sulfone nitric acid salt has been studied extensively for its anticancer properties, showing promising results in Chinese hamster ovary cells and urine samples from cancer patients. This drug also exhibits inhibitory effects on protein kinases that are involved in the regulation of cell cycle progression, angiogenesis, and metastasis. Overall, Fenticonazole sulfone nitric acid salt holds great promise as a potential anticancer agent.</p>

<p>Please enquire for more information about Acrolein-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Chloro-2-hydroxyimipramine is a potent anticancer agent that has shown promising results in preclinical studies. This compound is a kinase inhibitor that targets cancer cells and induces apoptosis, leading to tumor regression. It has been found in urine samples of Chinese medicinal herb users and shows an analog structure to imipramine, an antidepressant drug. 3-Chloro-2-hydroxyimipramine inhibits kinases involved in cell proliferation and survival, making it a potential treatment option for various types of cancer in humans. Its anti-cancer properties make it an attractive candidate for further research and development as a potential therapeutic agent.</p>

<p>NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.</p>

<p>(7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid di-gamma-lactone is a synthetic analogue of progesterone. It is used as a drug product for research and development purposes. The product has been shown to be metabolized through the 3beta hydroxysteroid dehydrogenase pathway or the side chain cleavage enzyme pathways. This product has not been evaluated in humans and should not be used for any human applications. (7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21 -dicarboxylic acid di gamma lactone is an impurity standard for HPLC analysis of progesterone in urine.</p>

<p>3-Dodecenal is a human analog that has been studied for its potential anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in tumor cells. This medicinal compound acts as an inhibitor of protein kinases, which play a crucial role in regulating the cell cycle and are often overactive in cancer cells. 3-Dodecenal has shown promising results in inhibiting cancer cell growth in Chinese hamster ovary cells and may have potential as a natural alternative to traditional cancer treatments. In addition, this compound has been detected in human urine and is believed to have potential health benefits beyond its anticancer properties.</p>

<p>Olaparib impurity 14 is a metabolite of olaparib. Olaparib is a drug used to treat cancer by inhibiting the activity of PARP1, an enzyme that repairs DNA damage. This impurity is a compound that can be synthesized in high purity and quality with a custom synthesis service. It has been shown to have niche applications in pharmacopoeia, drug development, and analytical studies.</p>

<p>(3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate is a synthetic metabolite of the drug etravirine. It is an impurity in the drug product. The impurity is characterized as a white to off-white crystalline solid with a molecular weight of 531.6 g/mol and melting point of 170°C. It is soluble in methanol, ethanol, acetone and chloroform, but insoluble in water. (3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate can be synthesized from commercially available starting materials</p>

<p>Please enquire for more information about 3-(2-Bromoethyl)-7-hydroxy-4-methyl-coumarin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>RS 45041-190 hydrochloride is a selective antagonist of the imidazoline receptor, which is a type of receptor ligand. RS 45041-190 hydrochloride blocks the binding of dopamine to its receptors in the cerebral cortex and blood pressure regulation. This drug also blocks adrenoceptors and 5-hydroxytryptamine (5-HT) receptors. RS 45041-190 hydrochloride is an equated drug that has been shown to be effective for inflammatory pain caused by nerve injury. It has not been proven to be effective for other types of pain.</p>

<p>Please enquire for more information about (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-vinyl-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Triclosan o-β-D-glucuronide sodium salt is an analog of Triclosan, which is a potent inhibitor of bacterial enoyl-acyl carrier protein reductase. It has been shown to have anticancer properties, inhibiting the growth of cancer cells by inducing apoptosis and inhibiting kinase activity. This compound has been found to be effective against a variety of tumors and cancers, including thyroid cancer. Triclosan o-β-D-glucuronide sodium salt has also been shown to inhibit the activity of human protein kinases, making it a potential candidate for the development of new anticancer drugs. This compound can be detected in urine samples from both humans and Chinese hamsters, indicating its potential for use as a diagnostic tool for cancer detection.</p>

<p>aR453588 is a human analog of Voriconazole, which has been found to have anticancer properties. This compound is a kinase inhibitor that works by inducing apoptosis in cancer cells. It has been shown to be effective against various types of tumors, including those resistant to other inhibitors. aR453588 also inhibits the growth of cancer cells by blocking protein synthesis and cell division. This compound is derived from cellulose and can be detected in urine samples after administration. Overall, aR453588 shows great promise as a potential treatment for cancer.</p>

<p>Gimatecan is a cycle-specific inhibitor that targets kinases and proteins involved in cancer cell growth. It is a medicinal compound that has been shown to be effective against various types of human cancers. Gimatecan works by inhibiting the activity of protein kinases, which are enzymes that promote cell division and proliferation. This inhibition leads to apoptosis, or programmed cell death, in tumor cells. Gimatecan has been tested extensively in Chinese hamster ovary cells and has demonstrated potent anticancer activity. The compound is excreted primarily through urine and has shown promising results as an anticancer agent in preclinical studies.</p>

<p>Please enquire for more information about Rosuvastatin EP Impurity C sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Xanthoxin is a medicinal compound with potent anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. Xanthoxin has been tested in various cancer cell lines, including Chinese and human cells, and has demonstrated strong inhibitory effects on the tumor cycle. This compound works by inhibiting kinases and other proteins involved in cancer cell growth and proliferation. Xanthoxin is also known to be an inhibitor of certain urinary proteins that are associated with cancer progression. Overall, Xanthoxin shows great potential as a natural product for the development of novel anticancer therapies.</p>

<p>Piquindone is a medicinal compound that has shown promising anticancer properties in human tumor cells. It acts as an inhibitor of protein kinases, which are enzymes that regulate cell growth and division. Piquindone is an analog of a natural product found in Chinese urine and has been studied for its ability to induce apoptosis, or programmed cell death, in cancer cells. This compound has shown potent activity against various types of cancer cells and may have potential as a therapeutic agent for the treatment of cancer. Its mechanism of action involves the inhibition of specific kinases involved in cancer cell proliferation and survival. Piquindone is being investigated further for its potential as a cancer cell inhibitor.</p>

<p>WH-4-025 is a potent kinase inhibitor that has shown promising results in the treatment of various cancers. It is derived from Chinese medicinal herbs and has been extensively studied for its anticancer properties. WH-4-025 works by inhibiting the activity of specific kinases that are involved in tumor growth and cell cycle regulation. It has been shown to induce apoptosis in cancer cells, leading to their death, and also inhibit the growth of leukemia cells. This protein inhibitor has been found to be effective against a wide range of human cancers and is currently being investigated as a potential therapy for cancer patients. WH-4-025 is excreted through urine, making it an attractive candidate for further development as an anticancer drug.</p>

<p>Surfactin is a cyclic lipopeptide that has been found in urine and has shown potential as an anticancer agent. It has been shown to inhibit kinases, including indirubin and Chinese hamster ovary cell tumor kinase, which are involved in cancer cell proliferation. Surfactin analogs have also been developed as inhibitors of cancer cell growth and inducers of apoptosis. In addition to its anticancer properties, surfactin has been found to have antimicrobial activity against a variety of bacteria, including Clostridium perfringens. Overall, surfactin shows promise as a multifunctional therapeutic agent with potential applications in both cancer treatment and microbial control.</p>

<p>Lincomycin impurity B is a chemical substance which is the result of the metabolism of lincomycin. It is found in the urine and feces of patients who have taken lincomycin orally. Lincomycin impurity B has been detected in various commercial formulations of lincomycin, but its concentration varies with different batches. The HPLC standard purity for lincomycin impurity B is up to 99%. Lincomycin impurity B can be used as an analytical standard for HPLC analysis and as an API impurity in drug development. It also may be used as a research metabolite or pharmacopoeia reference material.</p>

<p>CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.</p>

<p>Please enquire for more information about Tadalafil spiro-urethane impurity (EP impurity F) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Flupirtine-N2-β-D-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amlodipine EP Impurity F maleate is an impurity of amlodipine, a drug product. It is a natural substance that has been classified as an API impurity in the United States Pharmacopeia (USP). The chemical name for this drug is 3-(2-chlorophenyl)-1-methyl-5-(o-tolyloxy)-2,4-dihydro-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-one. Amlodipine EP Impurity F maleate has the following properties: C12H9ClNO2S and a melting point of 210°C with a purity of 99.5%. This compound was synthesized by custom synthesis and is used as an analytical standard for HPLC. This compound was also used during the development of amlodipine to determine its metabolism studies.</p>

<p>Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.</p>

<p>Sitagliptin monohydrochloride monohydrate is an inhibitor of dipeptidyl peptidase-4 (DPP-4), which is responsible for the degradation of incretin hormones. It is used in the treatment of type 2 diabetes mellitus, as it increases insulin secretion and reduces blood glucose levels. Recent studies have shown that Sitagliptin has anticancer properties, as it induces apoptosis in cancer cells. It also inhibits protein kinases, which are involved in tumor growth and metastasis. Capsaicin, a compound found in chili peppers, has been shown to enhance the anticancer activity of Sitagliptin in Chinese hamster ovary cells. The drug is excreted primarily through urine and has a low potential for drug interactions with other kinase inhibitors. Overall, Sitagliptin monohydrochloride monohydrate shows great promise as both a diabetes medication and an anticancer agent.</p>

<p>Please enquire for more information about Emtricitabine impurity 17 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,2',4,4',6,6'-Hexachlorobiphenyl (PCB-136) is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It acts as a kinase inhibitor by blocking the activity of specific kinases involved in tumor growth and progression. PCB-136 has been studied extensively in human and Chinese hamster ovary cells and has been found to be highly effective against various types of cancer. This medicinal analog also exhibits inhibitory effects on the protein kinases that regulate cell division and proliferation, making it a promising candidate for cancer therapy. In addition, PCB-136 shows potential for use as a urinary biomarker for exposure to environmental pollutants due to its persistence in the environment and ability to accumulate in body tissues.</p>

<p>(-)-Sabinene is a natural compound found in urine and various medicinal plants, including Chinese herbs. It has been identified as an analog of another natural compound that exhibits potent anticancer activity. (-)-Sabinene has been shown to inhibit the activity of certain proteins involved in cell cycle regulation and apoptosis, which are important processes for the growth and survival of cancer cells. In addition, (-)-Sabinene has been found to have inhibitory effects on tumor kinase activity, making it a promising candidate for the development of new anticancer drugs. Studies have shown that (-)-Sabinene can effectively inhibit the growth of various types of cancer cells, making it a potential therapeutic agent for the treatment of cancer.</p>