APIs for research and impurities

Polyethylene glycol monoisotridecyl ether (PEG-DTAE) is a polymer that can be used as an antimicrobial agent. It is active against Gram-positive bacteria but not against Gram-negative bacteria. PEG-DTAE has anti-angiogenic effects, which may be due to its ability to inhibit the growth of new blood vessels and thereby prevent the spread of infection. In vitro assays have shown that PEG-DTAE can induce cell lysis and hemolysis in test samples. PEG-DTAE has been shown to have hemolytic activity in vivo in rats, with histology sections showing inflammation and necrosis in the spleen and liver. This polymer also causes symptoms such as fever, chills, rigors, and hypotension in patients with chronic renal failure who are undergoing dialysis.

(-)-Nefopam is a medicinal compound that acts as an inhibitor of kinases, which are enzymes involved in many cellular processes. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. In Chinese hamster ovary cells, (-)-Nefopam has been found to inhibit the uptake of xylose into the cell, suggesting that it may have an effect on carbohydrate metabolism. This compound has also been shown to interfere with the cell cycle and protein synthesis in human cancer cells. Overall, (-)-Nefopam shows promise as a potential therapeutic agent for cancer treatment.

Ambrisentan is a drug product that is used in the treatment of pulmonary hypertension. Ambrisentan is metabolized to ambrisentan acyl β-D-glucuronide, a natural metabolite that has been synthesized as an analytical standard. It also shows antihypertensive activity and is currently under development for use in the treatment of heart failure.

Please enquire for more information about 4-(Diphenylmethylene)-1-methylpiperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7-Desmethyl-9-(5-oxohexyl) pentoxifylline including the price, delivery time and more detailed product information at the technical inquiry form on this page

(S,S)-Dihydro bupropion hydrochloride (Bupropion) is an antidepressant that is used for the treatment of major depressive disorder and seasonal affective disorder. It is a racemic mixture of the two enantiomers, (S,S) and (R,R), with the former being more active than the latter. The drug product contains a racemic mixture of (S,S) and (R,R) in a ratio of approximately 97:3. The analytical impurity in this product is N-desmethyl-bupropion. This impurity has not been found to be pharmacologically active. Bupropion may be synthesized by reacting benzaldehyde with propargyl bromide in presence of sodium hydroxide in ethanol to form a cyclic imine intermediate which is then hydrolyzed to yield bupropion

Please enquire for more information about Loxoprofen methyl-d3 ethyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

(2S, 4'S, 8'R)-α-Tocopherol is a natural form of vitamin E that is commonly found in Chinese medicinal herbs. It has been shown to have potent anticancer properties and can inhibit the growth of cancer cells by inducing apoptosis. This protein analog acts as an inhibitor of tumor cell kinase activity, which is essential for cell division and proliferation. (2S, 4'S, 8'R)-α-Tocopherol has been studied extensively for its ability to prevent cancer development and progression in humans. It has been found in human urine and may be used as a biomarker for cancer risk assessment. This compound has also been used in the development of novel kinase inhibitors that target specific kinases involved in cancer cell growth and proliferation.

4-(Acetylamino)-3-bromobenzenesulfonyl chloride is a white crystalline powder that is soluble in water, ethanol and chloroform. It has an analytical standard purity of 99% or greater. This compound can be used for research and development purposes as well as for the synthesis of pharmaceuticals. The impurity profile of 4-(acetylamino)-3-bromobenzenesulfonyl chloride includes 3-acetylbenzenesulfonic acid, sodium acetate, ammonium chloride, sodium sulfite, potassium bromide, potassium iodide, potassium carbonate, and potassium citrate.

Please enquire for more information about 2,5-Dioxabicyclo[2.2.1]heptane α-D-galactopyranoside including the price, delivery time and more detailed product information at the technical inquiry form on this page

Diclofenac dimer impurity is a synthetic impurity that is used as a research and development, impurity standard, custom synthesis, drug product, and analytical standard. It is a high purity, CAS No. 1609187-30-5, pharmacopoeia (USP), Drug development (DSD), Metabolite (MET), niche, analytical standard. Diclofenac dimer impurity is a natural metabolite of diclofenac in humans and other animals. The chemical name for the metabolite is 2-(dichlorophenyl) propionic acid or 2-[2-chloro-4-(2,2-dichlorovinyl)phenoxy]propanoic acid. Diclofenac dimer impurity may be synthesized by reacting diclofenac with paraformaldehyde followed by hydrolysis with sodium hydroxide or potassium hydroxide. HPLC analysis

Cefixime EP Impurity C disodium is an impurity in the drug Cefixime EP. It is a by-product of the synthesis process, which can be removed by a purification process. This product is an analytical standard and is used for qualitative analysis in HPLC. It is also used as a research and development standard for drug development. This product has been classified as a niche impurity since it only occurs at trace levels in the drug product, but it may have pharmacological relevance to some patients. This impurity can be synthesized from natural or synthetic sources and is available for custom synthesis to meet specific customer needs.

(3α)-Allopregnanolone sulfate is a medicinal compound with potential anticancer properties. It is an analog of the natural hormone allopregnanolone and has been shown to inhibit kinases involved in cancer cell proliferation and survival. This compound induces apoptosis, or programmed cell death, in cancer cells by targeting proteins that regulate cell growth and division. (3α)-Allopregnanolone sulfate has been studied as a potential inhibitor of tumor growth in human cancer cells and has shown promising results. It can be detected in urine samples and has also been used in Chinese traditional medicine for its medicinal properties.

Please enquire for more information about Des(methylpiperazinyl) imatinib dimer piperazinium chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,2'-Bisnalmefene is a short-acting opioid antagonist that has been used for the treatment of alcohol dependence. It is effective in reducing alcohol intake and craving and it may be used to help maintain abstinence from alcohol. 2,2'-Bisnalmefene is an injectable drug that can be administered intravenously or intramuscularly. The drug should not be injected into a vein or artery because this will cause serious adverse effects. The most common adverse effect of 2,2'-bisnalmefen is respiratory depression followed by nausea and vomiting.

Atorvastatin is a drug product that is designed for the treatment of dyslipidemia, hypercholesterolemia, and mixed dyslipidemia. It is an impurity in the drug product Atorvastatin EP. Impurity B is a natural metabolite that has been found to have a niche market as an analytical standard for HPLC. The metabolite can be synthesized with high purity and quality standards, which are suitable for use in pharmacopoeia and research and development.

Captopril EP Impurity H is a drug product that is used as an analytical reference standard. It is not intended for administration to humans or animals. Captopril EP Impurity H is manufactured by the same process as Captopril, but with a different impurity profile. The purity of this product is 99.5% at 25°C, and it has an impurity profile of less than 0.5%. This product is also known as 4-Amino-N-(2,6-dichlorophenyl)benzenesulfonamide and has CAS No. 205521-07-9.

Taiwanin C is an analog of dabigatran, a potent inhibitor of kinases that has been shown to have anticancer properties. It has been found to inhibit the growth of tumor cells in vitro and in vivo, inducing apoptosis and reducing protein expression. Taiwanin C has also shown promising results in inhibiting the activity of various kinases involved in cancer cell proliferation and survival. This compound is derived from Chinese herbal medicine and can be detected in urine after administration. Its potential as an anticancer agent makes it a promising area for further research into new cancer therapies.

Hydroxymethyl tolperisone is a medicinal compound that has been identified as a kinase inhibitor with potential anticancer properties. It has shown promising results in inhibiting the growth of leukemia cells and tumor cell lines in human studies. Hydroxymethyl tolperisone works by interfering with protein synthesis, disrupting the cell cycle, and inducing apoptosis in cancer cells. This compound has also been found to be effective against various types of cancer, including breast, lung, and colon cancer. Hydroxymethyl tolperisone is an analog of tolperisone, a muscle relaxant that is excreted primarily through urine. The use of this compound as an anticancer agent is still under investigation, but it holds great promise for the future of cancer treatment.

Profluazol is an inhibitor of protein kinases that has shown potential in the treatment of cancer. This Chinese indole derivative has been found to inhibit the proliferation of leukemia cells and induce apoptosis in tumor cell lines. Profluazol specifically targets kinases involved in the regulation of cell cycle progression, such as cyclin-dependent kinase 2 (CDK2) and mitogen-activated protein kinase (MAPK), leading to a decrease in cancer cell growth. In addition, this compound has shown selectivity towards human cancer cells while sparing normal cells, making it a promising anti-cancer agent with minimal side effects.

Propylthiouracil-d5 is a drug product that is used in the development of drugs. Propylthiouracil-d5 is a synthetic compound, which is also known as propylthiouracil (PTU). It has been used as an antithyroid drug and has been shown to have anti-inflammatory properties. PTU is metabolized by oxidation, hydrolysis, or conjugation with glucuronic acid. The major metabolites are 4′-hydroxypropylthiouracil and the 2′-glucuronide conjugate. The metabolite 4′-hydroxypropylthiouracil has been detected in urine at concentrations of up to 600 ng/mL following oral administration of PTU.

Roxithromycin impurity H is an analytical standard for Roxithromycin. It is a metabolite that has been identified in human urine and bile samples as well as in rat plasma following oral administration of Roxithromycin. It is also a byproduct of the synthesis of Roxithromycin, which can be eliminated through purification steps. This compound has not yet been evaluated in humans or animals, but it may cause adverse effects such as gastrointestinal disturbances, headache, or hepatotoxicity.

Please enquire for more information about 3-(2-Bromoethyl)-7-hydroxy-4-methyl-coumarin including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is a white to off-white solid that is soluble in water and acidic solutions. It has an impurity level of less than 0.5%. The melting point of 3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] balsalazide is approximately 195°C. This compound has been shown to have antibiotic activity against a variety of bacteria, including methicillin resistant Staphylococcus aureus (MRSA).

N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is an impurity in the drug product. It is a synthetic compound and is a metabolite of the drug product. N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] udenafil is present as a byproduct of the metabolism of the active ingredient. The CAS number for this substance is 319491-68-4. This impurity has been observed to have niche applications in research and development and analytical studies. It has also been found to be pharmacopoeia grade, which means it meets or exceeds purity standards set by regulatory authorities.