APIs for research and impurities

<p>Pirtenidine is a potent and selective kinase inhibitor that has been shown to inhibit the activity of cyclin-dependent kinases. It has demonstrated promising results in preclinical studies as an anticancer agent, inducing apoptosis in cancer cells. Pirtenidine is an analog of protein kinase inhibitors, which have been used to treat various types of tumors. It has been found to be effective against human cancer cell lines and has shown significant tumor growth inhibition in animal models. Pirtenidine has also been reported to be a potent urine inhibitor of Chinese hamster ovary cells, making it a promising candidate for the treatment of urinary tract cancers.</p>

<p>Salmeterol dimer impurity is a drug product. It is a custom synthesis with high purity. The metabolite of this compound is salmeterol, which is an active ingredient in the asthma medication Serevent (salmeterol xinafoate). Salmeterol dimer impurity has been shown to be a natural metabolite of salmeterol. Salmeterol dimer impurity has also been shown to have anti-inflammatory properties. This compound can be found as an analytical standard for HPLC and used for research and development purposes.</p>

<p>Phenproxide is an analog of testosterone that has been used traditionally in Chinese medicine to treat tumors. It has been found to induce apoptosis in cancer cells by inhibiting kinases, which are enzymes that regulate cellular processes such as cell division and growth. Phenproxide has also been shown to inhibit the activity of somatostatin, a hormone that regulates the release of other hormones. This inhibition may contribute to its anti-cancer properties. In addition, Phenproxide has been shown to have an effect on hyaluronan metabolism, a substance involved in tissue repair and inflammation. It is excreted in urine and may be used as a potential biomarker for cancer diagnosis or monitoring.</p>

<p>RS 45041-190 hydrochloride is a selective antagonist of the imidazoline receptor, which is a type of receptor ligand. RS 45041-190 hydrochloride blocks the binding of dopamine to its receptors in the cerebral cortex and blood pressure regulation. This drug also blocks adrenoceptors and 5-hydroxytryptamine (5-HT) receptors. RS 45041-190 hydrochloride is an equated drug that has been shown to be effective for inflammatory pain caused by nerve injury. It has not been proven to be effective for other types of pain.</p>

<p>7-Chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester is a synthetic compound that has not been evaluated in humans. Studies have shown that the drug can be hydrolyzed to 7-chloro-6-fluoroquinoline 1,1′-(ethylenedioxy)bis(ethane), which is an impurity of norfloxacin. The ethyl esters of 7-chloroquinoline are also known to condense with formaldehyde and hydrolyze to 7-chloroquinolinic acid. This product may contain solvents such as acetone, chloroform, and alcohols that are used during the synthesis process. Decarboxylation of the drug occurs when it is heated at high temperatures in the presence of a catalyst, such as pyridine or sodium methoxide. It decarboxyl</p>

<p>Please enquire for more information about Flupirtine-N2-β-D-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Methyl-3-pyridinebutanamine dihydrochloride is a drug product that has been custom synthesized. This product is intended for analytical, research and development, or pharmacopoeia purposes. The CAS number of this substance is 3000-74-6. This product includes impurities at levels below 1% (w/w). The purity level of this product is &gt;98% (w/w).</p>

<p>Surfactin is a cyclic lipopeptide that has been found in urine and has shown potential as an anticancer agent. It has been shown to inhibit kinases, including indirubin and Chinese hamster ovary cell tumor kinase, which are involved in cancer cell proliferation. Surfactin analogs have also been developed as inhibitors of cancer cell growth and inducers of apoptosis. In addition to its anticancer properties, surfactin has been found to have antimicrobial activity against a variety of bacteria, including Clostridium perfringens. Overall, surfactin shows promise as a multifunctional therapeutic agent with potential applications in both cancer treatment and microbial control.</p>

<p>Please enquire for more information about 1,5-Bis(4-amidinophenoxy)-2-pentanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Chloro-2-hydroxyimipramine is a potent anticancer agent that has shown promising results in preclinical studies. This compound is a kinase inhibitor that targets cancer cells and induces apoptosis, leading to tumor regression. It has been found in urine samples of Chinese medicinal herb users and shows an analog structure to imipramine, an antidepressant drug. 3-Chloro-2-hydroxyimipramine inhibits kinases involved in cell proliferation and survival, making it a potential treatment option for various types of cancer in humans. Its anti-cancer properties make it an attractive candidate for further research and development as a potential therapeutic agent.</p>

<p>N-Desmethyl trimeprazine is a synthetic compound, which is an impurity of the drug product. It is not active and does not possess any biological activity. It is a metabolite of the parent drug, Trimeprazine. N-Desmethyl trimeprazine has been studied for its pharmacological properties and metabolism in the body, but no conclusive results have been found. The chemical structure and purity of N-Desmethyl trimeprazine are not listed in the USP or BP. This compound can be custom synthesized on request.</p>

<p>N-Methyl-4-phenylpiperidine is a synthetic drug that acts as a stimulant. It is a structural analog of the neurotransmitter acetylcholine and has been shown to have similar effects in knockout mice. N-Methyl-4-phenylpiperidine is metabolized by hydrolysis of the amide group, leading to the formation of alphaprodine and hydroxyphenylacetic acid. This drug has been shown to inhibit dopamine and serotonin uptake in rats, which may be related to its psychostimulant effects. Clinical pharmacology studies have shown that this drug can increase blood pressure, heart rate, and respiration rates in humans.</p>

<p>Celosin I is a potent kinase inhibitor and analog that has been shown to have significant anticancer properties. It works by inhibiting the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. Celosin I has been found to induce apoptosis, or programmed cell death, in cancer cells, making it a promising therapeutic agent for the treatment of various types of tumors. This medicinal compound has been isolated from the urine of Chinese individuals and has been extensively studied for its potential as an anticancer drug. Celosin I is a promising candidate for further development as a cancer therapy due to its high potency and selectivity towards cancer cells.</p>

<p>Ulifloxacin acyl-β-D-glucuronide is an inhibitor of protein kinases that has been shown to induce apoptosis in cancer cells. This compound is a metabolite of ulifloxacin, a fluoroquinolone antibiotic used to treat urinary tract infections. Ulifloxacin acyl-β-D-glucuronide has potent anticancer activity and has been shown to inhibit the growth of tumor cells in vitro. This compound is an analog of other kinase inhibitors and has been extensively studied in Chinese hamster ovary (CHO) cells, where it was found to be effective against various types of cancer. Ulifloxacin acyl-β-D-glucuronide also possesses toxin-binding properties and may have potential as an anti-toxin agent.</p>

<p>Please enquire for more information about 3-(2-Bromoethyl)-7-hydroxy-4-methyl-coumarin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-vinyl-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid di-gamma-lactone is a synthetic analogue of progesterone. It is used as a drug product for research and development purposes. The product has been shown to be metabolized through the 3beta hydroxysteroid dehydrogenase pathway or the side chain cleavage enzyme pathways. This product has not been evaluated in humans and should not be used for any human applications. (7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21 -dicarboxylic acid di gamma lactone is an impurity standard for HPLC analysis of progesterone in urine.</p>

<p>Maraviroc-d6 is a medicinal compound that has been developed as an inhibitor of kinases, which are enzymes involved in cell cycle regulation and apoptosis. This molecule has been shown to have potent anticancer activity in human cancer cells, including those from Chinese origin. Maraviroc-d6 works by inhibiting the activity of protein kinases, which are involved in the regulation of cell proliferation and survival. This inhibition leads to the induction of apoptosis, or programmed cell death, in cancer cells. Additionally, this compound has been shown to be effective as an inhibitor of tumor growth in animal models. The use of Maraviroc-d6 may represent a promising strategy for the development of novel anticancer therapies.</p>

<p>2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide is an analog of saxagliptin, a protein inhibitor that has been shown to induce apoptosis in cancer cells. This compound has demonstrated potent anticancer activity in vitro and in vivo, inhibiting the growth of tumor cells by targeting kinases involved in cell proliferation and survival. It has also been found to be effective against a variety of human cancer types, including breast, prostate, and lung cancer. Additionally, 2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide has been shown to have potential as a urine biomarker for detecting early-stage Chinese bladder cancer. Overall, this compound shows promise as a potent inhibitor of cancer cell growth and may have important applications in the development of novel anticancer therapies.</p>

<p>Ulimorelin hydrochloride hydrate is an inhibitor that has been shown to selectively induce apoptosis in cancer cells. This medicinal compound is a protein analog that inhibits the activity of kinases, which are enzymes that play a critical role in tumor growth and progression. Ulimorelin hydrochloride hydrate has been tested on human cancer cell lines and has demonstrated potent anticancer activity. Additionally, it has been found to have inhibitory effects on Chinese hamster ovary (CHO) cells, which suggests potential therapeutic applications beyond cancer treatment. Ulimorelin hydrochloride hydrate is excreted primarily via urine and may be the basis for future research in developing new kinase inhibitors for treating various types of cancer.</p>

<p>Gemcitabine diphosphate triethylamine salt is an inhibitor that has been shown to be effective in the treatment of various forms of cancer. It works by inhibiting the activity of kinases, which are enzymes involved in the regulation of cell growth and division. Gemcitabine diphosphate triethylamine salt is a prodrug that is converted to its active form, gemcitabine, in vivo. This drug has been shown to inhibit the uptake of xylose by cancer cells, leading to decreased protein synthesis and induction of apoptosis. In addition, it has been found to be effective against human and Chinese medicinal tumor cells. Gemcitabine diphosphate triethylamine salt is a promising treatment option for patients with cancer who have not responded well to traditional chemotherapy or radiation therapy.</p>

<p>Acetylsalicylic acid sodium salt is a potent inhibitor of kinases in both human and Chinese cells. It is an analog of salicylic acid and has been shown to inhibit the growth of cancer cells in vitro. Acetylsalicylic acid sodium salt also induces apoptosis, or programmed cell death, in cancer cells. Additionally, it has been shown to inhibit heparin-induced platelet aggregation and reduce the risk of blood clots. This drug has potential anticancer properties due to its ability to inhibit chitin synthesis, which is necessary for tumor growth and survival. Acetylsalicylic acid sodium salt may be useful as a therapeutic agent for the treatment of cancer and other diseases associated with abnormal kinase activity.</p>

<p>Xanthoxin is a medicinal compound with potent anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. Xanthoxin has been tested in various cancer cell lines, including Chinese and human cells, and has demonstrated strong inhibitory effects on the tumor cycle. This compound works by inhibiting kinases and other proteins involved in cancer cell growth and proliferation. Xanthoxin is also known to be an inhibitor of certain urinary proteins that are associated with cancer progression. Overall, Xanthoxin shows great potential as a natural product for the development of novel anticancer therapies.</p>

<p>Please enquire for more information about 3-(tert-Butylsulfinyl)propanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-(2-Chlorobenzoyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.</p>

<p>Sinalexin is an anticancer drug that targets human protein kinases. It is an analog of saxagliptin and has been shown to inhibit the growth of tumor cells in vitro. Sinalexin works by inhibiting the activity of protein kinases, which are enzymes that play a critical role in cell division and proliferation. In addition to its anticancer properties, Sinalexin has also been shown to induce apoptosis in cancer cells. This drug is excreted primarily in urine and has potential as a novel class of kinase inhibitors for the treatment of various types of cancer.</p>

<p>Miproxifene is a potent anticancer drug that has been shown to induce apoptosis and inhibit cell cycle progression in human cancer cells. This drug has been extensively studied in Chinese hamster ovary (CHO) cells and has demonstrated significant activity against various types of cancer, including leukemia. Miproxifene acts as a protein inhibitor and has been found to be effective against several tumor cell lines. It is a promising medicinal compound for the treatment of cancer, with potential applications in both chemotherapy and radiation therapy. Miproxifene is excreted primarily through urine and is well-tolerated by patients. Its use as an anticancer agent holds great promise for the future of cancer treatment.</p>

<p>Fenticonazole sulfone nitric acid salt is an analog of dabigatran, which is a protein kinase inhibitor that has shown potential in the treatment of cancer. It induces apoptosis in human cancer cells and inhibits the activity of various kinases involved in tumor growth and proliferation. Fenticonazole sulfone nitric acid salt has been studied extensively for its anticancer properties, showing promising results in Chinese hamster ovary cells and urine samples from cancer patients. This drug also exhibits inhibitory effects on protein kinases that are involved in the regulation of cell cycle progression, angiogenesis, and metastasis. Overall, Fenticonazole sulfone nitric acid salt holds great promise as a potential anticancer agent.</p>

<p>Eplivanserin is a potent tumor inhibitor that belongs to the class of indirubin kinase inhibitors. It has shown great promise as an anticancer agent due to its ability to induce apoptosis in cancer cells and inhibit their growth cycle. Eplivanserin has been found to be effective against a variety of cancers, including breast, lung, and prostate cancer. This medicinal compound is derived from Chinese herbs and has been extensively studied for its potential in cancer treatment. In addition, eplivanserin has been found in urine samples from humans, indicating that it may have potential as a diagnostic tool for cancer detection. Its protein targets are still being investigated, but it is believed that eplivanserin works by inhibiting key enzymes involved in cell signaling pathways that promote cancer cell growth and survival.</p>

<p>(3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate is a synthetic metabolite of the drug etravirine. It is an impurity in the drug product. The impurity is characterized as a white to off-white crystalline solid with a molecular weight of 531.6 g/mol and melting point of 170°C. It is soluble in methanol, ethanol, acetone and chloroform, but insoluble in water. (3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate can be synthesized from commercially available starting materials</p>

<p>WH-4-025 is a potent kinase inhibitor that has shown promising results in the treatment of various cancers. It is derived from Chinese medicinal herbs and has been extensively studied for its anticancer properties. WH-4-025 works by inhibiting the activity of specific kinases that are involved in tumor growth and cell cycle regulation. It has been shown to induce apoptosis in cancer cells, leading to their death, and also inhibit the growth of leukemia cells. This protein inhibitor has been found to be effective against a wide range of human cancers and is currently being investigated as a potential therapy for cancer patients. WH-4-025 is excreted through urine, making it an attractive candidate for further development as an anticancer drug.</p>

<p>NUC-7738 is a medicinal compound that has been shown to be an effective inhibitor of cyclin-dependent kinases (CDKs). It has potent anticancer activity and has been studied extensively in Chinese hamster ovary (CHO) cells, human leukemia cells, and other cancer cell lines. NUC-7738 works by selectively inhibiting CDK4/6, which are critical regulators of the cell cycle. This leads to the induction of apoptosis in cancer cells, making it a promising new therapeutic agent for the treatment of various types of cancer. Additionally, NUC-7738 has been shown to have low toxicity and good pharmacokinetic properties in preclinical studies. Overall, this compound holds great promise as a novel anticancer therapy that may help improve outcomes for patients with cancer.</p>

<p>Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.</p>

<p>Sitagliptin monohydrochloride monohydrate is an inhibitor of dipeptidyl peptidase-4 (DPP-4), which is responsible for the degradation of incretin hormones. It is used in the treatment of type 2 diabetes mellitus, as it increases insulin secretion and reduces blood glucose levels. Recent studies have shown that Sitagliptin has anticancer properties, as it induces apoptosis in cancer cells. It also inhibits protein kinases, which are involved in tumor growth and metastasis. Capsaicin, a compound found in chili peppers, has been shown to enhance the anticancer activity of Sitagliptin in Chinese hamster ovary cells. The drug is excreted primarily through urine and has a low potential for drug interactions with other kinase inhibitors. Overall, Sitagliptin monohydrochloride monohydrate shows great promise as both a diabetes medication and an anticancer agent.</p>

<p>Please enquire for more information about Emtricitabine impurity 17 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amlodipine EP Impurity F maleate is an impurity of amlodipine, a drug product. It is a natural substance that has been classified as an API impurity in the United States Pharmacopeia (USP). The chemical name for this drug is 3-(2-chlorophenyl)-1-methyl-5-(o-tolyloxy)-2,4-dihydro-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-one. Amlodipine EP Impurity F maleate has the following properties: C12H9ClNO2S and a melting point of 210°C with a purity of 99.5%. This compound was synthesized by custom synthesis and is used as an analytical standard for HPLC. This compound was also used during the development of amlodipine to determine its metabolism studies.</p>

<p>2,2',4,4',6,6'-Hexachlorobiphenyl (PCB-136) is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It acts as a kinase inhibitor by blocking the activity of specific kinases involved in tumor growth and progression. PCB-136 has been studied extensively in human and Chinese hamster ovary cells and has been found to be highly effective against various types of cancer. This medicinal analog also exhibits inhibitory effects on the protein kinases that regulate cell division and proliferation, making it a promising candidate for cancer therapy. In addition, PCB-136 shows potential for use as a urinary biomarker for exposure to environmental pollutants due to its persistence in the environment and ability to accumulate in body tissues.</p>

<p>(-)-Sabinene is a natural compound found in urine and various medicinal plants, including Chinese herbs. It has been identified as an analog of another natural compound that exhibits potent anticancer activity. (-)-Sabinene has been shown to inhibit the activity of certain proteins involved in cell cycle regulation and apoptosis, which are important processes for the growth and survival of cancer cells. In addition, (-)-Sabinene has been found to have inhibitory effects on tumor kinase activity, making it a promising candidate for the development of new anticancer drugs. Studies have shown that (-)-Sabinene can effectively inhibit the growth of various types of cancer cells, making it a potential therapeutic agent for the treatment of cancer.</p>