APIs for research and impurities

<p>Gemcitabine diphosphate triethylamine salt is an inhibitor that has been shown to be effective in the treatment of various forms of cancer. It works by inhibiting the activity of kinases, which are enzymes involved in the regulation of cell growth and division. Gemcitabine diphosphate triethylamine salt is a prodrug that is converted to its active form, gemcitabine, in vivo. This drug has been shown to inhibit the uptake of xylose by cancer cells, leading to decreased protein synthesis and induction of apoptosis. In addition, it has been found to be effective against human and Chinese medicinal tumor cells. Gemcitabine diphosphate triethylamine salt is a promising treatment option for patients with cancer who have not responded well to traditional chemotherapy or radiation therapy.</p>

<p>Olaparib impurity 14 is a metabolite of olaparib. Olaparib is a drug used to treat cancer by inhibiting the activity of PARP1, an enzyme that repairs DNA damage. This impurity is a compound that can be synthesized in high purity and quality with a custom synthesis service. It has been shown to have niche applications in pharmacopoeia, drug development, and analytical studies.</p>

<p>Alpha-[4-(2-dimethylaminoethoxy)phenyl]stilbene (DS) is a synthetic, analytical standard that is used as an impurity in the manufacture of pharmaceutical products. DS is also sold as a reference material for HPLC and GC/MS analysis.</p>

<p>Please enquire for more information about Rosuvastatin EP Impurity C sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Desmethyl trimeprazine is a synthetic compound, which is an impurity of the drug product. It is not active and does not possess any biological activity. It is a metabolite of the parent drug, Trimeprazine. N-Desmethyl trimeprazine has been studied for its pharmacological properties and metabolism in the body, but no conclusive results have been found. The chemical structure and purity of N-Desmethyl trimeprazine are not listed in the USP or BP. This compound can be custom synthesized on request.</p>

<p>Xanthoxin is a medicinal compound with potent anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. Xanthoxin has been tested in various cancer cell lines, including Chinese and human cells, and has demonstrated strong inhibitory effects on the tumor cycle. This compound works by inhibiting kinases and other proteins involved in cancer cell growth and proliferation. Xanthoxin is also known to be an inhibitor of certain urinary proteins that are associated with cancer progression. Overall, Xanthoxin shows great potential as a natural product for the development of novel anticancer therapies.</p>

<p>3-Dodecenal is a human analog that has been studied for its potential anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in tumor cells. This medicinal compound acts as an inhibitor of protein kinases, which play a crucial role in regulating the cell cycle and are often overactive in cancer cells. 3-Dodecenal has shown promising results in inhibiting cancer cell growth in Chinese hamster ovary cells and may have potential as a natural alternative to traditional cancer treatments. In addition, this compound has been detected in human urine and is believed to have potential health benefits beyond its anticancer properties.</p>

<p>Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.</p>

<p>Amlodipine EP Impurity F maleate is an impurity of amlodipine, a drug product. It is a natural substance that has been classified as an API impurity in the United States Pharmacopeia (USP). The chemical name for this drug is 3-(2-chlorophenyl)-1-methyl-5-(o-tolyloxy)-2,4-dihydro-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-one. Amlodipine EP Impurity F maleate has the following properties: C12H9ClNO2S and a melting point of 210°C with a purity of 99.5%. This compound was synthesized by custom synthesis and is used as an analytical standard for HPLC. This compound was also used during the development of amlodipine to determine its metabolism studies.</p>

<p>Sitagliptin monohydrochloride monohydrate is an inhibitor of dipeptidyl peptidase-4 (DPP-4), which is responsible for the degradation of incretin hormones. It is used in the treatment of type 2 diabetes mellitus, as it increases insulin secretion and reduces blood glucose levels. Recent studies have shown that Sitagliptin has anticancer properties, as it induces apoptosis in cancer cells. It also inhibits protein kinases, which are involved in tumor growth and metastasis. Capsaicin, a compound found in chili peppers, has been shown to enhance the anticancer activity of Sitagliptin in Chinese hamster ovary cells. The drug is excreted primarily through urine and has a low potential for drug interactions with other kinase inhibitors. Overall, Sitagliptin monohydrochloride monohydrate shows great promise as both a diabetes medication and an anticancer agent.</p>

<p>2,2',4,4',6,6'-Hexachlorobiphenyl (PCB-136) is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It acts as a kinase inhibitor by blocking the activity of specific kinases involved in tumor growth and progression. PCB-136 has been studied extensively in human and Chinese hamster ovary cells and has been found to be highly effective against various types of cancer. This medicinal analog also exhibits inhibitory effects on the protein kinases that regulate cell division and proliferation, making it a promising candidate for cancer therapy. In addition, PCB-136 shows potential for use as a urinary biomarker for exposure to environmental pollutants due to its persistence in the environment and ability to accumulate in body tissues.</p>

<p>(-)-Sabinene is a natural compound found in urine and various medicinal plants, including Chinese herbs. It has been identified as an analog of another natural compound that exhibits potent anticancer activity. (-)-Sabinene has been shown to inhibit the activity of certain proteins involved in cell cycle regulation and apoptosis, which are important processes for the growth and survival of cancer cells. In addition, (-)-Sabinene has been found to have inhibitory effects on tumor kinase activity, making it a promising candidate for the development of new anticancer drugs. Studies have shown that (-)-Sabinene can effectively inhibit the growth of various types of cancer cells, making it a potential therapeutic agent for the treatment of cancer.</p>