APIs for research and impurities

(R)-Apremilast-d5 is a metabolite of apremilast, which is a small molecule drug that inhibits phosphodiesterase (PDE) enzymes. It has been shown to suppress inflammation in vitro and in vivo. Metabolism studies have shown that the main metabolites of apremilast are the acid form and the glucuronide form. Apremilast-d5 is a synthetic impurity generated by oxidation of an intermediate during synthesis. It can also be found as a natural metabolite in plants such as licorice or black pepper. This product is used for HPLC standards for apremilast and its metabolites.

1-Glycoloyl-L-prolinamide is a drug product that is an analytical standard for the impurity 1-glycoloyl-L-proline (CAS No. 96166-39-1) in the API 1,4,5,6-tetrahydrobenzothiazole (CAS No. 86687-93-0). It has been synthesized to be used as an impurity standard and is provided at a purity of 98.0% or greater by weight. This chemical compound can be used in research and development for the production of drugs as well as in pharmaceutical manufacturing.

aR453588 is a human analog of Voriconazole, which has been found to have anticancer properties. This compound is a kinase inhibitor that works by inducing apoptosis in cancer cells. It has been shown to be effective against various types of tumors, including those resistant to other inhibitors. aR453588 also inhibits the growth of cancer cells by blocking protein synthesis and cell division. This compound is derived from cellulose and can be detected in urine samples after administration. Overall, aR453588 shows great promise as a potential treatment for cancer.

9-[[(2,2,2-Trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is a research and development impurity standard. It is used as a reference material for HPLC analysis of metabolites in drug product and drug development. This compound has been synthesized using synthetic methods. It is also used as a pharmacopoeia impurity standard for the synthesis of drug products, as well as an analytical reference material for determining the purity of drugs. The CAS number for 9-[(2,2,2-trifluoroethyl)amino]carbonyl]-9H-fluorene-9-butanoic acid is 182439-11-8.

L-733,060 Hydrochloride is a drug product that was custom synthesized for the purpose of research and development. It is a white to off-white crystalline powder with a melting point of 178.5°C. The purity of L-733,060 Hydrochloride is greater than or equal to 98% by analytical HPLC. L-733,060 Hydrochloride has been studied in metabolism studies and has been shown to be metabolized by cytochrome P450 enzymes, oxidative metabolites, hydrolysis by esterases, glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Teopranitol is a potent inhibitor of kinases, which are enzymes that play a critical role in cellular signaling pathways. It belongs to the class of protein kinase inhibitors and has been shown to have inhibitory activity against a wide range of kinases. Teopranitol has been tested on various cell lines, including human cancer cells and Chinese medicine-derived cell lines. It has been found to be effective in inhibiting the growth of mutant cancer cells by blocking the activity of specific kinases. This inhibitor shows promise as a potential treatment for cancer and tumors due to its ability to target specific pathways involved in cancer progression.

Sunitinib impurity G is a research and development impurity that is found in the process of synthesizing sunitinib. Sunitinib impurity G is an analytical standard that is soluble in methanol and is suitable for HPLC analysis. It has been shown to have high purity, excellent stability, and a low level of toxicity.

Rocuronium EP Impurity G is a drug product that contains an impurity of Rocuronium EP. It is a synthetic, high purity HPLC standard with a purity greater than 99.5% and a CAS number of 119302-20-4. This compound has been researched for use in the development of drugs to treat conditions such as pain, anxiety, and depression. Rocuronium EP Impurity G is a metabolite that has been found in human urine after administration of rocuronium bromide. The metabolism of this substance has not been fully elucidated yet but it may be hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductase, or conjugated with glucuronic acid.

Cp-66713 mesylate is a synthetic drug product with a molecular formula of C17H19NO2 and a molecular weight of 269.34. It has the following CAS number: 91896-58-1. The purity of this compound is >99% (HPLC).

Impurity A is an impurity of the drug product, dexamethasone. The impurity is a natural metabolite of dexamethasone that is found in the urine of patients taking this medication. Impurity A is chemically identified using HPLC and its purity verified using GC-MS and LC-MS. This impurity can be used as a reference standard for analytical purposes and as an impurity standard for pharmacopoeia testing.