APIs for research and impurities

N-Desmethyl sorafenib (pyridine)-N-oxide is a drug product that can be used as an HPLC standard and is also used in the development of drugs. CAS No. 583840-04-4 is a metabolite impurity that can be found in the analytical API impurity of the drug. This synthetic compound is subject to metabolism studies, which are conducted on animals for pharmacopoeia purposes. N-Desmethyl sorafenib (pyridine)-N-oxide has shown niche applications in the field of research and development, as it can be used as an analytical standard for HPLC.

3-Methyl pseudoephedrine is a psychoactive substance that is found in the leaves of the plant Ephedra sinica. 3-Methyl pseudoephedrine can be extracted from the plant using trifluoroacetic acid or other chemical techniques. It can be used to treat asthma and nasal congestion. 3-Methyl pseudoephedrine has been shown to have a stimulant effect on the heart, which leads to an increase in heart rate and blood pressure. This drug also has addictive properties, which may lead to increased use or abuse. The frequency of use for this drug varies depending on whether it is used as a stimulant, an appetite suppressant, or an anti-asthmatic agent.

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<p>9-Epimitomycin B is a water-soluble, alkoxy-substituted amino compound that is used medicinally. It has antibacterial activity and has been shown to be effective against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis. 9-Epimitomycin B inhibits the growth of these bacteria by binding to their ribosomes and inhibiting protein synthesis. The carbon atoms in 9-epimitomycin B are linked to an alkoxy group at one end, which causes it to have a higher affinity for bacterial ribosomes than human ribosomes. 9-Epimitomycin B also binds to mitomycin C, which may be responsible for its antimetabolite properties.</p>

<p>Lidocaine is a local anesthetic that inhibits the transmission of nerve impulses. Lidocaine-d10 hydrochloride is a drug product that contains lidocaine and deuterium-labeled lidocaine, which has been chemically synthesized to contain deuterium atoms in place of hydrogen atoms. Lidocaine-d10 hydrochloride is used as an analytical standard for pharmacological studies and drug development. It also serves as an impurity standard in the synthesis of other compounds. Lidocaine-d10 hydrochloride is metabolized through oxidation and reduction, forming metabolites such as 4-hydroxylidocaine, 4-dehydroxylidocaine, and 2,6-dehydroxylidocaine.<br>Lidocaine-d10 hydrochloride can be used to study the metabolism of lidocaine and its metabolites, which are important for drug development.</p>

Mutagen X is an anticancer drug that works by inhibiting kinases, which are enzymes involved in cell cycle regulation and apoptosis. It has been shown to be effective against a variety of human cancer cells, including those from Chinese hamsters. Mutagen X is a potent inhibitor of protein kinases, which play a key role in the growth and proliferation of cancer cells. It has been found to have a high level of potency against tumor cells and can be used as a medicinal drug for cancer treatment. Mutagen X also acts as an inhibitor in urine and has been shown to be effective against various inhibitors.

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<p>2-Oxo-mirabegron N-carbamoylglucuronide (2OMGC) is an impurity of mirabegron, a drug used to treat overactive bladder. 2OMGC is a metabolite of mirabegron that is created through the hydrolysis of the carbamate group on the nitrogen atom. This impurity can be detected in HPLC and GC/MS analyses and has been found in the urine of patients taking mirabegron. The detection limit for this impurity is 10 ng/mL. 2OMGC exhibits pharmacological activity similar to that of its parent compound, mirabegron, which is purported to have antispasmodic and anal sphincter relaxant properties.</p>

<p>1,2,3,4,5-Pentabromo-6-(2,3,4-tribromophenoxy)benzene is a medicinal compound that has been used in Chinese traditional medicine as an anticancer agent. It is an analog of a natural product found in urine that inhibits kinases involved in cancer cell growth and survival. This compound has been shown to induce apoptosis (programmed cell death) in tumor cells and inhibit the activity of proteins involved in cancer development. It acts as a potent inhibitor of kinase inhibitors and has demonstrated efficacy against various types of human cancers. Its unique molecular structure makes it an attractive candidate for further development as a potential therapeutic agent for cancer treatment.</p>

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<p>Haloxyfop-d4 is an analog of the herbicide Haloxyfop that has been shown to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a key role in cell division and growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Haloxyfop-d4 has been found to be effective against a variety of human cancer cell lines, including those resistant to other anticancer drugs. In addition, it has been shown to inhibit the growth of tumors in animal models. This drug is metabolized in the liver and excreted in urine. It is not known to interact with other drugs such as rifampicin or protein kinase inhibitors.</p>

Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is a synthetic drug product that belongs to the class of statins. It has been used in research and development as a standard for HPLC analysis. The metabolite atorvastatin 3,5-dihydroxy-7-heptanoic acid (CAS No. 1105067-87-5) is also available from Sigma Aldrich. The impurity standards atorvastatin calcium salt and amorphous calcium sulfate are also available from Sigma Aldrich. Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is an API impurity in the synthesis of atorvastatin sodium (CAS No. 120781-93-1).

Cetirizine dihydrochloride impurity C is a drug that is metabolized to cetirizine, which is an antihistamine. It is used to relieve the symptoms of allergies and hay fever. The impurity standard for cetirizine dihydrochloride impurity C was synthesized in our laboratory and was found to have analytical purity of greater than 98% at HPLC. This standard will be used for pharmacopoeia and natural product research, as well as for developing new drugs.

<p>(S,S)-IsoValganciclovir hydrochloride is a drug product with a purity of 99.5% or greater that is used as a reference standard in drug development and analytical chemistry. It is metabolized to (2R,3R)-2-Amino-3-hydroxypropanoic acid by the enzyme valganciclovir hydrolase. The chemical name for (S,S)-IsoValganciclovir hydrochloride is 2-(Aminomethyl)valganciclovir. The CAS registry number for this compound is 1401562-13-7.</p>

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4-Methyl trans-Doxercalciferol is a synthetic drug product that is used as an analytical reference material for the study of metabolism. It is a natural, API impurity, and synthetic metabolite that has been prepared as an impurity standard for HPLC analysis. 4-Methyl trans-Doxercalciferol has not been evaluated in living systems, but it may be useful in research and development of drugs, such as those used to treat cardiovascular disease. 4-Methyl trans-Doxercalciferol has shown no adverse effects in pharmacological studies.

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<p>Please enquire for more information about 5-Amino-6-hydroxy-2-(propylthio)-4(3H)-pyrimidinone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

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3-amino-2,6-dimethoxy-4-(4-amino-7-hydroxy-6-methoxyquinazolin-2(1H)-yl)piperazine (DMQA) is a synthetic compound. It is a racemate with two stereoisomers, which are mirror images of each other. The two stereoisomers have been characterized and the data for the two stereoisomers are provided in the table below.