Pharmaceutical and Veterinary Compounds and Metabolites

<p>ScHEX1, a glycolytic hexokinase, is blocked by n-acetylglucosamine, detaching from the mitochondrial membrane and activating NLRP3 inflammasome.</p>

<p>trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine[1].</p>

<p>21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.</p>

<p>Sorbitol-6-phosphate 2-dehydrogenase, a dehydrogenase enzyme produced by Escherichia coli, catalyzes the interconversion of D-sorbitol 6-phosphate and D-fructose 6-phosphate. The enzyme oxidizes D-sorbitol 6-phosphate at a rate ten times faster than it reduces D-fructose 6-phosphate, playing a role in various cellular processes.</p>

<p>Crotonyl-CoA: key in butyric acid fermentation, lysine and tryptophan metabolism, crucial for fatty and amino acid processing.</p>

<p>Tuftsin (Tuftsin(3TFA)) is a natural activator of Phagocyte Cells</p>

<p>4β-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4.</p>

<p>Nuclease P1 cleaves single-stranded nucleic acids into 5'-mononucleotides; key in molecular biology, pharmaceuticals, and food.</p>

<p>AtGlcAK: GHMP-kinase family, specific for D-glucuronic acid, Km 0.7 mM, converts it with ATP to D-glucuronic-1-phosphate and ADP.</p>

<p>cGAMP is a second messenger that triggers interferon production via STING activation upon detecting cytosolic DNA.</p>

<p>Aspercolorin is a fungal metabolite produced by Aspergillus.</p>

<p>Citrulline malate is a cpd of anti-fatigue.</p>

<p>Galactonic acid, derived from galactose metabolism, is converted from galactonolactone.</p>

<p>2-Methylnicotinamide is an endogenous metabolite of nicotinamide and can be used for related research in the life sciences.</p>

<p>GyK, a bacterial sugar kinase, initiates glycerol metabolism by converting it into G3P, key for cell uptake.</p>

<p>ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.</p>

<p>A unique collection of 4454 human metabolites for high-throughput, high-content screening.</p>

<p>cGAMP disodium, a bacterial CDN, boosts interferon production and activates STING, enhancing immune responses as a sublingual adjuvant.</p>

<p>Pregnant mare serum gonadotropin (PMSG) functions as a gonadotropin that enhances follicular development and ovulation in animals. This compound operates by modulating blood hormones, gonadotropins, and cytoplasmic estradiol receptors in the anterior pituitary and hypothalamus. Commonly employed in livestock to boost reproductive efficiency, PMSG is also valuable for research focused on estrous cycle regulation.</p>

<p>9-cis-Vitamin A palmitate, a 9-cis isomer in corn flakes, has 26% activity of all-trans-vitamin A, the most active form.</p>

<p>Diacetinase, a member of the esterase family, catalyzes the hydrolysis of glyceryl diacetate (Diacetin). It is utilized in the measurement of lipase activity.</p>

<p>5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a 5β-reduced steroid and a significant metabolic derivative of dehydroepiandrosterone (DHEA</p>

<p>Sapropterin aids in amino acid breakdown and neurotransmitter synthesis, including dopamine and serotonin, and supports nitric oxide production.</p>

N-Lactylleucine is an endogenous metabolite detectable in patients with intermediate maple syrup urine disease.

<p>Glycerol-3-phosphate dehydrogenase from Saccharomyces cerevisiae is an enzyme that catalyzes the oxidation of glycerol-3-phosphate (G3P) to dihydroxyacetone phosphate (DHAP), playing a crucial role in glycerol metabolism and energy production. This enzyme acts as the rate-limiting step in glycerol production within Saccharomyces cerevisiae, regulating glycerol formation and accumulation to aid the yeast in adapting to hyperosmotic environments. Additionally, glycerol-3-phosphate dehydrogenase from Saccharomyces cerevisiae is relevant in research within the field of metabolic engineering.</p>

<p>Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.</p>

<p>TPI, a glycolytic enzyme, swiftly converts dihydroxyacetone phosphate to D-glyceraldehyde-3-phosphate at its dimer interface.</p>

<p>Galactose 1-dehydrogenase, pseudomonas fluorescens, a dehydrogenase found in Pseudomonas fluorescens, facilitates the oxidation of L-arabinose and D-galactose, utilizing NADP+/NAD+ as a cofactor. This enzyme is employed in diagnostic assays to quantify total galactose levels and serves as a biocatalyst in the production of galacturonic acid salts.</p>

<p>13-cis-Retinyl palmitate in corn flakes is 75% as active as all-trans form.</p>

<p>H-Arg-Lys-OH TFA is a dipeptide formed from L-arginyl and L-lysine residues [1] .</p>

<p>Ozolinone, an etozoline metabolite, is a loop diuretic treating hypertension and edema.</p>

<p>ESI1 is a small molecule inhibitor of epigenetic silencing. This compound induces the formation of nuclear aggregates of the key lipid metabolism regulator SREBP1/2, thereby concentrating transcription co-activators to drive lipid/cholesterol biosynthesis. Additionally, ESI1 promotes myelin regeneration in demyelination animal models and facilitates de novo myelination on regenerating CNS axons, reversing age-related cognitive decline.</p>

<p>Phosphate acetyltransferase, an enzyme, reversibly transfers acetyl groups to CoA, aiding in acetate assimilation/dissimilation.</p>

<p>Larsucosterol sodium: a liver-derived cholesterol byproduct; modulates lipid synthesis, inflammation, and cell death regulation.</p>

<p>Generates large inward currents at resting membrane potential</p>

<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>

<p>9(R)-HODE cholesteryl ester, from atherosclerotic lesions, may form enzymatically or by lipid peroxidation; used as a chiral analysis standard.</p>

<p>Propionylcarnitine (Propionyl carnitine) is a widely used dietary supplement that has been associated with glaucoma and does it ruptu</p>

<p>7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].</p>

<p>Trichodecenin I is a peptaibol isolated from Trichoderma viride.</p>

<p>2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β; binds weaker than 2'3'-cGAMP but stronger than other CDNs.</p>

<p>F-14329 is a tetramic acid fungal metabolite [1] .</p>

<p>10-Undecenoic acid (Undecylenic acid) is a natural or synthetic fungistatic fatty acid, with antifungal activity.</p>

<p>Maximiscin, a metabolite derived from fungi, causes DNA damage and exhibits selective cytotoxic activity towards a specific subtype of triple-negative breast</p>

<p>Coproporphyrin III is a derivative of porphyrin.</p>

<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>

<p>10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.</p>

<p>Epoxide hydrolase, an enzyme responsible for catalyzing the reaction of epoxides with water to convert epoxy groups into diols, plays a crucial role in the metabolism of environmental pollutants and lipids. It is instrumental in detoxification, inflammatory responses, and regulating the health of the cardiovascular system. Additionally, Epoxide hydrolase is used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, which are important for the synthesis of chiral pharmaceutical molecules.</p>

<p>(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.</p>

<p>Penicitide A: marine metabolite, moderately cytotoxic to A. brassicae, HepG2 cells.</p>

<p>NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.</p>

<p>Avellanin B is a fungal metabolite.</p>

<p>Neo-Inositol, a stable, polar compound, is a rare natural inositol stereoisomer.</p>

<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>

<p>L-Lactate dehydrogenase is an enantiospecific redox enzyme reducing pyruvate to L-lactate using NADH.</p>

<p>NAD Synthetase is responsible for the final step in the synthesis of Nicotinamide Adenine Dinucleotide (NAD). The enzyme sourced from Escherichia coli exhibits Km values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia. Conversely, NAD Synthetase derived from yeast demonstrates Km values of 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia. This enzyme is applicable in enzymatic assays for ATP, ammonia, urea, or creatinine and can also be used in enzymatic recycling methods. Additionally, NAD Synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative disorders.</p>

<p>DBPR-110: NS5A inhibitor, EC50 of 3.9 pM for HCV1b, SI &gt;12.8 million; EC50 of 228.8 pM for HCV2a, SI &gt;173,130.</p>

<p>5-(3'-Hydroxyphenyl)-γ-valerolactone, a metabolite resulting from the transformation of polyphenols such as (+)-catechin and (−)-epicatechin by gut microbiota,</p>

<p>Sarcinapterin is a coenzyme isolated from Methanosarcina barkeri.</p>

<p>Triacylglycerol with palmitic, oleic, arachidonic acids at sn-1, sn-2, sn-3; found in rat retina lipid extracts.</p>

<p>N-Trifluoroacetyladriamycin, Valrubicin's metabolite, treats bladder cancer; it's an analog of doxorubicin, infused into the bladder.</p>

<p>Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.</p>

<p>5(S)-HpETE is a PUFA made by 5-LO from arachidonic acid, metabolized into LTA4, a key leukotriene precursor.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>Pi-Methylimidazoleacetic acid is a potential neurotoxin.</p>

<p>(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile), an enantiomer of (+)-JA-L-Ile [1], is an inactive endogenous hormone.</p>

<p>ATP ditromethamine is key for energy storage, metabolism, and acts as a coenzyme and signaling molecule in immunity and inflammation.</p>

<p>Isariin C is a flavonoid glucoside derived from the Epimedium plant genus. It stimulates angiogenesis and exhibits antioxidant activity.</p>

<p>Vitamin B12a monohydrochloride (Hydroxocobalamin) is an essential water-soluble vitamin.a cyanide detoxifier and nutritional supplement, injection, inhalation.</p>

<p>Ribulose: key in pentose metabolism, aids L-ribose isomerase study, yeast engineering, and chiral compound research.</p>

<p>(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.</p>

<p>8-Isoprostaglandin F2α is a natural product for research related to life sciences. The catalog number is T37164 and the CAS number is 27415-26-5.</p>

<p>Hydroxycotinine is the main nicotine metabolite detected in smokers' urine.</p>

<p>Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle.</p>

<p>Maltodextrin (DE 16.5-19.5) is an inactive pharma excipient that enhances drug stability, solubility, and processing.</p>

<p>An endogenous blood metabolite, 1-heptadecanoyl-glycerophosphocholine, researches pregnancy/sepsis.</p>

<p>Fellutanine A is a useful organic compound for research related to life sciences. The catalog number is T129801 and the CAS number is 175414-35-4.</p>

<p>Cis-Vitamin K1 is an endogenous metabolite of Vitamin K [1] .</p>

<p>Phosphofructokinase, a crucial glycolytic enzyme, catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate in the glycolysis pathway. Its activity is inhibited by the binding of Phosphoenolpyruvate (PEP), which regulates the rate of glycolysis. Additionally, Phosphofructokinase is utilized in the measurement of fructose-6-phosphate (fructose-6-phosphate) levels.</p>

<p>Hydroorotic acid（Dihydroorotic acid） is an endogenous metabolite，a potential biomarker for diabetic nephropathy and adrenal pheochromocytoma.</p>

<p>P-orlandin, a fungal compound, blocks FREP1, halting P. falciparum's mosquito infection.</p>

<p>α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.</p>

<p>TDC, a PLP-dependent enzyme, removes carboxyl groups from tyrosine, producing tyramine and CO2, found in plants, insects, and microbes.</p>

<p>Stephacidin B, from A. ochraceus, forms avrainvillamide in vitro. Cytotoxic to various cancer cells; induces apoptosis in hepatocarcinoma at 4 μM.</p>

<p>Picornain 3C, a protease in picornaviruses, cleaves Gln-Gly bonds in poliovirus polyproteins and similar sites in others.</p>

<p>18:0,18:1 PS sodium, a lipid found in synaptic vesicles and cholesterol, serves a role in metabolic research [1].</p>

<p>Penicillinase is a β-lactamase and secretory enzyme capable of degrading and inactivating penicillin and similar compounds.</p>

<p>Orotidine 5′-monophosphate, a pyrimidine ribonucleoside, functions as an endogenous metabolite in human, E.</p>

<p>C24 3'-sulfo Galactosylceramide is a key myelin sulfatide, high in leukodystrophy patients, non-immunogenic compared to C24:1 variant.</p>

<p>Peptide that activates gut guanylyl cyclase, secreted by GI mucosa, regulates water and electrolytes in gut and kidneys.</p>

<p>Tetrahydrothiophen-3-one can be used as food spices.</p>

<p>N-Acetyl-α-D-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, plays a crucial role as an intermediate in the biosynthesis of N-linked</p>

<p>sLeX: sialylated, fucosylated tetrasaccharide, ligand for selectins, inhibits neutrophil recruitment.</p>

<p>LTB3, a LTA3-derived leukotriene, matches LTB4's inflammation effect but is 5x weaker in neutrophil chemotaxis.</p>

<p>Phytin has a wide range of applications in life science related research.</p>

<p>C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin.</p>

<p>7-Hydroxydichloromethotrexate is a methotrexate metabolite.</p>

<p>Hydroxypyruvic acid lithium hydrate is a metabolic intermediate for serine, glycine, threonine, and a substrate for specific aminotransferases.</p>

<p>ADR-925 has the ability to protect neonatal rat cardiomyocytes from doxorubicin-induced injury.Cost-effective and quality-assured.</p>

<p>D-Xylono-1,4-lactone, a biochemical reagent, serves as a biological material or organic compound for life science research.</p>