Amino Acids (AA)

<p>Applications Myristoyl-L-carnitine Hydrochloride is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 4-(Boc-amino)-1-methylpyrrole-2-carboxylic Acid is an unnatural amino acid for preparing heteroaromatic oligoamides for regulating gen expression in biotechnology.<br>References Baird, E., et al.: J. Am. Chem. Soc., 118, 6141 (1996); White, S., et al.: Nature, 391, 468 (1998)<br></p>

<p>Applications Methyl 4-Methoxybenzoate is also used in the synthesis of oxadiazole-based, GSK-3 inhibitors. Methyl 4-Methoxybenzoate is used in the synthesis of substituted hydrazides for their antitubercular properties.<br>References Lo Monte, F. et al.: Eur.J. Med. Chem., 61, 26 (2013); Gupta, R. et al.: Asian J. Pharm. Clin. Res., 5, 251 (2012);<br></p>

<p>Applications D-Glutamic acid 1-tert-butyl ester is a protected form of D-Glutamic acid (G596965). D-Glutamic acid is an unnatural isomer of L-Glutamic acid (G596960), and is found in bacterial cell wall peptidoglycan of gram-positive and gram-negative bacteria. D-Glutamic acid also occurs as poly-gamma-Glutamic acid, which is a weak immunogen but is capable of acting as a hapten (a small molecule that induces the production of antibodies, as well as binding to them).<br>References Dougherty, T., et al.: J. Bacteriol., 175, 111 (1993); Goodman, J. &amp; Nitecki, D.: Immunology, 13, 577 (1967); Robinson, T.: Life Sci., 19, 1097 (1976)<br></p>

<p>Applications Labelled L-Methionine, an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.<br>References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),<br></p>

<p>Applications 3-Methylnonane-2,4-dione is a compound that possesses a butter-like and beany off flavour that is a result of flavour reversion of soya-bean oil. 3-Methylnonane-2,4-dione is also present in Japanese green tea and pressure-cooked hen meat.<br>References Farkaš, P., et al.: Food Chem., 60, 617 (1997); Guth, H. &amp; Grosch, W.: Flav. Chem., No vol. given, 377 (1999); Kumazawa, K. &amp; Masuda, H.: J. Agr. Food Chem., 47, 5169 (1999)<br></p>

<p>Applications 2-Azido-2-deoxy-D-glucose is a glucose derivative that have been used to study the substrate specificity of galactokinase.<br>References Zou, W., et al.: Bioorg. Med. Chem. Lett., 22, 3540 (2012);<br></p>

<p>Applications 3-N-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.<br>References Ringseis, R., et al.: Biochem. Biphys. Gen. Subject., 1830, 2105 (2013); Ubhi, B.K., et al.: Molec. Biosys., 8, 3125 (2012);<br></p>

<p>Applications 4-(4-Methoxyphenyl)-2-butanone is also used in the synthesis of novel axially chiral Rh-NHC complexes. Used to synthesize carbonyl complexes as novel traceless linkers.<br>References Duan, W. et al.: Chem. Comm., 23, 2916 (2003); Gibson, S. et al.: Tetrahedron. Lett., 40, 1417 (1999);<br></p>

<p>Impurity Iohexol EP Impurity K<br>Applications 5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.<br></p>

<p>Applications L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Brandon, C. &amp; Lam, D.: Proc. Nat. Acad. Sci., 80, 5117 (1983); McDermott Jr, W., et al.: New Engl. J. Med., 253, 1093 (1955)<br></p>

<p>Applications L-Methionine Sulfoxide 13C1 is a labelled analogue of L-Methionine Sulfoxide ( M260450). L-Methionine Sulfoxide ( M260450) an intermediate in the synthesis of the acyclic amino carboxylic acid L-Methionine sulfoximine.<br>References Lee, B., et al.: J. Biol. Chem., 283, 28361 (2008), Nordqvist, A., et al.: Bioorg. Med. Chem., 16, 5501 (2008);Balog, E., et al.: Biochem., 48, 3005 (2009);<br></p>

<p>Applications 3-Methoxypropanoic acid<br></p>

<p>Applications DL-Homocysteine-d4 is used in the detection of the biosynthetic pathway for the formation of volatile aroma compound 2-methyltetrahydrothiophen-3-one by the bacterium Chitinophaga.<br>References Nawrath, T., et al.: ChemBioChem., 11, 1914-1919 (2010)<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>

<p>Applications cis-Propenylphosphonic Acid (R)-(+)-α-Methylbenzylamine Salt is used as a reagent in the microbial production of Fosfomycin (F727505); a compound used as an antibiotic in the treatment of urinary tract infections.<br>References Watanabe, M., et al.: Appl. Environ. Microb., 65, 1036 (1999); Itoh, N., et al.: Appl. Microbiol. Biot., 43, 394 (1995); White, R.F., et al.: Appl. Microbiol., 22, 55 (1971); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013)<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Labelled 2-Methylfuran (M305440). 2-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>

<p>Applications N-Methylformanilide is an aromatic reagent used in the synthesis of dye-sensitized solar cells. Also used in the synthesis of potent tyrosinase inhibitors.<br>References Meyer, T et al.: J. Org. Chem., 77, 3704 (2012); Nihei, K. et al.: Bioorg. Med. Chem. Lett., 14, 681 (2004);<br></p>

<p>Applications 1-Methyl-4-(phenylmethyl)piperazine hydrochloride is a useful synthetic intermediate.<br></p>

<p>Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.<br>References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)<br></p>

<p>Applications (R)-N-(1-Carboxyethyl)-D-norvaline 1-Ethyl Ester is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications 2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.<br>References Peuchmaur, M. et al.: Bioorg. Med. Chem. Lett., 21, 1018 (2013); Roemmele, R. et al.: Org. Proc. Res. Devel., 17, 422 (2013);<br></p>

<p>Applications 3-Methyl-2-furoic Acid-d is a deuterated version of 3-Methyl-2-furoic Acid (M219553), a useful reactant in the synthesis of therapeutic agents.<br>References Dragovich, Peter S., et al.: Bioorg. &amp; Med. Chem. Let., 24(3), 954-962 (2014);Garcia-Barrantes, Pedro M., et al.: J. of Med. Chem., 58(20), 7959-7971 (2015)<br></p>

<p>Impurity Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E<br>Applications 2-(2-Methoxyphenoxy)ethylamine Hydrochloride (Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E) is an impurity of Carvedilol synthesis.<br>References Smith, L., et al.: J. Med. Chem., 20, 1653 (1977),<br></p>

<p>Applications 4-Methylcatechol is a potent inducer of nerve growth factor (NGF) synthesis in vitro and in vivo.<br>References Kaechi, K., et al.: J. Pharmacol. Exp. Ther., 272, 1300 (1995); Hanaoka, Y., et al.: J. Neurol. Sci., 122, 28 (1994)<br></p>

<p>Applications D-Lysine, HCl<br></p>

<p>Applications Used in the synthesis of Capsaicin analogues, useful for their anti-tumor activity.<br>References Fusco, B., et al.: Drugs, 53, 909 (1997), Buisman, G., et al.: Biotechnol. Lett., 20, 131 (1998), Kobata, K., et al.: Bios. Biotechnol. Biochem., 66, 319 (2002), Aluru, M., et al.: J. Exp. Bot., 54, 1655 (2003),; Wang, W. et al.: Gaodeng Xuexiao Huaxue Xuebao 31, 2400(2010)<br></p>

<p>Applications MNC is on the metabolic pathway for 2,4-Dinitotoluene degradation.<br>References Spangoord, R.J., et al.: App. and Environ. Microbiology, 57, 11, 3200 (1991)<br></p>

<p>Applications 3-Methanesulfinylpropan-1-amine is used in preparation of Amide compounds as pesticides including acaricides, insecticides, and parasiticides.<br>References Furukawa, H., et al.: Jpn. Kokai Tokkyo Koho, (2018);<br></p>

<p>Impurity Ciclopirox EP Impurity B/ USP Ciclopirox Related Compound B<br>Applications 6-Cyclohexyl-4-methyl-2H-pyran-2-one (Ciclopirox EP Impurity B) is a a dialkylated pyranone derivative.<br></p>

<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>

<p>Applications 5-Methoxy-1-methylindole-2-boronic acid pinacol ester (cas# 1256360-41-4) is a useful research chemical.<br></p>

<p>Applications Derivative of monoenoic and trienoic analogs of Sorbic Acid with antifungal activity.<br>References Guerin, J. et al.: Annales Pharmaceutiques Francaises 44, 373 (1987)<br></p>

<p>Applications N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.<br>References Kwon, Y.E. et al.: Bioorg. Med. Chem., 15, 6596 (2007); Knutsen, L.J.S. et al.: J. Med. Chem., 42, 3463 (1999);<br></p>

<p>Applications Perfluoro(2-methyl-3-pentanone) (cas# 756-13-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>

<p>Applications Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents<br>References Zhao, H., et al.: Bioorg. Med. Chem. Lett., 12, 3105 (2002),<br></p>

<p>Applications 2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides.<br>References Liu, J., et al.: Org. Biomol. Chem., 18, 4019 (2020)<br></p>

<p>Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.<br></p>

<p>Applications 1-[1-(2-methoxyethyl)piperidin-3-yl]methanamine (cas# 936940-49-7) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-2-methylaniline Hydrochloride (cas# 3165-93-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Temperature Sensitive, Light Sensitive<br>Applications 2-Ethyl-4-methylpentyl Acrylate<br></p>

<p>Applications Dl-lysine monohydrate<br></p>

<p>Applications N-(4-Bromo-2-methylphenyl)-2-chloroacetamide (cas# 96686-51-0) is a useful research chemical.<br></p>

<p>Applications Intermediate for the preparation of Glimepiride.<br></p>

<p>Applications 5-Carboxy-2-methylphenylboronic Acid acts as a reagent in the synthesis of pyrazolopyridinone-based p38 MAP kinase inhibitor<br>References Milburn, R. R., et al.: Org. Process Res. Dev., 15, 31 (2011); Achmatowicz, M., et al.: J. Org. Chem., 74, 795 (2009)<br></p>

<p>Applications 2-Bromo-4'-methylpropiophenone (cas# 1451-82-7) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Methylglyceric Acid is a biogenic secondary organic aerosol used in air quality diagnosis.<br>References Ru, P., et. al.: Environ. Sci. Technol., 48, 8491 (2014); Napelenok, S.L., et. al.: Environ. Sci. Technol., 48, 464 (2014); Stone, E.A., et. al.: Environ. Chem., 9, 263 (2012)<br></p>

<p>Applications N-Methylcaprolactam is a reagent that is used in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct.<br></p>

<p>Applications 4-(4-Chloro-2-methylphenoxy-d3)butyric Acid (CAS# 1219803-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Amino-3-methylpyridine is used in the synthesis of ketones from aldehydes.<br>References Jun, C. et al.: J. Org. Chem., 62, 1200 (1997); Jun, C. et al.: Angew. Chem. Int. Ed., 37, 145 (1998);<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications Labelled 4-Methylimidazole (M312990). 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);<br></p>

<p>Applications Intermediate in the preparation of Epinephrine metabolites<br>References Mizuta, H., et al.: Bioorg. Med. Chem., 10, 675 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Methoxyphenyl)piperazine Hydrobromide is a useful reagent for improving the synthesis of Eapidil.<br>References Wang, H., et al.: Anhui Huagong, 37, 23 (2011)<br></p>

<p>Applications Isotope labelled β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.<br></p>