Amino Acids (AA)

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Labelled L-Methionine, an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.<br>References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),<br></p>

<p>Applications Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Prochazka, Z., et al.: Collection Czechoslov. Chem. Commun., 45, 1982 (1980), Yorek, M.A. &amp; Spector, A.A.: Prog. Clin. Biol. Res., 179, 361 (1985)<br></p>

<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>

<p>Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).<br>References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)<br></p>

<p>Applications Phytosiderophores are produced in higher plants as iron chelating amino acids that promote uptake of iron from soil.<br>References Klair, S., et al.: J. Plant Nutr., 19, 1295 (1996),<br></p>

<p>Applications Potent crosslinking inhibitors.<br>References Sloan, J., et al.: J. Biol. Chem., 274, 23740 (1999).<br></p>

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Applications A product from thermal and hydrolytic degradation of Orlistat. Orlistat impurity.<br>References Stalder, H., et al.: Helv. Chimica Acta, 75, 1593 (1992),<br></p>

<p>Applications Ac-lys(ac)-oh was used in the reaction of HOCl with amino acids and peptides with ESR evidence for rapid rearrangement and fragmentation reactions of nitrogen-centered radicals.<br>References Hawkins, C., et al.: J. Chem. Soc. Perkin Trans. 2, 9, 1937 (1998);<br></p>

<p>Stability Volatile<br>Applications N-Isopropyl-N-methylamine (cas# 4747-21-1) is a compound useful in organic synthesis.<br> E0<br></p>

<p>Applications N-Methylformanilide is an aromatic reagent used in the synthesis of dye-sensitized solar cells. Also used in the synthesis of potent tyrosinase inhibitors.<br>References Meyer, T et al.: J. Org. Chem., 77, 3704 (2012); Nihei, K. et al.: Bioorg. Med. Chem. Lett., 14, 681 (2004);<br></p>

<p>Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.<br>References Andrews, D., et al.: Bioorg. Med. Chem. Lett., 18, 2580 (2008), Mahboobi, S., et al.: J. Med. Chem., 52, 2265 (2009),<br></p>

<p>Applications (E)-3-Methoxy-5-styrylphenol (cas# 35302-70-6) is a useful research chemical.<br></p>

<p>Applications DL-Proline is the racemic mixture of both L-Proline (P755995) and D-Proline (P755990).<br>References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);<br></p>

<p>Applications L-Serine-13C3 is the isotope labelled analog of L-Serine (S270995); a compound used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012)<br></p>

<p>Stability Very Hygroscopic<br>Applications 6-N-Trimethyl L-Lysine-d9, is the labeled analogue of Nε,Nε,Nε-Trimethyllysine, a metabolite and cofactor on the metabolic pathways.<br>References Rebouche C.J., et. al, J. Nutrition, 116(5), 751-759 (1986); Vaz, F.M et. al, J. Bio. Chem., 276(36), 33512-33517 (2001);<br></p>

<p>Applications N-Methyl-p-tyramineúHCl (cas# 370-98-9) is a useful research chemical.<br></p>

<p>Applications 7-Methoxy-4-(trifluoromethyl)coumarin is a biochemical for proteomics research.<br></p>

<p>Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications L-Homocysteine is the hydrolysis product of adenosine (A280400), a purine nucleoside. Metabolic fate of L-Homocysteine is converted back to L-Methionine( M260440) via tetrahydrofolate.<br>References Liu, X.D., et al.: Org. BIomolec. Chem., 11, 4258 (2013); Chen, C.S., et al.: Nueroendocrinol., 97, 232 (2013);<br></p>

<p>Applications 3-N-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.<br>References Ringseis, R., et al.: Biochem. Biphys. Gen. Subject., 1830, 2105 (2013); Ubhi, B.K., et al.: Molec. Biosys., 8, 3125 (2012);<br></p>

<p>Applications Glycyl-L-Tyrosine Dihydrate is used in process for producing N-Glycyltyrosine. Glycyl-L-Tyrosine Dihydrate is the anhydrous form of Glycyl-L-tyrosine(G720108); which is used in preparation method of high quality Aspartame and Aspartame crystallization-inducing agent.<br>References Mimura, T., et al.: Eur. Pat. Appl., (1999); Gao, Z., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications 1,2,3-Trichloro-5-methylbenzene is useful in calculating 21 physical properties of organic compounds strictly from molecular structure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jain, N., et al.: J. Pharm. Sci., 88, 852-860 (1999)<br></p>

<p>Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.<br>References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)<br></p>

<p>Applications 4-(3-HYDROXYPROP-1-EN-1-YL)-2-METHOXYPHENOL (cas# 458-35-5) is a useful research chemical.<br></p>

<p>Applications D-Homotyrosine hydrobromide<br></p>

<p>Applications 2-amino-5-methylhexanoic acid (cas# 3558-32-5) is a useful research chemical.<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Applications 3-Methanesulfinylpropan-1-amine is used in preparation of Amide compounds as pesticides including acaricides, insecticides, and parasiticides.<br>References Furukawa, H., et al.: Jpn. Kokai Tokkyo Koho, (2018);<br></p>

<p>Applications L-Glutamine (Alpha-15n, 98%) (cas# 80143-57-3) is a useful research chemical.<br></p>

<p>Applications N-Acetylglycine-d5 is an isotopic analog of N-Acetyl-glycine (A178260), a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003),<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Acrylonitrile (ACN).<br>References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),<br></p>

<p>Applications N-Methyl-N-nitroso Urea-d6 is the labelled form of N-Methyl-N-nitroso Urea (M325815), which is a precursor of Diazomethane. It has a cytotoxicity effect.<br>References Huggins, C., et al.: J. Exp. Med., 131, 321 (1970); Gullino, P.M., et al.: J. Natl. Cancer Inst., 54, 401 (1975)<br></p>

<p>Applications N-Acetyl-S-(3-hydroxypropyl)-L-cysteine Dicyclohexylamine Salt (unlabelled) (CAS# 14369-42-7) is a useful research compound.<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>Applications: Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999);<br></p>

<p>Applications L-Leucine is an essential amino acid. L-Leucine acts as a nutrient signal to stimulate protein synthesis. It has also activates the mammalian target of rapamycin kinase that regulates cell growth.<br>References Demant, T. et al.: Am. J. Physiol., 270, E1022 (1996); Diraison, F. et al.: Am. J. Physiol., 277, E529 (1999); Suryawan, A. et al.: J. Anim. Sci., 89, 2004 (2011); Peyrollier, K. et al.: Biochem. J., 350, 361 (2000);<br></p>

<p>Applications D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011);<br></p>

<p>Applications 2-Methyl-1-phenyl-1-propene can be used in analytical study of analysis and comparison of aroma compounds from traditional Tangshan sorghum liquor and samples of improved fermentation process by GC-​MS.<br>References Jiang, X., et al.: Shipin Gongye Keji, 37, 87 (2016)<br></p>

<p>Applications 5'-O-Methylthymidine (cas# 14504-60-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Chlorobutanol is used as a preservative and sedative. It has also been shown to exhibit antibacterial properties.<br>References Dutta, T., et al.: PCT Int. Appl., 22, (2020); Ibibia, E., et al.: Asian. J. Pharm. Clin. Res., 9, 179-182 (2016)<br></p>

<p>Applications 4,4-methylenebis(N,N-diethylaniline) (cas# 135-91-1) is a useful research chemical.<br></p>

<p>Applications N,N-Dimethylglycine HCl (cas# 2491-06-07) is a useful research chemical.<br></p>

<p>Applications 2-Methoxy-3-methylaniline is an important building block.<br></p>

<p>Applications 4-(4-Chloro-2-methylphenoxy-d3)butyric Acid (CAS# 1219803-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.<br>References Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011)<br></p>

<p>Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.<br>References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);<br></p>

<p>Applications 2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also used as a metabolomic biomarkers in preeclampsia.<br>References Nakagawa, K. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 878, 942 (2010); Kenny, L.C. et al.: Reprod. Sci., 15, 591 (2008); Garcia, A. et al.: Clin. Chem., 44, 1905 (1999);<br></p>