Amino Acids (AA)

<p>Applications 2-(4-methylphenyl)oxirane (cas# 13107-39-6) is a useful research chemical.<br></p>

<p>Applications 2-Methoxyethanol is used in the synthesis of 2-aminothiazoles in the treatment of prion disease (1). 2-Methoxyethanol is also used in the preparation of Rho-associated kinase inhibitors or (ROCK) inhibitors, for treatment of cardiovascular disease (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Li, Z. et al.: ChemMedChem. 2013 May;8(5):847-57.2. Boland, S. et al.: Bioorg. Med. Chem. Lett. 2013 Dec 1;23(23):6442-6.<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>M06199 - BOC-SER(TBU)-OH DCHA</p>

<p>Applications 1-Methyl-1h-1,2,4-triazol-3-amine (cas# 49607-51-4) is a useful research chemical.<br></p>

<p>Applications 3-Methoxy-4-methylaniline (cas# 16452-01-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline is a useful reagent to prepare benzofuranyl derivatives for treating solid tumours. It is also an impurity of Bosutinib.<br>References Hennequin, L. F. A. PCT Int. Appl. (2003), WO 2003047585 A1 20030612 (2003); Hennequin, L. F. A., Gibson, K. H., Foote, K. M. PCT Int. Appl. WO 2003047582 A1 20030612 (2003)<br></p>

<p>Applications (±)-2-Methyl-d3-succinic-2,3,3-d3 Acid (CAS# 347840-08-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methyl-1,3-butanediol is a useful compound in carbon oxygen coupling reactions.<br></p>

<p>Applications 2-ethyl-6-methylpyrazine (cas# 13925-03-6) is a useful research chemical.<br></p>

<p>Applications N-(Carboxymethyl)-N-[2-[(carboxymethyl)amino]ethyl]-glycine Calcium Salt Hydrate is an intermediate used to prepare copper alkylenediaminetriacetic acid complexes.<br>References Matovic, Z., et al.: Inorganica Chimica Acta, 360, 2420 (2007)<br></p>

<p>Applications L-Threonine-2,3-d2 (CAS# 1202936-45-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications 2-Fluoro-4-methylphenylboronic Acid (cas# 170981-26-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Valeric Acid Sodium Salt (cas# 6106-41-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications L-Glutamic Acid-d5 is an non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. It is also a key molecule in cellular metabolism.<br>References McEntee, W., et al.: Psychopharmacology, 111, 391 (1993), Manev, H., et al.: Mol. Pharmacol., 36, 106 (1989)<br></p>

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-2(5H)-furanone (cas# 6124-79-4) is a useful research chemical.<br></p>

<p>Stability Moisture sensitive<br>Applications Hexahydro-4-methylphthalic Anhydride, can be used in the mixture of other isomers nanofiber supported 3D interconnected BN nanosheets for epoxy nanocomposites with ultrahigh thermal management capability<br>References Chen, J., et al.: Adv. Funct. Material., 27, 5 (2017)<br></p>

<p>Applications 2-Methyl-2-(1-Methylbutyl)-propanedioic Acid 1,3-Diethyl Ester is an intermediate in the synthesis of 2,3-Dimethyl-hexanoic Acid (D473405) which is used to prepare Mono-2,3-dimethylhexyl Phthalate (M539400), a metabolite of Dibutyl phthalate (DBP) (D429495), which is widely used in consumer products.<br>References Silva, M., et al.: Arch. Toxicol., 77, 561 (2003), Silva, M., et al.: Toxicology, 210, 123 (2005), Silva, M., et al.: J. Anal. Toxicol., 29, 819, (2005)<br></p>

<p>Applications 2-Amino-3-methylpyridine is used in the synthesis of ketones from aldehydes.<br>References Jun, C. et al.: J. Org. Chem., 62, 1200 (1997); Jun, C. et al.: Angew. Chem. Int. Ed., 37, 145 (1998);<br></p>

<p>Applications 3-Methyl-1,3,5-pentanetriol is used in the synthesis of Mevalonolactone (M339040), in the synthesis of vitamins and isoprenoids such as steroids.<br>References Yamashita, H. et al.: Frag. J., 28, 62 (2000); Huang, F. et al.: J. Am. Chem. Soc., 97, 4144 (1975);<br></p>

<p>Applications 5-Amino-6-methylbenzimidazolone<br></p>

<p>Applications 2-Ethyl-2-methylpentanoic Acid is a derivative of 2,5-Dimethyl-2-ethylhexanoic Acid (D461540), used in biological studies to evaluate environmental chemicals for estrogenicity.<br>References Rabinowitz, J.R., et al.: Chem. Res. Toxicol.,22, 1594 (2009); Judson, R., et al.: Environ. Health Perspect, 117, 685 (2009)<br></p>

<p>Applications (2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).<br>References Hampson, D., et al.: J. Biol. Chem., 274, 33488 (1999), Jensen, A., et al.: Eur. J. Pharmacol., 397, 247 (2000),<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Applications 4-(4-Methoxyphenyl)-2-butanone is also used in the synthesis of novel axially chiral Rh-NHC complexes. Used to synthesize carbonyl complexes as novel traceless linkers.<br>References Duan, W. et al.: Chem. Comm., 23, 2916 (2003); Gibson, S. et al.: Tetrahedron. Lett., 40, 1417 (1999);<br></p>

<p>Applications N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.<br>References Lopez, B., et al.: Chem. Commun., 47, 1054 (2011); Albert, J., et al.: Organometallics, 32, 649 (2013);<br></p>

<p>Applications 4-Methyl-6-(methylamino)-1,3,5-triazin-2(1H)-one is a heterocyclic Triazine based building block useful in organic synthesis. It is related to 2-Amino-4-methoxy-6-methyl-1,3,5-triazine (A616880), which is used to synthesize pesticides.<br>References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006);<br></p>

<p>Applications p-Methoxytoluene is a building block that has been used as a reactant for the preparation of electrophilic fluorinating agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baudoux, J., Cahard, D.: Org. Reactions, 69, 347 (2007)<br></p>

<p>Applications 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Also used as a reagent in the synthesis of Metolachlor (M338700); a selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Titchenell, P.M., et al.: Bioorg. Med. Chem. Lett., 23, 3034 (2013); Zhang, H.: Nongyao Kexue Yu Guanli, 32, 26 (2011)<br></p>

<p>Applications N-Methyl-N-nitroso-ethenamine is used as research reagent for base induced fragmentation to give aldehydes or ketones and smaller alkylnitrosamine<br>References Leoppky, R.N., et al.: J Org. Chem, 23, 135(1982)<br></p>

<p>Applications Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, R., et al.: J. Med. Chem., 52, 4481 (2009); Picard, F., et al.: J. Med. Chem., 45, 3406 (2002)<br></p>

<p>Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.<br>References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)<br></p>

<p>Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.<br>References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);<br></p>

<p>Stability Hygroscopic<br>Applications 4-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride (cas# 106261-49-8) is a compound useful in organic synthesis.<br></p>

<p>Applications A metabolite of S-propylcysteine.<br>References Jones, A.R., et al.: Xenobiotica, 10, 827 (1980), 25) Ramu, K., et al.: Chem. Res. Toxicol., 8, 515 (1995), Krause, R., et al.: Drug Metab. Dispos., 25, 1013 (1997), Powley, M., et al.: Chem. Res. Toxicol., 16, 1448 (2003),<br></p>

<p>Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.<br>References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)<br></p>

<p>Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.<br>References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)<br></p>

<p>Applications 1-(2-Chloroethoxy)-2-methoxy benzene, is an impurity of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);<br></p>

<p>Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.<br>References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7<br></p>

<p>Stability Hygroscopic<br>Applications Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe.<br>References McRee, D., et al.: J. Struct. Biol., 125, 156 (1999), Wang, L., et al.: Science, 292, 498 (2001), Ioerger, T., et al.: Methods Enzymol., 374, 244 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications Pantothenic Acid is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.<br>References Gardner, P., et al.: Food Chem., 68, 471 (2000); Ou, B., et al.: J. Agric. Food Chem., 50, 2772 (2002); Bahorun, T., et al.: J. Sci. Food Agric., 84, 1553 (2004)<br></p>

<p>Applications Fructose-histidine is an amadori compound formed in food.<br>References Wang, J., et al.: J. Mass Spec., 43, 262 (2008); Hashiba, H.: J. Agri. Food Chem., 24, 70 (1976)<br></p>

<p>Applications 4-Aminobutyl-d8 Guanidine is the labelled analog of the decarboxylation product of the amino acid arginine (A769500) and also an intermediate in polyamine biosynthesis.<br>References Golding, B.T., et al.: Biochem. Soc. Trans., 22, 391S (1994);<br></p>

<p>Applications L-Arginine-2,3,3,4,4,5,5-d7 HCl (CAS# 204244-77-9) is a useful isotopically labeled research compound. It can be used with Raman scattering for imaging living cells and organisms.<br>References Min, W., et al., PCT Int. Appl. (2014), WO 2014205074 A2<br></p>

<p>Applications A metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>

<p>Applications A serine derivative. Used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics.<br>References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),<br></p>

<p>Applications 3,3’-Methylimino-di-propionitrile (cas# 1555-58-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>