Amino Acids (AA)

Applications Methyl 4-Methoxysalicylate, is an organic building block, used for the synthesis of (+)-coriandrone A and B, two bioactive natural products. It can also be used for the preparation of Dimethoxybenzofuran derivatives as potent and selective inhibitors of CYP2A6.
References Wang, W., et al.: Org. Biomol. Chem., 11, 6686 (2013); Yamaguchi, Y., et al.: Heterocycles, 87, 1727 (2013);

Applications 2-Methyl-3-(4-trifluoromethoxyphenyl)benzoic Acid is a useful research chemical used in the clinical discovery of NVP-LDE225 as selective Smoothened antagonist.
References Pan, S., et al.: ACS Med. Chem. Lett., 1, 130 (2010)

Applications DL-N-Boc-alanine is a derivative of Alanine and is used in peptide synthesis.
References Flohr, S., et al.: Chem. Eur. J., 5, 669 (1999); Kadereit, D., et al.: ChemBioChem., 1, 144 (2000); Volkert, M., et al.: Biol. Chem., 382, 1133 (2001)

Applications 5-Methylhexanol is an intermediate used in the synthesis of flavolipids as antitumor agents.
References Weaver, R., et al.: Bioorg. Med. Chem. Lett., 6, 2405 (1996), Guo, H., et al.: J. Med. Chem., 45, 2056 (2002), Hurley, L., et al.: Nat. Rev. Cancer, 2, 188 (2002),

Applications 1-(2-Methylphenyl)ethanamine (cas# 42142-17-6) is a useful compound for the synthesis and screening of macamides analogs as TNF-​α inhibitors.
References Perez, T., et al.: RSC Med. Chem., 11, 1196 (2020)

Applications (4R)-4,6-Dihydroxy-2-methyl-1-(3-methoxy-4-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-d3 is labelled (4R)-4,6-Dihydroxy-2-methyl-1-(3-methoxy-4-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline which is an impurity of (R)-Phenylephrine Hydrochloride (P320640), an α-Adrenergic agonist.
References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946), Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974)

Applications 3-methylpyrrolidin-3-ol hydrochloride (cas# 921592-91-8) is a useful research chemical.

Stability Moisture Sensitive
Applications 1-Methyl-7-nitroisatoic Anhydride is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in <70 seconds.

Applications N2-Cbz-D-glutamine is an N-Cbz-protected form of D-Glutamine (G597295). D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.
References Almassy, R., et al.: Nature, 323, 304 (1986); Frank, H., et al.: J. Chromatog. B: Biomed. Sci. Appl., 224, 177 (1981); Jayme, D.: Cytotechnology, 5, 15 (1991); Kagan, H. & Meister, A.: Biochemistry, 5, 725 (1966); Levintow, L. & Meister, A.: J. Am. Chem. Soc., 75, 3039 (1953); Raj, D., et al.: Am. J. Phys. Endo. Metab., 280, E214 (2001); Varadi, M., et al.: Biosens. Bioelect., 14, 335 (1999)

Applications 1-(2,5-dimethoxy-4-methylphenyl)-2-propanone Oxime is a reagent used in research.
References Gal, J., et al.: J. Med. Chem., 18, 683 (1975);Weinkam, R., et al.: Anal. Chem., 48, 203(1976);Coutts, R.T., et al.: Org. Mass Spec., 7, 985 (1973)

Applications 4-Anilinomethylenepentenedioic Acid-d5 5-Methyl Ester (cas# 1185237-80-2) is a compound useful in organic synthesis.

Applications 4-Methyl-3-nitrobenzoic Acid-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications 3-Hydroxy-2-methylbutanoic Acid Ethyl Ester_x000D_(Mixture of Diastereomers) (cas# 27372-03-8) is a compound useful in organic synthesis.

Applications Ethyl 3-Hydroxy-3-methyl-d3-butyrate-4,4,4-d3 (CAS# 30385-86-5) is a useful isotopically labeled research compound.