Amino Acids (AA)

Applications 6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one is used as a reactant in the preparation of pyrido[2,3-d]pyrimidin-7-one derivatives as selective inhibitors of cyclin-dependent kinases 4 and 6.
References VanderWel, S., et al.: J. Med. Chem., 48, 2371 (2005); Toogood, P., et al.: J. Med. Chem., 48, 2388 (2005);

Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.
References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)

Applications 2-Methoxycarbonylphenylboronic acid

Applications (4R)-6-Methoxycarbonyl-4-phenyl-3,4-dihydrocoumarin is an intermediate in the synthesis of (R)-5-Hydroxymethyl Tolterodine Formate (H949480), a metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence.
References Palmer, L., et al.: J. Pharm. Biomed. Anal., 16, 155 (1997); Hills, C., et al.: Drugs, 55, 813 (1998); Wefer, J., et al.: World J. Urol., 19, 312 (2001)

Applications D-Leucine methyl ester hydrochloride is a protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.
References Chuan, Y., et al.: Chin. J. Anim. Vet. Sci., 4, 003 (1985); Fox, S., et al.: J. Biol. Chem., 155, 465 (1944); Gillillad, S. & Speck, M.: J. Dairy Sci., 51, 1573 (1968); Schoenheimer, R., et al.: J. Biol. Chem., 130, 703 (1939); Seltzer, S., et al.: Pain, 11, 141 (1981)

Applications Fmoc-d-3-pyridylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Applications Chlorophenprop-methyl

Applications L-tert-Leucine Methyl Ester Hydrochloride is used in the preparation of peptidomimetic protease inhibitors.
References Babine, R., et al.: PCT Int. Appl. (2002), WO 2002018369 A2 20020307

Applications 2-amino-6-methylbenzamide (cas# 1885-31-0) is a useful research chemical.

Applications Methyl 1-Methyl-1,2,3-triazole-5-carboxylate (cas# 105020-38-0) is used as a reagent in the composition and method for treating cognitive impairments in Down syndrome subjects.
References Potier, M. C., et al.: U.S. (2015) CODEN:USXXAM