Amino Acids (AA)

Applications A precursor to 3-Methyl-2-butenyl-1-thiol-d6 which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request.

Stability Hygroscopic
Applications 2,2-Diselanediyldiethanamine dihydrochloride (cas# 3542-13-0) is a useful research chemical.

Applications 4-Bromo-3-fluoro-N-methylbenzamide

Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).

Applications methyl 2-hydroxy-5-methylbenzoate (cas# 22717-57-3) is a useful research chemical.

Applications (4-Chloro-3-nitrophenyl)phenyl-methanone is a useful starting material for organic synthesis.

Applications Ethyl N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-amino-propanoate is used in the preparation of dibenzothiazepines as opioid receptor agonists; Also, it is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine (C424340), which is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.
References Kruegel, A., et al.: PCT Int. Appl. (2017) WO 2017049158; Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)

Applications 1-[(S)-3-(Acetylthio)isobutyryl]-L-proline Hydrate is used in the preparation of captopril derivatives, used as angiotensin converting enzymes.
References Li, H. et al.: Res. Chem. Intermed., 2, 621 (2013);

Applications N6-(2-Carboxyacetyl)-L-lysine Trifluoroacetate Salt is an intermediate used in the synthesis of N6-(2-Carboxyacetyl)-L-lysine (C178063), which is a malonylated conjugate of L-lysine (L468895) essential amino acid.
References Tosha, L. et. al.: Biochem. J., 435, 509 (2011); Peng, C., et al.: Mol. Cell. Proteomics, 10, 012658/1 (2011);

Applications 2-(4-Methylthiazol-5-yl)ethanamine is used in the synthesis and biological testing of several new H2 (Histamine) agonists.
References Timmerman, H., et al.: J. Quant. Struct-Act. Rel., 11, 219 (1992)

Applications A new glutamate analogue as potential neuroprotective agent.
References Takahashi M, et al. 1997. J Exp Biol. Jan;200(Pt 2):401-9. Michaelis EK. 1998. Prog Neurobiol. Mar;54(4):369-415Koch HP, et al. 1999. Mol Pharmacol. Jun;55(6):1044-8 O’Kane RL, et al.1999. J Biol Chem. Nov 5;274(45):31891-5

Stability Moisture Sensitive
Applications Contains approximately 12% dichloromethane and 8% ethyl acetate