Amino Acids (AA)

<p>Applications 3-methyleneazetidine hydrochloride (cas# 1443624-17-6) is a useful research chemical.<br></p>

<p>Applications 3-Amino-4-methyl-pyridazine is a reactant used in the synthesis of antiinflammatory agents such as 2-​phenylimidazo[1,​2-​b]​pyridazine-​3-​acetic acid.<br>References Sacchi, A. et al.: Eur. J. Med. Chem., 34, 1003 (1999);<br></p>

<p>Applications N-Boc-4-phenyl-L-phenylalanine is a reactant used in the synthesis of novel phenylalanines derived diamides as factor XIa inhibitors used in the treatment.<br>References Smith, L. et al.: Bioorg. Med. Chem. Lett., 26, 472 (2016);<br></p>

<p>Applications 2-Methyl-4,5,7-trichloroquinoline (cas# 203626-80-6) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-D-phenylalanine Methyl Ester Hydrochloride is one of the enatiomer in 4-Chloro-DL-phenylalanine Methyl Ester Hydrochloride (C377780) which is a tryptophan (T947200) hydroxylase (TPH) inhibitor and a serotonin (S274980) synthesis inhibitor. 4-Chloro-D-phenylalanine methyl ester hydrochloride is also known to induce memory deficits in rats.<br>References Aristieta, A., et al.: Psychopharmacology, No vol. given, 1 (2013); Bechtholt, A., et al.: Psychopharmacology, 190, 531 (2007); Jensen, J., et al.: Eur. Neuropsychopharm., 24, 148 (2014);<br></p>

<p>Applications Alanine derivative<br>References Wenzel, T., et al.: Anal. Bioanal. Chem., 378, 1536 (2004), Piscitelli, F., et al.: J. Med. Chem., 52, 1922 (2009),<br></p>

<p>Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.<br>References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)<br></p>

<p>Applications 2-Methoxycarbonylphenylboronic acid<br></p>

<p>Applications Fmoc-d-3-pyridylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications 4-Chloro-4'-methyl-3-nitrobenzophenone is a benzophenone derivative used in the preparation of nitrogen-containing heterocycles.<br>References Orlov, V.Y. et al.: Azot. Geterot. Alkal., 1, 452 (2001);<br></p>

<p>Applications DL-2-Pyrrolidone-5-carboxylic Acid is used in the preparation of AZT steroid conjugates as potent anti-HIV agents.<br>References You, Z. et al.: Nucleos. Nucleot. Nucl. Acids, 25, 37 (2006);<br></p>

<p>Applications 3-Methoxy-10H-phenothiazine is used in the synthesis of 10-Dechlorovancomycin (D226740), which is an impurity of Vancomycin (V096500, HCl salt) which is an amphoteric glycopeptide antibiotic produced by Streptomyces orientalis discovered in soil. Vancomycin inhibits bacterial cell wall synthesis by binding to peptidoglycan.<br>References Marshall, F.J., et al.: J. Med. Chem., 8, 18 (1965), Cunha, B.A., et al.: Med. Clin. North Am., 79, 817 (1995), Li, L., et al.: Ther. Drug Monit., 17, 366 (1995)<br></p>

<p>Applications 3-Bromo-4-methylphenol is a component of the marine alga polysophornia Sphaerocarpa. It is also a useful raw material for organic synthesis and pharmaceuticals.<br>References Flodin, C., et al.: Phytochemistry, 53, 77 (2000); Munday, S. D., et al.: ChemCatChem, 9, 2512 (2017)<br></p>

<p>Applications L-Aspartic Acid (13c4, 99%; 15n, 99%) (cas# 202468-27-7) is a useful research chemical.<br></p>

<p>Applications 4-Methylphenethylamine is the monomethylated derivative of phenethylamine (P321335) and can readily cross the blood-brain barrier in rats showing a brain-uptake index of 98%.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mosnaim, A. D., et al.: Neurochem. Res., 38, 842 (2013)<br></p>

<p>Applications 1,3-Dichloro-3-methylbutane is used as a reagent in the synthesis of Precocene analogs which exhibit anti-juvenile hormone activity against Oxycarenus lavaterae.<br>References Camps, F., et al.: Pestic. Chem.:  Hum. Welfare Environ., Proc. Int. Congr. Pestic. Chem., 5, 183 (1983)<br></p>

<p>Applications (±)-1-Bromo-2-ethyl-3-methyl-d3-butane-3,4,4,4-d4 (CAS# 1219805-84-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-ylboronic acid, pinacol ester (cas# 1220696-32-1) is a useful research chemical.<br></p>

<p>Applications Sarcosine ethyl ester hydrochloride is a metabolite of Sarcosine (S140500), which as been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression.<br>References Baumann, et al.: J. Biol. Chem., 21, 563 (1915), Novellie, L., et al.: Nature, 173, 450 (1954); Arun, S., et al.: Nature, 457, 910 (2009),<br></p>

<p>Applications A substituted Glycine (G615990) used as parakeratosis inhibitor and external composition for skin.<br>References Pucci, B., et al.: Eur. Polymer J., 26, 731 (1990),<br></p>

<p>Applications 6-Methoxy-m-cresol is a useful chemical reagent. It has been found as one of the chemical constituent of phytoncides and has antioxidative activity.<br>References Abe T., et al., Aroma Res., 7, 56-62 (2006)<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 3-methylpentanal (cas# 15877-57-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-methylpentane-1,3-diol (cas# 54876-99-2) is a useful research chemical.<br></p>

<p>Stability Temperature Senstive<br>Applications D,L-3-Indolylglycine (cas# 6747-15-5) is a compound useful in organic synthesis.<br>References J. Chem. Soc., 458 (1940)<br></p>

<p>Applications Intermediate in the preparation of labelled Trimebutine metabolites.<br></p>

<p>Applications: 4-Methoxy-[7-13C]-benzoic Acid (cas# 69838-89-7) is a compound useful in organic synthesis.<br></p>

<p>Applications DL-3-Bromophenylalanine is used in the synthetic preparation of hydroxyethylene sulfones as scaffolds for design, synthesis, and structural characterization of aspartic proteinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Specker, E.; et al.: J. Med. Chem, 48, 6607 (2005)<br></p>

<p>Applications Building block in peptide synthesis.<br>References Pansare, S. V.; Org. Synth. 70, 10(1992)<br></p>

<p>Applications 2-HYDROXY-N,N-DIMETHYLACETAMIDE (cas# 14658-93-6) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 3-Dimethylamino-1-(3-methoxyphenyl)propan-1-one is an intermediate in the synthesis of Oxyfedrine (O870700), which acts as a vasodilator affecting the coronary base flow.<br>References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);<br></p>

<p>Applications Boc-D-serine is D-serine (S270975) with amine protected from eletrophiles by tert-butyloxycarbonyl group in organic synthesis. Boc-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>

<p>Applications L-Aspartic Acid salcium salt is used in three high-dose oral calcium salts model (CaCO3, CaCl2, Ca-aspartate-hydrochloride) which has effects on acid-base metabolism, plasma electrolytes and urine parameters in rats.<br>References Classen, H.G., et al.: Experim. Clin. Pharmacol., 17, 437 (1995),<br></p>

<p>Applications N,N-Dimethyl-2'-O-methylguanosine is a modified nucleoside in tRNA of hyperthermophilic archaebacteria.<br>References Kowalak, J. A., et al.: Biochemistry, 33, 7869 (1994);<br></p>

<p>Applications 1-BOC-1,2,3,4-Tetrahydroquinoline-6-boronic acid<br></p>

<p>Applications L-Alanine Ethyl Ester Hydrochloride is used in the synthesis of nucleoside phosphoramidates as antiviral agents for human immunodeficiency and hepatitis B viruses. Also used in synthesis of enantiomerically pure amino acid ester isocyanates.<br>References Bondada, L. et al.: ACS, Med. Chem. Lett., 4, 747 (2013); Nowick, J. et al.: J. Org. Chem., 57, 7364 (1992);<br></p>

<p>Applications Cisatracurium-20-methyl Dibenzenesulfonate is an impurity of Cisatracurium (C496700), an enantiomer of Atracurium Besylate (A794500), a neuromuscular blocking agent. It could be used in liver transplant patient with safety.<br>References Hughes, R., et al.: Br. J. Anaesth., 53, 31 (1981); Basta, S.J., et al.: Anesth. Analog., 61, 723 (1982); Neill, E.A., et al.: Xenobiotica, 12, 203 (1982); Bangsbo, J., et al.: J. Physiol., 422, 539 (1990)<br></p>

<p>Applications 5-(t-Boc-amino)-1-pentyl-p-toluenesulfonate (cas# 118811-34-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(4-Chloro-6-methoxyphenyl)-2,2-dimethylpropanamide (cas# 113137-29-4) is a compound useful in organic synthesis.<br></p>

<p>Applications A Glycine ester, a non-essential amino acid for human development.<br>References Tamura, M., et al.: Peptide Chem., 26, 35 (1989),<br></p>

<p>Applications 2-(2-Boc-aminoethoxy)ethanol is a reactant that has been used in the synthesis of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, X., et. al.: Molecules, 18, 13957 (2013)<br></p>

<p>Applications N-[(Phenylmethoxy)carbonyl]-L-serine Methyl Ester is used to inhibit the activity of Mycobacterium tuberculosis in studies. Also used in the synthesis of pyrazinecarboxamide-based compounds acting as inhibitors of diacylglycerol acetyltransferases regarding treatment of obesity.<br>References Barlind,J.G. et al.: J. Med. Chem., 55, 10610 (2012); Pinheiro, A.C. et al.: J. Res. Chem., 3, 180 (2007);<br></p>

<p>Applications DL-Homocystine is used in the synthesis of potential antitumor agents through inhibition of L-asparagine. There is growing clinical evidence that elevated homocysteine levels are associated with an increased risk of venous and arterial thrombosis.<br>References Brynes, S. et al.: J. Pharm. Sci., 67, 1550 (1978); Lauricella, A. et al.: Thromb. Res., 107, 75 (2002);<br></p>

<p>Applications L-Serine-d7 (CAS# 935275-35-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Methyl-2-butenal is used in the synthesis of L-Felinine (F231250), which is an amino acid found in the urine of species of the Felidae family; believed to either possess pheromone activity or give rise to compounds with such activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Daniels, D.L. and Richert, C.: Tetrahedron Letters, 40, 4463 (1999)<br></p>

<p>Applications N-Benzyloxycarbonylglycine thioamide (cas# 49548-40-5) is a useful research chemical.<br></p>

<p>Applications Fmoc-Cop is used in the synthesis of disubstituted pyrimidines as Lck inhibitors.<br>References Hunt, J., et al.: Bioorg. Med. Chem. Lett., 19, 5440 (2009)<br></p>

<p>Applications 5-Methyl-2-hexanone is used in the preparation od S1P1 receptor agonists. Also used in the preparation of indoles in an efficient synthesis involving the use of TCT (2,4,6-trichloro-1,3,5-triazine).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bolli, M. et al.: J. Med. Chem., 57, 78 (2014); Siddalingamurthy, E. et al.: Tetrahedron Lett., 54, 5591 (2013);<br></p>

<p>Applications Ethyl β-Alanine-2,2,3,3-d4 Ester is an intermediate used in the synthesis of N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine-d4 (C424342), which is an isotope labelled N-(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)-β-alanine is a metabolite of Tianeptine (T436800), a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991), Nair, M. et al.: Analyst, 123, 2267 (1998)<br></p>

<p>Applications Fmoc-valine is a sterically hindered, Fmoc protected amino acid and is a derivative of L-Valine (V094205). Fmoc-valine (in addition to the other amino acids) is commonly used to synthesize 4-thiazolidinones (e.g. (E)-5-(4-Ethylbenzylidene)-2-thioxothiazolidin-4-one [E925745]) and 4-metathiazanones as well.<br>References Bernatowicz, M., et al.: Tetrahed. Lett., 30, 4645 (1989); Holmes, C., et al.: J. Org. Chem., 60, 7328 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications Lauryl Betaine is an amphoteric surfactant derived from N-dodecyl-N,N-dialkanol amine with protein denaturing potency. Lauryl Betaine is mainly used in shampoo, personal hygiene products and oil field chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kimura, Y. et al.: J. SCCJ, 29, 106 (1995); Qin, C. et al.: GUang. Huag., 34, 30 (2006); Peng, Z. et al.: Riy. HUax. Gong., 37, 135 (2007);<br></p>

<p>Stability Light Sensitive<br>Applications 4-Bromo-1,2-methylenedioxybenzene<br></p>

<p>Applications 5-Methyl-pyrazine-2-carboxylic Acid (cas# 5521-55-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>

<p>Applications 5-(4-Methyl-1,3-Dioxolan-2-yl)-1,3-Benzodioxole (cas# 61683-99-6) is a useful research chemical.<br></p>

<p>Applications 2-methoxy-4-methyl-5-nitropyridine (cas# 6635-90-1) is a useful research chemical.<br></p>

<p>Applications N2-[(Phenylmethoxy)carbonyl]-L-lysine id used in the synthesis of hydroxamic acids and mycobacterium inhibitors.<br>References Hu, J. et al.: J. Am. Chem. Soc., 119, 3462 (1997); Xue, C. J. Med. Chem., 44, 2636 (2001);<br></p>

<p>Applications L-Lysine-DL-amphetamine-d6 2HCl (propane-1,1,2,3,3,3-d6) (CAS# 1276056-89-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-fluoro-4-methoxybutan-1-amine hydrochloride (cas# 2098022-94-5) is a useful research chemical.<br></p>

<p>Applications L-Isoleucine methyl ester is a protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>