Amino Acids (AA)

<p>Applications 2-Methyl-3-furoic Acid-d3 is a deuterated version of 2-Methyl-3-furoic Acid (M304063), a useful reactant in the synthesis of therapeutic agents.<br>References Jin, Hong, et al.: Bioorg. Chem., 73, 76-82 (2017);Paul, Rakesh, et al.: ACS Chem. Bio., 12(6), 1576-1583 (2017)<br></p>

<p>Applications DL-Lysine-2-15N 2HCl (CAS# 2747-89-9) is a useful isotopically labeled research compound. This compound can be used for spectrophotometric analysis to determine the mechanism of electron-capture-induced dissociation of various peptides.<br>References Holm, A., et.al., J. Phy. Chem.A.,111,9641-9643,(2007); Nakamura, A. Nippon Kagaku Zasshi,86,500-505,(1965);<br></p>

<p>Applications (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester (cas# 54393-21-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloroethyl 4-methylbenzenesulfonate is a useful reactant for the synthesis of triphenylethanamine derivatives, and fluorinated carbazole derivatives.<br>References Qiao, J.X., et al.: J. Med. Chem., 58, 9010-26 (2015); Mizuno, Y., et al.: J. Phys. Chem. C, 116, 20681-87 (2012);<br></p>

<p>Applications A useful deuterated synthetic intermediate.<br></p>

<p>Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.<br></p>

<p>Applications Tetrabutylammonium 8-Hydroxy-5-methyloctanoate is an intermediate in the synthesis of 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester-d8 (C987317), which is labelled 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester (C987315) which is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications Fmoc-1-pyrrolidine-3-carboxylic acid<br></p>

<p>Applications 2-Methyl-5-oxo-1-cyclopentenyl Propionate (cas# 87-55-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 1-Methyl-1H-pyrazole-4,5-diamine sulfate is used as a coupling reagent in synthetic hair dye products.<br>References Clausen, T., et al. Preparation of Diaminopyrazole Derivatives for Oxidative Hair Dyes. Ger. Offen. 3843892. Jun 28. 1990.<br></p>

<p>Applications 4-(4-Boc-piperazine-1-carbonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications rel-(4R,5R)-5-(4-Chlorophenyl)-4-methyl-2-thiazolidinone is a useful building block and has been used in the synthesis of hexythiazox (H298500).<br>References Lou, J.; et al.: Nongyao, 47, 328 (2008).<br></p>

<p>Applications 2-Methyl-2H-1,2-benzothiazin-4(3H)-one 1,1-Dioxide is an intermediate used in the synthesis of Amido Methyl Meloxicam (A576790), which is an impurity of Meloxicam (M216100).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lazer, E., et al.: J. Med. Chem., 40, 980 (1997),<br></p>

<p>Applications Reagent used in preparing Dibenzocycloheptenes.<br></p>

<p>Applications 4-(4-Methoxyphenyl)-1-butanol is used as a reactant in nonimidazole histamine H3 receptor ligands preparation with combined inhibitory histamine N-methyltransferase activity.<br>References Apelt, J., et al.: J. Med. Chem., 45, 1128 (2002);<br></p>

<p>Applications 5-Fluoro-2-methylbenzothiazole is a useful reactant in the preparation of antileishmanial drug candidates.<br>References Lasing, T., et al.: Bioorg. Med. Chem., 28, 115187 (2020)<br></p>

<p>Applications Ethyl 4-Methyl-3,5-dioxoheptanoic Acid Ester is an intermediate used in the synthesis of Helipyrone A (H230500), which is anti-inflammatory natural product related to Arzanol isolated from the flowering plant Helichrysum italicum of the Mediterranean coast.<br>References Appendino, G., et al.: J. Nat. Prod., 70, 608 (2007);<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications (2E)-4-Methoxy-2-butenoic Acid is used in the protection of hydroxy groups in molecules forming esters such as cronate.<br>References Arentzen, R. et al.: J. Chem. Soc. Chem. Comm. 8, 270 (1977);<br></p>

<p>Applications 1-[4-[3-(4-Acetyl-2-methoxyphenoxy)propoxy]-3-ethoxyphenyl]ethanone is an impurity of Iloperidone (I267200); an atypical antipsychotic drug used in the treatment of schizophrenia.<br>References Ichikawa, J., et al.: Brain Res., 956, 349 (2002); Potkin, S. G., et al.: J. Clin. Psychopharm., 28, S4 (2008)<br></p>

<p>Applications 1-methyl-1,2-dihydropyrimidin-2-one (cas# 3739-81-9) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-2-(N-methylamino)pyridine is useful for the synthetic preparation of halo aminopyridines.<br>References Sun, C., et al.: ACS Omega, 4, 10534 (2019)<br></p>

<p>Applications N-Cbz-N'-isopropyl-DL-phenylglycinamide is a derivative of [α-​[(2-​Hydroxyethyl)​carbamoyl]​benzyl]​-carbamic Acid Benzyl Ester (CAS# 94068-23-2), which could have anticonvulsant properties.<br>References Schloegl, K., et al.: J. Med. Pharma. Chem., 4, 231 (1961)<br></p>

<p>Applications N-t-Boc-valacyclovir-d8 is an intermediate in the synthesis of Valacyclovir-d8 Hydrochloride, a labeled impurity of Acyclovir (A192400), an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications 1-((S)-1-(3-Methoxyphenyl)ethyl)-4-((S)-1-(4-methoxyphenyl)ethyl)piperazine-2,5-dione is an intermediate in the synthesis of labelled L-2-Aminobutyric Acid-d1 (A602931).<br>References O’Reilly, E., et al.: Amino. Acids., 39, 849 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications A heterobifunctional polyethyleneglycol (PEG) derivative used in the preparation of intramolecular linking agents.<br>References Moreau, J. et al.: Eur. J. Org. Chem., 9, 1641 (2011);<br></p>

<p>Applications 4-[(4-Methoxyphenyl)formamido]butanoic Acid is a derivative of Aniracetam(A672800) which is a cognition enhancer related to Piracetam. Nootropic.<br>References Foltyn, P., et al.: Arzneim.-Forsch., 33, 865 (1983), Yamada, K., et al.: Pharmacol. Biochem. Behav., 22, 645 (1985), Schlappi, B., et al.: Drug Invest., 5, 50 (1993); Yu, Yang. et al., Handbook of Metabolic Pathways of Xenobiotics. 3, 895-897(2014);<br></p>

<p>Applications 1-Chloro-3-methoxy-2-propanol is used in the synthesis of O-Methylganciclovir (M275440), an analogue of Ganciclovir (G235000) and displays excellent antiviral activity when tested in vivo against herpes simplex virus type 1 infection in mice.<br>References Winkelmann, E., et. al.: Arzneimittel-Forsch, 38, 1545 (1988)<br></p>

<p>Applications bis(4-(2-Methoxyphenyl)piperazine-1-carboximidamide) Sulfuric Acid is an aminopyrimidines derivatives that are used as glycogen synthase kinase 3 inhibitors<br>References Nuss, John M. et al., U.S. Pat. Appl. Publ. (2002)<br></p>

<p>Applications 3-Methyl-2-phenylbutanenitrile is used as a reagent in the synthesis of disubstituted aminopiperidines as calcium channel blockers which are active on pain and neuropathic pain. 3-Methyl-2-phenylbutanenitrile is also used as a reagent in the synthesis of (methylethyl)(oxopropyl)benzeneacetonitrile and noremopamil enantiomers.<br>References Teodori, E., et al.: J. Med, Chem., 47, 6070 (2004); Gilmore, J., et al.: J. Chem. Soc., Perkin Trans. 1., no vol., 2845 (1996)<br></p>

<p>Applications 6-Methyloctanoic acid is a branched fatty acid derivative found in ewe's milk and cheese. 6-Methyloctanoic acid is converted to lactones via antimycin biosynthetic pathways.<br>References Zviely, M.: Perfumer &amp; Flavorist, 37, 30 (2012); Riclea, R.; et al.: ChemBioChem, 13, 1635 (2012).<br></p>

<p>Applications 2-Methyl-4,5,7-trichloroquinoline (cas# 203626-80-6) is a useful research chemical.<br></p>

<p>Applications 1-Methylnaphthalene-d10 (CAS# 38072-94-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Amino-5-methoxy-2-methyl-n-methylbenzenesulfonamide<br></p>

<p>Applications N-(2-Methoxyethyl)-2,6-xylidine-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 3-Ethoxy-5-methylphenylboronic acid<br></p>

<p>Applications (αR)-α-(Methylamino)-methyl ester Hydrochloride (1:1) Benzeneacetic Acid is useful in the synthesis of N-methylated amino acids.<br>References Spengler, J., et al.: Sythesis, 1, 67 (1998)<br></p>

<p>Applications N-[4-(Aminocarbonyl)phenyl]-2-methyl-4-oxazolecarboxamide (cas# 1119444-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications N-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranos-1-yl]-L-valine is an intermediate used in the synthesis of Fructose Valine (F792595), which is an amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.<br>References Horiuchi, T., et al.: Agric. Biol. Chem., 55, 333 (1991), Sosnovsky, G., et al.: J. Pharm. Sci., 82, 649 (1993), Glinsky, G., et al.: Cancer Res., 56, 5319 (1996),<br></p>

<p>Applications (S)-2-(tert-Butoxycarbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid is a novel photo-cross linker for live-cell imaging.<br>References Pan, S., et al.: Angewandte Chemie Int. Ed., 56, 11816(2017)<br></p>

<p>Applications 9-(Acetyloxy)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one can be synthesized from 3-(2-Chloroethyl)-2-methyl-9-(benzyloxy)-4H-pyrido[1,2a]pyrimidin-4-one (C366140).<br></p>

<p>Applications 2-Methyl-9H-carbazole (cas# 3652-91-3) is a useful research chemical.<br></p>

<p>Applications 6,6'-Methylenebis(2-(tert-butyl)-4-ethylphenol) (cas# 88-24-4) is a useful research chemical.<br></p>

<p>Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.<br>References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);<br></p>

<p>Applications N-Benzoyl-3-methoxytyrosine is an intermediate used in the synthesis of rac 3-O-Methyl DOPA (M303805), which is an impurity of Levodopa (D533751). A useful marker that can be used to screen for the absense of Aromatic L-amino acid decarboxylase (AADC).<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003)<br></p>

<p>Applications 2-(2-Formyl-6-methoxyphenoxy)propanoic Acid has been used as a reactant for the preparation of leukotriene B4 antagonists.<br>References Ando, K., et. al.: Org. Biomol. Chem., 6, 296 (2008)<br></p>

<p>Applications A precursor to 3-Methyl-2-butenyl-1-thiol-d6 which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request.<br></p>

<p>Applications Methyl 5-Chloro-2-methoxy-d3-benzoate (CAS# 1219803-33-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glycyl-DL-serine (cas# 687-38-7) is used in the proton magnetic resonance studies of the interaction of amino acids and dipeptides with sRNA.<br>References Kwon, S. J., et al.: Taehan Hwahakhoe Chi, 21, 171 (1977); Bekker, Z. M., et al.: Biochem. Biophys. Res. Commun., 38, 871 (1970);<br></p>

<p>Applications 2,4-Dimethoxy-beta-methylcinnamic Acid (cas# 7706-67-4) is a useful research chemical.<br></p>

<p>Applications 4-Methoxytoluene-2,3,5,6-d4 (CAS# 350818-57-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(Cinnamoyl)-4-methoxyaniline (cas# 76228-15-4) is a compound useful in organic synthesis.<br></p>

<p>Applications (3R)-1-Methyl-3-Pyrrolidinemethanol is a reactant in the synthesis of heterocyclic carboxylic acid amides with potential as PDK1 inhibitors.<br></p>

<p>Applications 1-(2-hydroxy-5-methoxyphenyl)propan-1-one (cas# 49710-99-8) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-N-methylacetamide is an intermediate used to prepare piperidinylamino pyrrolopyrimidines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.<br>References Flanagan, M., et al.: J. Med. Chem.,53, 8468 (2010); Alam, M., et al.: Bioorg. Med. Chem. Lett., 17, 3463 (2007)<br></p>

<p>Applications 2,4-DICHLORO-7-METHYLQUINOLINE (cas# 102878-19-3) is a useful research chemical.<br></p>

<p>Applications 5-Methyl Tetrazole is used in the preparation of novel antifungal agents based derived from N-iodopropargylazoles and N-triiodoallylazoles. 5-Methyl Tetrazole also in the preparation of novel quinoline derivatives against mycobacterium tuberculosis.<br>References Koyama, M. et al.: J. Med. Chem., 30, 552 (1987); Upadhayaya, R. et al.: Bioorg. Med. Chem., 17, 2830 (2009);<br></p>

<p>Applications 2-Methoxy-d3-phenol-3,4,5,6-d4 (CAS# 1065473-05-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Bis(bromomethyl)-2-(4-methoxyphenyl)ethanamine is an intermediate used in the synthesis of 1,2,3,4-Tetrahydro-4-(1-hydroxycyclohexyl)-2-methyl-7-isoquinolinol (T293623), which is a useful synthetic compound.<br></p>

<p>Applications Methyl N-(4-Hydroxyphenyl)-N-phenylglycinate is a methyl ester of N-(4-Hydroxyphenyl)-N-phenylglycine (H947680).<br></p>