Amino Acids (AA)

<p>Applications 1-(3-ACETYL-2-HYDROXY-5-METHYL-PHENYL)-ETHANONE (cas# 55108-28-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Light Sensitive<br></p>

<p>Applications 2-Methoxyethyl 3-oxobutanoate (cas# 22502-03-0) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2-methyl-5-pyrimidinemethanesulfonic acid is used in the biosynthesis of Thiamine (T344185) in yeast.<br>References White, R., et al.: Journal of the American Chemical Society, 104, 4934 (1982).<br></p>

<p>Applications 5-(2-Hydroxyethylamino)-2-methoxylaniline sulfate (cas# 83763-48-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-(methyl-d3)-1H-Indole-2,4,5,6,7-d5 is the labeled analogue of 3-Methylindole (M313470), a naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor; however in lower concentrations the compound has a pleasent aroma, giving orange blossoms and jasmine their pleasing scent. It is often a component of commercial fragrances and perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009), Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009), Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009), Naskar, S., et al.: J. Chem. Res., 3, 174 (2009), Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009),<br></p>

<p>Applications VINYLTRIS(2-METHOXYETHOXY)SILANE (cas# 1067-53-4) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also used as a metabolomic biomarkers in preeclampsia.<br>References Nakagawa, K. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 878, 942 (2010); Kenny, L.C. et al.: Reprod. Sci., 15, 591 (2008); Garcia, A. et al.: Clin. Chem., 44, 1905 (1999);<br></p>

<p>Applications A red azoic dye. Dyes and metabolites, Environmental Testing<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Applications 5-Methylcytosine (cas# 554-01-8) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-6-(methylamino)-1,3,5-triazin-2(1H)-one is a heterocyclic Triazine based building block useful in organic synthesis. It is related to 2-Amino-4-methoxy-6-methyl-1,3,5-triazine (A616880), which is used to synthesize pesticides.<br>References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006);<br></p>

<p>Applications 2-Azido-2-deoxy-D-glucose is a glucose derivative that have been used to study the substrate specificity of galactokinase.<br>References Zou, W., et al.: Bioorg. Med. Chem. Lett., 22, 3540 (2012);<br></p>

<p>Applications 4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). 4-Chloromethyl-5-methyl-1,3-dioxol-2-one is also used in the preparation of prodrugs of ampicillin.<br>References Ikeda, S. et al.: Chem. Pharmac. Bull., 32, 4316 (1984); Wu, T. Yaox. Xueb., 41, 537 (2006);<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>Applications Cyclic propano guanine adduct DNA acetaldehyde histone.<br>References Nath, R., et al.: Cancer Res., 58, 581 (1998), Wang, M., et al.: Chem. Res., 13, 1065 (2000), Terashima, I., et al.: Biochemistry, 40, 4106 (2001), Yokoyama, A., et al.: Carcinogenesis, 23, 1851 (2002),<br></p>

<p>Applications 3-Chloro-2-methyl-1-propene has been used in the synthesis of 2-S-substituted pyrimidines as antimetabolites of nucleic acid precursors for cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kaldrikyan, M.A., Melik-Ohanjanyan, R.G.: Hayastani Kimiakan Handes, 67, 321 (2014)<br></p>

<p>Applications 4-(1-Methylethyl)benzoic Acid is used in the synthesis of quinuclidine benzamides as agonists for nicotinic acetylcholine receptors. Also used in the synthesis of nifuroxazide analogues showing antimicrobial activity against methicillin-resistant Staphylococcus.<br>References Bodnar, A. et al.: J. Med. Chem., 48, 905 (2005); Masunari, A. et al.: Bioorg. Med. Chem. Lett., 15, 4229 (2007);<br></p>

<p>Applications N-Boc-L-glutamic Acid 5-Methyl Ester is an intermediate used in the synthesis of Isodesmosine Chloride Hydrate (Synthetic) (I815051), which is a component of elastin and also it is extremely hygroscopic and must be stored over a desiccant such as silica gel.<br>References Partridge, S., et al.: Nature, 209, 399 (1966)<br></p>

<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>

<p>Applications N-Cbz-L-aspartic acid is an N-Cbz-protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Honey, C., et al.: Neurosci. Lett., 61, 135 (1985); MacDonald, J., et al.: Brain Res., 237, 248 (1982)<br></p>

<p>Applications D-Lysine Methyl Ester is a protected form of D-Lysine (L468930). D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.<br>References Chen, Q. et al.: J. Biol. Chem., 269, 26602 (1994); Sensi, M., et al.: Diabetologia, 36, 797 (1993); Vermeersch, H. &amp; Remon, J.: J. Control. Rel., 32, 225 (1994)<br></p>

<p>Stability Hygroscopic<br>Applications L-Ornithine is a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications L-Asparagine-d3 Hydrate is an isotope labelled L-Asparagine Hydrate, a naturally occurring amino acid that is not a essential for humans and can be synthesized from central metabolic pathway intermediates.<br>References Burda, P., et al.: Biochim. Biophys. Acta., 1426, 239 (1999); Yamane, H., et al.: Animal. Sci. J., 80, 286 (2009);<br></p>

<p>Applications D-Glutamic acid 1-tert-butyl ester is a protected form of D-Glutamic acid (G596965). D-Glutamic acid is an unnatural isomer of L-Glutamic acid (G596960), and is found in bacterial cell wall peptidoglycan of gram-positive and gram-negative bacteria. D-Glutamic acid also occurs as poly-gamma-Glutamic acid, which is a weak immunogen but is capable of acting as a hapten (a small molecule that induces the production of antibodies, as well as binding to them).<br>References Dougherty, T., et al.: J. Bacteriol., 175, 111 (1993); Goodman, J. &amp; Nitecki, D.: Immunology, 13, 577 (1967); Robinson, T.: Life Sci., 19, 1097 (1976)<br></p>

<p>Applications Perfluoro-3-methoxypropanoic acid (cas# 377-73-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>