Amino Acids (AA)

<p>Applications Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.<br>References Senten, K., et al.: J. Med. Chem., 46, 5005 (2003);<br></p>

<p>Applications A serine derivative. Used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics.<br>References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),<br></p>

<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>

<p>Applications A metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>

<p>Applications 2-Methoxytetrahydrofuran is a reactant in the preparation of ruthenium(III) chloro benzimidazolylmethylamine derivative complexes as oxidation catalysts.<br>References Murali, M., et. al.: Eur. J. Inorg. Chem., 22, 3238 (2009)<br></p>

<p>Applications Boc-(S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid is a reactant used in the preparation of peptidase IV inhibitors.<br>References Park, W. et al.: Bioorg. Med. Chem. Lett., 21, 1366 (2011);<br></p>

<p>Applications This compound contains up to 25% of the two other regioisiomers.<br></p>

<p>Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>

<p>Applications Fructose-histidine is an amadori compound formed in food.<br>References Wang, J., et al.: J. Mass Spec., 43, 262 (2008); Hashiba, H.: J. Agri. Food Chem., 24, 70 (1976)<br></p>

<p>Applications An intermediate used in the synthesis of Pregabalin (P704800) and related compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Posadas, I., et al.: Br. J. Pharmacol., 142, 331 (2004),<br></p>

<p>Applications Perfluoro(4-methyl-3,6-dioxaoct-7-ene)sulfonyl Fluoride is used as a reagent in the synthesis of novel perfluorinated vinyl ether containing sulfonimide functionality which can be copolymered with tetrafluoroethylene to yield a novel perfluorinated copolymer.<br>References Zhu, S., et al.: Chinese J. Chem., 21, 921 (2003);<br></p>

<p>Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.<br>References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)<br></p>

<p>Applications 1-Methoxy-4-(1E)-1-propen-1-ylbenzene is a component of essential oils extracted from natural sources. It is also a possible inhibitor of protein kinase CK2α and CK2α’.<br>References Liang, Zhi-yuan, et al.: Shizhen Guoyi Guoyao, 25(7), 1602-1604 (2014);Benelli, Giovanni, et al.: Indus. Crops and Prod., 124, 236-243 (2018);Baier, Andrea, et al.: Phytochem., 136, 39-45 (2017)<br></p>

<p>Applications A potential chiral building blocks for the synthesis of different α -methyl α -amino acids.<br>References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),<br></p>

<p>Applications 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012)<br></p>

<p>Applications An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.<br>References Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);<br></p>

<p>Impurity Tinidazole EP Impurity A/ Metronidazole EP Impurity A<br>Applications 2-Methyl-5-nitroimidazole (Tinidazole EP Impurity A) is a Floconazole impurity.<br>References Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009), Kumar, L., et al.: Eur. J. Med. Chem., 45, 817 (2010),<br></p>

<p>Impurity Paliperidone USP Related Compound A<br>Applications 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone USP Related Compound A) is used in the synthesis of Paliperidone (P141000). Intermediate.<br>References Rein, A., et al.: Curr. Opin. Drug Discovery Dev., 3, 734 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.<br>References Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),<br></p>

<p>Applications L-Arginine-2,3,3,4,4,5,5-d7 HCl (CAS# 204244-77-9) is a useful isotopically labeled research compound. It can be used with Raman scattering for imaging living cells and organisms.<br>References Min, W., et al., PCT Int. Appl. (2014), WO 2014205074 A2<br></p>

<p>Applications 2-Bromo-4'-methylpropiophenone (cas# 1451-82-7) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications δ-Valerolactam-d4 is a labeled analog of δ-Valerolactam (V091440), which is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.<br>References Potts, K., et al. J. Org. Chem., 58, 5040 (1993); Klibanov, O., et al.: Curr. Opinion Invest. Drugs, 11, 940 (2010);<br></p>

<p>Applications L-Lysine-2,6,6-d3 HCl is a useful isotopically labeled compound of L-Lysine HydrochlorideDISCONTINUED PLEASE SEE L486915 (L468923)<br></p>

<p>Applications 4,4'-Methylenebis(2,6-dimethylphenol) is used in thermosetting resin composition for the industrial manufacture of metal-clad laminates and printed circuit boards.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References You, J., et al.: Faming Zhuanli Shenqing. 19 pp. (2019)<br></p>

<p>Applications Useful for the synthesis of Biocytin containing peptides to study the mechanism of reactions catalyzed by biotin - containing enzymes.<br>References Bodanszky, M., and Fagan, D.T.: J. Am. Chem. Soc., 99, 235 (1977)<br></p>

<p>Applications Carbamoyl-guanidine Amidino Urea Salt, Hydrochloride salt (cas# 926-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Pivaloylglycine is used in the biological study between dogs and rats. In a high dose toxicity study of pivalic acid (PA), PA caused skeletal muscle disorder in dog, and a significant increase of pivaloyl carnitine (PC) was observed in canine muscle, but not in rat muscle.<br>References Yamaguchi, T., et al.: Toxicol. Appl. Pharmacol., 214, 61-68 (2006)<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications 3-Mercapto-3-methylbutyl formate is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications 7-CHLORO-L-TRYPTOPHAN (cas# 73945-46-7) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-1-methylquinolinium tetrafluoroborate (cas# 16843-24-6) is a useful research chemical.<br></p>

<p>Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.<br>References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>

<p>Applications L-Abrine is an indoleamino acid that displays radical scavenging and antioxidant properties.<br>References Yang, M., et al.: Food. Funct., 5, 2268 (2014);<br></p>

<p>Applications D-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.<br>References Albanese, A.: J. Biol. Chem., 157, 613 (1945); Martin, R. &amp; Kirk, K.: Blood, 109, 2217 (2007)<br></p>

<p>Applications 1,2-Dichloro-2-methylpropane (cas# 594-37-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Temperature Sensitive<br>Applications Methyl 2,3,4-Tri-O-isobutyryl-D-glucopyranuronate (cas# 1190403-86-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (4-Hydroxyphenyl)glycine, is a key intermediate for the synthesis Cefpiramide (C243400), used as a β-lactam antibiotic.<br>References Xiao, R. Q., et al.: Guangzhou Huagong, 41, 111 (2013);<br></p>

<p>Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.<br></p>

<p>Applications L-Allo-isoleucine-d10 is a derivative compound of L-allo-isoleucine (A548200), which has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications S-Phenylmercapturic Acid-d5 is the labelled analogue of S-Phenylmercapturic Acid (P335600), an important metabolite of Benzene.<br>References Qu, Q., et al.: Am. J. Ind. Med., 37, 522 (2000); Ghittori, S., et al.: Int. Arch. Occup. Environ. Health, 67, 195 (1995);<br></p>