Amino Acids (AA)

<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>

<p>Applications 2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.<br>References Peuchmaur, M. et al.: Bioorg. Med. Chem. Lett., 21, 1018 (2013); Roemmele, R. et al.: Org. Proc. Res. Devel., 17, 422 (2013);<br></p>

<p>Applications N-Acetyl-S-benzyl-d5-L-cysteine is deuterium labelled N-Acetyl-S-benzyl-L-cysteine, which is a metabolite of toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Stability Moisture Sensitive<br>Applications An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).<br>References Muth, W., et al.: J. Biol. Chem., 249, 7463 (1974), Hanukoglu, I., et al.: Eur. J. Biochem., 180, 479 (1989), Khaw, L., et al.: J. Bacteriol. 180, 809 (1998), Gallagher, D., et al.: J. Mol. Biol., 342, 119 (2004),<br></p>

<p>Applications Dihydro-5-methyl-4H-1,3,5-dithiazine is used as a reagent in the synthesis of neovibsanin derivatives which have the ability to induce neuronal differentiation in PC12 cells.<br>References Annette, P.-J. C., et al.: Tetrahedron, 66, 6842 (2010)<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methyl-2-(1-Methylbutyl)-propanedioic Acid 1,3-Diethyl Ester is an intermediate in the synthesis of 2,3-Dimethyl-hexanoic Acid (D473405) which is used to prepare Mono-2,3-dimethylhexyl Phthalate (M539400), a metabolite of Dibutyl phthalate (DBP) (D429495), which is widely used in consumer products.<br>References Silva, M., et al.: Arch. Toxicol., 77, 561 (2003), Silva, M., et al.: Toxicology, 210, 123 (2005), Silva, M., et al.: J. Anal. Toxicol., 29, 819, (2005)<br></p>

<p>Applications 4-Methoxy-3-nitrobenzonitrile<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications 2-Methyl-2-propen-1-ol has been used in the synthesis of C2-methyl-1,2-di-O-hexadecylglycerophosphocholine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bittman, R., Witzke N.M.: Chem. Physics Lipid, 50, 99 (1989)<br></p>

<p>Applications 1,3,5-Trichloro-2-methylbenzene can be used as reactant/reagent in hydrodechlorination process and catalysts for the production of 2,​6-​dichlorotoluene from polychlorotoluene-​containing mixtures. Also, it is derived from 2,4,6-Trichlorobenzoic Acid (T774715), which is a possible degradation intermediate of Polychlorinated Biphenyls (PCBs) in contaminated soil, suggesting the occurrence of microbial transformation processes over time.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eichinger, W., et al.: PCT Int. Appl., WO 2001017932 A1 20010315 (2001); Stella, T., et al.: Sci Total Environ, 533, 177-186 (2015)<br></p>

<p>Applications 4-Hydroxy-4-methyl-2-pentanone-d12 (CAS# 114253-85-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.<br>References Ma, L. et al. : J. Anitibiot. 64, 645 (2011); Elleuch, L. et al.: Appl. Biochem. Biotech. 162, 579 (2010)<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.<br>References Kumar, A., et al.: Eur. J. Med. Chem., 93, 55 (2015)<br></p>

<p>Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications N-Boc-propargylamine is used in the preparation of triazolobenzylidene-thiazolopyrimidines which act as CDC25 phosphatase inhibitors. Also used in the synthesis of β-glucan polysaccharide analogs.<br>References Duval, R. et al.: J. Comb. Chem., 11, 947 (2009); Tanaka, H. et al.: Tetrahedron Lett., 53, 4104 (2012);<br></p>

<p>Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>

<p>Applications 3-Bromo-L-tyrosine is used in the preparation and synthesis of polyclonal antibodies that work against brominated protein related allergic responses and afflictions. Also effective in asthma control and prediction in children.<br>References Kambayashi, Y. et al.: J. Clin. Biochem., 44, 95 (2009); Wedes, S. et al.: J. Ped., 159, 248 (2011);<br></p>

<p>Applications Boc-L-aspartic Acid β-Methyl Ester is used to prepare isoxazoline glycoprotein IIb/IIIa antagonists. It is also used to synthesize glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.<br>References Xue, C., et al.: J. Med. Chem., 40, 2064 (1997); Kirkland, T., et al.: Bioorg. Med. Chem., 16, 4963 (2008)<br></p>

<p>Applications 1-AMINO-2-METHYLNAPHTHALENE (cas# 2246-44-8) is a useful research chemical.<br></p>

<p>Applications E677525<br>References Shimizu, T., et al.: Chem. Pharm. Bull., 53, 313 (2005)<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications Derivative of monoenoic and trienoic analogs of Sorbic Acid with antifungal activity.<br>References Guerin, J. et al.: Annales Pharmaceutiques Francaises 44, 373 (1987)<br></p>

<p>Applications 1,3,5-Trimethoxy-2-methylbenzene AldrichCPR (cas# 14107-97-2) is a useful research chemical.<br></p>

<p>Applications N-Acetyl-DL-aspartic acid (cas# 2545-40-6) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Methoxysalicylate, is an organic building block, used for the synthesis of (+)-coriandrone A and B, two bioactive natural products. It can also be used for the preparation of Dimethoxybenzofuran derivatives as potent and selective inhibitors of CYP2A6.<br>References Wang, W., et al.: Org. Biomol. Chem., 11, 6686 (2013); Yamaguchi, Y., et al.: Heterocycles, 87, 1727 (2013);<br></p>

<p>Applications 3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine, can beused in the synthesis of Dibenzo[c,f][1,2]thiazepine derivatives.<br>References Gilleron, P., et al.: Bioorg. Med. Chem. Lett., 17, 5465 (2007),<br></p>

<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>

<p>Stability Temperature Sensitive, Light Sensitive<br>Applications 2-Ethyl-4-methylpentyl Acrylate<br></p>

<p>Applications A red azoic dye.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers.<br>References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),<br></p>

<p>Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.<br></p>

<p>Stability Hygroscopic<br>Applications L-Formiminoglutamic acid is a useful research chemical. It is used medically in the diagnosis of Cobalt deficiencies in Cattle and sheep.<br>References Marsh, K. B., et al.: New Zeal. J. Agric. Res., 31, 273 (1988); Quirk, M. F., et al.: J. Agric. Sci., 110, 465 (1988); Quirk, M. F., et al.: Aust. J. Agric. Res., 38, 1071 (1987)<br></p>

<p>Applications N-PHENYL-4-METHOXYBENZYLAMINE (cas# 3526-43-0) is a useful research chemical.<br></p>

<p>Applications N-ACETYLISOLEUCINE (cas# 3077-46-1) is a useful research chemical.<br></p>

<p>Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.<br>References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);<br></p>

<p>Applications 3-Mercapto-3-methylbutyl formate is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>