Amino Acids (AA)

<p>Applications 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one is a reagent used in the enantioselective aminoalkylation of pyrazol-3-ones.<br>References Carceller-Ferrer, L. et al.: Org. Biomol. Chem., 17, 9859 (2019);<br></p>

<p>Applications An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.<br>References Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications 2,2-Diselanediyldiethanamine dihydrochloride (cas# 3542-13-0) is a useful research chemical.<br></p>

<p>Applications N-Fmoc-L-tyrosine Benzyl Ester is used to synthesize truncated analogues of preptin-(1-16) as possible osteoblast proliferation stimulant. It is also an intermediate used to prepare phosphotyrosinyl phosphoramidite derivatives useful in the incorporation of multiple reporter groups on synthetic oligonucleotides.<br>References Kowalczyk, R., et al.: Bioorg. Med. Chem., 22, 3565 (2014); Misiura, K., et al.: Nucl. Acids Res., 18, 4345 (1990)<br></p>

<p>Applications An amino acid isolated from Cholera vibrio.<br>References Windsor, et al.: J. Biol. Chem., 192, 595 (1951), Scott, A.I., et al.: Synth. Commun., 10, 127 (1980),<br></p>

<p>Applications A metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>

<p>Applications A serine derivative. Used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics.<br>References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),<br></p>

<p>Applications 2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides.<br>References Liu, J., et al.: Org. Biomol. Chem., 18, 4019 (2020)<br></p>

<p>Applications N-Methyl-dl-valine, HCl<br></p>

<p>Applications (2R,3S,4S,5R,6S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an enantiomer of dapagliflozin(D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>

<p>Applications 4-Methyl-1-octanol is an intermediate in the synthesis of 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyloctan-1-ol Ester which is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications N-Boc-L-Allylglycine is a boc-protected allylglycine used in the preparation of arginine analogues including the natural amino acid enduracididine.<br>References Saniere, L. et al.: Tetrahedron, 60, 5889 (2004): Leman, L. et al.: ARKIVOC, 6, 126 (2003);<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Used in the manufacturing of L-tryptophan by enzymic reaction.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Stability Unstable in Aqueous Solution<br>Applications 2-METHYL-1,4-BUTANEDIOL (cas# 2938-98-9) is a useful research chemical.<br></p>

<p>Applications Ethametsulfuron-methyl Sodium Salt, a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications (4R, 2S)-4-Hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-proline Methyl Ester (cas# 179990-59-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.<br>References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Potassium 2-hydroxy-4-methoxybenzoate (cas# 152312-71-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.<br>References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);<br></p>

<p>Applications 5-Methyl-5-phenylhydantoin is a reactant for synthesis of beta-amino alcohols as inhibitors of anti-tubercular target N-acetyltransferase, chlorohydantoins and specific MMP inhibitors.<br>References Fullam, E., et al.: Bioorg. Med. Chem. Lett., 21, 1185 (2011); Whitehead, D., et al.: Tetrahedron Lett., 50, 3 (2009); Chollet, A., et al.: Bioorg. Med. Chem., 10, 531 (2002)<br></p>

<p>Applications Acetyl-L-carnitine is a mitochondrial metabolite that helps to transport fatty acids into the mitochondria for energy (1). Acetyl-L-carnitine also upregulate metabotropic glutamate receptor 2 (mGlu2) via NF-κB p65 acetylation (2,3). It exhibits antidepressant and neuroprotective properties.<br>References (1) Stephens, F. B., et al.: J Physiol. 581, 431 (2007) (2) Wang, S. M., et al.: J Psychiatr Res. 53, 30 (2014) (3) Cuccurazzu, B., et al.: Neuropsychopharmacology 38, 2220 (2013)<br></p>

<p>Applications 3-Methylindole metabolite.<br>References Skordos, K., et al.: Chem. Res. Toxicol., 11, 741 (1998), Lanza, D., et al.: Drug Metab. Disposition, 29, 950 (2001), Hoenicke, K., et al.: J. Agric. Food Chem., 50, 4303 (2002),<br></p>

<p>Applications N-Methyl-3,3-diphenylpropylamine is an intermediate for the synthesis of SNRI-NMDA antagonist and neuroprotectants.<br>References Olney, J. et al.: Sci., 244, 1360 (1989); Williams, W., et al.: Mol. Pharmacol. 44, 851 (1993);<br></p>

<p>Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>