Amino Acids (AA)

<p>Impurity Esomeprazol EP Impurity A/ Omeprazole EP Impurity A<br>Applications 5-Methoxy-2-mercaptobenzimidazole (Esomeprazol EP Impurity A) is used in the synthesis of COX-2 inhibitors<br>References Frechette, S., et al.: Bioorg. Med. Chem. Lett., 18, 1502 (2008), Zhang, R., et al.: Eur. J. Med. Chem., 44, 3771 (2009),<br></p>

<p>Impurity Betahistine EP Impurity C (Free Base)<br>Applications N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.<br>References Mautner, F.A. et al.: Inorg. Chim. Acta, 362, 4073 (2009);<br></p>

<p>Applications 3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-amine (cas# 20529-23-1) is a useful research chemical.<br></p>

<p>Applications Glycyl-L-tyrosine<br></p>

<p>Applications 1,2-Dichloro-2-methylpropane (cas# 594-37-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Acetyl-L-tyrosine is an analogue of L-tyrosine which stimulate the transport of L-Tyr, mainly by the ASC system.<br>References Jara, J. et al.: Melanoma Res., 1, 15 (1991),<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Methyl-1H-imidazole-1-carboxamide is a useful Methyl Isocyanate (MIC) substitute.<br></p>

<p>Applications 1-[1-(2-methoxyethyl)piperidin-3-yl]methanamine (cas# 936940-49-7) is a useful research chemical.<br></p>

<p>Applications Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents<br>References Zhao, H., et al.: Bioorg. Med. Chem. Lett., 12, 3105 (2002),<br></p>

<p>Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.<br>References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);<br></p>

<p>Applications 1-Methyluracil (cas# 615-77-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).<br>References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)<br></p>

<p>Applications 2-Amino-5-cyano-3-methylbenzoic Acid (cas# 871239-18-8) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.<br>References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)<br></p>

<p>Applications 2-(6-methoxynaphthalen-2-yl)propanenitrile (cas# 86603-94-3) is a useful research chemical.<br></p>

<p>Applications N-[(R)-1-Carbethoxybutyl]-(S)-alanine is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications VINYLTRIS(2-METHOXYETHOXY)SILANE (cas# 1067-53-4) is a useful research chemical.<br></p>

<p>Applications 4-Methoxy-d3-benzoic Acid (CAS# 27914-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-METHYL-2-PHENYL-2-PENTENAL (cas# 26643-91-4) is a useful research chemical.<br></p>

<p>Applications Labelled Tiopronin. It is used as antidote against heavy metal poisoning; hepatoprotectant; mucolytic.<br>References Capasso, F., et al.: Agents Actions, 11, 741 (1981), Amor, B., et al.: Arthritis Rheum., 25, 698 (1982), Ichida, F., et al.: J. Int. Med. Res., 10, 325 (1982),<br></p>

<p>Applications Isotope labelled N-Isovalerylglycine is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isovalerylglycine is found in the urine of patients with isovaleric acidemia, an inborn error of leucine metabolism.<br>References Tanaka, K. et al.: J. Biol. Chem., 242, 2966 (1967); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000);<br></p>

<p>Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)<br></p>

<p>Applications D-Homophenylalanine<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Amino-2-methyl-5-pyrimidinemethanesulfonic acid is used in the biosynthesis of Thiamine (T344185) in yeast.<br>References White, R., et al.: Journal of the American Chemical Society, 104, 4934 (1982).<br></p>

<p>Applications 2-Methoxyethanol is used in the synthesis of 2-aminothiazoles in the treatment of prion disease (1). 2-Methoxyethanol is also used in the preparation of Rho-associated kinase inhibitors or (ROCK) inhibitors, for treatment of cardiovascular disease (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Li, Z. et al.: ChemMedChem. 2013 May;8(5):847-57.2. Boland, S. et al.: Bioorg. Med. Chem. Lett. 2013 Dec 1;23(23):6442-6.<br></p>

<p>Applications 2-Deoxy-2-chloro-D-glucose is a D-Glucose (G595000) derivative used in the synthesis of sugar nucleotides and oligosaccharides.<br>References Herr, D., et al.: Euro. J. App. Microbiol., 1, 41 (1975);<br></p>

<p>Applications 5-Methylcytosine (cas# 554-01-8) is a useful research chemical.<br></p>

<p>Applications N-Methylsuccinimide is used as a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP<br>References Takahashi, O., et al.: Chem. Biodivers., 7, 1349 (2010)<br></p>

<p>Applications 4-Methyl-6-(methylamino)-1,3,5-triazin-2(1H)-one is a heterocyclic Triazine based building block useful in organic synthesis. It is related to 2-Amino-4-methoxy-6-methyl-1,3,5-triazine (A616880), which is used to synthesize pesticides.<br>References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006);<br></p>

<p>Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.<br>References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),<br></p>

<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications (2R,3S,4S,5R,6S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an enantiomer of dapagliflozin(D185370), which is a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications 1-Chloro-3-methoxypropane (cas# 36215-07-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Azido-2-deoxy-D-glucose is a glucose derivative that have been used to study the substrate specificity of galactokinase.<br>References Zou, W., et al.: Bioorg. Med. Chem. Lett., 22, 3540 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine Acetate is an impurity of Granisetron HCl (G780000), a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>

<p>Applications Dl-valine<br></p>

<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>066621 - 5-Amino-4-oxopentanoic acid hydrochloride</p>

<p>Stability Very Volatile<br>Applications 2-Methoxy Propane is a synthetic intermediate used for the preparation of various biosynthetic molecules and pharmaceutical goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gharagheizi, F., et al.: Indust. Engin. Chem. Res., 51, 6265 (2012); Vandendriessche, S., et al.: Phy. Chem. Chem. Phy., 14, 1860 (2010); Moon, J.K., et al.: J. Agr. Food. Chem., 58, 5465 (2010);<br></p>