Amino Acids (AA)

Applications A metabolite of carboxylic acid.
References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),

Stability Moisture Sensitive
Applications 5-(chlorosulfonyl)-3-methylthiophene-2-carboxylic acid (cas# 1114823-93-6) is a useful research chemical.

Applications 5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridineethanol (cas# 184766-50-5) is a compound useful in organic synthesis.

Applications N-Methyl-d3-epsilon-caprolactam (CAS# 203645-60-7) is a useful isotopically labeled research compound.

Applications N-Cbz-D-alanine is the Cbz-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.
References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. & Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)

Applications 2,3-Bis(1-methylethyl)-2-cyclopropen-1-one is a useful reagent for the cyclodehydration of diols to cyclic ethers.
References Kelly, B.D., et al.: Org. Lett., 13, 740-43 (2011);

Applications 2-(carboxymethyl)-5-methoxybenzoic Acid (cas# 52962-25-1) is used in making heat-developable photographic film with improved storage stability.
References Sakai, M., et al.: Jpn. Kokai Tokkyo Koho. 88 pp. (2008)

Applications A useful synthetic intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-(4-Methylthiazol-5-yl)ethanamine is used in the synthesis and biological testing of several new H2 (Histamine) agonists.
References Timmerman, H., et al.: J. Quant. Struct-Act. Rel., 11, 219 (1992)

Applications 3-Methylcrotonic acid is used as a starting material to synthesize 3-Methylcrotonyl-CoA, an intermediate in the metabolism of Leucine.
References Anderson, M., et al.: Plant Physiol., 118, 1127 (1998); Hector, M., et al.: Biochemistry, 15, 3465 (1976)

Applications 5-Bromo-3-methyl-2(5H)-furanone is used as a reactant in the synthesis of strigolactone analogs.
References Artuso, Emma, et al.: J. of Nat. Products, 78(11), 2624-2633 (2015);Jia, Kun-Peng, et al.: Mol. Plant, 9(9), 1341-1344 (2016)

Applications 2-Fluoro-1-methoxy-3-methylbenzene

Applications (R)-1-Methyl-prop-2-ynylamine hydrochloride (cas# 869349-15-5) is a useful research chemical.

Applications 4'-Methylacetophenone-d10 (CAS# 358730-83-3) is a useful isotopically labeled research compound.

Applications N2-[(Phenylmethoxy)carbonyl]-L-lysine id used in the synthesis of hydroxamic acids and mycobacterium inhibitors.
References Hu, J. et al.: J. Am. Chem. Soc., 119, 3462 (1997); Xue, C. J. Med. Chem., 44, 2636 (2001);

Applications 4-Methoxybenzoic-2,3,5,6-d4 Acid (CAS# 152404-46-1) is a useful isotopically labeled research compound.

Applications N-Boc-L-serine is an N-Boc-protected form of L-Serine (S270975). L-Serine is a nonessential amino acid that is required for the synthesis of sphingolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells.
References de Koning, T., et al.: Biochem. J., 371, 653 (2003); Furuya, S.: Asia Pac. J. Clin. Nutr., 17, 312 (2008); Hirabayashi, Y. & Furuya, S.: Prog. Lipid. Res., 47, 188 (2008)

Applications L-Isoleucine-2-d1 (CAS# 127290-60-2) is a useful isotopically labeled research compound.

Applications (±)-Aspartic Acid, is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.
References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);

Applications 2-Amino-4-methylphenylboronic acid, pinacol ester

Applications 4-(1,3-Benzodioxol-5-yl)-1,4,6,7-tetrahydro-1-methyl-7-oxo-3-phenyl-8H-pyrazolo[3,4-e][1,4]thiazepine-8-acetic Acid

Applications (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide has been used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor.
References Conrow, R.E., et. al.: Org. Process Res. Dev., 3, 114 (1999)

Applications PEPA is an allosteric potentiator of AMPA desensitization.

Applications N-Methyl 1,2-Dihydro-4,5,6-trimethyoxy-3H-indol-3-one is a derivative of 1,2-Dihydro-4,5,6-trimethoxy-3H-indol-3-one (M303555) which is a derivative of aurone as a potential miccrobicide.
References Chu, W., et al.: U. S., US 6307070 B1 20011023 (2001)

Applications A metabolite of Acrylonitrile (ACN).
References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),

Applications A cysteine derivative as potential antitumor agent. (A609645)A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. (F680300)
References Paul, B., et al.: J. Med. Chem., et al.: 19, 1002 (1976), Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications 4-[(Aminocarbonyl)amino]-D-phenylalanine can be used a reactant in continuous flow solid-phase peptide synthesis.
References Fulop, Ferenc, et al.: PCT Int. Appl., WO 2015128687 A1 20150903 (2015)

Applications α-[[[2-(4-Methoxy-3-methylphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-3-nitro-4-(phenylmethoxy)benzenemethanol is an intermediate in the synthesis of (3R,5S)-Fluvastatin.
References Faming Zhuanli Shenqing (2014), CN 103896795 A 20140702.

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications Fmoc-Asp(OMe)-OH is a useful research intermediate used in the solid phase synthesis of peptides as selective caspase-3 peptide inhibitors.
References Grimm, Erich L., et al.: Bioorg. Med. Chem., 12, 845 (2004); Vickers, C. J., et al.: J. Am. Chem. Soc., 135, 12869 (2013)

Applications N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

Applications D-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.
References Albanese, A.: J. Biol. Chem., 157, 613 (1945); Martin, R. & Kirk, K.: Blood, 109, 2217 (2007)

Applications 2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (cas# 1114596-35-8) is a useful research chemical.