Amino Acids (AA)

<p>2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde (2MMPP) is a minor constituent of piperonal. It has been shown to be a potent inhibitor of intracellular calcium levels in humans and rat prostate cancer cells. The mechanism of action is thought to be through an interaction with fatty acid receptors and alterations in cytosolic calcium levels. 2MMPP has been found to act as an odorant binding agent that binds to the olfactory receptor OR5AN1 and alters its function. 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde has also been shown to have high electrochemical impedance spectroscopy values, which may indicate its ability to remove organic contaminants from wastewater treatment systems.</p>

<p>4-Methoxyphenyl boronic acid is a molecule with a hydroxyl group and a boronic acid. It is synthesized by reacting biphenyl with trifluoroacetic acid in the presence of sodium carbonate and palladium-catalyzed coupling. 4-Methoxyphenyl boronic acid has shown to bind to the receptor for fatty acids, which may be due to its structural similarity to p-hydroxybenzoic acid. The protonated form of this molecule has been shown to react with an electrophilic carbon atom and an electron-deficient alkyl or vinyl halide, resulting in ring formation. This reaction is known as the Suzuki coupling reaction.</p>

<p>Please enquire for more information about Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fmoc-Phe-Ser(tBu)-OH is a pentafluorophenyl ester of the amino acid phenylalanine. It is used in solid-phase peptide synthesis to link amines and carboxylic acids. Fmoc-Phe-Ser(tBu)-OH is used as an intermediate in the synthesis of peptides with a C-terminal amidated or methyl esters. The coupling reaction is catalyzed by 1-hydroxybenzotriazole (HOBT) and N,N'-dicyclohexylcarbodiimide (DCC). HOBT reacts with the hydroxyl group on the β carbon of the ester to form an acetoxy group, which reacts with the amine on the opposite side of the peptide chain to form a new amide bond. DCC reacts with both reactive groups, forming an iminoester intermediate. This intermediate can be hydroly</p>

<p>Please enquire for more information about Myelin Basic Protein (85-99) Peptide Antagonist trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Lys(Z)-AMC·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ac-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bond) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Ala-Pro-Val-EDANS including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-m-Tyrosine is a nonessential amino acid that is synthesized from phenylalanine. It has been shown to have antioxidant properties and protects against oxidative injury by scavenging reactive oxygen species such as hydrogen fluoride. L-m-Tyrosine has also been shown to modulate dopamine levels in the brain and may be used in the treatment of Parkinson's disease. The biological effects of L-m-Tyrosine are mediated through the transcriptional regulation of genes encoding proteins involved in dopamine β-hydroxylase and hydrogen fluoride detoxification. L-m-Tyrosine is also an experimental model for studying drug resistance in bacteria, including methicillin resistant Staphylococcus aureus (MRSA).</p>

<p>Fmoc-Lys(Boc)-Pro-OH is a residue that is used in the optimization of peptide synthesis. It is an acid labile protecting group that can be removed by treatment with trichloroacetic acid or hydrogen fluoride. Fmoc-Lys(Boc)-Pro-OH can be used for chemical ligation to other protected amino acids, such as Boc-Lys(Bzl)-OH, to form peptides. The residue has been shown to be useful in systematic optimization of peptide pairings and in the stepwise synthesis of peptides. The residue has also been shown to have a high yield and purity when synthesized by x-ray crystallography.<br>Fmoc-Lys(Boc)-Pro-OH is an amino acid with a molecular weight of 120 Da and consists of two alpha amino acids, L -lysine and L -proline, joined by a peptide bond.</p>

<p>Please enquire for more information about Boc-D-Asn-ONp including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about L-allo-Threoninol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Gly-Tyr-NH2·HCl is a peptide that has been shown to have an inhibitory effect on 5-hydroxytryptamine (5-HT) receptors. It can be used as a diluent for pharmaceuticals and as a potential treatment for autoimmune diseases, which are caused by the immune system attacking healthy cells. H-Gly-Tyr-NH2·HCl has also been shown to have antiestrogenic effects in breast cancer cells. This compound may be useful for treating inflammation associated with infectious diseases, such as Stenotrophomonas maltophilia, and other inflammatory diseases, such as inflammatory bowel disease. The amide group in this peptide may also be important for its antimicrobial properties against gram negative bacteria, such as Escherichia coli.</p>

<p>Ac-Ala-Pro-Ala-pNA is a transition-state analog inhibitor of serine proteases. In the catalytic cleft, Ac-Ala-Pro-Ala-pNA mimics the carbonyl group and minimizes the active site serine. The hydroxyl group in this compound is responsible for its transition state buildup that leads to hydrolytic reactions. Acetal formation can be observed as an intermediate step in this reaction. Acetal formation occurs when a hydroxylic oxygen atom reacts with a terminal alkoxy or thiohydroxylic carbon atom on the reactant molecule. This reaction is catalyzed by enzymes such as alcohol dehydrogenase, acetaldehyde dehydrogenase, and acetyl transferase.</p>

<p>1-(4-Hydroxy-3-methoxyphenyl)-2-nitroethene is an experimental molecule that was not previously known to exist. The intramolecular reaction of 1,4-dihydroxynitrobenzene and glyoxylic acid yields the product. It is a phenolic compound with biological activity, which has been shown to inhibit glycosidases and alkaloids.</p>

<p>Amyloid beta-protein (Aβ) is a protein that is involved in the metabolic processes that are thought to be associated with Alzheimer's disease. Aβ is a peptide of 39-43 residues and is found in amyloid plaques, which are aggregates of Aβ. The amino acid sequence of human Aβ has been determined by sequencing the cDNA and gene for this protein. The structure of the protein has been studied using molecular modeling, kinetic data, and predictive biomarker studies. Cleavage products have been identified from the protein, including beta-amyloid peptide (1-40), which can be used as a diagnostic marker for Alzheimer's disease. Structural analysis has also shown lysine residues that may serve as pharmaceutical targets for therapeutic intervention.</p>

<p>H-Asp-Asn-Gln-OH is a basic amino acid that is cleaved by endopeptidase to form H-Asp, H-Asn, and H-Gln. It is also cleaved by serine proteases to form the amino acid residues of arginyl, aspartyl, and glutamyl. The residue sequence can be determined through hplc analyses of microsomal proteins. This amino acid has been shown to have a regulatory effect on the metabolism of other amino acids in rat liver cells. Asparaginyl and glutamyl are essential for the synthesis of proproteins.</p>

<p>Gamma-L-glutamyl-alpha-naphthylamide is an enzyme that catalyzes the conversion of L-glutamic acid to L-glutamate. It is expressed in red blood cells, human liver, and human serum. Gamma-L-glutamyl-alpha-naphthylamide has been shown to have various specificities for different tissues and isoenzymes. This enzyme also has immunoassay procedures that are used to detect it in tissues or cells. These assays use monoclonal antibodies or solubilized gamma-L-glutamyl-alpha-naphthylamide molecules as detection agents.</p>

<p>Z-Phe-Leu-OH is a protease inhibitor that belongs to the group of peptidyl-protease inhibitors. It inhibits the activity of a wide range of proteases and is specifically active against carboxypeptidases A and B. Z-Phe-Leu-OH has been shown to be specific for these enzymes, with no inhibitory activity against other proteases such as aminopeptidases, serine proteases, or metalloproteases. The amino acid composition of this protease inhibitor is different from other inhibitors that have been studied in detail. This agent was found to be more effective than phenylmethylsulfonyl fluoride (PMSF) at inhibiting carboxypeptidase A and B.<br>Z-Phe-Leu-OH has been shown to be an acidic compound with a pKa of 5.5; however, it does not react with chloromethyl ketone</p>

<p>Please enquire for more information about Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ac-Glu-Glu-Val-Val-Ala-Cys-pNA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ac-Arg-Leu-Arg-AMC trifluoroacetate salt is a mitochondrial biogenesis activator that has been shown to increase the levels of proteins in the mitochondria. These proteins are required for mitochondrial membrane potential, ATP production, and protein homeostasis. Ac-Arg-Leu-Arg-AMC trifluoroacetate salt has been shown to increase the number of pluripotency markers in human liver cells and to reduce insulin resistance in animals. The drug also increases the expression of ubiquitin ligases and proteasomes, which are enzymes that degrade damaged proteins. Ac-Arg-Leu-Arg-AMC trifluoroacetate salt may be used for treating liver diseases or disorders as well as obesity.</p>

<p>Please enquire for more information about KR-12 (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (H-Cys-4MbNA)2 acetate salt (Disulfide bond) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Fluorogenic Human CMV Protease Substrate trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Aloc-OSu is a glycosylated glycopeptide antibiotic that belongs to the class of degradable antibiotics. The drug binds to the enzyme UDP-N-acetylglucosamine:glycoprotein glucosyltransferase, thereby inhibiting bacterial cell wall synthesis. Aloc-OSu has been shown to be effective against methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. Aloc-OSu has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Please enquire for more information about H-beta-Ala-Leu-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Thr(tBu)-pNA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>The compound Z-Pro-Leu-OH is a peptidomimetic that has been shown to be an effective inhibitor of the enzyme l-amino acid oxidase, which catalyzes the oxidation of l-amino acids. This inhibition may be due to the protonation of the substrate and/or solvents in the enzyme active site. The molecule is hydrophobic, making it suitable for use in simulations and theoretical studies. Furthermore, this compound is identifiable by its retention time on high performance liquid chromatography (HPLC) and can be rationalized by its amide group.</p>

<p>H-ADAQHATPPKKKRKVEDPKDF-OH peptide, which can act as a substrate of Protein Kinase P34 (cd2). The peptide is supplied as a trifluoroacetate salt.</p>

<p>S-(p-Nitrobenzyl)glutathione acts as a competitive inhibitor of glutathionase.</p>

<p>S-Fcme activates multidrug resistance transporter by boosting ATPase activity and competing for drug binding.</p>

<p>S-Benzylglutathione acts as a competitive inhibitor of glutathionase and undergoes conversion by rat kidney microsomes into its cysteine derivatives.</p>

<p>Please enquire for more information about H-Glu(Gly-OH)-OH trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Methyl-5-(2-phosphorylethyl)thiazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt is an experimental model system that has been shown to replicate the physiological effects of thymopoietin in vitro. It has also been shown to inhibit the growth of Candida glabrata, a fungus that causes infection in patients with HIV or AIDS. Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt has been shown to activate both toll like receptor and IL2 receptor, which may be due to its ability to stimulate polyamine synthesis.</p>

<p>4-Methyl-3-nitrophenyl isocyanate (4MPN) is a chiral diisocyanate that can be used as an activated diisocyanate. 4MPN is prepared by the carbonylation of 3-nitrobenzaldehyde and xylene with hydrogen chloride in the presence of a catalyst. Impurities, such as chlorides or sulfurs, can be detected using surface methodology techniques. The feedstock for this compound is usually xylene, which has a high boiling point. This product contains reactive functional groups that can be used to modify surfaces and create polyurethane products.</p>

<p>Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.</p>

<p>Please enquire for more information about 2,6-Difluoro-4-methoxyphenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Fmoc-a-Me-Lys-OH hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Boc-4-aminopiperidine is a molecule that is used as a substrate in chemical reactions. It reacts with sodium hydroxide solution to form an imine, which is hydrogenated by reducing agents such as NaBH4. This reaction yields the products 4-aminopiperidine and acetaldehyde. Boc-4-aminopiperidine is also utilized as a cholinesterase inhibitor, which inhibits the breakdown of acetylcholine at nerve endings. The inhibitory activity of Boc-4-aminopiperidine can be determined using diagnostic techniques and it can be used to inhibit viruses such as HIV and influenza A virus.</p>

<p>Please enquire for more information about 4-Acetylamino-5-bromo-2-methoxy-benzoic acid methylester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Endogenous heptapetide which causes vasodilation and has anti-hypertensive properties.</p>

<p>N3-PEG(45)-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, N3-PEG(45)-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is a potential anticancer drug that has been shown to inhibit the polymerase chain reaction in human osteosarcoma cells. It also inhibits the signaling pathway of nuclear factor-κB (NF-κB), which is involved in cell death and tumorigenesis. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has shown significant cytotoxicity against murine hepatoma cells and bowel disease cells, but not against normal tissue. This drug is also an inhibitor of the drug transporter Pgp. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has been shown to be effective in experimental models for cancer, AIDS, and other infectious diseases.</p>

<p>7-Fluoro-2-methylquinoline is a multistep synthetic compound that belongs to the family of quinoxalines. It has been shown to have potent antibacterial activity against a wide range of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. 7-Fluoro-2-methylquinoline was developed as an analog of the natural product quinoxaline. The key step in its synthesis is the reaction between an aldehyde and hydroxyalkylating reagent in the presence of iron catalyst. This process results in the formation of functional groups such as hydroxyls, alkoxy, or halogens.</p>

<p>Please enquire for more information about 10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>8-Phenyltheophylline (8PT) is an adenosine receptor agonist that is used as a bronchodilator for the treatment of asthma. It has been shown to increase the intracellular calcium concentration in hl-60 cells and in rat papillary muscles. 8PT also has locomotor activating effects, which are thought to be due to its ability to block potassium channels in the hippocampal formation. These effects may be related to ATP-sensitive potassium channels, which have been shown to be sensitive to ATP in untreated mice. 8PT also has anti-arrhythmic properties, which may be due to its ability to inhibit sodium channels and its effect on heart rate and contractility.</p>

<p>Sildenafil is a drug that is used to treat erectile dysfunction. It inhibits the action of phosphodiesterase type 5 (PDE-5), an enzyme that breaks down the messenger cyclic guanosine monophosphate (cGMP) within the corpus cavernosum. This leads to increased levels of cGMP, which relaxes smooth muscle cells in the corpus cavernosum and allows for more blood flow into the penis. Sildenafil is synthesized from chrysanthemum morifolium, a plant also known as "shamrock." Sildenafil has been shown to have no effects on insulin resistance or lipid metabolism, but it does cause side effects such as headache, visual disturbances, and hearing loss.</p>

<p>5-Methyl-2-(1-methylbutyl)-5-propyl-1,3-dioxane is a bitter compound that is found in the fruit of the prickly pear cactus. It has been shown to be a protein-coupled receptor (PCR) ligand and a sweetener. 5-Methyl-2-(1-methylbutyl)-5-propyl-1,3-dioxane activates taste receptors on the tongue and in the gut. It also has been shown to function as an inhibitor of chemosensation in mammals.</p>