CAS 131438-79-4: Amyloid beta-protein fragment 1-40

Description: Amyloid beta-protein fragment 1-40 (Aβ1-40) is a peptide that plays a significant role in the pathogenesis of Alzheimer's disease. It is derived from the amyloid precursor protein (APP) through enzymatic cleavage by beta-secretase and gamma-secretase. This fragment consists of 40 amino acids and is one of the most prevalent forms of amyloid beta in the brain. Aβ1-40 is known for its propensity to aggregate, forming oligomers and fibrils that contribute to amyloid plaque formation, a hallmark of Alzheimer's disease. The peptide is hydrophobic, which influences its aggregation behavior and interactions with cell membranes. Aβ1-40 can induce neurotoxicity and disrupt synaptic function, leading to cognitive decline. Its solubility and aggregation properties are influenced by factors such as pH, temperature, and ionic strength. Research on Aβ1-40 is crucial for understanding Alzheimer's disease mechanisms and developing potential therapeutic strategies. The CAS number 131438-79-4 uniquely identifies this specific peptide in chemical databases, facilitating its study in various scientific contexts.

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Synonyms:

• L-Valine,L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-a-glutamyl-L-a-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-
• Amyloidb-peptide(1-40)(human)
• H-asp-ala-glu-phe-gly-his-asp-ser-gly-phe-glu-val-arg-his-asp-ser-gly-phe-glu-val-arg-his-gln-lys-leu-val-gly-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-oh
• ss-Amyloid (1-40), rat
• Beta-Amyloid Protein(1-40)
• Beta-Amyloid 1-40,human
• Abeta 1-40
• β-Amyloid(1-40)Human

Amyloid β-Protein (1-40)

CAS: 131438-79-4

Amyloid β-peptide (1-40) showed both neurotrophic and neurotoxic effects in dependence on the neuronal age …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: 95.9%
• Color and Shape: White Lyophilisate
• Molecular weight: 4329.86

Amyloid β-Protein (1-40)

CAS: 131438-79-4

Compared to the TFA salt, the HCl salt of amyloid β-protein (1-40) easily forms β-structures …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: 93.7%
• Color and Shape: White Lyophilisate
• Molecular weight: 4329.86

Amyloid β-Protein (1-40) (HFIP-treated)

CAS: 131438-79-4

The peptide was obtained by dissolving Amyloid β-Protein (1-40) in HFIP, aliquoting, and removing the …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: 95.1%
• Color and Shape: White Solid Material
• Molecular weight: 4329.86

β-Amyloid (1-40)

CAS: 131438-79-4

Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 4329.82

Amyloid β Protein fragment 1-40 HCl Salt

CAS: 131438-79-4

Amyloid β Protein fragment 1-40

CAS: 131438-79-4

• Molecular weight: 0.00g/mol

β-Amyloid (1-40)

CAS: 131438-79-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S₁
• Molecular weight: 4,329.86 g/mol

Amyloid beta peptide(1-40) trifluoroxalate - synthetic

CAS: 131438-79-4

Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S·C₂HF₃O₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 4,443.83 g/mol

Amyloid β-Protein (Human, 1-40) (HCl Form)

CAS: 131438-79-4

Amyloid beta-protein (Aβ) is a peptide that is derived from amyloid precursor protein (APP). Aβ …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: Min. 95%
• Molecular weight: 4,329.89 g/mol

Amyloid β-Protein (Human, 1-40) (TFA Form)

CAS: 131438-79-4

Amyloid beta-protein (Aβ) is a peptide that is believed to play an important role in …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: Min. 95%
• Molecular weight: 4,329.8 g/mol

Amyloid beta-Protein (1-40) trifluoroacetate salt

CAS: 131438-79-4

Amyloid beta-protein (Aβ) is a protein that is involved in the metabolic processes that are …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: Min. 95%
• Molecular weight: 4,329.81 g/mol

(Asn7)-Amyloid b-Protein (1-40) trifluoroacetate salt

CAS: 131438-79-4

(Asn7)-Amyloid b-Protein (1-40) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asn-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys The product is a compound that has been shown …

• Formula: C₁₉₄H₂₉₆N₅₄O₅₇S
• Purity: Min. 95%
• Molecular weight: 4,328.82 g/mol

Amyloid β-Protein (1-40) hydrochloride salt

CAS: 131438-79-4

Amyloid beta-protein (1-40) hydrochloride salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln is a secretase inhibitor that binds to the active …

• Formula: C₁₉₄H₂₉₅N₅₃O₅₈S
• Purity: Min. 95%
• Molecular weight: 4,329.81 g/mol

AMYLOID β-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE

CAS: 131438-79-4

• Formula: C₆₇H₁₄₂N₂₅O₆
• Purity: 95%
• Molecular weight: 1394.0083