Amino Acids (AA)

Applications Norvaline, a hydrogen analogs of an amino acid, was found to be racemates from the Murchison meteorite show. Norvaline was used in chiral separation by electrokinetic chromatography.
References Cronin, J., et al.: Science, 275, 951 (1997); Pizzarello, S., et al.: Geochim. Cosmochim. Acta., 64, 329 (2000); Gerabe, S., et al.: J. Chromatogr., 480, 403 (1989);

Applications (4-Hydroxyphenyl)glycine, is a key intermediate for the synthesis Cefpiramide (C243400), used as a β-lactam antibiotic.
References Xiao, R. Q., et al.: Guangzhou Huagong, 41, 111 (2013);

Impurity Betahistine EP Impurity C (Free Base)
Applications N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.
References Mautner, F.A. et al.: Inorg. Chim. Acta, 362, 4073 (2009);

Applications H-PHE-GLY-OH (cas# 721-90-4) is a useful research chemical.

Applications 5-Amino-2-methylbenzotrifluoride is used to prepare azoles as inhibitors of VEGF receptors 1 and 2 with high intestinal permeability. It can also be used to prepare curcumin analogs conjugated with antiandrogens.
References Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 17, 1369 (2007); Shi, Q., et al.: Bioorg. Med. Chem., 20, 4020 (2012)

Stability Hygroscopic
Applications Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is commonly used as a precursor in the food and pharmaceutical industries. Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.
References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);

Applications Intermediate for the preparation of Glimepiride.

Applications 2-Chloro-1-methylquinolinium tetrafluoroborate (cas# 16843-24-6) is a useful research chemical.

Applications N-t-Boc-2-bromoethylamine (Technical grade, ~90%) (cas# 39684-80-5) is a compound useful in organic synthesis.

Applications 3-Methoxy-2',4',6',4-tetrahydroxychalcone piperidine complex (cas# 52218-19-6) is a useful research chemical.

Applications An intermediate in the synthesis of Erlotinib (E625000).

M06199 - BOC-SER(TBU)-OH DCHA

Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.
References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),

Applications 1-(2-Chloroethoxy)-2-methoxy benzene, is an impurity of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);

Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.
References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7

Applications N-(4-Bromo-2-methylphenyl)-2-chloroacetamide (cas# 96686-51-0) is a useful research chemical.

Applications L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.
References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Applications D,L-o-Tyrosine is a metabolite of Phenylalanine (P319415). A precursor in the formation of catecholamines. Used as biomarkers of protein oxidative damage in β-thalassemia.
References Tsugita, A., et al.: Eur. J. Biochem., 124, 585 (1982), Nielsen, F., et al.: Clin. Chem., 43, 1209 (1997), Mates, J., et al.: Clin. Biochem., 32, 595 (1999),

Applications 2-Amino-5-chloro-3-methylbenzoic Acid is a useful research chemical for the preparation of benzoyl urea containing anthranillic acid groups with insecticidal activity.
References Peng, Y., et al.: Nongyao, 48, 326 (2009);

Applications N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

Applications 4'-Methylacetanilide (cas# 103-89-9) is a compound useful in organic synthesis.

Applications 5-Methylfurfural is a common chemical reagent used in a wide variety of chemical reactions and organic synthesis. Polycyclic pyridazine based derivatives are synthesized with this compound to form antimicrobial agents. Also used in the preparation of antiinflammatory diarylpentanoid analogues.
References Deeb, A. et al.: Eur. Chem. Bull., 3, 897 (2014); Leong, S. et al.: Molecules, 19, 16058 (2014);

Applications N-Carbobenzoxyglycine is used in the dipeptide synthesis.
References Hans, D., et al.: Med. Chem., 2, 627 (2006), Guzman, F., et al.: J. Biotechnol., 10, 279 (2007), Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010),

Impurity Ranitidine EP Impurity H
Applications N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).
References Sharma, N. et al.: Sci. Pharmac., 79, 309 (2011); Haywood, P.A. et al.: J. Chem. Soc., 5, 951 (1987);

Applications 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid (cas# 144059-86-9) is a useful research chemical.

Stability Volatile
Applications 1-Chloro-2-methylpropene is a reagent in the synthesis of pyrrolyl and indolyl diketo acids and esters as nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Costi, R., et al.: J. Med. Chem., 56, 7431 (2013);

Applications N-Acetyl-S-benzyl-d5-L-cysteine is deuterium labelled N-Acetyl-S-benzyl-L-cysteine, which is a metabolite of toluene.
References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),

Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.

Applications 4-methoxy-3-methylaniline (cas# 136-90-3) is a useful research chemical.

Applications Used in the methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins. Also used in the studies on the separation and photometric determination of antiepileptics.
References Quednow, B., et al.: Pharmazie, 34, 724 (1979),

Stability Moisture Sensitive
Applications An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).
References Muth, W., et al.: J. Biol. Chem., 249, 7463 (1974), Hanukoglu, I., et al.: Eur. J. Biochem., 180, 479 (1989), Khaw, L., et al.: J. Bacteriol. 180, 809 (1998), Gallagher, D., et al.: J. Mol. Biol., 342, 119 (2004),