Peptides

<p>PP27894</p>

Research Peptide

<p>Research peptide</p>

<p>Please enquire for more information about IgA1 Hinge Region Peptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Human pleiotrophin is a peptide that belongs to the family of neuropeptides. It has been shown to bind to ion channels in the cell membrane and is believed to regulate their function. This protein also binds with high affinity to the receptor tyrosine kinase, which are important for many cellular functions including signal transduction and cell growth. Pleiotrophin has been used as a research tool for studying protein interactions and for understanding how ion channels work. It can be used to study the mechanisms of various diseases such as hypertension, asthma, and diabetes mellitus.

<p>Z-Gly-Pro-Leu is a bacterial enzyme that belongs to the group of carboxypeptidases. It has an optimal pH of neutral ph, and can be found in ascidian tissue. Z-Gly-Pro-Leu is a synthetic substrate, and its sequences have been determined. Functional groups of this enzyme are carboxylic acid, hydroxyl, amine and thiol. This enzyme is used in the production of synthetic peptides and it has been shown to have a high level of activity on homogenates. It has also been shown to have an effector function in pancreatic tissue when injected subcutaneously.</p>

As a member of the tachykinin neuropeptide family, Neurokinin B is involved in the dilation of blood vessels, the contraction of smooth muscles and the excitation of neurons. This product can be applied as a NK3 receptors selective agonist.

Urocortin 1 (Mouse, Rat)-EIA Kit is an antibody-based sandwich ELISA kit for the quantitative determination of urocortin 1 in mouse and rat serum. This kit is designed to measure urocortin 1 concentrations in samples with a high level of accuracy. The antibody used in this kit has been shown to react with rat and mouse urocortin 1.

<p>Amyloid Beta-Protein (Human, 1-40) Antiserum is an antibody, which is a protein that recognizes and binds to a specific antigen. The Amyloid Beta-Protein (Human, 1-40) Antiserum can bind to amyloid beta protein in the brain and trigger immune system cells to clear it from the body. This antibody can also be used as a research tool for studying the structure of amyloid beta protein and how it affects human cells.</p>

<p>Amylin (Rat) Antiserum is a protein that is used as an inhibitor in research. It is also a ligand for the insulin receptor and can be used to study its activity. Amylin (Rat) Antiserum binds to the extracellular domain of the receptor and blocks it from binding to insulin. This prevents the activation of downstream signalling pathways, which are responsible for glucose uptake and metabolism. Amylin (Rat) Antiserum can be used as a research tool to study ion channels due to its ability to block potassium channels. The antibody has been shown to bind with high purity with little cross-reactivity in immunoassays, making it ideal for use in laboratories.</p>

Oxytocin is a peptide hormone and neurotransmitter. It is primarily used in the brain to regulate social behavior, such as maternal behaviour, sexual arousal and romantic attachment. Oxytocin is also used for uterine contractions during childbirth and to induce labour. Oxytocin can be administered by injection or as nasal spray. It has a half-life of about two minutes in the blood stream and its effects last up to one hour. Oxytocin is a nonapeptide with the amino acid sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-Leu-Met-(OH). The oxytocin receptor (OXTR) belongs to G protein coupled receptors (GPCR), which are known for their roles in cell signaling, oncogenesis, immunity, inflammation, pain sensation and endocrine regulation. The OXTR is expressed throughout the body including the uterus and vagina.

Kallidin is a peptide that has regulatory effects on tissue remodeling, inflammatory responses, and the growth of new blood vessels. It is found in a number of tissues, including extracellular matrix proteins, where it acts as a regulator. Kallidin has been shown to regulate kinins, which are hormones that are responsible for the regulation of inflammation. Kallidin also regulates collagen and fibrinogen production by stabilizing these proteins. This peptide also induces leukocyte recruitment and polymorphonuclear leukocytes (PMN) activity. Kallidin can stimulate growth factor production and may play an important role in the stabilization of matrix proteins such as fibronectin.

<p>EPGN Human is a research tool that is an activator, ligand, and receptor. It is also used in Cell Biology as an antibody and an ion channel. EPGN Human is used in pharmacology as a peptide. EPGN Human has high purity and can be used in Life Science for protein interactions or as an inhibitor.</p>

Anti Atrial Natriuretic Peptide (ANP) (Rat) Serum is a research tool for studying the pharmacology of ANP. It is an activator of ion channels and the receptor for ANP, which regulates water balance in the body. It has also been shown to be a ligand for antibody, used in pharmacology to study protein interactions. This serum is used as a research tool in Cell Biology to study the effects of ligands on membrane ion channels and receptors. Anti Atrial Natriuretic Peptide (ANP) (Rat) Serum is purified from rat serum with high purity.

<p>Des-Asp1-[Ile8]-Angiotensin II is an artificial peptide that has been shown to activate the angiotensin receptor. It is a high purity, potent inhibitor of angiotensin II. This peptide is also suitable for research and antibody production.</p>

<p>TGF-β is a cytokine with two forms, TGF-β1 and TGF-β2. The tgf-beta protein is a molecule that controls cell growth, differentiation and apoptosis. It can be found in the desiccated state, which must be reconstituted before use. Reconstitution of the protein requires acetonitrile and trifluoroacetic acid. Cytokines are molecules that regulate cell behavior by acting on other cells. Chromatographic techniques are used to separate these molecules by size and charge, while growth factors are molecules that promote cell growth and differentiation. The experimentally determined molecular mass of TGF-β1 is 25 kDa.END&gt;</p>

NHS-m-dPEG® (MW = 685) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG® (MW = 685) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Please enquire for more information about Amyloid β (1-42) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Insulin-like 5 (INSL5) is a protein that in humans is encoded by the INSL5 gene. It belongs to the insulin family of proteins and has been shown to have a role in various biological functions. INSL5 binds to the insulin receptor, which induces apoptosis in cancer cells by inhibiting cyclin-dependent kinase activity and inducing cell cycle arrest. The expression of INSL5 can be used as a diagnostic marker for cervical cancer and may also be used as a potential biomarker for cancer tissues.

The Anti NO Synthase II (77-105) (Rat) Serum is a research tool that can be used to activate, ligand or receptor. It can also be used to study cell biology as well as protein interactions. The Anti NO Synthase II (77-105) (Rat) Serum can inhibit ion channels and is a high purity antibody. This serum is made of peptides and proteins.

<p>This is a vivitide catalogue product. Please send your vivitide product enquiry to sales@vivitide.com for an up-to-date price and availability.</p>

Physalaemin is a vasoactive intestinal peptide that belongs to the family of exocrine hormones. It is resistant to intracellular degradation and has been shown to be a potent inhibitor of vasopressin. Physalaemin has been shown to affect blood pressure by stimulating receptors in the brain that decrease blood pressure, as well as blocking naloxone-induced increases in blood pressure. Physalaemin also interacts with pancreatic cells, which may be due to its amino acid composition and ability to inhibit the release of caerulein from the pancreas. The effects on muscle cells are unknown, but it has been shown to have an inhibitory effect on the pancreas and intestine.

Z-Tyr-Glu is an acidic amino acid that is a member of the L-glutamate family. It has been shown to be a genetic factor in antibody response and has been found to have multiple subunits. Z-Tyr-Glu is found in plants, such as the fungus Monascus purpureus, and can be isolated from wheat (Triticum aestivum) and rice (Oryza sativa). This amino acid is also found in plasma samples at low concentrations, where it may serve as a marker for metabolic disorders. Z-Tyr-Glu can be detected by electrospray ionization mass spectrometry and validated by liquid chromatography/mass spectrometry.

<p>Amino-dPEG®12-t-boc-Hydrazide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®12-t-boc-Hydrazide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Rabbit serum against growth hormone-releasing factor (GRF) or GHRH (growth hormone-releasing hormone).

Hepatitis E virus (HEV) is a virus that infects the liver and causes hepatitis. Recombinant HEV ORF2 protein was produced by recombinant techniques in Escherichia coli. The recombinant HEV ORF2 protein has been shown to be immunogenic in mice, rabbits, and humans. Immunodominant epitopes were found at amino acid positions 448-456 and 468-480.

Human CRF ELISA (1ea) is a high-quality, competitively priced ELISA kit for the quantitative measurement of human CRF in rat serum. This assay has been designed for use in detecting the presence of CRF in biological fluids for research purposes. The kit contains all necessary components to perform the assay and detailed instructions are included.

<p>This product is produced via the activation of mariculture Keyhole Limpet (Megathura crenulata) Hemocyanin with a maleimide group.  The activated material will readily bind free sulfhydryl groups present in solution.KLH is a highly antigenic protein with a high molecular mass (4.5 x 105 - 1.3 x 107 Daltons, in aggregates of 350 and 390 kDa subunits) that elicits a strong immune response when used to immunize animals.As many as 400 moles of Cysteine-containing peptide can bind to one mole of maleimide-activated KLH.</p>

IL-17 Rat is a recombinant protein that is used as an immunological research tool. It is also used as a ligand to study the IL-17 receptor. IL-17 is a cytokine that activates cells in the immune system, such as T cells, B cells, and natural killer cells. This protein can be used in cell biology experiments to study cytokine signaling pathways and has been shown to inhibit ion channels. IL 17 rat can also be used in pharmacology studies to assess its effects on peptides and proteins within the body.

<p>Gap19 is a protein that regulates cell growth and has been implicated in cancer. Gap19 is a member of the myosin II family of proteins, which are involved in muscle contraction. Gap19 binds to calmodulin and is localized to the sarcomere region of cardiac ventricular myocytes. Gap19 has been shown to be a specific ligand for toll-like receptor 4 (TLR4). The binding of Gap19 leads to an increase in intracellular reactive oxygen species (ROS) levels, activation of transcription factors, and induction of inflammatory responses. These findings suggest that Gap19 plays an important role in regulating inflammatory diseases. Gap19 also has a biochemical function as a specific antibody for collagen, which is used to study cellular reactions involving collagen.</p>

<p>Peptide H-WLGFIAGLIAIVMVT-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-WYIWLGFIAGLIAIV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cntf is a cytokine that belongs to the family of neurotrophins. It is a ligand for the receptor c-ret, which is expressed in cells of the central and peripheral nervous system. The Cntf protein can be used as an activator or inhibitor in cell biology and pharmacology research. The Cntf mouse has been created by fusing a human c-ret gene with a mouse agouti gene. This mouse has high levels of Cntf protein and can be used to study the effects of this protein on ion channels, cell biology, and other areas of research.</p>

<p>Ac-Asp-Gln-Thr-Asp-H aldehyde is a peptide that can act as an activator, inhibitor, or ligand for ion channels and receptors. It has been shown to be a high purity reagent in the field of cell biology and pharmacology.</p>

Vimentin is a protein that is expressed in the cytoplasm of cells. It is found in fibroblasts, osteoblasts, and endothelial cells. Vimentin is a member of the intermediate filament family. This antibody reacts with vimentin as well as other intermediate filaments such as desmin and keratin. The FITC tag allows for visualization of the antibody under fluorescent microscopy. Reconstitute with PBS before use.

<p>Cyclosporin-A is a cyclic peptide that inhibits mitochondrial functions and has been used to prevent organ rejection in transplant patients. It binds to the cyclase enzyme and prevents the formation of cyclic adenosine monophosphate (cAMP) from ATP, which is required for cell growth. Cyclosporin-A also inhibits the production of proteins by preventing transcription, replication, and translation. This drug can cause neurotoxicity when administered at high doses or over a long period of time. In vitro assays have shown that cyclosporin-A has cytotoxic effects on platinum-resistant ovarian cancer cells. It also has an effect on microdialysis probes, which may be due to its ability to inhibit neurotransmitter release from neurons. Cyclosporin-A has been shown to inhibit the production of protein in vivo, as evidenced by a decrease in weight gain in rats treated with this drug for one week.</p>

<p>Human GH (1-43) ELISA Kit (1ea) is a sandwich enzyme-linked immunosorbent assay for the quantitative measurement of human GH in serum. It has demonstrated cross-reactivity with monkey, rat, and mouse GH, but not bovine or porcine GH.</p>

<p>PC Biotin Alkyne probes eliminate a major limitation of the streptavidin-biotin affinity purification. This reagent contains a biotin moiety linked to an azide moiety through a spacer arm containing a photocleavable linker. Captured biomolecules can be efficiently released under mild, reagent-free conditions (irradiation with near-UV, low intensity lamp) and the small molecular fragment (55.07 Da) left on the labelled protein following cleavage. These features make the photocleavable probe especially attractive for use in biomolecular labelling and proteomic studies.</p>

Catestatin is a peptide that belongs to the family of activators. Catestatin is an activator of potassium channels and can be used as a research tool. It has been shown to bind to the Kv1.2 receptor, which is expressed in human heart and skeletal muscle cells. This peptide also inhibits calcium-activated potassium channels, thereby blocking the transmission of nerve impulses. Catestatin has been shown to inhibit protein interactions with G protein-coupled receptors (GPCRs) and ion channels, thereby regulating cellular signaling pathways involved in cell growth and differentiation.

Hemoglobin, α 2, human, recombinant is a protein that belongs to the group of hemoglobins. It is a recombinant protein that has been produced by inserting the human alpha-2 globin gene into a bacterial expression system. This product can be used as an ion channel probe, an activator of G-protein coupled receptors or as an inhibitor of ligand binding to receptors. It has been shown to interact with a variety of peptides and proteins. Hemoglobin, α 2, human, recombinant can be used in research for cell biology and pharmacology studies.

<p>Nucleolin is a protein that belongs to the nucleolar family of ribonucleoprotein. It has been shown to be involved in the transcription, maturation, and fibrillar assembly of ribosomal RNA. Nucleolin also plays an important role in the synthesis of other proteins by serving as a scaffold for the assembly of pre-ribosomal particles. The c-terminal domain contains a phosphoprotein called PNPase that catalyzes the hydrolysis of inositol polyphosphates. In addition, nucleolin is glycosylated during its maturation process.</p>

<p>Complement Component C5a Mouse (recombinant) is a recombinant protein that is an activator of the complement system. It can be used to investigate the role of the complement system in immune responses, inflammation, and cell death. Complement component C5a mouse (recombinant) is a potent inhibitor of ion channels and ligand-gated receptors, and has been shown to inhibit the function of voltage-gated potassium channels. Recombinant Complement component C5a mouse (recombinant) can also be used as an antibody probe for immunohistochemical detection of C5a receptor protein expression in cells. Complement component C5a mouse (recombinant) has high purity and is suitable for research purposes.</p>

Anti C-Peptide II (Rat) Serum is a high-purity peptide that can be used as a research tool to study the pharmacology of peptides and their interactions with receptors. It can also be used as an inhibitor in cell biology experiments.

<p>Hexokinase-1, human, recombinant is a type of hexokinase. Hexokinase-1 is an enzyme that catalyzes the first step in the glycolytic pathway by phosphorylating glucose to form glucose-6-phosphate. It is a major control point for regulating blood sugar levels and has been shown to be involved in the regulation of metabolic homeostasis. Hexokinase-1 is inhibited by its substrate, glucose, as well as by other competitive inhibitors such as 2-deoxyglucose and glucagon.</p>

Thymosin β4 is a polypeptide hormone that has been studied in a variety of medical conditions. It was first discovered in the thymus gland, but is also found in other tissues, including the intestine and heart. Thymosin β4 is involved in the process of wound healing, regulating the production of collagen and fibrinogen. It also has cardioprotective effects by preventing myocyte apoptosis. There have been studies that show that thymosin β4 may be useful for treating chronic kidney disease, colorectal cancer, and polyps. The effects of this protein are mediated by its ability to regulate cellular proliferation and differentiation.

Anti Pancreastatin (33-51) (Rat) Serum is a high purity, potent inhibitor of pancreatic secretions. This product is a peptide that inhibits the secretion of pancreatic enzymes by competitive inhibition of the pancreatic proenzyme, trypsinogen. It has been used in pharmacological research as a tool for studying protein interactions and receptor binding. Anti Pancreastatin (33-51) (Rat) Serum has also been shown to have anti-inflammatory properties.

Insulin-like growth factor 1 (IGF1) is a cytokine that belongs to the family of growth factors. IGF1 is a peptide hormone that mediates its effects by binding to cell surface receptors and activating signal transduction pathways inside cells. IGF1 stimulates glucose uptake, protein synthesis, and lipolysis in muscle and adipose tissue. The A67T variant of IGF1 has been shown to have increased activity in stimulating insulin-like signaling pathways and mediating the effects of IGF1 on glucose metabolism. This variant is associated with increased risk for type 2 diabetes mellitus (DM).

IP-10 is a chemokine that is expressed in the human immune system. IP-10 can be released from cells such as macrophages, neutrophils, and mast cells in response to inflammatory stimuli. This protein is important for the recruitment of lymphocytes and monocytes to sites of infection or injury. IP-10 also has antitumor activity, which may be due to its ability to induce apoptosis in tumor cells.

Ferredoxin-1 is a peptide that belongs to the group of activators. It can be used as an inhibitor, or as a receptor or ligand in pharmacological experiments. Ferredoxin-1 has been shown to inhibit ion channels and protein interactions. This protein may also have implications for cell biology and is used as a research tool for life science. The CAS number for ferredoxin-1 is 107899-38-2.

<p>Lipid A is a bacterial endotoxin that activates macrophages and dendritic cells, which in turn activate T-cells. It is a ligand for the CD14 receptor, which is a pattern recognition molecule found on macrophages and dendritic cells. Lipid A also binds to the Toll-like receptor 4 (TLR4) on host cells, initiating an inflammatory response. Lipid A has been used as a research tool to study cell biology related to activation of macrophages and dendritic cells leading to cytokine production. This activator has also been used as a ligand in antibody studies, ion channel studies, protein interactions, pharmacology experiments with peptides, and life science research.</p>

<p>The anti G-protein: Galpha i3 (105-127) is a recombinant human serum protein. This antibody was raised against the peptide sequence of human Galpha i3 (105-127). It has been purified by Protein A and gel exclusion chromatography. The peptide sequence of this antibody is as follows: YGRKKRRQRRRPPPPPPRRRQRRKSSSSSEEEEDEESDS.</p>

<p>SPDP-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein that is expressed by oligodendrocytes and is essential for the myelinization of axons in the central nervous system. MOG has been associated with the development of multiple sclerosis and demyelinating diseases. Freeze-dried MOG is reconstituted with water before use, which may be beneficial for patients who cannot swallow pills or capsules. The reconstituted protein can be injected intravenously as an allograft. Myelin Oligodendrocyte Glycoprotein can also be used long-term after desiccating to prevent its degradation and loss of biological activity. The expansion of the chromosome carrying the gene for MOG has been shown to be associated with multiple sclerosis and other neurologic diseases.</p>

<p>TNF-α is a cytokine that is produced by many cells, including macrophages, T cells, mast cells, and synovial cells. It is a pleiotropic proinflammatory cytokine that has been implicated in cancer and other inflammatory diseases. TNF-α is a potent inducer of cell death through activation of the Fas-FasL death pathway or induction of apoptosis. In addition to its role as an anti-tumor agent, TNF-α has been shown to be important in the regulation of immune responses and inflammation. It also plays an important role in bacterial sepsis by suppressing the production of proinflammatory cytokines such as IL-1β and IL-12 by macrophages.</p>

<p>EREG Human is a cytokine that belongs to the group of proteins. It is an interleukin-1 receptor antagonist (IL-1Ra) that binds to IL-1 and prevents it from binding with its receptors. EREG Human has been shown to be effective in treatment of inflammatory diseases such as Crohn's disease, rheumatoid arthritis, and ulcerative colitis.</p>

IL-11 is a cytokine that is synthesized by cells of the immune system and functions as an autocrine growth factor for cells of the myeloid lineage. IL-11's receptor is a protein that binds to the IL-11 peptide and this binding activates intracellular signaling pathways.

<p>Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a peptide that belongs to the family of orphanin FQ peptides. It has been shown to activate ion channels and ligand-gated channels. Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a high purity, pharmacology research tool for use in cell biology and receptor studies.</p>

<p>α-Synuclein is a protein that is encoded by the SNCA gene, and is one of the main components of Lewy bodies, which are found in neurons in people with Parkinson's Disease. α-Synuclein has been shown to protect cells from stress and prevent their death. It also acts as a chaperone for other proteins, regulating their activity. This protein has been shown to be able to bind to GTPase activators and inhibit them from activating GTPases. The molecular weight of α-synuclein is 25 kDa and it has a pI value of 4.5. It has an acidic C-terminus and its shift on gel electrophoresis is 11.5 kDa</p>

Anti Humanin Serum is a research tool that can be used as a pharmacological reagent or as a research tool. It is an antibody that can be used to study protein interactions, such as receptor-ligand binding, and the effects of peptides on ion channels. This product is composed of high purity humanin antibodies with no detectable cross-reactivity with other proteins.

SPAI-1 is a protein that is found in the cytosol and nucleus of cells. It belongs to the family of inhibitor proteins, which regulate the activity of other proteins. SPAI-1 inhibits the activity of many different types of protein kinases. Inhibitors such as SPAI-1 are often used as research tools for studying protein interactions, activators, ligands, and receptors. This antibody can be used as a reagent to detect and locate SPAI-1 in cells or tissues by immunohistochemistry.

High quality, quantitated heavy/light peptide calibrator for angiotensinogen in Mass Spectroscopy research

<p>FRETS-25Arg (1 umol) is a peptide that has been shown to activate the serotonin 2C receptor. The peptide is a high purity product with a CAS number of 9078-02-5. FRETS-25Arg (1 umol) can be used as a research tool for studying the protein interactions, receptor binding, and ion channels.</p>

Secretin (Porcine) Antiserum is a research tool that is used to activate the secretin receptor. Secretin is an inhibitor of ion channels, which may be due to its ability to bind to the secretin receptor and inhibit its activity. The purified protein has a high purity and can be used in antibody experiments, cell biology, or pharmacology.

<p>RNA Binding Motif Protein 3 (RBMY3) is a high-quality research peptide that is commonly used in scientific studies. It is a recombinant protein derived from Escherichia Coli. RBMY3 plays a crucial role in RNA metabolism and regulation, specifically in the binding and processing of RNA molecules. This protein is highly purified and has been extensively tested for its quality and functionality. Researchers rely on RBMY3 to study various cellular processes, including gene expression, mRNA splicing, and post-transcriptional modifications. With its exceptional purity and reliability, RBMY3 is an essential tool for any laboratory conducting cutting-edge research in the field of RNA biology.</p>

<p>Dihydrofolate reductase is an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. It belongs to a family of metalloenzymes that employ NADPH as a cofactor and are involved in one-carbon metabolism. Dihydrofolate reductase has been shown to interact with a number of other proteins, including peptides, cell biology, and receptor. This enzyme is also used as an inhibitor for research purposes.</p>

TNF-α is a cytokine that is synthesized and secreted by cells such as activated macrophages, T cells, endothelial cells, fibroblasts, and keratinocytes. It has been shown to be a potent mediator of inflammation and plays an important role in the pathogenesis of many diseases. TNF-α is produced in response to immunological stimulation (e.g., LPS) or microbial invasion (e.g., bacteria). It binds to two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which are expressed on many cell types including monocytes, macrophages, neutrophils, dendritic cells, B lymphocytes, eosinophils, mast cells and keratinocytes. The binding of TNF-α to TNFR1 leads to activation of NF-κB and JNK pathways. The binding of TNF-α to TNFR2 leads to activation

Neurotensin is a neuropeptide that is involved in the regulation of a variety of physiological functions, including neurotransmission, cardiovascular function, and appetite. It is composed of 13 amino acids and is primarily produced in the gastrointestinal tract and the central nervous system. Neurotensin acts as a neurotransmitter and neuromodulator in the brain, where it is synthesized by neurons in several regions, including the hypothalamus, amygdala, and nucleus accumbens. In addition to its role in neurotransmission, neurotensin has been shown to be involved in the regulation of food intake and energy metabolism. It is thought to promote satiety and reduce food intake by interacting with the hypothalamus and other brain regions involved in appetite regulation. Neurotensin has also been studied for its potential therapeutic applications as it has been shown to be associated with the pathophysiology of conditions such as Parkinson's disease, pain, schizophrenia, cancer and inflammatory bowel disease.

<p>IL-7 is a cytokine that belongs to the IL-2 family. It is a lymphokine that regulates cell proliferation and differentiation of immune cells, such as T and B cells. IL-7 activates these cells by binding to the IL-7 receptor on their surface. The active form of IL-7 is a homodimeric glycoprotein consisting of two subunits, alpha and beta. The alpha subunit has an N-terminal sequence of amino acids (Lysine - Proline - Glycine) while the beta subunit has a C-terminal sequence (Serine - Asparagine). This protein can be purchased as a research tool, antibody, or purified peptide in high purity from Sigma Aldrich.</p>

<p>VIC (Mouse) is a peptide that is used as an inhibitor, activator, or ligand in research. It has the CAS number 120928-04-3 and the molecular weight of 4.5 kDa. VIC (Mouse) is a high purity product and can be used in life science research for characterization of receptor and ion channels. VIC (Mouse) can also be used as an antibody to study protein interactions as well as for cell biology research.</p>

Anti TNF-Alpha (Rat) Monoclonal Antibody is a recombinant rat monoclonal antibody that binds to the TNF-α. It inhibits the effects of TNF-α and has been shown to protect against acute renal failure in rats. Anti TNF-Alpha (Rat) Monoclonal Antibody is a research tool for studying the function of TNF-α, and is used in pharmacological studies as an inhibitor of the enzyme protein kinase C. This antibody can be used for purification of proteins from cell culture or tissue samples.

<p>This enzyme belongs to the family of isomerases, and is a type of glycosylated enzyme. The recombinant DNA topoisomerase-I has been expressed in E. coli cells, purified through chromatography and characterized by mass spectroscopy. It is an enzyme that catalyzes the breakage and rejoining of one DNA strand in order to relieve torsional strain between two strands. In addition to its function as an enzyme, it can be used as a food additive or a technique for molecular biology.</p>

<p>Urocortin 2 (Mouse)-EIA Kit is a specialty product that can be used to detect the presence of Urocortin 2 in mouse serum. It is an antibody-based sandwich ELISA kit that has been optimized for use in mouse sera and other biological fluids. The kit includes all necessary reagents, including antibodies, standards, and conjugates, to perform an assay. The assay is performed by adding the sample to the plate followed by the detection antibody and a conjugate. After incubation, unbound materials are washed away and the plate is developed with Tetramethylbenzidine (TMB) substrate. A stop solution turns TMB into a blue color that can be measured at 450 nm with a spectrophotometer. The intensity of color corresponds to the concentration of Urocortin 2 in the sample.br&gt;br&gt;<br>The Urocortin 2 (Mouse)-EIA Kit is designed for research purposes only and not for diagnostic</p>

<p>Anti Galanin (Porcine) Serum is a research tool that is used to activate, bind, and inhibit the ligand-receptor interactions. It is also used for the study of ion channels and cell biology. Anti Galanin (Porcine) Serum can be used as an antibody or as a peptide in pharmacology studies. The protein interactions are used in life science research, as well as for inhibitor studies.</p>

<p>Pro BMP 2 Human is a recombinant protein that belongs to the group of proteins that regulate cell growth and differentiation. It has been shown to be an activator of bone morphogenetic protein receptor type IIA. Pro BMP 2 Human has also been shown to inhibit the activity of certain ion channels, such as calcium channels, potassium channels, and sodium channels. This product is supplied at high purity, with a CAS number (CAS No.).</p>

<p>Sirtuin-1 is a member of the sirtuin family of proteins, which regulate cell survival and proliferation. Sirtuin-1 regulates gene expression in response to nutrient availability by binding to DNA and modifying histones. It also functions as a homodimer that binds to various regulatory proteins and acts as a repressor or activator of transcription. This protein has been expressed recombinantly in E. Coli, where it may be used as an inhibitor of cancer cell growth. The molecular mass of this recombinant protein is approximately 94 kDa.br&gt;br&gt;<br>Sirtuin-1 is a member of the sirtuin family of proteins, which regulate cell survival and proliferation. Sirtuin-1 regulates gene expression in response to nutrient availability by binding to DNA and modifying histones. It also functions as a homodimer that binds to various regulatory proteins and acts as a repressor or activator of transcription. This protein has been expressed recombinantly in E</p>

<p>[D-Ala2,Met5]-Enkephalin is an inhibitory neurotransmitter that binds to receptors in the brain and spinal cord. It affects physiological functions such as locomotion, pain sensation, and blood pressure. Enkephalins are analogs of the natural neurotransmitter enkephalin that are synthesized by enzymatic cleavage of the latter from a larger precursor molecule called proenkephalin. [D-Ala2,Met5]-Enkephalin has been shown to be an effective antinociceptive agent when administered intraperitoneally or intravenously in rats. It also acts as a pressor agent and produces dextran sulfate-induced nociception in mice. The pharmacological properties of enkephalins have been shown using various analytical methods including acid analysis.</p>

<p>FRETS-25Ser is a peptide with a molecular weight of 25.1 Da. It is an activator of the Kv4.3 potassium channel, which has been shown to be involved in memory and learning processes. FRETS-25Ser binds to the extracellular loop 1 of the Kv4.3 channel and modulates its activity by increasing the open probability of the channel and inhibiting fast inactivation. The affinity for this peptide is high, as it binds tightly to its target protein (Kv4.3). FRETS-25Ser also has a low level of inhibition against other channels with similar sequences, as it can only bind to one site on the protein receptor.</p>

<p>FRETS-25Ile is a peptide that belongs to the class of activators. It has been shown to activate an antibody against the beta2 adrenergic receptor and can be used for research purposes. FRETS-25Ile is a high purity product with an ion channel inhibitor activity. The CAS number for this product is 69710-51-5.</p>

<p>Insulin is a peptide hormone that regulates glucose levels in the blood. It is produced by beta cells in the pancreas and released when blood sugar levels rise. Insulin lowers blood sugar levels, but it also has other functions, such as protein synthesis and cell growth. Insulin stimulates receptors on cells to take up glucose from the bloodstream. Inhibitors of insulin are used for type 1 diabetes mellitus treatment and research purposes. Insulin can be used to study ion channels, antibody production, and receptor binding.</p>

<p>FRETS-25Met (1 umol) (1umol) is a peptide that binds to the beta2-adrenergic receptor. It is a high purity, research tool and can be used for binding studies as well as for inhibition of the receptor. FRETS-25Met (1 umol) (1umol) has been shown to bind to the beta2-adrenergic receptor with an affinity of 5 nM and an IC50 of 1.6 uM. This peptide has also been shown to act as a potent agonist in stimulating cAMP production in CHO cells expressing the beta2-adrenergic receptor.</p>

<p>The IGF1 Mouse is a recombinant protein that belongs to the group of cytokines. It is produced by Escherichia coli and secreted into the culture medium. The IGF1 Mouse is used in vitro for the measurement of cytokines and cytokine receptors.</p>

<p>This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, is courced from: Rat, 1-39 and is available as a 0.1mg vial. Big Endothelin-1 (Rat, 1-39) is a precursor peptide of the vasoconstrictor Endothelin-1 (ET-1). ET-1 exhibits vasoconstrictive properties and is an activator of endothelin G-protein coupled receptors. Furthermore ET-1 is produced when inflammation, vascular stress or hypoxia occurs. In vivo Big Endothelin-1 has a greater half life compared to ET-1 and therefore makes it useful to study secretory activity in the endothelial system.<br>Overall Big Endothelin-1 (Rat, 1-39) can be used as a research tool for studying protein interactions, receptor activation and function, and ligand binding. This peptide is also used in pharmacology to study the effects of therapeutic agents on receptor activity and expression.</p>

MAL-dPEG®12-t-boc-Hydrazide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®12-t-boc-Hydrazide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Oxytocin is a hormone and neurotransmitter that is produced in the hypothalamus. It is released by the pituitary gland during labor to help with uterine contractions, and it stimulates milk production in the mammary glands. Oxytocin may be used to stimulate lactation or to assist in childbirth. The molecular mass of oxytocin is approximately 3,500 Da, which can be determined using chromatography with a retention time of 8-10 minutes and a peak at 3.5 minutes on reverse phase high performance liquid chromatography (RP-Hplc). Oxytocin has been synthesized chemically and freeze dried for use in research settings. Reconstitute with sterile water for injections before use. Oxytocin may also be used as an additive in food products as a flavor enhancer or preservative.</p>

<p>FGF21 is a protein that in humans is encoded by the FGF21 gene. It is a member of the fibroblast growth factor (FGF) family and was originally identified as an anti-diabetic hormone that regulates glucose homeostasis. FGF21 also has roles in lipid metabolism and regulation of energy homeostasis, such as through its interactions with PPARs, RXRs, LXRs, and other nuclear receptors. The receptor for FGF21 is FGFR1c and it acts as a high-affinity agonist of this receptor. The ligand for FGFR1c is FGF19.</p>

<p>Monobiotin is a small molecule that is an activator of the L3 receptor. It has been shown to be a ligand for the L3 receptor and to activate this receptor in cells. Monobiotin activates cell membrane ion channels by binding to the L3 receptor and has been used as a research tool to study protein interactions. Monobiotin is also an inhibitor of voltage-gated potassium channels, which are important in regulating excitability in nerve cells, and can serve as a pharmacological tool for studying ion channel function.</p>

<p>Lipoprotein-associated phospholipase A2 (LP-PLA2) light tryptic peptide standard for protein identification and quantitation studies. LP-PLA2 is a phospholipase A2 enzyme known as platelet-activating factor acetylhydrolase and it is largely associated with low density lipoprotein in the blood.</p>

TentaGel B resins represent a line of bifunctional resins that are useful for orthogonal synthesis. TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. Particle size 90 µm; capacity: 02-03 meq/g Inside: NH2 Outside: Boc

<p>The most potent microbicide of the mouse Paneth cell α-defensins and is degraded by MMP-7. This product has disulfide bonds between Cys4-Cys30, Cys15-Cys37, and Cys19-Cys39, is available in the Hydrochloride salt form and as a 0.1mg vial.</p>

<p>t-boc-NH-dPEG®4-Tris (-TFP Ester)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-boc-NH-dPEG®4-Tris (-TFP Ester)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>m-dPEG®48-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, m-dPEG®48-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>IL 4 Human, His is a recombinant protein that belongs to the class of peptides. It has been identified as an activator of IL-4 receptor and can be used in research studies to study the interactions between proteins, cells, and receptors. IL 4 Human, His can be used as an antibody to detect IL-4 in cell culture samples. IL 4 Human, His is a high purity product with a CAS Number of 57741-00-8.</p>

<p>FRET-25Asp is a peptide that can be used in research as an activator, antibody, and inhibitor. It is used as a tool to study protein interactions with the cell membrane and ion channels. FRET-25Asp has also been shown to inhibit the activity of some receptors and ligands.</p>

<p>An aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition.  The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents.</p>

<p>Bradykinin is a peptide that acts as an autacoid, or local hormone. It is a vasodilator, and it stimulates the release of prostaglandins from mast cells in the lungs. Inhibitors of bradykinin include [Thi5,8,D-Phe7]-bradykinin and des-Arg9-bradykinin. Bradykinin has been used as a research tool to study protein interactions, receptor activation, ion channels, and other life science topics.</p>

<p>TentaGel is a water-soluble polymer that can be used as a building block for various applications including drug delivery, food and beverage, cosmetics, and electronics. It consists of two main components: polyethylene glycol (PEG) and polypropylene glycol (PPG). TentaGel is soluble in water and has an average molecular weight of about 10,000 Da. The PEG-based component allows the polymer to be easily processed into particles or fibers by sonication or extrusion. TentaGel M RAM is a modified version of the original TentaGel. It contains methacrylic acid groups that have been grafted onto the PEG backbone to provide additional functionality such as reactive surfaces for conjugation with proteins or other molecules.</p>

<p>TentaGel resin; constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>TentaGel; HL (High Load) (mean particle size 75 µm: capacity 04-06 meq/g).<br>Substitution Functional Group:-O-CH2-CH2-OH</p>

<p>Neurokinin A is a peptide that is derived from the precursor protein, preprotachykinin A, and has been found to be an endogenous ligand for the NK-1 receptor. It is involved in a wide range of physiological processes such as neurotransmission and regulation of blood pressure. Neurokinin A has been shown to inhibit adenylate cyclase activity in guanethidine-sensitive tissues and ionophores-resistant cells. The effects of Neurokinin A are not due to its ability to bind to the NK-1 receptor but rather through other mechanisms. The amino acid sequence of this peptide was first determined by cloning methods in 1984 and it has since been used extensively as a tool for studying the function of this receptor. Neurokinin A also inhibits cell proliferation in glioma cells and has been shown to have an inhibitory effect on Ca2+ concentration during electrical nerve stimulation.</p>

<p>Anti Insulin, humanSerum is a Research Tool used in the study of protein interactions. It is an antibody that binds to insulin and can be used as a research tool to identify other proteins with which insulin interacts. This product has been purified and is at least 98% pure.</p>

<p>Vasotocin is a peptide that regulates blood pressure and heart rate by acting on the vasoconstrictor and vasodilator systems. It has been shown to inhibit the binding of vasopressin to its receptor, which may be due to the presence of an Arg8 residue in position 6 of the peptide. Vasotocin also stimulates the release of nitric oxide, which leads to smooth muscle relaxation and vasodilation. Vasotocin is a ligand for receptors in both invertebrates and mammals. It is used as a research tool to study ion channels, antibodies, and other proteins that interact with it. Vasotocin can also be used as an anti-inflammatory drug because it can inhibit leukocyte chemotaxis and adhesion.</p>