Peptide Synthesis

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Ramage Linker,Fmoc-Suberol is a synthetic derivative of the antimicrobial peptide guanylate. It is used as an inhibitor of congestive heart failure. Ramage Linker,Fmoc-Suberol has been shown to be effective in reducing the severity of congestive heart failure by inhibiting the production of brain natriuretic peptides. The chemical structure and sequence have been determined using a combination of structural analysis and degradable linkers that are cleaved in vivo by hydrolysis or enzymatic degradation. Ramage Linker,Fmoc-Suberol has also been shown to reduce blood pressure and inhibit platelet aggregation.

Poly-L-lysine hydrochloride, MW20000 is a water soluble polymer with an average molecular weight of 20000 Da. It is used in the synthesis of peptides and proteins due to its high purity, high quality, and low cost. Poly-L-lysine hydrochloride, MW20000 has been shown to bind to a wide range of surfaces such as glass, plastic, silicon dioxide, and stainless steel. This makes it useful for surface modification. Poly-L-lysine hydrochloride can be used as a scaffold for chemical reactions or as an intermediate in the synthesis of complex compounds.

Please enquire for more information about L-Lysyl-L-phenylalanyl-L-lysine trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fmoc-Thr(tBu)-D-Ser(Psi(Me,Me)pro)-OH is a speciality chemical that is used as a reagent for peptide synthesis. It is also useful in the synthesis of complex compounds and scaffolds. This compound has high quality with a CAS number of 56610-81-8. Fmoc-Thr(tBu)-D-Ser(Psi(Me,Me)pro)-OH is a versatile building block that can be used in reactions involving amines and carboxylic acids. Fmoc-Thr(tBu)-D-Ser(Psi(Me,Me)pro)-OH is an intermediate that can be used in the synthesis of many different compounds.

Fmoc-Cys-(CAMTrt)-OH is an amino acid derivative, which is a synthetic compound essential for peptide synthesis. It is derived from natural cysteine, an amino acid found in proteins, and is modified with an Fmoc (9-fluorenylmethoxycarbonyl) protective group and a CAMTrt (trityl sulfonium ion) moiety. This derivative is used primarily in solid-phase peptide synthesis, where the Fmoc group protects the amine during chain elongation, and the CAMTrt group safeguards the thiol function of cysteine, preventing unwanted side reactions during synthesis.

D-methionine is a form of the amino acid methionine that is synthesized in plants. It has been studied for its potential to help with various metabolic disorders, including osteoarthritis and primary sclerosing cholangitis. D-methionine provides methionine to the body, which is essential for the formation of collagen and elastin. In addition, it has been shown to have a protective effect against neuronal death in a model system. D-methionine may be beneficial for people with liver disease, but more research is needed.

Crosslinker reacting rapidly with primary amines.  It is used as a protein crosslinker where it reacts with cysteine to yield specific conjugates.  The cyclohexane bridge confers added stability to the maleimide group making it ideal for maleimide activation of proteins.  It is soluble in water and many other aqueous buffers although it is less stable then in DMSO or DMF.

Cbz-L-glutamine is a water soluble compound that is used in the synthesis of pomalidomide. It is synthesized through a stepwise amide formation from methylamine and ethylene diamine. Cbz-L-glutamine has been shown to have an inhibitory effect on cancer cells, which may be due to its ability to break down hydroxamic acids. This chemical reaction causes the release of hydrogen ions, which leads to the disruption of various cellular processes, such as DNA replication and protein synthesis. The uptake of Cbz-L-glutamine by cancer cells has been shown in tissue culture experiments.

Solid phase peptide anchor; tool for the Fmoc solid phase synthesis of peptide amides.
100-200 mesh. 1% DVB, substitution range 0.3-0.6 meq/g

Fmoc-L-Cys(StBu)-OH is a synthetic molecule that is used in pharmaceutical formulations. It can be synthesized from Fmoc-L-Cys and L-serine methyl ester by the chemical ligation of the two molecules. The chloride group at the end of this molecule provides a functional group for conjugation with other biomolecules, such as fatty acids. This molecule has been shown to have high purity with an isolated yield of about 98%.