Peptides

<p>Peptide H-QGVEHEASRDEEPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-TSTTVDLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LPFFSNVTWF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LAWHC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>A glucose analog; can enter mammalian cells and be used as a glucose tracer</p>

<p>Acid-dPEG®5-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Acid-dPEG®5-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>IL 21 Mouse is a recombinant protein that belongs to the IL-21 family and is used as a research tool in cell biology and pharmacology. It is an activator of IL-21 receptor, which plays an important role in the immune system. The protein has been shown to promote T-cell proliferation, differentiation, and cytokine production. It binds to the IL-21 receptor and activates it by inducing a conformational change in the receptor. This binding induces activation of signaling pathways such as phosphoinositide 3-kinase (PI3K) or extracellular signal-regulated kinases 1/2 (ERK1/2).<br>IL 21 Mouse can be used for studying protein interactions, peptides, and antibodies.</p>

<p>SPDP-dPEG®8-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®8-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Pancreastatin is a peptide that has been shown to inhibit pancreatic cancer cell proliferation. Pancreastatin binds to the receptor for pancreatic polypeptide and inhibits the release of insulin, leading to inhibition of protein synthesis. This drug is also an activator of voltage-gated potassium channels, which are proteins that regulate the flow of positively charged potassium ions across the membranes of cells. Pancreatastatin is purified from porcine pancreas and has a purity greater than 95%.</p>

<p>Elafin is a peptide that belongs to the family of activators. It is a member of the human elafin family that activates neutrophil elastase, which belongs to the group of serine proteases. Elafin has been shown to inhibit the activity of ion channels and receptor-ligand interactions in cell biology studies. Elafin also binds to antibodies and is an inhibitor for protein interactions. Elafin has been shown to be a caspase-3 substrate, but its role in apoptosis is not yet clear.</p>

<p>Peptide H-EHHG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VMTPRTLVL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Boc-SC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-SLQAFQDYIR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-LGFDC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-SSLLDVLAAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DAGTIAGLNVMR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-ILVDWLVEV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GCGGGYGRKKRRQRRR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Anti-Secretin (Rat) Serum is a high purity antibody that can be used as a research tool for studying the interactions between proteins. It is suitable for use in immunoassays, such as ELISA and Western blotting. Anti-Secretin (Rat) Serum has been shown to inhibit the activation of ion channels and receptors, as well as protein synthesis and ligand binding.</p>

<p>Myelin Oligodendrocyte Glycoprotein Peptide (35-55) is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-HGEGTFTSDVSSYLEEQAAK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-NYRWRCKNQN-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>H-ANALLANG-OH is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>The micro spherical shape and the monosized character of this resin allows applications in automated sorters, for creating huge libraries and high speed synthesis.<br>Particle size: 10 µm monosized capacity: 0.7 - 1.3 mmol/g</p>

<p>Peptide H-LTPVSPESSSTEEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. These copolymers are pressure stable.  They have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water.   Can be used in a wide variety of applications such as acylations.</p>

<p>Peptide H-VMTPRTLLL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VGEIYKRWIILGLNK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DNEAYEMP-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VLDAVR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CMVpp65 - 137 is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>H-VLYVGSKT-OH is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-QLAPVLGYLGSR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GGH-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CRF is a human antibody that is used as a research tool. It has reactivity with cells that are activated by CRF, and binds to the receptor on these cells. CRF is also known as a ligand, which can bind to the receptor and trigger changes in the cell, such as ion channels or protein interactions. CRF is an activator of G-protein coupled receptors.</p>

Standard for use in proteomics studies

Please enquire for more information about Fmoc-[D10]Leu-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page

Protein Thymine-DNA Glycosylase, human, recombinant is a recombinant protein that contains the same amino acid sequence as the natural protein. It is used as an activator in peptide research and as an antibody to identify DNA glycosylases. This recombinant protein can be used in the study of ion channels and cell biology. Protein Thymine-DNA Glycosylase, human, recombinant has been shown to inhibit the activity of a variety of receptors and ligands.

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198</p>

Anti Acidic-FGF (1-15) (Bovine) Serum is a research tool used to study the activation of FGF receptors and their ligands. It contains peptides that are derived from the extracellular domain of human acidic FGF (1-15). This serum stimulates the activation of FGF receptors, which are important in cell growth, proliferation, and survival. Anti Acidic-FGF (1-15) Serum is purified by ion exchange chromatography and contains no detectable amounts of other proteins. It is supplied as a lyophilized powder at a concentration of 10 mg/mL.

<p>Please enquire for more information about Favipiravir-5-hydroxy including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

For Protein Identification and Quantitation

Bis-dPEG®2-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®2-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Insulin II is a peptide hormone that is secreted by the beta cells of the pancreas. Insulin II regulates glucose metabolism, promotes protein synthesis and inhibits lipolysis. It can be used as a research tool to study protein interactions, activators and ligands, receptor binding and ion channel activity. Insulin II can also be used to generate monoclonal antibodies against insulin II. This product has the three code sequence: A-chain: Gly-Ile-Val-Asp-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn ; B-chain:Phe-Val-Lys-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Met-Ser, has the disulfide bonds: CysA6-CysA11, CysA7-CysB7, and CysA20-CysB19 and is available as a 50 µg vial.

Endokinin D is a peptide that is derived from the precursor of kininogen. Endokinin D binds to endothelin receptors and activates ion channels, which are proteins that control the flow of ions across cell membranes. It has been shown to be an inhibitor of phospholipase C activation and an activator of potassium channels. It also has high purity and is a research tool for studying cell biology and pharmacology.

Big Endothelin-2 is a 38 amino acid peptide formed as a result of furin cleavage of proendothelin which in turn is produced from EDN2 gene transcription. Due to the actions of the Endothelin-Converting Enzymes: ECE-1 and ECE-2, Big Endothelin-2 is converted into Endothelin-2 (ET-2) peptide. ET-2 has affinity for ETA and ETB G-protein coupled receptors which are found in a variety of tissues, including lungs, heart, kidneys, uterus and vasculature. It is believed that ET-2 is a potent vasoconstrictor and may play a role in cancer, immunology and heart failure. This product has is available as a 0.1mg vial.

<p>This Thyroglobulin Heavy Tryptic Peptide Standard is useful in protein identification and quantitation studies such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). The use of tryptic peptides overcomes the challenges of quantifying serum thyroglobulin levels using immunoassays through removing the risk of interferences from Thyroglobulin antibodies. Thyroglobulin is a thyroid hormone production substrate and thus an important biomarker for differentiated thyroid cancer.</p>

<p>Please enquire for more information about ICI 174864 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Thyrotropin Releasing Hormone (TRH) is a hormone that stimulates the release of thyroid hormones. TRH has been used to diagnose and treat conditions such as autoimmune diseases, infectious diseases, and thyroid disease. It is also used in the treatment of patients with hypothyroidism who are not responding to levothyroxine therapy. TRH is administered intravenously or intramuscularly. This drug is primarily used for diagnostic purposes in women who have symptoms of hyperthyroidism but normal serum levels of TSH and thyroxine levels. TRH administration can result in a rise in serum prolactin levels, which may be useful for diagnosis of the condition hyperprolactinemia.</p>

DBCO-dPEG®4-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DBCO-dPEG®4-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

High density lipoproteins (HDL) are a major component of the blood plasma, which is believed to play an important role in cholesterol metabolism. High-density lipoprotein human is a population of cells that has been isolated from the peripheral blood of healthy donors and cryopreserved. The cells can be used for cell therapy or as a source of extracellular matrix proteins, such as collagen and glycol, for the culture of various cell types.

PAMP is an inhibitor of the protein kinase C (PKC). It binds specifically to the PKC-alpha isozyme and inhibits its enzymatic activity. PAMP also interacts with other proteins in a ligand-dependent manner. This peptide is a potent activator of PKC-beta, PKC-delta, and PKC-epsilon.

Mouse antibody against the human sequence of the enzyme Acyl-coenzyme A thioesterase 11 (StAR-related lipid transfer protein 14 or STARD14). Acyl-coenzyme A thioesterase 11 is part of the thioesterase family of enzymes that have roles in regulating levels of Coenzyme and intracellular fatty acids.

<p>Decorsin is a research tool that is an activator and ligand for the human receptor. It binds to the receptor by altering its conformation, which leads to cell signaling. Decorsin has been shown to inhibit ion channels, such as potassium channels, and may also function as a receptor antagonist. Decorsin is a high-purity protein with a purity of &gt; 95%. This protein is used in cell biology, pharmacology, and life science research. It can be used as an inhibitor of peptides in the field of protein interactions.</p>

<p>IL-1α is a cytokine that belongs to the IL-1 family of cytokines. It has been shown to activate ion channels, bind to receptors, and inhibit ligand binding. IL-1α has been shown to have an anti-inflammatory effect by inhibiting the transcription of pro-inflammatory genes. IL-1α is not active against bacteria or fungi. The anti IL-1alpha (rat) serum was developed for use in research studies involving peptides and other small molecules that interact with IL-1α.</p>

<p>Neurofilament Medium Polypeptide Bovine is a freeze-dried preparation of the protein neurofilament medium polypeptide. It is used for the quantitative determination of neurofilaments in spinal cord tissue and for functional studies of neurofilaments in neuronal cells. The protein is purified from bovine spinal cord by fractionation with ammonium sulfate precipitation and desalting on a DEAE-cellulose column, followed by two cycles of freeze-drying. The molecular mass is about 190 kDa. Reconstitute in 0.1 M methylammonium chloride and store at 4°C before use.</p>

<p>PDZ1 domain inhibitor peptide is a specialized biochemical compound, which is a synthetic peptide designed to disrupt specific protein-protein interactions. This inhibitor is derived from sequences that mimic or compete with natural ligands for binding to PDZ1 domains, common motifs in signaling proteins. With precise modulation, it functions by binding to the PDZ1 domain, blocking or altering its interaction with other cellular proteins. This targeted action allows for the selective interference with cellular pathways that depend on these interactions, thus offering a powerful tool for investigating signal transduction processes.</p>

Human IgG3 (hinge) light tryptic peptide standard for use in protein identification and quantitation studies. Human IgG3 is one of the four subclasses of IgG and it induces complement-mediated cellular lysis. Its hinge region is extended and is made up of 62 amino acids.

IFN a is a type of cytokine that is produced by T cells and natural killer cells. IFN a 2a Human is an inhibitor of protein interactions, which can be used as a research tool to study the structure and function of proteins. It binds to receptor and activator proteins on the surface of cells, triggering changes in ion channels and other cellular functions. IFN a 2a Human has been shown to inhibit the growth of cancer cells. This drug is also an antibody for the detection of human IFN-α2A or mouse IFN-α2A in cell culture supernatant, serum, or plasma samples.

<p>The Ras-related C3 botulinum toxin substrate (Rac2) is a protein that has been shown to be an inhibitor of RhoA and Rac1. Rac2 can also act as an activator for the small GTPase, CDC42. Rac2 is a member of the Ras superfamily and shares sequence similarity with other members of this family. Rac2 is a high purity, recombinant protein with a CAS number. It has been shown to inhibit the activity of RhoA, Rac1, and CDC42 in vitro. Rac2 can be used as a research tool or as an affinity reagent for antibody production.</p>

SH3-domain GRB2-like 2, human, recombinant is a protein that in humans is encoded by the SH3GLB2 gene. This protein is a member of the GRB2/SOS1 protein family and contains a SH3 domain. It has been reported to interact with Sos1 and Grb2, and to act as an activator for Ras-dependent signaling pathways. SH3GLB2 has been shown to be involved in the regulation of ion channels, such as calcium-activated potassium channels, and ligand-gated ion channels such as NMDA receptors. Antibodies against this protein are used as research tools for cell biology or immunoassays. SH3GLB2 has also been shown to inhibit the growth of cancer cells by inhibiting their ability to proliferate and migrate.

A soluble transferrin receptor (sTfR) heavy tryptic peptide standard for protein identification and quantitation studies. sTfR is a cleaved extracellular segments of the transferrin receptor 1 and it can be used to measure the status of iron in the blood and thus help in studies into anemia, where iron is deficient.

Protein A/G is a recombinant protein that is used to purify immunoglobulins and other proteins. It has been shown to inhibit binding of IgE to mast cells, which may be due to its ability to bind to the Fc receptor on the surface of these cells. Protein A/G has also been shown to bind with high affinity and specificity to the Fc receptor on human platelets, which may be due to its ability to activate phospholipase C-γ (PLC-γ) in these cells. This activation leads to an increase in intracellular calcium concentrations and subsequent activation of protein kinase C (PKC). Protein A/G binds with high affinity and specificity for membrane-bound receptors for many ligands, such as epidermal growth factor (EGF), transforming growth factor β1 (TGFβ1), erythropoietin (EPO), prolactin, follicle stimulating hormone (FSH), lute

<p>RBP4 is a member of the retinol binding protein family. It binds to the retinoid X receptor, which is involved in ligand-dependent transcriptional regulation of gene expression. RBP4 has been shown to act as an inhibitor and activator of several different proteins, such as ion channels and receptors. It has also been used as a research tool for studying protein interactions, with high purity. RBP4 is used for life science research and antibody production.</p>

<p>FRETS-25Thr (1 umol) (1umol) is a peptide that was derived from the human erythrocyte membrane protein band 3. It is an activator of ion channels and receptor, and has been shown to inhibit cell proliferation. FRETS-25Thr (1 umol) (1umol) also binds to the C3b component of complement, which is an important part of the immune system.</p>

<p>1-Naphthalenylsulfonyl-Ile-Trp-aldehyde is a recombinant protein that has protease activity. It is a serine protease that cleaves proteins at the amino acid sequence Ser-Xaa-Gly or Ser-Xaa. The recombinant protein has been shown to have proteolytic activity and can be used in assays to measure the amount of β-catenin, collagen, and growth factor in cells. 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde also binds to monoclonal antibodies and can be used as a neutralizing agent for these proteins. This recombinant protein also has been shown to inhibit the growth of lung fibroblasts.</p>

<p>Staphylococcal protein A (SPA) is a protein that binds to and removes foreign substances, such as bacteria and toxins, from the body. SPA has been shown to bind to the Fc region of antibodies and prevent their activation. This may be due to its ability to inhibit calpains, which are enzymes that cleave proteins at specific sites. Recombinant SPA has been shown to have an approximate molecular mass of 45 kDa. It can be used in chromatographic techniques for purification of proteins and as an additive for protein solutions. SPA also has catalytic properties, which may be due to its ability to act as a catalytic subunit in Escherichia coli.br&gt;</p>

Homoglutathione is a glutathione analog that contains an extra b-alanine residue. Homoglutathione has been shown to be a potent inhibitor of fatty acid synthesis. It inhibits the activity of the enzyme, acetyl-CoA carboxylase, which catalyzes the conversion of acetyl-CoA to malonyl-CoA. Homoglutathione also binds to and inhibits cytoplasmic proteins, such as glutamine synthetase and glutamate synthase. The binding of homoglutathione to these proteins prevents the formation of the active site by preventing the hydrogen bonding between amino acid residues. This process is important in energy metabolism because it regulates the production of ATP from ADP and phosphate.

Tyrosyl-BNP-32, human is a peptide that is used as a research tool to study the activation of ion channels and protein interactions. Tyrosyl-BNP-32, human has been shown to be an inhibitor for the receptor for angiotensin II. It also binds to the beta-adrenergic receptor, which is a G protein coupled receptor. Tyrosyl-BNP-32, human is classified as a high purity reagent and has CAS No. 633007-74-2.

DOTA tris(TBE)-Amido-dPEG®23-Maleimide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA tris(TBE)-Amido-dPEG®23-Maleimide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

H-Leu-D-Leu-OH is a nonproteinogenic amino acid that is used in the biosynthesis of proteins. It is formed from glutamic acid and leucine through an amide bond, and has a protonated amino group. The specificities of H-Leu-D-Leu are not yet known, but it has been shown to have antibacterial activity against Staphylococcus aureus and Streptococcus pyogenes. H-Leu-D-Leu may be transported across the cytoplasm membrane by means of a transport rate that is significantly higher than other amino acids. This amino acid also exhibits significant homology with nanosized molecules.

Please enquire for more information about H-Leu-Pro-OH hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>AIP-III is a peptide that belongs to the group of activators. It binds to the nicotinic acetylcholine receptor, thereby activating it. AIP-III has been shown to cause significant changes in the activity of ion channels and is used as a research tool for pharmacology and protein interactions. AIP-III has been found to be a potent inhibitor of various types of cancer cells in cell culture experiments, although its effects on humans are unknown.</p>

Lissamine Rhodamine B Sulfonamide-dPEG®4-Acid is a PEG compound containing a rhodamine used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.

The 2'-5' oligoadenylate synthetase 1 (2-5A-1) is a protein that in humans is encoded by the OAS1 gene. This enzyme catalyzes the synthesis of 2'-5' oligoadenylates, which are potent activators of PKC and MAPK. 2-5A-1 has been shown to increase intracellular calcium levels, activate PKC and MAPK, and induce apoptosis in human cells.

<p>Anti NPY (1-19) is a peptide that binds to the NPY receptor. It is an agonist of the NPY receptor, which is a G-protein coupled receptor. This peptide has been shown to activate ion channels, such as nicotinic acetylcholine receptors and glutamate receptors. Anti NPY (1-19) has also been shown to inhibit ligand binding to the NPY receptor, and may be used as a research tool for studying this receptor in cell biology.</p>

CBZ-N-amido-dPEG®6-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CBZ-N-amido-dPEG®6-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Relaxin H2 is a hormone that is produced in the ovaries and has significant interactions with cyclase. It has been shown to bind to the receptor for relaxin and inhibit its activity. Relaxin H2 has been shown to be a potent inhibitor of cardiac growth factor-β1, which may contribute to its anti-fibrotic effects. This drug is also an inhibitor of fatty acid synthesis and can lead to metabolic disorders, such as glomerular filtration rate, by inhibiting the production of natriuretic peptide levels.</p>

<p>Portion of HCMV</p>

MAGE-A2 protein: MAGE-A2 (157-166) is an epitope of Melanoma Antigen Gene A2 and is one of the most Cancer-Testis Antigens (CTA) overexpressed in tumors of different histological types, such as prostate cancer. Type of MAGE-A expressed in tumors cells varies according to the type of tumor. The expression of MAGE-A2 causes the proliferation of prostate cancer cells and decreases the chemosensitivity. Applications of MAGE-A2 (157-166): MAGE-A2 (157-166) is used to stimulate specific immune response, cytotoxic T cell response and to analyze the cytokine production in PBMCs by ELISPOT assay. In transgenic mouse, it has been demonstrated that MAGE-A2 (157-166) was capable of eliciting a CTL response presented by HLA-A*02:01 molecules. MAGE-A2 (157-166) has been reported to elicit CTL that could lyse tumor cell expressing both HLA-A*02:01 and MAGE-A2 by stimulation of peripheral blood mononuclear cells (PBMCs) with MAGE-A2 (157-166).

Portion of CMV pp65

<p>NY-ESO-1 (157-165) C165V – SLLMWITQV – General analogue epitope of tumor cells</p>

<p>Portion of EBV EBNA3A</p>

<p>HER-2/neu protein:<br>HER-2/neu (85-94) is an epitope from the extracellular region of Human Epidermal Growth Factor Receptor-2, receptor tyrosine kinase, also known as CD340, ERBB2 and proto-oncogene Neu. HER-2/neu contains a binding domain for HLA-A*02:01 molecule. It has been demonstrated that the over-expression of HER-2/neu plays an important role in the development and progression in primary breast cancer but also in ovarian colorectal and pancreatic adenocarcinoma. HER-2/neu has become an important biomarker and target of therapy for 30% of breast cancer patients.<br>Applications of HER-2/neu (85-94):<br>HER-2/neu (85-94) has shown its capacity to induce both cellular and humoral immune response in vivo. HER-2/neu (85-94) is used to analyze specific cytotoxic CD8 T cells responses, it has been demonstrated by ELISPOT analyses that the stimulation of cytotoxic T cells in PBMCs by HER-2/neu (85-94) produce IFN-γ against cancer cell expressing HLA-A*02:01 molecules and HER-2/neu.<br>It has been also demonstrated that HER-2/neu (85-94) is the single peptide of HER-2/neu which involve an increase frequency of cytotoxic CD8 T cells in the peripheral blood of breast cancer patients. HER-2/neu (85-94) is also used for vaccine development to treat diagenous rat from allied ALC cancer cells co-expressing HLA-A*02:01 and HER-2/neu.</p>

<p>Survivin protein:<br>Survivin, also called BIRC5, is a member of the apoptosis inhibitor protein family containing a baculovirus domain. Survivin is overexpressed in most human cancers but rarely express in normal differentiated adult tissues. Survivin protein inhibits caspase activation leading to negative regulation of cell death and promote cell proliferation. Survivin localizes in G2/M phase in cell cycle and interacts with tubulin during mitosis. It has been demonstrated that Survivin expression seems to be regulated by the tumor protein p53. Human Survivin contains HLA-A*02:01 binding motifs.<br>Applications of A*02:01/Human Survivin (96-104):<br>A*02:01/Human Survivin (96-104) HLA-A*02:01-restricted can be recognized by cytotoxic T lymphocytes on MHC I. Therefore, A*02:01/Human Survivin (96-104) may serve as a target for therapeutics CTL responses and for anticancer immunotherapeutic strategies. A*02:01/Human Survivin (96-104) is used to stimulate CTL responses in peripheral blood mononuclear cells (PBMCs). Then, ELISPOT assay is used to quantify peptide epitope specificity and IFN-γ releasing effector cells. A*02:01/Human Survivin (96-104) have shown spontaneous T-cell reactivity in chronic lymphatic leukemia and in melanoma (1). A*02:01/Human Survivin (96-104) has also demonstrated the ability to induce CTL responses in lung cancer and may serve for developing cancer vaccines.</p>

<p>antigen</p>

<p>Monoglyceride lipase is a recombinant human enzyme used as a research tool in pharmacology, cell biology and other life sciences. It is used to study the molecular mechanisms of lipid metabolism, signal transduction, and receptor-ligand interactions. Monoglyceride lipase has been shown to activate various peptides by hydrolyzing their ester bonds. It can also be used as an antibody against the peptide substrate. This enzyme has a high purity and is supplied with a CAS Number for quality control purposes.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PKP2 antibody, catalog no. 70R-6030</p>

<p>Portion of Influenza NP</p>

β-Pompilidotoxin is a neurotoxin that is found in the venom of the scorpion Pompilus. It binds to the ryanodine receptor, which is a type of calcium channel protein that regulates intracellular calcium levels. β-Pompilidotoxin blocks the release of calcium from the sarcoplasmic reticulum and inhibits the entry of calcium into cells by blocking voltage-gated sodium channels. It has been shown to be cytotoxic to ventricular myocytes and cerebellar purkinje neurons. β-Pompilidotoxin also has a physiological function in regulating glomerular filtration rate and preventing accumulation of intracellular calcium, which can lead to overload.

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CLDND1 antibody, catalog no. 70R-6340</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SHB antibody, catalog no. 70R-5762</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GNAO1 antibody, catalog no. 70R-5236</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of HNF1A antibody, catalog no. 70R-9560</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of LTB antibody, catalog no. 70R-6690</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GCNT4 antibody, catalog no. 70R-7414</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of LOC653186 antibody, catalog no. 70R-1184</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CRISP1 antibody, catalog no. 70R-5306</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of DCUN1D3 antibody, catalog no. 70R-3750</p>