Peptides

<p>Neuromedin-U-23 is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide Ac-SGRGKQGGKAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-EANQSTLENFLER-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-VQDAFAAAK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VVGGE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VTAPRTLIL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Melanoma-overexpressed antigen 1 (36-44) is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DGRGYVPATIK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-KLYDPLYHPSM-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GPRPPGGGC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-IIGGSDADIK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-RKKRRARRR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-IKNNLKDCGLF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Midkine (114-122) is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-LAQEAGNFERISGDL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-SLEPWIPYL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AEDTAVYYCAK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-HHHHHHLPETGG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-YGRKKRPQRRR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Angiotensin Heavy Tryptic Peptide Standard f use in protein identification and quantitation studies. Angiotensin is a peptide hormone that causes vasoconstriction and is responsible for an increase in blood pressure. Furthermore angiotensin stimulates aldosterone release.

<p>Peptide H-VLAPRTLLL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-VVAPRTLVL-OH is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-ILLAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-GKQGGKVR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Glutaminyl-Methionyl-Glutamyl-Glutamyl-Glutamyl-Alanyl-Valyl-Arginine Trifluoroacetate is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-IEELEEEIEAER-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-TYWHLLNAF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-QGVEHEASRDEEPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-TSTTVDLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LPFFSNVTWF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LAWHC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-EHHG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VMTPRTLVL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CMVpp65 - 21 is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

Peptide H-IQVLVEPDHFK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-ESGGGGSPGRRRRRRRRRRR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CMVpp65 - 9 is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-SIIPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Leptin (57 - 74) is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide Elicitor peptide AtPep1 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-YKQTSV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Melanocyte Protein PMEL 17 (256-264) (human, bovine, mouse) is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide Cell Penetrating Peptide IMT-P8 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide PEP1 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-NYRWRCKNQN-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-EDVYVVGTVLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-ANALLANG-OH is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-LTPVSPESSSTEEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-SLDDYNHLV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-NLYDIGEQLDSEDLASLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AKAKSR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LSPSFADLFR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>This Thyroglobulin VIF Light Tryptic Peptide Standard is useful in protein identification and quantitation studies such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). The use of tryptic peptides overcomes the challenges of quantifying serum thyroglobulin levels using immunoassays through removing the risk of interferences from Thyroglobulin antibodies. Thyroglobulin is a thyroid hormone production substrate and thus an important biomarker for differentiated thyroid cancer.</p>

Bromoacetamido-dPEG®12-Tris(-dPEG®11-Bromoacetamide)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®12-Tris(-dPEG®11-Bromoacetamide)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Bz-Gly-Ala-Pro is a synthetic tripeptide. It has been shown to have a carboxypeptidase activity, which hydrolyzes the C terminal of peptides and proteins. Bz-Gly-Ala-Pro was found to be active at a pH range of 2.0 to 10.0, with optimum activity at pH 4.5 to 6.0. The enzyme was found to be stable in captopril perfusates and showed no inhibition from trypsin or pepsin digestion. This peptide binds specifically to the carboxy terminal amino acid of dietary proteins, such as casein, soy protein, and egg albumen, and may play an important role in intestinal digestion and absorption by acting on these sites as well as on other peptidases that are present in the intestinal tract.

For Protein Identification and Quantitation

Anti Acidic-FGF (1-15) (Bovine) Serum is a research tool used to study the activation of FGF receptors and their ligands. It contains peptides that are derived from the extracellular domain of human acidic FGF (1-15). This serum stimulates the activation of FGF receptors, which are important in cell growth, proliferation, and survival. Anti Acidic-FGF (1-15) Serum is purified by ion exchange chromatography and contains no detectable amounts of other proteins. It is supplied as a lyophilized powder at a concentration of 10 mg/mL.

Insulin II is a peptide hormone that is secreted by the beta cells of the pancreas. Insulin II regulates glucose metabolism, promotes protein synthesis and inhibits lipolysis. It can be used as a research tool to study protein interactions, activators and ligands, receptor binding and ion channel activity. Insulin II can also be used to generate monoclonal antibodies against insulin II. This product has the three code sequence: A-chain: Gly-Ile-Val-Asp-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn ; B-chain:Phe-Val-Lys-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Met-Ser, has the disulfide bonds: CysA6-CysA11, CysA7-CysB7, and CysA20-CysB19 and is available as a 50 µg vial.

Please enquire for more information about TCO Agarose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Methyltetrazine agarose is a 6% crosslinked agarose resin that is activated with methyltetrazine functional groups for covalent immobilization of TCO-modified biomolecules via a Diels–Alder  reaction. Applications are preparation of protein agarose media with almost quantitative capture of proteins. Activation level: 10-20 µmol methyltetrazine groups per mL resin Bead size: 50-150 µm

<p>This Thyroglobulin Heavy Tryptic Peptide Standard is useful in protein identification and quantitation studies such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). The use of tryptic peptides overcomes the challenges of quantifying serum thyroglobulin levels using immunoassays through removing the risk of interferences from Thyroglobulin antibodies. Thyroglobulin is a thyroid hormone production substrate and thus an important biomarker for differentiated thyroid cancer.</p>

<p>O-6-Methylguanine-DNA Methyltransferase, human, recombinant is a recombinant protein that belongs to the class of proteins and enzymes. It is an enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine to guanine in DNA. The methylated guanines are recognized by proteins that bind to DNA and inhibit transcription. This enzyme has been shown to be important in the development of cancer cells, which may be due to its ability to inhibit DNA repair.</p>

<p>Human-monoFITC (PheB1) is a peptide with the amino acid sequence Phe-B1. It is a fluorescent ligand that is used as a research tool for receptor binding studies. The antibody conjugated to human-monoFITC (PheB1) can be used to detect and quantify the protein in Western blots.</p>

<p>CCL2 (Chemokine C-C Motif Ligand 2), also known as monocyte chemoattractant protein 1 (MCP1) or small inducible cytokine A2 (SCYA2), is a protein classified as a chemotactic cytokine or chemokine. CCL2 binds to the chemokine receptors CCR2 and CCR5.<br>CCL2 belongs to the CC chemokine family, small soluble proteins whose main function is to regulate cell trafficking and that act as molecular signals to induce cellular migration during inflammation.<br>Chemokines are secreted in response to signals such as proinflammatory cytokines and induce chemotaxis through the activation of G-protein-coupled receptors (GPCRs), which involves adhesion molecules and glycosaminoglycans.<br>CCL2 is produced by a lot of cell types (endothelial, fibroblasts, epithelial, smooth muscle, monocytic, and microglial cells which are important for antiviral immune responses and in tissue), often after induction by oxidative stress, cytokines or growth factors.<br>Unlike other chemokines such as RANTES, CCL2 exhibits a chemotactic activity only for monocytes, T-cells, basophils, NK cells and immature dendritic cells. CCL2 doesn’t attract and activate neutrophils or eosinophils.<br>But like RANTES, CCL2 has the ability to target memory T-cells, which is not the case with other chemokines.</p>

<p>MOCAc-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-NH₂ is a protein inhibitor with a molecular weight of 1405.8 g/mol. It has a CAS number of 129857-88-6 and is available at high purity. MOCAc-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-NH₂ is used in research as an inhibitor, activator, or ligand for proteins. This product has been used in the study of ion channels, receptor binding, and cell biology.</p>

<p>Muscle-type nAChRs blocker</p>

<p>Universal Major Histocompatibility Complex (MHC) H2 I-Ab epitope for CD4+ T-cell recruitment and activation<br>SB-PEPTIDE offers I-Ab restricted PADRE peptide ak(Cha)VAAWTLKAAa-Ahx-C.<br>Pan DR-binding epitope (PADRE) is a universal synthetic peptide binding Major Histocompatibility Complex (MHC)-II receptors, of which H2 complex (mouse MHC), present on specific immune cells. 4 class II loci exist in the region I of the H2 complex gene (see image below), known as Aa &amp; Ea loci (α encoded) and Ab &amp; Eb loci (β encoded), that are similar to the DR, DP and DQ loci of the Human Leukocyte Antigen (HLA) complex.<br>I-Ab restricted PADRE peptide interacts specifically with mouse H2-I-Ab receptors that activate antigen specific CD4+ T-cells in the same way as PADRE peptide’s interaction with HLA-DR receptors. This feature places I-Ab restricted PADRE as promising adjuvant for immunotherapeutic vaccines against chronicle diseases such as infections, Alzheimer or cancer. Similarly to the original PADRE peptide, the restricted version also acts as a Toll-like receptor (TLR) agonist and was described as alternative carrier, such as KLH/BSA or OVA, for prophylaxis and therapeutic vaccines. An aminocaproic acid (Ahx) linker, attached to an additional C-terminal Cysteine, was added to the sequence to allow both the peptide and its loading to interact independently and freely with molecules exposed to them. This modification is used for the loading of antigenic determinants in solution in order to enhance the immune response against a specific antigen (AG).</p>

<p>Selective agonist of Nav1.1</p>

<p>Thiol-TAT peptide.</p>

<p>SARS-CoV-2 Spike RBD 319-335 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). SARS-CoV-2 Spike RBD 319-335 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBD:<br>The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.<br>SB-PEPTIDE also offers SARS-CoV-2 Spike RBD 319-335 (Biotin-LC) peptide</p>

<p>Kv4.2 activator and Kv1.3 blocker</p>

<p>Selective Nav1.7 blocker</p>

<p>MAGE-A3 (195-203) peptide – IMPKAGLLI – Epitope of Melanoma Antigen Gene A3</p>

<p>Selective blocker of TTX-S VGSC</p>

<p>Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 371-394 peptide. SARS-CoV-2 Spike RBD 371-394 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 371-394 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBD:<br>The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.</p>

<p>TET 830/Tetanus Toxin (830-844) peptide – QYIKANSKFIGITEL</p>

<p>Voltage-gated sodium channels blocker</p>

<p>Nav1.5 channel activator</p>

AT (47-57) peptide, also known as HIV-1 TAT protein, is the most characterized fragment of the HIV transactivator protein (TAT). TAT (47-57) peptide was show to be a cell-penetrating peptide (CPP). TAT (47-57) is an arginine-rich peptide which directly penetrates plasma membrane and stabilized DNA. TAT (47-57) has the ability to translocate the plasma membrane and facilitate the delivery of various cargoes such as protein, peptide, antibodies, and liposomes. It represents an important tool to increase the biodistribution of drugs.

Fluorescent Arg9 peptide.

<p>Ovalbumin 154-159, also nammed TNGIIR peptide, is a portion of interest of the egg white albumen.</p>

<p>NPY is a peptide that belongs to the family of neuropeptides. It is an endogenous regulator of appetite and energy expenditure in the central nervous system, which has been shown to act as a neurotransmitter and neuromodulator. NPY is also an activator of ion channels, such as potassium channels, sodium channels, and calcium channels. NPY has been shown to bind with high affinity to receptors in the brain, heart, lungs, kidneys, and intestines. The binding of NPY to its receptor leads to activation of protein interactions. This process can lead to changes in cell physiology or regulation of physiological functions by altering gene expression or changing the concentration of ions in the blood. NPY has also been shown as an inhibitor for many different ligands and receptors including dopamine D1 receptors and serotonin 5-HT2A/C receptors.</p>

<p>Blocker of mid-low- (M-LVA) and high-voltage-activated (HVA) insect calcium channel (Ca(v)) currents</p>

<p>Biotin-SARS-CoV-2 Spike RBD 319-335 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 319-335 peptide. SARS-CoV-2 Spike RBD 319-335 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 319-335 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBD:<br>The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.</p>

<p>RANTES (or Regulated upon Activation, Normal T-cell Expressed and Secreted), also known as CCL5 (Chemokine (CC chemokine ligand 5), is a protein classified as a chemotactic cytokine or chemokine.<br>Chemokines are small soluble proteins that act as molecular signals to induce cellular migration during inflammation.<br>RANTES is a member of the CC chemokine family and is involved in immunoregulatory and inflammatory processes.<br>RANTES is expressed in a lot of immune cells and acts as a potent chemoattractant for T-cells, basophils, eosinophils, monocytes and other cell types by playing a major role in recruiting leukocytes into inflammatory sites and to activate them. RANTES also induces proliferation and activation of certain natural killer cells.<br>RANTES synthesis is induced by TNF-alpha and IL-1 alpha, interacts with CCR3, CCR1 and CCR5 and activates some G-protein coupled receptors.<br>Many of the biological activities of RANTES (Ca2+ influx, chemotactic response, basophil activation, T-cell signaling) are observed between 40 and 8000 ng/mL.</p>

<p>Angiotensin-converting enzyme 2 (ACE2) is an enzyme involved in the cardiovascular system by decreasing arterial pressure by catalyzing the conversion of angiotensin II to angiotensin (1-7). Angiotensin II is a vasoconstrictor and angiotensin (1-7) is a vasodilatator. This effect makes ACE2 a therapeutic target for cardiovascular disease.</p>

<p>Nav1.7 selective blocker</p>

<p>SARS-CoV-2 Spike RBM 500-509 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Motif (RBM). SARS-CoV-2 Spike RBM 500-509 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBM:<br>The receptor-binding domain in SARS-CoV-2 Spike protein contains a receptor-binding motif RBM. SARS-CoV-2 Spike RBM is the main functional motif in RBD and allows contacts between the S protein and the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.<br>SB-PEPTIDE also offers SARS-CoV-2 Spike RBM 500-509 (Biotin-LC) peptide</p>

<p>Clickable TAT peptide.</p>

<p>Angiotensin II plays an essential role in the maintenance of blood pressure and blood volume. It is a peptide hormone that causes vasoconstriction, a sensation of thirst, and stimulation of the adrenal cortex and aldosterone.<br>Derived from the cleavage of angiotensin I by the angiotensin converting enzyme, angiotensin II is involved in the renin-angiotensin system (RAS).<br>Angiotensin II is the subject of much scientific research and is already the target of many anti-hypertensive drugs (ACE inhibitors, ARBs or AT1 receptor antagonists).</p>

MBP (85-99) peptide competes with Myelin Basic Protein, it inhibits its binding to HLA-DR2 and IL-2. MBP (85-99) peptide is able to suppress experimental autoimmune encephalomyelitis (EAE).

<p>SIL peptide for Adalimumab detection and quantification</p>

<p>SK2 channel blocker</p>

Heavy calcitonin peptide – Stable Isotope PeptideHuman Calcitonin (hCT) is a 32-amino acid hormone peptide belonging to the Calcitonin/Calcitonin-gene related peptide (CGRP) family, that also comprises amylin, adrenomedullin (AM) and adrenomedullin2/intermedin (AM2/IMD). Calcitonin is characterized by a N-terminal disulfide bond that forms a 7 amino acid ring structure, a region with a α-helix tendency and an amidated C-terminus1.Calcitonin peptide is produced by C cells of the thyroid gland and binds preferentially to the G-protein coupled receptor, calcitonin receptor (CTR)1. Calcitonin receptor signals through activated Gs protein and the production of cAMP second messenger molecules by adenylyl cyclase1. The dissociation constant (Kd) of calcitonin receptors expressed by a human ovarian small cell carcinoma line is approximately 4.6 nM for human Calcitonin2.Calcitonin is involved in the homeostasis of calcium and phosphorus, and the regulation of bone dynamics. At the basal state, calcitonin secretion reduces plasma calcium and phosphorus levels, and promote bone formation. In Calca -/- mice, a murin particle-induced osteolysis model, Calcitonin peptide has been used as a test compound for studying the effects of calcitonin deficiency. It has been shown that artificial calcitonin subsitution inhibits bone resorption by reducing the formation of osteoclasts and thereby the resulting osteolytic reaction3. The Hypocalcemic Human calcitonin was also used as a positive control to monitor changes in serum calcium levels in HHD transgenic mice vaccinated with Parathyroid hormone-related protein (PTH-rP)-derived peptides in the context of anti-cancer immunotherapy study4. Moreover, it has been reported that calcitonin peptide is a potent stimulator of uncapacitated mouse spermatozoa by regulating a specific isoform of adenylyl cyclase and the production of cAMP, which plays a pivotal role in mammalian sperm function5.sb-PEPTIDE provides stable isotope labeled calcitonin peptide. This peptide has been quantified accurately using amino acid analysis.

<p>Blocker of Kv4.2 and Kv4.3 channels</p>

<p>Biotin-FluM1 (58-66) is the N-ter biotinylated version of FluM1 (58-66). Biotin-FluM1 (58-66) can be used in the analysis of antigen-specific T cells.<br>FluM1 (58-66):<br>FluM1 (58-66) is a short part of the matrix protein of Influenza A virus which is the most abundant component of this enveloped virus localized under the viral lipid envelope. The GILGFVFTL epitope is highly conserved in Influenza A virus strains at a rate of 93% for 69 strains tested. Human Influenza epitopes may bind MHC molecules and then may be recognized by CD8+ cytotoxic T cells.<br>Applications of FluM1 (58-66):<br>FluM1 (58-66) is used to stimulate CTL responses in peripheral blood mononuclear cells (PBMCs). Then, ELISPOT assay is used to quantify peptide epitope specificity and IFN-γ releasing effector cells.<br>FluM1 (58-66) has shown CTL responses qualified of immunodominant with restriction by HLA-A*02:01. It has also been detected CTL responses when FluM1 (58-66) is restricted by all HLA-C. Therefore, FluM1 (58-66) may help to understand the reaction of immune system against Influenza virus of each populations having different HLA type.<br>FluM1 (58-66) has indeed prompted research to develop T-cell vaccine strategies capable of inducing specific CTL responses in patients upon immunization with Influenza M1 antigenic epitope. MVA-NP+M1 vaccine use GILGFVFTL epitope and is tested in clinical trial.<br>Potential cross-reactivity with HIV-1 p17 Gag (77-85):<br>Moreover, FluM1 (58-66) share similarities with HIV-1 p17 Gag (77-85) which can potentially show a cross-reactivity between these epitopes. It has been demonstrated a cross-reactivity and results suggest that immunity following infection by Influenza virus causes specific immune response to HIV-1 p17 Gag (77-85).<br>Sequence: Biotin-GILGFVFTL</p>

<p>CMV pp65 protein:<br>CMV pp65 (113-121) is an epitope of the main component of the enveloped subviral particle pp65 (phosphoprotein ppUL83) of Cytomegalovirus, member of herpes virus group. CMV pp65 antigens are used as target for the diagnosis of concomitant CMV end-organ disease. CMV specific cytotoxic T lymphocyte response is highly focused to pp65 in the context of HLA-A24:02.<br>Applications of CMV pp65 (113-121):<br>CMV pp65 (113-121) is used to stimulate peptide-specific CTL response and to analyze interferon γ production by flow cytometry and ELISPOT assay. CMV pp65 (113-121) contains HLA-A24 binding site and elicits CMV pp65 (113-121)-specific CTL in PBMCs which recognize pp65 expressed on CMV-infected fibroblast of HLA-A24 positive patients. CMV pp65 (113-121) might be implicated in improvement of immunotherapeutic strategies for efficient vaccine development against HCMV.</p>

<p>MBP (Myelin Basic Protein – UniProtKB – P04370) is a major constituent of the myelin in nerves. This protein permits the maintain of the myelin structure. MBP contains various epitopes implicated in Multiple Sclerosis.<br>MBP (84-97) induces EAE</p>

<p>Scrambled LL-37 has the same peptide sequence as LL-37 but loses helixforming property.<br>Scrambled LL-37 can be used as a negative control of LL-37 studies.</p>

SB-peptide offers the scrambled version of Melan-A/MART-1 (26-35). AIEIAGGLTV can be used as a negative control of Melan-A/MART-1 (26-35) studies. SB-peptide offers also Melan-A/MART-1 (26-35) (see section Melan-A/MART-1 (26-35)). Native Melan-A (26-35) decapepetide derives from the melanocyte lineage-specific protein Melan-A/MART-1, which is expressed in almost 75-100% of primary and metastatic melanomas1.