Peptides

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of KCTD19 antibody, catalog no. 70R-5057</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of RPL9 antibody, catalog no. 70R-1401</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of VISA antibody, catalog no. 70R-6462</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CLEC4M antibody, catalog no. 70R-8545</p>

<p>Please enquire for more information about H-QDVH-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-2kb tetramer peptide - A2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide T is a synthetic peptide that has been shown to inhibit the activity of protein kinase C. This inhibition may be due to its ability to bind with high affinity and specificity to a site on the receptor protein. Peptide T is a research tool used in studies of cell biology, pharmacology, and physiology. It has been used as an inhibitor for studies of ion channels and has also been used as an activator for studies of receptor-ligand interactions. Peptide T is also known by its CAS number, which is P25657-1-2.</p>

<p>Z-Arg-OBzl(p-NO2) hydrobromide is a research peptide that is commonly used as an enzyme substrate in various biochemical studies. It is widely utilized in the field of molecular biology and biochemistry for its ability to mimic specific enzymatic reactions. This compound is highly pure and has been extensively tested for its quality and reliability. Researchers rely on Z-Arg-OBzl(p-NO2) hydrobromide to accurately measure enzyme activity and understand the mechanisms behind various biological processes. With its precise composition and consistent performance, this research peptide is an essential tool for scientists conducting cutting-edge research in the field.</p>

<p>ACE2 (18-740) is a human protein that is encoded by the ACE2 gene. ACE2 is a member of the enkephalinase family, which cleaves peptides at the carboxy terminal amino acid. ACE2 has been shown to be an effective inhibitor of coronavirus and other viral proteases, including those from SARS-CoV and MERS-CoV. It has also been shown to inhibit angiotensin converting enzyme 2 (ACE2), which plays an important role in regulating blood pressure.</p>

<p>Amino-dPEG® Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG® Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Urocortin is a peptide hormone that belongs to the corticotropin-releasing factor (CRF) family. It stimulates the release of adrenocorticotropic hormone (ACTH) and other hormones from the anterior pituitary gland. Urocortin has been shown to bind to three different types of ion channels: voltage-gated calcium channels, potassium channels, and chloride channels. The purified peptide is a colorless or white crystalline powder with a molecular weight of 542.6 Daltons. The antibody against urocortin is used in pharmacological research as an activator or inhibitor of protein interactions.</p>

<p>This product contains disulfide bonds between Cys3-Cys14 can is suitable for use in radioimmunoassays. Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, insulin, and glucagon. It is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.</p>

<p>VIP is a polypeptide that belongs to the vasoactive intestinal peptide family. VIP is a potent stimulator of adenylate cyclase, which increases intracellular cAMP levels and activates protein kinase A. VIP has been shown to interact with ion channel receptors, such as the nicotinic acetylcholine receptor, and regulate membrane potentials in neuronal cells. It also functions as a ligand for G protein-coupled receptors and can be used as an immunogen or antibody against VIP. VIP has been shown to have a variety of pharmacological effects including the ability to stimulate cell proliferation and inhibit apoptosis. VIP has also been shown to function as an activator of latent TGF-β1, which may play a role in tumor suppression.</p>

<p>m-dPEG®15-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, m-dPEG®15-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Corticotropin-Releasing Factor (CRF) (Human, Rat) is a peptide hormone product that is available as a 0.5mg vial and has the potential to be used as a research tool to study the effects of CRF in the body. CRF is a natural hormone that regulates many physiological processes, such as blood pressure, temperature control, and food intake. CRF binds to receptors on cells and triggers a number of cellular responses within the cell. This peptide can be used for pharmacological studies or for antibody production.</p>

<p>t-Boc-N-Amido-dPEG®11-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-Boc-N-Amido-dPEG®11-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>SPDP-dPEG®24-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®24-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bis-dPEG®2-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®2-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>[Val5]-Angiotensin I (Bovine) is a peptide that activates angiotensin receptors. It is used as a research tool in the study of ion channels and protein interactions. The antibody recognizes the C-terminal region of angiotensin I, which can be used to inhibit the activation of these receptors by preventing binding to their ligands.</p>

<p>Encoded for by mitochondrial DNA, Humanin is an endogenous peptide known to be a ‘rescue factor’ with the ability to abolish neuronal cell death. This characteristic has promoted Humanin as a potential treatment for Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.<br>Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.<br>Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance. This product is available as a 0.5mg vial.</p>

<p>Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe is a peptide that inhibits the interaction between the beta2 adrenergic receptor and its ligand. It is a high purity, nonpeptide inhibitor of the beta2 adrenergic receptor that is useful for research purposes. The antibody to Lys-Thr-Glu-Glu-Ile-Ser-Glu Val Asn Sta Val Ala Glu Phe can be used to identify this peptide in Western blot or ELISA experiments.</p>

<p>Leucine-Enkephalin is a peptide that is composed of the amino acids leucine and enkephalin. It functions as an endogenous opioid with effects on the brain that include analgesia, sedation, and appetite suppression. Leucine-Enkephalin stimulates κ-opioid receptors in the brain and has been shown to reduce neuronal death caused by energy metabolism deficiency or cerebral ischemia. This peptide also causes autophagy and neurokinin-1 receptor activation, which can lead to significant interactions with physiological effects such as symptoms of anxiety, depression, or addiction.</p>

<p>Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide that induces delta sleep in mammals. Studies have shown that DSIP plasma concentrations and the human circadian rhythm are correlated and that DSIP concentrations are dependent on the initiation of sleep. Interestingly DSIP has the ability to cross the blood-brain barrier and can be absorbed from the gut.  This neuropeptide is found in plasma, peripheral organs and neurons and its functions extend beyond inducing sleep. For example it has the ability to affect levels of hormones, neurotransmitters and psychological performance. It has also been found that schizophrenia and depression patients have lower concentrations of DSIP in their cerebrospinal fluid and plasma. Clinically DFSIP has already been used to treat opioid and alcohol withdrawal in reducing symptoms felt by patients.</p>

<p>Biotin-dPEG®11-NH2 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®11-NH2 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Propargyl amine is a biologically active compound that has been shown to induce neuronal death in hl-60 cells. It also inhibits the production of neurotrophic factors and induces the formation of coumarin derivatives. Propargyl amine is structurally related to other known neurotoxic compounds, such as coumarin and pyridine. The mechanism of action is currently unknown, but it may involve interactions with ubiquitin ligases or receptor activity. Propargyl amine was found to be an active analogue for the treatment of skin cancer and has shown good analytical properties for use in quantitative analysis. This product should be stored at room temperature in a dry place away from light in order to avoid chemical degradation.</p>

<p>NHS-m-dPEG® (MW = 333) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG® (MW = 333) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>This product is an ovine, Corticotropin Release Factor (CRF) and is available as a 0.5mg vial. CRF is a peptide hormone and a key regulator of the hypothalamic-pituitary adrenal (HPA) axis. In response to stress the hypothalams releases CRF which stimulates the production of glucocorticoids and adrenocorticotropin, which are stress hormones. Glucocorticoids are then involved in a negative feedback loop, in that they prevent the pituitary gland and hypothalamus from exhibiting any further endocrine activity. Studies have shown that symptoms of depression can be caused by the over production of CRF due to the overstimulation of the hypothalamic-pituitary adrenal axis. Interestingly CRF receptors are expressed in both glial cells and T cells. Elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments.</p>

<p>Bis-dPEG®13-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®13-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Glu(pNA) • H2O is a substrate for the enzyme glutaminase, which hydrolyzes the peptide bond between glutamate and pyranose. The hydrolysis of Glu(pNA) • H2O to produce L-glutamic acid (Glu) and pyranose (pNA) is the first step in Glu metabolism. This reaction is important for both the production and degradation of Glu. In addition, Glu is a potent growth factor that plays a role in kidney physiology. The presence of this molecule in the extracellular space may indicate kidney disease or damage, as well as systemic effects on other organs.</p>

<p>Azido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Stresscopin is a peptide that belongs to the family of activators. It is a molecular "switch" that can be used to control the activity of ion channels and protein interactions. Stresscopin is purified from human tissue and is supplied as lyophilized powder.</p>

<p>m-dPEG®4-Azide (Azido-m-dPEG®4) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®4-Azide (Azido-m-dPEG®4) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Propargyl Amine is a monoamine neurotransmitter that is an active analogue of the neurotransmitter epidermal growth factor. It has been shown to have biological effects on skin cancer cells and have potential for use as a drug in the treatment of skin cancer. Propargyl amine has been shown to be an effective inhibitor of rat striatal dopamine uptake and amines, which may be due to its hydroxyl group. This propargylamine binds to the surface of the skin cancer cells, causing them to die. The asymmetric synthesis of propargyl amine has been studied using molecular modeling techniques.</p>

<p>Bis-dPEG®21-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®21-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Amylin is a peptide hormone that is found in the pancreas. It regulates blood glucose levels and plays an important role in diabetes. Amylin is also used as a research tool for studying the function of ion channels, cell biology, protein interactions, and pharmacology.</p>

<p>m-dPEG®8-Lipoamide is a PEG molecule conjugated with a lipid moiety. m-dPEG®8-Lipoamide, conjugated to this lipid constituent, is very important especially in drug delivery and vaccine development as it helps improve the stability and circulation time of lipid nanoparticles (LNPs) and liposomes.</p>

<p>CGP 42112 is a peptide that inhibits the binding of ligands to their receptors. It has been shown to be an effective inhibitor of protein interactions and has been used in research tools for the study of protein-protein interactions. CGP 42112 is an activator of the Ligand-gated ion channels and can be used as an antibody for receptor detection. This compound has a high purity with a CAS number 127060-75-7.</p>

<p>Tertiapin is a synthetic bee venom peptide (Honey Bee, Apis mellifera) containing disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It is an inward rectifier K+ channel blocker and also blocks the activity of calcium activated large conductance potassium channels. The pain and inflammation symptoms experienced after a bee sting is caused by this peptide eventhough bee venom also has the potential to treat pain and inflammation in conditions such as rheumatoid arthritis and multiple sclerosis. This product is available as a 0.1mg vial.</p>

<p>[Tyr8]-Bradykinin is a peptide that is an activator of the B2 receptor. It has been shown to have high purity, and can be used as a research tool. This product is also an inhibitor of ion channels, and has been shown to bind to antibody.</p>

<p>Azido-dPEG®7-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®7-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>CCK-33 is a synthetic peptide that is used as a research tool. It binds to the CCK2 receptor and activates it, triggering the release of the neurotransmitter acetylcholine. CCK-33 is also an inhibitor of voltage-gated potassium channels, which are important for neuronal communication. CCK-33 can be used to identify other ligands for this receptor, or as an antibody epitope tag in cell biology studies.</p>

<p>m-dPEG®24-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>PTH-rP is a peptide that has been used as a research tool for the study of ion channels, protein interactions, and receptor signaling. It is an inhibitor of PTH/PTH-related protein receptor. PTH-rP is a ligand for the PTH/PTH-related protein receptor and can be used to identify novel receptors or ligands. This compound has been shown to have the ability to inhibit cellular proliferation and induce apoptosis in certain cell lines.</p>

<p>MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg is a peptide with ion channel activity. It is a potent activator of potassium channels and has been used in research as a tool for studying ion channel function. MOCAc is not an inhibitor of voltage sensitive sodium channels but does inhibit calcium currents. MOCAc also has been shown to be a ligand for the nicotinic acetylcholine receptor and is able to bind to the beta subunit of this receptor. This peptide binds to the alpha subunit of the calcium channel, leading to inhibition of calcium currents and activation of potassium channels.</p>

<p>Azido-dPEG®36-Alcohol is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®36-Alcohol is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Amino-dPEG®12-ODMT is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®12-ODMT is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>GLP-1 is a peptide hormone that is released by the pancreas in response to food intake. This hormone activates receptors on the L cells of the ileum and duodenum, which causes increased production of insulin and decreased production of glucagon. GLP-1 also decreases appetite, slows gastric emptying, and reduces blood glucose levels by increasing the uptake of glucose into muscle cells. GLP-1 has been shown to be effective in reducing body weight, lowering blood pressure and cholesterol levels, improving glycemic control, and preventing diabetes. The GLP-1 receptor is found in ion channels and cell biology as well as pharmacology.</p>

<p>Adropin is a peptide that binds to the activator domain of phospholipase A2 (PLA2) and inhibits the enzyme. It has been shown to be an inhibitor of PLA2 in human, mouse, and rat cells. Adropin can also inhibit ion channels and cell signaling pathways by binding to cell surface receptors. This research tool may be used for studying protein interactions and pharmacology.</p>

<p>Bz-Arg-AMC is a fluorescent probe that binds to the nicotinic acetylcholine receptor (nAChR) in the presence of calcium ions and emits light when excited by ultraviolet light. It can be used to study the activation of nAChRs, as well as their interactions with other proteins such as peptides. Bz-Arg-AMC has a molecular weight of 551.9 g/mol, with a purity of &gt; 98% and an optical purity of &gt; 99%. This product can be used for research purposes only, not for diagnostic or therapeutic purposes.</p>

<p>Met-Met is a dipeptide that is synthesized from the amino acids methionine and methyltetrahydrofolate. It is used in the synthesis of peptides and biochemicals, as well as in pharmacological treatments for diseases including bacterial infections. Met-Met has significant interactions with dopamine, catechol-o-methyltransferase, and energy metabolism. The enzyme catechol-o-methyltransferase catalyzes the conversion of dopamine to 3,4-dihydroxyphenylacetic acid (DOPAC), which may lead to a decrease in dopamine levels. Met-Met also inhibits the metabolism of catecholamines, leading to an increase in cellular levels of catecholamines such as dopamine and norepinephrine. This inhibition may be responsible for metabolic disorders such as obesity or low body mass index (BMI)</p>

<p>Azido-dPEG®4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bis-dPEG®9-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®9-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Fibronectin is an extracellular matrix protein that plays a critical role in cell adhesion, migration, and differentiation. Fibronectin subunits are composed of repeating units of three types of modules: type I, type II, and type III. The active fragment of fibronectin refers to a small peptide sequence within the type III modules of fibronectin that has been shown to have potent biological activity.<br>The fibronectin active fragment, also known as the cell-binding domain or RGD domain, is a short peptide sequence consisting of the amino acid sequence Arg-Gly-Asp (RGD). This peptide sequence interacts with cell surface receptors known as integrins, which are important for mediating cell adhesion, migration, and signaling.<br>The fibronectin active fragment has been extensively studied as a research tool to investigate the mechanisms of cell adhesion and migration. It has also been used in tissue engineering applications to promote cell attachment and proliferation on synthetic biomaterials. This product is available as a 0.5mg vial.</p>

<p>(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.</p>

<p>Amylin is a peptide that belongs to the group of activators. It has been shown to be an inhibitor of ion channels, and has also been demonstrated to activate cell signaling pathways. Amylin can be used as a research tool for studying protein interactions, receptor ligands, and pharmacology. Amylin can be used in antibody production or as a high-purity reagent for life science or cell biology applications.</p>

<p>Adenylate kinase 4 (AK4) is a protein that in humans is encoded by the AK4 gene. AK4 catalyzes the conversion of adenosine triphosphate (ATP) to adenosine monophosphate (AMP). The enzyme has been shown to play an important role in the regulation of cell proliferation and survival, as well as in the regulation of ion channels, neurotransmitter release, and other biological processes. AK4 is also an activator of G-protein coupled receptors and a ligand for certain nuclear receptors. It can also function as an inhibitory receptor for certain G-protein coupled receptors.</p>

<p>Peptide YY (Human, 3-36) is a peptide that is a potent activator of the gut hormone, ghrelin. Peptide YY (Human, 3-36) has been shown to inhibit the activity of ion channels and receptor binding. It is also a ligand for G protein coupled receptors (GPCRs). It has been used as an inhibitor in research for studying protein interactions and receptor signaling pathways.</p>

<p>Secretin is a peptide that is used as a research tool in the study of ion channels, cell biology, and pharmacology. Secretin is a peptide hormone that is produced in the duodenum and is involved in the regulation of pancreatic bicarbonate, gastric acid and osmoregulation. Secretin binds to secretin receptors which are G-protein coupled receptors and are expressed in pancreatic centroacinar cells. Secretin binds to these receptors and activates adenylate cyclase which converts ATP into cAMP which results in the secretion of bicarbonate from the pancreas. Secretin plays a role in osmoregulation through its effects on the kidney, pitutiary gland and the hypothalamus. This product is available as a 0.5mg vial.</p>

<p>Bis-Maleimide Amine, TFA Salt is a pharmacological research tool that is used to study protein interactions. It is also used as an inhibitor and activator of proteins, specifically ion channels. This product has a CAS number of 62921-76-0, which can be found on the Chemical Abstracts Services website. This product is high purity and is used in life science research. The salt form of this product is used as a ligand for receptor binding studies.</p>

<p>This product is a Substance P antagonist and is available as a 0.5mg vial. Substance P is a neuropeptide that is involved in the transmission of pain signals and inflammation. It is a member of the tachykinin neuropeptide family and is produced in the central nervous system and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>t-Boc-N-Amido-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-Boc-N-Amido-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Calcitonin is a hormone produced by the C cells (also known as parafollicular cells) in the thyroid gland. Its main function is to regulate the levels of calcium and phosphate in the blood. Calcitonin works by inhibiting the activity of osteoclasts, which are cells that break down bone tissue and release calcium and phosphate into the bloodstream. This leads to a decrease in the amount of calcium and phosphate in the blood.<br>Calcitonin is released in response to high levels of calcium in the blood, and it acts to reduce these levels by increasing the excretion of calcium by the kidneys and inhibiting the absorption of calcium by the intestines. It also promotes the storage of calcium in the bones, which helps to maintain their strength and density.<br>Calcitonin may be used therapeutically to treat conditions such as osteoporosis and hypercalcemia (high levels of calcium in the blood) or even diagnostically as a marker for tumors in medullary thyroid cancer.<br>This product has a disulfide bond between Cys1-Cys7 and is available as a 0.5mg vial.</p>

<p>MAL-dPEG®11-Lipoamide is a PEG molecule conjugated with a lipid moiety. MAL-dPEG®11-Lipoamide, conjugated to this lipid constituent, is very important especially in drug delivery and vaccine development as it helps improve the stability and circulation time of lipid nanoparticles (LNPs) and liposomes.</p>

<p>Boc-Leu-Gly-Arg-AMC is a peptide that binds to the receptor for N-methyl-D-aspartate (NMDA) and inhibits the ion channel. It has been used as a research tool to study NMDA receptor interactions, as well as in cell biology and pharmacology. Boc-Leu-Gly-Arg-AMC is a high purity, ionic analog of glutamate that binds to the NMDA receptor without activating it, thereby inhibiting ion flow through the channel. This inhibition can be reversed by adding excess glutamate or glycine. The binding of this compound to the NMDA receptor has been shown to block activation of voltage gated calcium channels and reduce neuronal excitation, which may provide an alternative therapeutic strategy for controlling seizures or other neurological disorders.</p>

<p>m-dPEG®12-Azide (Azido-m-dPEG®12) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Azide (Azido-m-dPEG®12) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>DCCD is a chemical inhibitor of the enzyme pyruvate dehydrogenase kinase that is used to study metabolic pathways. It inhibits the activity of this enzyme by binding reversibly to its active site, thereby blocking its phosphorylation of pyruvate dehydrogenase and thus inhibiting the conversion of pyruvate into acetyl-CoA. DCCD also has been shown to have antidiabetic effects in an experimental model. This drug has been used as a reagent for polymyxin B and other chemical inhibitors in vitro experiments.</p>

<p>CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther</p>

<p>2-NBDG is a fluorescent dye that exhibits high affinity for nucleic acid and protein. It has been used as an inhibitor of protein interactions, activator of ligands, and research tool in the study of ion channels. 2-NBDG has also been used as an antibody to identify receptors, and can be used to measure the concentration of proteins, lipids, and carbohydrates. 2-NBDG is listed by CAS No. 186689-07-6.</p>

<p>FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the rejection of transplanted organs and to treat a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. FK-506 binds to the IL-2 receptor on T-cells and inhibits their proliferation, thereby preventing activation of other immune cells. FK-506 has been shown to be effective in treating a number of diseases, including myocardial infarcts, coronary heart disease, and oral hypoglycaemic. The optimum concentration for this drug is not known, but it appears that higher concentrations are more beneficial in treating some conditions.</p>

<p>Obestatin is a peptide that was originally isolated from rat and mouse brain. It is a potent inhibitor of Kv1.3 and Kv1.5 potassium channels, with an IC50 of about 1 nM for both channels, but has no effect on other ion channels. Obestatin also inhibits the binding of antibodies to epitopes on the surface of cells, which may be due to its ability to inhibit cell-cell adhesion. The antibody-binding activity of obestatin is also inhibited by peptides corresponding to residues in the N-terminal region of obestatin, but not by peptides corresponding to residues in the C-terminal region. Obestatin has been shown to activate receptor tyrosine kinase (RTK) pathways and induce signaling cascades that lead to the proliferation and differentiation of tumor cells.</p>

<p>Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.</p>

<p>Dnp-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg is a peptide that has been shown to be an inhibitor of protein interactions. It has been shown to activate the G protein and inhibit the enzyme phospholipase C, which may provide a potential treatment for Alzheimer's Disease. Dnp-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg also has a high purity and is used as a research tool in life science.</p>

<p>Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg is a synthetic peptide that is used as a research tool, an activator, and an inhibitor. This peptide is not expected to have any adverse effects on the environment or on animal or human health. It can be used in antibody production and has been shown to inhibit the activity of ion channels. Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg binds to receptors and ligands, which may be involved in protein interactions.</p>

<p>Dynorphin A is a peptide that belongs to the dynorphin family and has affinity for all three of the opioid receptors. However it has been found that Dynorphin A favors kappa-opioid receptors which are expressed in the brain, peripheral tissues and the spinal cord and are located in areas involved in pain. For example when Dynorphin A binds to kappa-opioid receptors, dopamine is inhibited in areas of the brain prevalent in drug addiction, thus demonstrated Dynorphin A to have antagonistic effects on the brain reward circuit. Dynorphin A could be a useful research tool for studying analgesia, reward and addiction.<br>This product is available as a 0.5mg vial.</p>

<p>Angiotensin A is a research tool that is used to study the activation of angiotensin receptors. It can be used to identify ligands and receptors and to investigate the pharmacology of peptides. Angiotensin A is soluble (1-2 mg/ml) in water, dimethyl sulfoxide (DMSO), and phosphate buffered saline. It has a CAS number of 51833-76-2.</p>

<p>Kisspeptin-10 (Rat) / Metastin (Rat, 43-52) is a Research Tool that belongs to the group of Activators and Ligands. It is an agonist for G protein coupled receptor 54 (GPR54). Kisspeptin-10 (Rat) / Metastin (Rat, 43-52) has been shown to inhibit ion channels and act as a potent inhibitor of phosphoinositide 3-kinase. This compound has high purity and can be used in pharmacological research.</p>

<p>Z-Gly-Pro-Leu-Gly-Pro is a synthetic substrate that has been shown to be hydrolyzed by human liver collagenase. It is used as a substrate in enzymatic assays, such as the determination of collagenase activity. The peptide is synthesized from glycine, proline, and glycolic acid. Z-Gly-Pro-Leu-Gly-Pro has an optimal ph of 7.0 and shows signals at 2.8 ppm (HNCH) and 3.5 ppm (HNCO). This peptide also binds to bacterial enzymes such as trypsin and chymotrypsin.</p>

<p>Hydroxy-dPEG®12-t-Butyl Ester is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, hydroxy-dPEG®12-t-Butyl Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Small Conductance Ca2+-Activated K+ Channel Blocker derived from bee venom (Honeybee, Apis mellifera). This product has disulfide bonds between Cys1-Cys11 and Cys3-Cys15 and is available as a 0.5mg vial.</p>

<p>FRETS-25Gln is a peptide that can be used as a research tool in the fields of pharmacology and protein interactions. FRETS-25Gln binds to ion channels and activates them, which makes it useful for researching ligand-receptor interactions. The peptide has been shown to bind to the receptor P2X7 and activate the receptor, which may be useful for treating various diseases including arthritis and cancer. FRETS-25Gln also binds to the receptor P2Y1 and inhibits its activity, which may be useful for studying how activation of this receptor leads to increased vascular permeability.</p>

<p>Carboxyl-dPEG®4-(m-dPEG®24)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Carboxyl-dPEG®4-(m-dPEG®24)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Ac-Tyr-OEt • H2O is a peptide with biological properties. It is used as a signal peptide, which is a short sequence of amino acids that directs the protein to the endoplasmic reticulum. Ac-Tyr-OEt • H2O has been shown to have colony stimulating factor activity and can be used in the treatment of diseases such as anemia and cancer. The solid state structure of Ac-Tyr-OEt • H2O was determined by X-ray crystallography and found to be a dimer with two molecules bound together through hydrogen bonding. This peptide interacts with enzymes in the proteolytic pathway, inhibiting their ability to function. Ac-Tyr-OEt • H2O also has inhibitory properties against transfer reactions, which are reactions in which one molecule transfers a part of its chemical group or atoms from one molecule to another. Ac-Tyr-OEt •</p>

<p>Ac-Tyr-Val-Ala-Asp-CH2Cl is a peptide that interacts with the receptor. It is a high purity, research tool that has been shown to inhibit ion channels and ligand binding. Ac-Tyr-Val-Ala-Asp-CH2Cl is an antibody that can be used in Cell Biology for research tools and cell culture.</p>

<p>A synthetic cone snail toxin, sourced from the marine snail, Conus geographus and can be applied as a blocker for the nicotinic acetylcholine receptor. This product is available as a 0.5mg vial with disulfide bonds between Cys2-Cys7 and Cys3-Cys13 and in the hydrochloride salt form.</p>

<p>Midkine is a protein that belongs to the group of proteoglycans. It is expressed in many tissues, and its function is unknown. Midkine has been shown to have ion channel activity, and it may be involved in receptor binding and ligand-receptor interactions. It may also play a role in cell growth and differentiation due to its ability to activate various cells types. The midkine 1-59 peptide, which corresponds to amino acids 1-59 of the midkine protein sequence, can be used as an inhibitor of this protein. This antibody can also be used as a research tool for investigating protein interactions or studying the effects of peptides on proteins.</p>

<p>Angiotensin I (Human) is a protein that is found in the blood and other tissues. It is a peptide hormone, which acts on the kidneys to increase blood pressure and on the heart to increase cardiac output. This protein has been detected in several biological samples such as plasma, serum, or urine. Angiotensin I (Human) can be used as an enzyme form of angiotensin 1-converting enzyme (ACE). ACE catalyzes the conversion of angiotensin I to its active form, angiotensin II. Angiotensin II has been shown to reduce the production of inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. It also stimulates vascular smooth muscle cells and increases the production of nitric oxide by these cells, leading to vasodilation. The measurement of this enzyme form in a sample may help determine disease activity in patients with bowel disease or squamous cell cancer of the skin.</p>

<p>(Z-Leu-Leu-NHCH2)2CO is a research tool that activates the receptor. It is a ligand which binds to the receptor and can be used as an inhibitor of ion channels or as a reagent for protein interactions. The molecular weight is 584.8 g/mol and the chemical formula is C10H16N4O3. (Z-Leu-Leu-NHCH2)2CO has been shown to bind to antibodies, ion channels, and cell biology. This product has high purity and can be used in pharmacology, peptides, and life science research.</p>

<p>Bz-DL-Arg-pNA • HCl [DL-BAPA] is a trypsin and trypsin-like protease substrate. It is used as a tool in biochemical studies to investigate the degradation of proteins by these enzymes. Bz-DL-Arg-pNA • HCl [DL-BAPA] is also used as an experimental model for diseases that affect enzyme activity, such as rheumatoid arthritis and multiple sclerosis.</p>

<p>Cyclo(Arg-Gly-Asp-D-Phe-Val) is a cyclic peptide that inhibits the activity of surface glycoprotein enzymes. It has shown to be effective against malignant brain tumor cells and has anti-angiogenic effects. Cyclo(Arg-Gly-Asp-D-Phe-Val) also inhibits integrin receptor function by binding to the αVβ3 or αVβ5 integrin, which may be useful for biomarker identification. This compound is potent as an antagonist to epidermal growth factor (EGF), which may have potential use in treating benign prostatic hyperplasia.</p>

<p>Suc-Ala-Ala-Ala-AMC is a peptide that is used as a research tool to study protein interactions. It can be used to activate an antibody or receptor and to inhibit the activity of ion channels. This compound has been shown to bind to the Ligand Binding Domain of the Beta2 adrenergic receptor, which is expressed in the heart and lungs. Suc-Ala-Ala-Ala-AMC is also known as 73617-90-0, and has CAS No. 73617-90-0.</p>

<p>Relaxin-2 is a peptide hormone that belongs to the insulin family of hormones. It is produced by the corpus luteum and placenta. The relaxin-2 receptor is a G protein coupled receptor belonging to the superfamily of class A receptors, which are known as rhodopsin-like receptors. Relaxin-2 has been shown to activate ion channels in cells, leading to an increase in intracellular calcium levels. This hormone has also been shown to inhibit protein interactions and regulate cell growth and differentiation through its interaction with the receptor. The pharmacological effects of relaxin-2 are mediated by binding to the ligand-binding domain on the receptor, which leads to activation of a number of intracellular signaling pathways.</p>

<p>N-Ethyl-2,6-dimethylbenzene-1,4-diamine (EDA) is a building block in the synthesis of peptides. N-Ethyl-2,6-dimethylbenzene-1,4-diamine is used to prepare dPEG�� by reacting with ethylene diamine. The product is purified by vacuum distillation and used for reagents.</p>

<p>2-Deoxy-2-Phthalimido-3,4,6-Tri-O-Acetyl-α-D-Galactopyranosyl Fluoride is a glycosyl. It is a building block for the synthesis of peptides and other biochemicals. This compound is used in the preparation of fluorinated analogs of carbohydrates and glycosides to study their properties. 2DGTF has been shown to inhibit the activity of many enzymes, including DNA polymerase, topoisomerase II, protein kinase C, phospholipase A2, mitochondrial ATP synthase and proteases.</p>

<p>Chymostatin is a protein-based inhibitor that binds to the receptor site of amyloid beta peptides, preventing them from aggregating and thereby inhibiting the formation of amyloid plaques. It has been shown that chymostatin inhibits ion channels, ligand-gated channels, and voltage-gated channels. Chymostatin is a high purity product with an average purity of 99% by HPLC analysis. It is also available in a variety of concentrations (0.5 mg vial).</p>

<p>E-64 is a research tool that is used to study protein interactions. It has been shown to inhibit ion channels, such as the nicotinic acetylcholine receptor and the voltage-gated calcium channel. E-64 binds to receptors in the cell membrane, blocking ion channels and altering intracellular signaling pathways. E-64 has been shown to inhibit nitric oxide synthase, which may account for its anti-inflammatory properties. E-64 also inhibits an enzyme called protein tyrosine phosphatase 1B (PTP1B), which is involved in insulin resistance and type 2 diabetes mellitus.</p>

<p>m-dPEG®4-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®4-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Stresscopin-Related Peptide (Human) is a protein that belongs to the class of peptides. The peptide is an activator of receptor for glucocorticoids, and it also can bind with other receptors. Stresscopin-Related Peptide (Human) has been shown to interact with ion channels and ligands, such as antibodies, in the human body. This product is purified to ≥98% and available in a research grade form. It is not intended for use in humans or animals.</p>

<p>Galanin is a peptide that belongs to the family of neuropeptides and is found in the endocrine system, the central and peripheral nervous systems. It has been shown to inhibit the release of acetylcholine in the central nervous system and interestingly in Alzheimer’s disease patients, hyperinervation of galanin fibres has been found. Galanin is also known to have a variety of physiological effects including inhibition of insulin release, stimulation of prolactin and growth hormone secretion and it also plays a role in feeding, mood, cognition, neuroendocrine regulation and affects gastrointestinal motility. Galanin asserts its effects through associated with G-protein coupled receptors. This product is available as a 0.5mg vial.</p>

<p>m-dPEG®Acid (MW = 148) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®Acid (MW = 148) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Boc-Ile-Glu-Gly-Arg-AMC is a cell permeable inhibitor of protein interactions that binds to the peptide sequences of the extracellular domain of the epidermal growth factor receptor (EGFR). Boc-Ile-Glu-Gly-Arg-AMC can be used as a research tool to study protein interactions, as well as an inhibitor for EGFR. It is soluble in DMSO and water. This product has been shown to inhibit the activity of ion channels such as voltage dependent calcium channels, potassium channels, and sodium channels. Boc-Ile-Glu-Gly-Arg-AMC also inhibits antibody binding to its antigen.</p>