Peptides

<p>ProTx-I is a research tool that can be used in cell biology, pharmacology and biochemistry. It has been shown to block the activation of Ligands by Receptors and is an inhibitor of Cell Biology. ProTx-I binds to the receptor and inhibits ion channels, which are responsible for the transmission of nerve impulses. ProTx-I also binds to antibodies in order to inhibit the activity of Protein interactions. The compound is high purity with a CAS number (534963-97-7).</p>

<p>Synthetic peptide toxin derivative of; M-lycotoxin from the Carolina wolf spider, Hogna carolinensis. This peptide can be used for transport into the cytoplasma and is available as a 0.5mg vial.</p>

<p>P-selectin is a protein that belongs to the group of selectins, which are receptors found on the surfaces of cells. P-selectin is a receptor for phosphatidylserine (PS) and binds to PS on the surface of activated platelets, neutrophils, and macrophages. P-selectin is also an activator of the complement system, which is a series of proteins that work together in sequence to attack and destroy foreign materials such as bacteria or viruses. The recombinant human P-selectin is a research tool that can be used in cell biology experiments. It has been shown to be an excellent inhibitor of ion channels and ligands.</p>

<p>Follicle stimulating hormone (FSH) is a glycoprotein that is secreted by the anterior pituitary gland. FSH stimulates follicular growth in the ovary and regulates the production of estrogen and progesterone. FSH can be used to treat infertility in women, as well as male hypogonadism. It can also be used for assisted reproduction techniques such as in vitro fertilization, gamete intrafallopian transfer, testicular sperm extraction, and ovarian hyperstimulation. FSH is synthesized from human recombinant DNA and is chromatographically purified with a freeze-dried process. Additives may include antibiotics to prevent bacterial contamination during production or storage. FSH has been shown to act synergistically with estradiol to promote follicular growth in ovaries of immature rats.</p>

<p>Sourced from the marine snail, conus striatus, this synthetic cone snail toxin is a nicotinic acetylcholine receptor blocker. This product has disulfide bonds between Cys2-Cys7 and Cys3-Cys7.</p>

<p>m-dPEG®24-Propionaldehyde is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Propionaldehyde is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bone morphogenetic protein-2 is a secreted signaling protein that belongs to the transforming growth factor beta (TGF-β) superfamily. It has been shown to stimulate bone formation, inhibit bone resorption and stimulate cartilage production. BMP 2 is an activator of receptors for type I and II receptors for TGF-β. This peptide has also been shown to activate ion channels and inhibit ligands of receptor tyrosine kinases. BMP 2 binds to cell surface receptors and can be used as a research tool in the study of cell biology, pharmacology, and receptor function.</p>

<p>Fmoc-N-Amido-dPEG®8-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-N-Amido-dPEG®8-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Alpha-1-Acid Glycoprotein light tryptic peptide standard for protein identification and quantitation. Alpha-1-Acid Glycoprotein is an acute phase protein whose concentration in serum increases during, infection, inflammation and tissue injury.</p>

<p>Insl3 is a protein that is localized in the ovary and human chorionic gonadotropin. It is also found in human serum. In animals, Insl3 causes fertility. In humans, it stimulates the development of the gubernaculum, which attaches to the testes. The expression of Insl3 increases during puberty and continues to be expressed throughout adulthood. Insl3 is translated from mRNA as a precursor protein with an N-terminal signal peptide sequence that directs its secretion from the cell into the extracellular space. The Insl3 precursor protein has two C-terminal domains: an internal domain and a carboxy-terminal domain. These domains are translated from separate initiation codons on one mRNA molecule. The internal domain contains sequences for translation initiation, ribosome binding sites, and translational stop codons; these sequences are not present in the carboxy-terminal domain. Insl3 can be detected by using an</p>

<p>β-Defensin-2 is a protein that belongs to the class of defensins. It has been shown to have antimicrobial activity against a wide range of microorganisms and to be an activator of ion channels. β-Defensin-2 is also a ligand for the GPR18 receptor, which may be involved in the regulation of pain perception. β-Defensin-2 is purified from human leukocytes and has a purity of &gt;98%.</p>

<p>NPY is a peptide that is released by neurons and acts as an activator. It is also found in the central nervous system and regulates appetite, as well as other autonomic, behavioral, and endocrine functions. NPY has been shown to be an inhibitor of ion channels in the central nervous system. NPY has been shown to bind to receptors on the surface of cells, which are ligands for NPY. This binding activates or inhibits the receptor's signaling pathway. The CAS number for NPY is 1139-14-1 and it has a molecular weight of 9.6 kDa.END&gt;</p>

<p>[D-Ala2,Met5]-Enkephalinamide is a peptide that belongs to the group of opioid peptides. It acts as an agonist and binds to the µ-opioid receptor. This receptor is involved in transmitting signals from outside the cell to inside the cell by regulating ion channels and controlling protein interactions. The binding of [D-Ala2,Met5]-Enkephalinamide to this receptor results in an inhibitory effect on neurotransmitter release, leading to a decrease of pain sensation. It has also been shown that [D-Ala2,Met5]-Enkephalinamide can act as an antagonist at other opioid receptors, such as the κ-opioid receptor.</p>

<p>Orexin-A is a peptide that has been shown to activate orexin receptors, which are ligand-gated ion channels. It is used as a research tool in cell biology and pharmacology. Orexin-A, also known as hypocretin-1, is an endogenous neuropeptide that regulates arousal and wakefulness. The activation of the orexin receptor by Orexin-A leads to the opening of voltage-gated Ca2+ channels, resulting in Ca2+ influx into the cell and increased neurotransmitter release. Orexin-A binds to both orexin receptor subtypes (orexins 1 and 2) with similar affinity but with different binding modes. This antibody can be used for western blotting or immunohistochemistry studies in order to detect the presence of Orexin-A in cells or tissues.</p>

<p>Cytochrome P450 3A4 is an enzyme that is involved in the metabolism of a wide range of compounds, including drugs and other xenobiotics. CYP3A4 can metabolize a drug from one chemical to another by adding or removing a functional group. CYP3A4 also has monooxygenase activity, meaning it can convert one compound into another using oxygen as a reactant. CYP3A4 is responsible for the metabolism of many drugs and is commonly found in humans, mice, rats, dogs and cattle.</p>

<p>Mu-conotoxin GIIIB is a peptide that acts as an inhibitor of the nicotinic acetylcholine receptor. This toxin blocks the activation of the receptor, which leads to paralysis and death. Mu-conotoxin GIIIB is a highly purified peptide that has been shown to be a useful research tool for studying ion channels and their interactions with other proteins. The protein has also been used as an effective drug in treating myasthenia gravis and neuromuscular disorders.</p>

<p>Lys(1-Deoxyfructosyl) is a research tool used in cell biology and pharmacology. It interacts with many receptor types, such as ion channels, ligands, and antibodies. Lys(1-Deoxyfructosyl) binds to receptors and activates them. This leads to changes in the cells that are observed under a microscope. Lys(1-Deoxyfructosyl) has also been shown to inhibit protein interactions in living cells.</p>

<p>Haemagglutinin (HA) peptide YPYDVPDYA – HA Tag</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of MTHFSD antibody, catalog no. 70R-4964</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PCDH8 antibody, catalog no. 70R-6180</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of NAPE-PLD antibody, catalog no. 70R-3193</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of VPS4A antibody, catalog no. 70R-2376</p>

<p>IFN-α2b is a cytokine that regulates the immune system. It binds to the receptor, Interferon-alpha/beta receptor (IFNAR) and activates intracellular signal transduction pathways. It has been shown that IFN-α2b can be used as an inhibitor of influenza virus replication in vitro and in vivo. This cytokine also has the ability to activate protein kinase C and inhibit phospholipase A2, leading to the inhibition of cellular activation. IFN-α2b is a high purity research tool with a CAS number of 9071-87-7.</p>

<p>NRG1 B1 Human is a cytokine that is produced by human cells. It belongs to the group of interleukins and functions as an inflammatory mediator. NRG1 B1 Human is involved in a wide range of biological processes, such as the regulation of cellular proliferation, differentiation, and immune response. It may also be used as a treatment for cancer.</p>

<p>Beta-ANP is a peptide that belongs to the class of activators. It is an inhibitor of ion channels and has been shown to be a ligand for the beta-1 adrenergic receptor. Beta-ANP has been used as a research tool in cell biology, pharmacology, and biochemistry.</p>

<p>t-boc-N-Amido-dPEG®23-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. t-boc-N-Amido-dPEG®23-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>ANP (human, 5-28) is a peptide that is used as a research tool for studying the function of ion channels. It is also an antibody that can be used to measure protein interactions. ANP (human, 5-28) has been shown to inhibit protein interactions with the receptor and ligand. This peptide has been shown to act as an activator at high concentrations and an inhibitor at low concentrations.</p>

<p>Carboxyfluorescein-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>Gly-Gly-Tyr-Arg acetate dihydrate is a tetrapeptide and a ligand for the enzyme papain. It binds to the active site of papain and inhibits its proteolytic activity. Gly-Gly-Tyr-Arg acetate dihydrate has been shown to be an inhibitor of trypsin and chymotrypsin, but not other proteases. It has also been shown to inhibit the polymerase chain reaction and RNA synthesis in vitro.</p>

<p>Bromoacetamido-dPEG®23-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®23-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>A TIMP1 Heavy Tryptic Peptide Standard for protein identification and quantitation studies. TIMP1, also known as TIMP metallopeptidase inhibitor 1 is an inhibitor of matrix metalloproteinases, which are enzymes that break down the extracellular matrix. It has also been associated with cell proliferation promotion and may have a role in apoptosis.</p>

<p>Streptavidin-NC is a recombinant protein that is used in immunoassays. It binds to biotin and can be used as an alternative to the antigen-antibody reaction. Streptavidin-NC binds to the biotinylated antigen at the same time as it binds to the specific antibody, forming a sandwich complex. Streptavidin-NC has been shown to be more sensitive than antibodies in cardiac muscle and skeletal muscle immunoassays, with better specificity for cardiac troponin I and T than monoclonal antibodies. The molecular mass of this protein is about 50000 Da, which corresponds to a chain with about 500 amino acids.</p>

<p>SPDP-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Portion of EBV RTA</p>

<p>Big Gastrin, is a hormone which exerts its effects through activating the G-protein coupled receptor CCK2R and plays a role in gastric acid secretion. Big Gastrin can be used in research applications such as pharmacology and cell biology. This product is also a potential growth factor in some cancer tumors, including prostate cancer. It is available as an ammonium salt and as a 0.1mg vial.</p>

<p>H-Trp-2-ClTrt-Resin is a resin that has been used for the synthesis of peptides. It can be used as a building block for peptides, or as a building block in the synthesis of other compounds. H-Trp-2-ClTrt-Resin is available in two mesh sizes: 200 mesh and 400 mesh. The resin is soluble in ethyl acetate and alcohols, but insoluble in water.</p>

<p>Maleimide-activated BSA (BSA-M) is a maleimide-activated form of Bovine Serum Albumin (BSA). It is a peptide that can be used for immunization, as well as in biochemistry experiments. BSA-M has been shown to stimulate antibody production and can be used in the development of new vaccines.</p>

<p>Please enquire for more information about H-2kb tetramer peptide - VSV including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-2kb tetramer peptide - Q7 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-2kb tetramer peptide - E1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Elafin is a peptide that is secreted by human neutrophils. It has been shown to inhibit the activity of ion channels and play a role in the regulation of cell proliferation and differentiation. Elafin also interacts with receptors and ligands, which are molecules that bind to other molecules. It is also used as a research tool for studying protein interactions in cell biology. Elafin has been shown to have an anti-inflammatory effect on cells, which may be due to inhibition of the production of prostaglandins.</p>

<p>Anti-Rattin-24 is a monoclonal antibody that binds to the major allergen of rat R. rattus, Rattin-24. It has been shown to inhibit the binding of this protein to its receptor, which prevents activation of the receptor and the subsequent release of inflammatory mediators. Anti-Rattin-24 can be used as a research tool for studying protein interactions, receptor signaling pathways, peptide ligands, and ion channels. This antibody can also be used in cell biology and immunology studies as an inhibitor that blocks or inhibits certain biological processes.</p>

<p>Peptide T is a synthetic peptide that has been shown to inhibit the activity of protein kinase C. This inhibition may be due to its ability to bind with high affinity and specificity to a site on the receptor protein. Peptide T is a research tool used in studies of cell biology, pharmacology, and physiology. It has been used as an inhibitor for studies of ion channels and has also been used as an activator for studies of receptor-ligand interactions. Peptide T is also known by its CAS number, which is P25657-1-2.</p>

<p>Z-Arg-OBzl(p-NO2) hydrobromide is a research peptide that is commonly used as an enzyme substrate in various biochemical studies. It is widely utilized in the field of molecular biology and biochemistry for its ability to mimic specific enzymatic reactions. This compound is highly pure and has been extensively tested for its quality and reliability. Researchers rely on Z-Arg-OBzl(p-NO2) hydrobromide to accurately measure enzyme activity and understand the mechanisms behind various biological processes. With its precise composition and consistent performance, this research peptide is an essential tool for scientists conducting cutting-edge research in the field.</p>

<p>Cytochrome B5 Reductase 3, human, recombinant is a high-quality protein used in research and scientific studies. Produced using Escherichia Coli, this protein is essential for various biological processes. Cytochrome B5 Reductase 3 plays a crucial role in electron transfer reactions and is involved in the metabolism of drugs and toxins. It has been extensively studied for its ability to catalyze the reduction of cytochrome b5, an important component of the electron transport chain. This recombinant protein provides researchers with a reliable tool to investigate cellular processes and advance scientific knowledge.</p>

<p>Der P1 Protein is a recombinant protein that inhibits the activity of the protease dermaseptin-1. This protein is mainly found in the skin and is an important regulator of epidermal permeability barrier function. Der P1 Protein binds to the protease and prevents it from degrading other proteins, which are essential for maintaining skin integrity. Der P1 Protein can also be used as a research tool to study protein interactions, activators, ligands, receptors, ion channels, and antibodies.</p>

<p>Anti GIP (18-42) (Rat) Serum is a research tool used to activate the Ligand, Receptor, Cell Biology, Antibody, Ion channels, High purity, Protein interactions, Pharmacology, Peptides, Life Science. It can be used in the inhibition of GIP receptor and is an excellent choice for pharmacological studies.</p>

<p>Arg-MCA is a synthetic peptide that activates the receptor for bradykinin. It is used as a research tool in cell biology and pharmacology to study the interactions of peptides with various receptors and ion channels. Arg-MCA has been shown to inhibit the activity of ligand-gated ion channels, such as nicotinic acetylcholine receptors and glutamate receptors.</p>

<p>This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.</p>

<p>SMRT peptide (amino acids 1414-1430 corresponding to the SMRT BCL6 binding domain.</p>

<p>Alyerserin-1b is a C-terminally α-amidated 23 residue Cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards these peptides compared to conventional antibiotics.</p>

<p>The RGD peptide is an adhesive peptide present in extracellular matrix proteins allowing them to attach to a range of biological materials. It is labelled with Alexa Fluor 647.</p>

<p>Amino acids 195-209 of tubulin-associated unit (tau). This region represents a tau tryptic peptide and is part of the core of the tau protein. Tau is a phosphoprotein involved in microtubule (MT) assembly and stability as well as brain development. Tau is phosphorylated at multiple sites by several protein kinases, including cyclic-AMP-dependent protein kinases and casein kinase type-1. Tau phosphorylation causes tau to change shape, negatively regulating its ability to stimulate MT assembly. Tau is also glycosylated, and-O-glycosylation may have a role in its subcellular localisation and degradation.Malfunctioning tau protein contributes to the structural core of the paired helical filaments (PHFs), which make up neurofibrillary tangles (NFTs). NFTs are often observed in neurodegenerative disorders, such as Alzheimer disease and other tauopathies. Tau is expressed from a single gene and is alternatively spliced to yield six different isoforms in the adult central nervous system (CNS).</p>

<p>Light chain of the bevacizumab monoclonal antibody, sold as the antitumour therapeutic Avastin. It prevents vascular endothelial growth factor (VEGF) from binding to VEGF receptors 1 and 2 thus inhibiting angiogenesis in tumours.</p>

<p>The ability to modify ubiquitin chains would be a useful research tool for understanding ubiquitin signalling in health and disease. The initial step in ubiquitin signalling is attachment of a ubiquitin molecule to a lysine residue, further ubiquitins can then be added to the initial monomer creating a chain. The chain length and location can affect the fate of the protein. The most well studied are lysine 48 (K48) linked ubiquitin chains. K48 polyubiquitin chains are recognised by deubiquitinating enzymes (DUBS) and targeted for proteasomal degradation. Macrocyclic peptides are being explored as ubiquitin ligands to better understand ubiquitin signalling.Ub4ix is a macrocyclic peptide that selectively binds to lysine48-linked ubiquitin dimer (K48-Ub2), with much higher affinity than linear counterparts. Importantly, binding of ub4ix to K48-Ub2 prevents recognition by DUBS thus inhibiting protein targeting for proteosomal degradation. This has been shown to promote apoptosis in cancer cells. Therefore, molecules like ub4ix could be a valuable tool in understanding ubiquitin signalling as well as lead to future disease treatments. Potentially, the ubiquitin system in could be a target for cancer therapy to alter the polyubiquitin recognition by interacting proteins, further work with ubi4x could provide vital steps along this path.</p>

<p>Lys-Glu dipeptide.</p>

<p>ALPHA FACTOR SIGNALING PEPTIDE</p>

<p>This HER-2 Light Tryptic Peptide standard can be applied to protein identification and quantitation studies. HER-2 is the human epidermal growth factor receptor 2, which has tyrosine kinase activity and is involved the control of epithelial cell growth and differentiation. The overexpression of HER2 has been implicated with adenocarcinomas such as cervix, lung, ovary and breast.</p>

<p>FRETS-25-STD1 is a synthetic peptide that binds to and activates the TRPA1 receptor. It has been shown to inhibit the activity of the TRPA1 receptor in vitro, but has not been tested for in vivo activity. FRETS-25-STD1 competitively inhibits binding of various ligands to the TRPA1 receptor, including allyl isothiocyanate, cinnamaldehyde, and 4-hydroxybenzoic acid. FRETS-25-STD1 also inhibits activation of the TRPA1 receptor by agonists such as AITC or cinnamaldehyde.</p>

<p>Insulin is a peptide hormone that regulates blood glucose levels and promotes the uptake of glucose by cells. Insulin is produced in the pancreas and consists of 51 amino acids. It has a molecular weight of 5808 Da and consists of two chains, A (21-amino acid) and B (30-amino acid). The A chain is primarily responsible for insulin's activity, while the B chain improves its stability. Insulin binds to receptors on the cell surface, which activates an intracellular signaling cascade that subsequently leads to changes in gene expression. Insulin has been widely used as a research tool to study protein interactions, ligand binding, receptor activation, ion channel modulation, antibody production, and other cellular processes. Insulin I (Rat) is isolated from rat pancreas using a purification process that yields high purity insulin with minimal contaminating proteins or peptides. This product can be used in life science research applications such as pharmacology studies and antibody production.<br>This product has the three letter code: A-chain: Gly-Ile-Val-Asp-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn ; B-chain: Phe-Val-Lys-Gln-His-Leu-Cys-Gly-Pro-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ser has the disulfide Bonds: CysA6-CysA11, CysA7-CysB7, and CysA20-CysB19 and is available as a 50µg vial.</p>

<p>m-dPEG®12-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>FGF 8 is a protein that is involved in the regulation of cell growth, differentiation and survival. It can bind to FGF receptors on cells, which triggers a signal transduction pathway. The activation of this pathway leads to the inhibition of GSK3β activity and the activation of Akt. FGF 8 also binds to FGFR4, which activates phospholipase C (PLC) and increases intracellular Ca2+. This leads to the activation of PKC and calpain, which then activate nitric oxide synthases (NOS). Activation of NOS leads to increased production of nitric oxide, which causes vasodilation.</p>

<p>Sar1,Ala8]-Angiotensin II is a peptide that has been shown to bind to the angiotensin receptor and activate it. This peptide is a research tool for studying ion channels, ligand-receptor interactions, and protein interactions. The peptide can be used to study the pharmacology of the angiotensin receptor, as well as its role in cell biology and other biological processes. Sar1,Ala8]-Angiotensin II binds to the angiotensin receptor with high affinity, making it an excellent candidate for use in antibody production against this receptor.</p>

<p>Anti G-Protein: Galpha olf (23-38), humanSerum is a research tool that is used to study protein interactions. It can be used for the investigation of ion channels, cell biology, and pharmacology. The antibody reacts with the specific antigen for which it was raised. The antibody may be used in immunohistochemistry on tissue sections or in ELISA as a detection tool.</p>

<p>Anti VIP (Human, Porcine) Serum is a research tool for the study of protein interactions. It inhibits the binding of VIP to its receptor. Anti VIP (Human, Porcine) Serum is an inhibitor and activator of ion channels. It has been shown to bind to a wide variety of receptors and ligands, including those involved in cell biology and pharmacology. This product is highly purified and can be used in life science research as well as antibody production.</p>

<p>Centromere protein B (CENP-B) is a protein that belongs to the histone H3 family. It is one of the proteins involved in regulating chromosome segregation during mitosis and meiosis. CENP-B has been shown to be involved in the activation of kinetochores, which are structures on the surface of chromosomes that attach to microtubules and help with mitotic chromosome movement. Centromere protein B can also be used as a ligand or receptor, or a tool for cell biology, immunology, and pharmacology research.</p>

<p>Cancer antigen 125 (CA 125) heavy tryptic peptide standard for proteomics studies. CA 125 is an antigenic tumor marker which can be used to diagnose epithelial ovarian cancers. It is expressed by epithelial ovarian neoplasms and cells lining the fallopian tubes, endometrium, pericardium, peritoneum and pleura.</p>

<p>m-dPEG®48-CO(CH2)3-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®48-CO(CH2)3-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>NH2-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.</p>

<p>Please enquire for more information about Methoxytrityl-S-dPEG®12-Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TGF-b3 is a cytokine that belongs to the transforming growth factor beta family. It has been shown to be involved in the regulation of cell proliferation, differentiation, and apoptosis. TGF-b3 has also been implicated in the pathogenesis of inflammatory diseases and chronic obstructive pulmonary disease (COPD). The protein sequence for TGF-b3 is available for Cytokine. <br>The protein sequence for TGF-b3 can be found in the following databases: GenBank, SwissProt, EMBL, DDBJ and PDB.<br>Protein sequences are typically identified by their 'accession number'. For example, the accession number for TGF-b3 is NP_001408.1.<br>The sequences of genes may be found at NCBI's nucleotide database (NCBI).<br>The sequences of proteins may be found at NCBI's protein database (NCBI).</p>

<p>Histone acetyltransferase 1 (HAT1) is a protein that transfers an acetyl group to histones. It is mainly found in the nucleus and is involved in gene regulation. HAT1 interacts with many other proteins such as receptors, peptides, activators, and ion channels. The recombinant form of this enzyme has been shown to be a potent inhibitor of L-type calcium channels, which are important for the transmission of nerve impulses. This enzyme also inhibits glutamate receptors and can affect the activation of phospholipase C. HAT1 has also been shown to inhibit various types of cancers by suppressing tumor growth and invasion.</p>

<p>MAL-dPEG®4-(m-dPEG®4)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-(m-dPEG®4)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amyloid β (42- 1) SCR is a peptide that inhibits the interaction of amyloid β with its receptor, which may be useful for research purposes. Amyloid β (42- 1) SCR is an inhibitor that prevents the binding of amyloid β to its receptors. This peptide is a high purity product and has been shown to be effective in inhibiting the interaction between amyloid beta and its receptor.</p>

<p>Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.</p>

<p>IL-7 is a colony-stimulating factor that is expressed in the stromal cells of human cells. IL-7 has been shown to have modulatory effects on neutrophils and myeloid cells, which are important for immune responses. IL-7 stimulates phagocytosis and the production of reactive oxygen species by neutrophils and myeloids. IL-7 also has autocrine and paracrine effects on lymphoblasts and amplifies their proliferation. This protein may be used as a tumor marker for some malignant tumors because it can be detected in autocrine loops and in the circulation of patients with cancer.</p>

<p>Parathyroid Hormone (Human, 69-84) is a peptide hormone that regulates the levels of calcium and phosphate in the blood. It regulates bone formation and remodeling by targeting bone mineralization. Parathyroid hormone binds to to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available has a 0.5mg vial.</p>

<p>Human Prorenin ELISA kit is a solid-phase competitive immunoassay for the quantitative measurement of prorenin in human serum. This kit has been designed to provide accurate and reproducible results. The assay employs a monoclonal antibody to the analyte and a polyclonal antiserum that recognizes the analyte. The antibodies are used in an indirect sandwich assay with horseradish peroxidase-conjugated goat anti-mouse IgG as the second antibody.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of FBXO24 antibody, catalog no. 70R-2249</p>

<p>Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.</p>

<p>Azido-dPEG®4-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®4-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Glicentin is a rat-specific serum protein that is the major component of the alpha-2 macroglobulin (A2M) in the rat. Glicentin binds to various peptides, including beta-endorphin, vasopressin, angiotensin II, and oxytocin. This kit contains 1 vial of antibody against glicentin. The antibody has been purified by immunoaffinity chromatography on a column of immobilized peptide-glicentin complex. This kit can be used for detection of glicentin in rats.</p>

<p>LR3 IGF1 Human is a cytokine that is a member of the interleukin family. It is one of the two forms of human insulin-like growth factor 1 (IGF-1), which plays an important role in regulating cell growth and differentiation. LR3 IGF1 Human has been shown to stimulate the proliferation of various cells, such as lymphocytes and fibroblasts, in vitro. In addition, this cytokine has been shown to inhibit apoptosis induced by serum deprivation.</p>

<p>Anti ACTH (Rat) Serum is a research tool that can be used to study the biological effects of ACTH. This serum contains activated rat ACTH, which is a ligand and binds to the receptor and activates the cell. The anti-ACTH antibody is used to detect ACTH in blood and tissue samples. Anti-ACTH serum has been shown to inhibit ion channel activity, protein synthesis, and peptide binding. It also inhibits the binding of an antibody specific for rat ACTH.</p>

<p>Anti Gastrin 17 (G17) is a recombinant peptide that is used to study the gastrin receptor. It is an activator of the gastrin receptor, which belongs to the class of G protein-coupled receptors. The binding of G17 to gastrin receptor induces conformational changes in it and stimulates adenylate cyclase activity. This leads to increased levels of cAMP and activation of protein kinase A (PKA). Anti Gastrin 17 has a high purity, with a yield up to 95%. It can be used as a research tool or as an antibody in Western blot analysis.</p>

<p>Azido-dPEG®36-TFP ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®36-TFP ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ is a synthetic peptide that belongs to the group of Ligands. It interacts with receptors, ion channels, and other proteins. DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ can be used as a research tool in pharmacology, protein interactions, cell biology, and antibody production. This compound is also an activator or inhibitor depending on the type of receptor it binds to.</p>

<p>Vasopressin is a peptide hormone that is synthesized from the amino acid arginine and stored in vesicles. It is released into the bloodstream by the hypothalamus, where it acts as an antidiuretic and also stimulates vasoconstriction and contraction of smooth muscle. Vasopressin has been shown to inhibit the binding of ligands to their receptors, which may be due to its ability to activate these receptors. This protein has been used as a research tool for studying receptor-ligand interactions, cell biology, and pharmacology. It can also be used as a reagent for Western blotting or immunohistochemistry.</p>

<p>FGF 9 is a protein that belongs to the FGF family. It is a ligand of FGFR3 and FGFR4, which are receptor tyrosine kinases. FGF 9 has been shown to have many biological activities, including the ability to activate other ligands such as EGF and PDGF. FGF 9 also has been shown to be able to stimulate the proliferation of cells, promote cell migration, and regulate ion channels. This protein may also be involved in angiogenesis by stimulating endothelial cell proliferation and migration.</p>

<p>Insulin I is a mouse insulin. Insulin I is an ion channel activator, which means that it can open and close ion channels in the cell membrane to regulate the flow of ions into and out of cells. Insulin I is a receptor ligand, which means that it binds to a receptor on the surface of cells to activate or inhibit their function. Insulin I is used as a research tool for pharmacology and cell biology, as well as for the study of protein interactions. It has been shown to have high purity. Insulin I has also been shown to be an inhibitor of cellular growth, but not always an apoptosis inducer.</p>

<p>m-dPEG®36-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, m-dPEG®36-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.<br>Application: (90 µm)<br>Substitution Functional Group:-CH2-CH2-SH</p>

<p>IL 10 rat (IL-10) is a cytokine that belongs to the family of IL-10 cytokines. IL-10 binds to the IL-10 receptor and inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. This cytokine has been shown to inhibit the production of reactive oxygen species by macrophages and neutrophils. The physiological role of this cytokine is not yet fully understood, but it is believed to be important for immune regulation in response to bacterial infections.</p>

<p>AC 253 is an amylin (AMY3) receptor antagonist.</p>

<p>Big ET-1 is a peptide hormone that is a potent activator of the endothelin receptors. It has been shown to be involved in the regulation of blood pressure and intracellular ion concentrations. Big ET-1 (Porcine, 22-39) Antiserum can be used in immunohistochemical studies, Western blotting and ELISA. This product is suitable for use in research on the role of endothelin in cell biology, pharmacology, and molecular biology. The antiserum recognizes Big ET-1 with high specificity and affinity.</p>

<p>Schizophrenia Related Peptide is a research tool that can be used to study ion channels and receptors. It is an artificial peptide that has the same amino acid sequence as the part of the human brain that is believed to be responsible for schizophrenia. The Schizophrenia Related Peptide can bind to cell membranes and inhibit protein interactions, which may lead to new pharmacological treatments for schizophrenia.</p>

<p>TFF3 is a human protein that is encoded by the TFF3 gene. The TFF3 protein binds to the TGF-β1 receptor and activates it, which causes downstream signaling in cells. It is also a ligand for the activator protein 2 (AP-2) transcription factor, which regulates cell proliferation and differentiation. TFF3 has been shown to inhibit ion channels and may play a role in regulating cellular functions such as metabolism, growth, or apoptosis.</p>

<p>Hirudin is a protein that has been isolated from the salivary gland of the medicinal leech. It is used to treat thrombosis, or blood clots, and works by neutralizing the activity of thrombin. Hirudin is an enzyme that contains a peptide sequence that binds to thrombin and prevents it from activating other factors in the blood clotting process. The recombinant form of hirudin is produced in Escherichia coli and can be purified using chromatographic techniques. This form of hirudin has increased biological activity than native hirudin due to its higher stability and solubility.</p>

<p>Insulin Chicago is a recombinant human insulin produced in E. coli. It is an insulin analog that has improved pharmacokinetic properties and a more rapid onset of action after subcutaneous injection, with a duration of activity approximately twice as long as regular insulin. Insulin Chicago has been shown to be effective in reducing the incidence of hypoglycemia in type 1 diabetes mellitus patients, especially when used in combination with sulfonylureas or metformin. This product can also be used as a research tool for the study of protein interactions, peptides, and antibodies. Insulin Chicago has high purity and is supplied in vials containing 100 units/mL or 500 units/mL.</p>

<p>Heat Shock Protein-90 alpha (HSP-90α) is a molecular chaperone protein that is involved in the folding and stabilization of proteins. HSP-90α is a member of the HSP family, which are known to be involved in many processes such as apoptosis, cell cycle regulation, DNA repair, and intracellular signaling. HSP-90α has been shown to inhibit the replication of viruses such as HIV by binding to viral proteins and preventing their assembly into virus particles. This protein also has antiviral effects on other viruses such as influenza and herpes simplex virus type 1.</p>