Peptides
Peptides are short chains of amino acids linked by peptide bonds, serving as important biological molecules that play key roles in cellular processes. They function as hormones, neurotransmitters, and signaling molecules, and are widely used in therapeutic and diagnostic applications. Peptides are also crucial in research for studying protein interactions, enzyme activities, and cell signaling pathways. At CymitQuimica, we provide a diverse selection of high-quality peptides to support your research and development needs in biotechnology and pharmaceuticals.
Subcategories of "Peptides"
Found 29634 products of "Peptides"
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Dystrophin (2690-2700)
Forms of inherited muscular dystrophy such as Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) result from mutations targeting the dystrophin gene. These disorders are X-linked, progressive, and cause the gradual weakening of the muscles leading to respiratory failure and ultimately reduces the patient lifespan.In DMD, mutations lead to the production of premature stop codons and hence the truncated dystrophin protein product is vulnerable to nonsense mediated decay and degradation. Therefore, dystrophin production in muscle cells is reduced. On the other hand, nonsense mutations which also contribute to DMD, cause exon skipping in BMD and result in an internally truncated protein product which are partially functional. The symptoms of BMD are later onset compared with DMD which develop in patients between 2 to 7 years.Treatments of dystrophin disorders are in clinical trial including antisense oligonucleotide exon skipping and gene therapy. However, the efficacies of these treatments are not easily quantified. Currently levels of muscular dystrophin are quantified by western blot which can be unreliable. The peptide provided here, aligning residues dystrophin (2690-2700), has been tested via western blot, mass spectrometry, immunostaining and RT-PCR to try and provide the most robust method of validation of dystrophin levels possible. Further study with this dystrophin fragment could prove to be a vital step in the understanding and treatment of dystrophin disorders. Within our catalogue we also have other peptides tested for dystrophin quantification available plus the full-length dystrophin protein.CREB327/active transcription factor CREB-A (113-126) [5-FAM] amide, Human
CREB is a transcription factor that regulates diverse cellular responses including: proliferation- survival and differentiation- adaptive immune responses- glucose homeostasis- spermatogenesis- circadian rhythms and synaptic plasticity associated with memory. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-alpha. In the immune system, CREB induces an anti-apoptotic survival signal in monocytes and macrophages, has a role in promoting the proliferation, survival and regulation of T and B lymphocytes and is required for the generation and maintenance of regulatory T cells. CREB also often promotes anti-inflammatory immune responses, such as through the inhibition of NF-KB activity, the induction of IL-10, and the generation of Tregs. These anti-inflammatory responses could be protective by inhibiting unwanted inflammation, tissue damage, and autoimmune responses, or they could be pathogenic in the context of infection and tumour immunosurveillance. Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Molecular weight:2,087.1 g/molcAC 253
Cyclic AC253 is an antagonist of the amylin receptor with neuroprotective effects against Aβ toxicity. Cyclic AC253 eliminates Aβ-induced impairment of hippocampal long-term potentiation and is able to penetrate the blood-brain barrier.Molecular weight:3,007.5 g/molDystrophin (2765-2777)
Forms of inherited muscular dystrophy such as Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) result from mutations targeting the dystrophin gene. These disorders are X-linked, progressive, and cause the gradual weakening of the muscles leading to respiratory failure and ultimately reduces the patient lifespan.In DMD, mutations lead to the production of premature stop codons and hence the truncated dystrophin protein product is vulnerable to nonsense mediated decay and degradation. Therefore, dystrophin production in muscle cells is reduced. On the other hand, nonsense mutations which also contribute to DMD, cause exon skipping in BMD and result in an internally truncated protein product which are partially functional. The symptoms of BMD are later onset compared with DMD which develop in patients between 2 to 7 years.Treatments of dystrophin disorders are in clinical trial including antisense oligonucleotide exon skipping and gene therapy. However, the efficacies of these treatments are not easily quantified. Currently levels of muscular dystrophin are quantified by western blot which can be unreliable. The peptide provided here, aligning residues dystrophin (2690-2700), has been tested via mass spectrometry to provide a more reliable method of validation of dystrophin levels. Further study with this dystrophin fragment could prove to be a vital step in the understanding and treatment of dystrophin disorders. Within our catalogue we also have other peptides tested for dystrophin quantification available plus the full-length dystrophin protein.Molecular weight:1,401.7 g/molGlucagon (1-29)-[Cys(Cy5)]
Glucagon (1-29)-[Cys(Cy5)] is derived from glucagon, which is a peptide hormone secreted by alpha cells located in the islet of Langerhans region of the pancreas. Glucagon is an essential catabolic hormone that is responsible for the regulation of blood glucose levels. Once released into the bloodstream, glucagon stimulates the production of hepatic glucose, which means it is considered to be a glucose-mobilizing agent. Excessive levels of glucagon can result in the development of hyperglycaemia, since the action of glucagon results in abnormally high blood glucose levels.This peptide contains Cyanine 5 (Cy5), which is a widely used red fluorescent dye.Molecular weight:4,189 g/molInfliximab Heavy chain (46-60)
Infliximab is a biologic medicine used in the treatment of numerous autoimmune diseases including Crohn disease, rheumatoid arthritis, and ankylosing spondylitis. Infliximab binds with high affinity to tumour necrosis factor-α (TNF-α) blocking most of the cytokine effects, which includes mediating the inflammatory responses. Infliximab is a chimeric human-mouse IgG monoclonal antibody- the constant regions of the heavy and light chains are human-derived. The heavy chain peptide (46-60) has been identified as an antigen for antigen-specific T cell analysis. Numerous methods of immunological analysis can be applied to this peptide to hopefully provide further insight to these autoimmune conditions.Molecular weight:1,689.9 g/molXL 13m
Inhibits the epigenetic reader YEATS domain of the Eleven-nineteen leukemia (ENL) protein and perturbs the recruitment of ENL onto chromatin. Induces downregulation of a set of genes that are essential for leukemogenesis and leukaemia maintenance.Molecular weight:509.3 g/molXenin
Leptin and melanocortin are well characterised for their roles in energy balance and the regulation of feeding. However, xenin was subsequently isolated from human gastric mucosa and identified as a gastrointestinal peptide hormone. Evidence shows xenin plasma levels rise after meals while administration of xenin leads to feelings of satiation. Unfortunately, the mechanism of xenin regulation on food uptake is still not fully understood. Work has shown xenin negatively effects food intake by a dose dependent manner, the hypothalamus seems to have a key role in this. Furthermore, the signally pathways activated by xenin is independent of those used by leptin or melanocortins. Further work with xenin could provide vital answers to the inhibitory mechanism of this gastrointestinal hormone. It would provide more data to help tackle the ongoing obesity crisis and rise in the number of diabetic patients.Color and Shape:PowderMolecular weight:2,969.7 g/molNangibotide
Nangibotide, also referred as LR12, is an antagonist of triggering receptor expressed on myeloid cells (TREM)-1, and was derived from residues 94 to 105 of TREM-like transcript-1 (TLT-1).TREM-1 plays a crucial role in the onset of sepsis by amplifying the host immune response. TLT-1- and TLT-1-derived peptides therefore exhibit anti-inflammatory properties by dampening TREM-1 signalling. LR12 blocks TREM-1 by binding to the TREM-1 ligand and provides protective effects during sepsis such as inhibiting hyper-responsiveness, organ damage, and death, without causing deleterious effects. The protective effects of modulating TREM-1 signalling are also evident in other models of inflammation such as: pancreatitis- haemorrhagic shock- inflammatory bowel diseases and inflammatory arthritis.Color and Shape:PowderMolecular weight:1,342.5 g/molSyntide 2
Syntide-2 is a substrate peptide which was specifically designed to be homologous to site 2 in glycogen synthase. Syntide-2 is therefore phosphorylated by Ca2+ calmodulin-dependent protein kinase II as well as other calcium dependant kinases and protein kinase C. Synthase-2 can also be phosphorylated by CAMP-dependent protein kinase and to a lesser extent- phosphorylase kinase, but not by myosin light chain kinase.
Color and Shape:PowderMolecular weight:1,506.9 g/molSARS-CoV-2 Membrane protein (172-188)
SARS-CoV-2 Membrane protein (172-188)
Color and Shape:PowderMolecular weight:1,900 g/molAc-TPSLPTPPTR-NH2
Peptide Ac-TPSLPTPPTR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SAMS peptide
SAMS peptide was originally designed as a selective substrate for mammalian 5' adenosine monophosphate-activated protein kinase (AMPK) for use in kinase assays. However it is also able to be phosphorylated by the yeast AMP homologue- sucrose non-fermenting 1 kinase (SNF1) and SNF1-related kinases (SnRK1) in plants.The conserved family of kinases containing SnRK1, SNF1 and AMPK plays an important role in regulating cellular energy homeostasis.
Color and Shape:PowderMolecular weight:1,779.15 g/molHistone H3 (1-21) K4Me3
Histone H3 (1 - 21) K4Me3 is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Lysine 4 of Histone H3 (1 - 21) K4Me3 has been tri-methylated.Molecular weight:2,296.4 g/molANP 1-28 Human
ANP (1-28) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in cardiovascular remodelling.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in pro-ANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.
Molecular weight:3,078.4 g/molANP (7-23)
ANP (7-23) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in the cardiovascular remodelling process.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in proANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.Color and Shape:PowderMolecular weight:1,724.8 g/mol[5-FAM] Histone H3 (1-14) K4Me3
Histone H3 (1-14) K4Me3 is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter to change the positioning of the nucleosome, allowing the DNA it to be either available to the transcription machinery or inaccessible.The Histone H3 (1-14) lysine 4 has been trimethylated and contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Color and Shape:PowderMolecular weight:1,888 g/molKinetensin
Kinetensin was originally isolated from pepsin-treated plasma, and it shares some sequence homology with the C-terminal end of neurotensin (NT), having four of its nine amino acids in common with NT. Kinetensin is a potent histamine releaser and therefore may serve as an inflammatory mediator, it also has a role as a human metabolite and can increases vascular permeability. Kinetensin can be cleaved by ACE2.
Molecular weight:661.4 g/mol3x FLAG peptide
The synthetic canonical Flag sequence has been shown to be most effective with the Asp-Tyr-Lys-Xaa-Xaa-Asp motif triplicated for applications in protein analysis followed by the eight amino acids at the C-terminus of the classic FLAG sequence (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys). Due to the hydrophilic nature of the peptide the Flag tag typically resides on the surface of the recombinant protein thus minimising any effects on the function or transport of the fusion protein. The tag can be used in conjunction with other tags such as HA or myc depending on the application. FLAG is an artificial antigen to which high affinity monoclonal antibodies have been raised, therefore allowing for highly effective protein purification by affinity chromatography as well as accurate localisation of FLAG tagged proteins within living cells, or Western blots. FLAG peptide can be used to effectively purify complexes with multiple proteins as its mild purification procedure tends not to disrupt such complexes. It can be used to obtain proteins of sufficient purity for x-ray crystallography. The 3 x Flag peptide provides powerful detection and purification of recombinant proteins that has been characterised in numerous applications including affinity chromatography, binding assays and structural analysis.Molecular weight:3,649.8 g/molN-formylated PSMalpha2
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides. Peptides starting with an N-formylated methionyl group constitute a unique hallmark of bacterial as well as mitochondrial metabolism, and professional phagocytes of our innate immune system recognise this microbial/mitochondrial pattern as a danger signal that guides innate immune cells.All PSMα peptides have the same basic functions and promote virulence through effects on discrete neutrophil functions (i.e. chemotaxis) and by being cytotoxic at higher concentrations. PSMα2 and PSMα3 can both bind to FPR2 and trigger superoxide release in neutrophils at low nanomolar concentrations. In addition, at high nanomolar concentrations they display cytotoxicity selectively on apoptotic neutrophil membranes and this occurs in an FPR2 independent manner.Color and Shape:PowderMolecular weight:2,304.4 g/molARF peptide
ARF peptide, is the alternative frame (ARF) tumour suppressor protein which is expressed on the occurrence of oncogenic stimuli. It functions to prevent abnormal cell proliferation through inhibiting the p53 ubiquitin ligase protein Mdm2 from degrading p53. This results in the increased stability of the p53 tumour suppressor causing G1 cell cycle arrest. Additionally mouse ARF proteins can localise E2F1 and c-Myc transcriptions factors to the nucleolus therefore they are no longer able to activate S-phase promoting target gene. Again this results in cell cycle arrest, ultimately preventing tumour cell growth. It is evident that if the expression of the ARF peptide is inhibited tumour formation is more likely to occur.Color and Shape:PowderMolecular weight:1,867.1 g/molShepherdin (79 - 87)
Shepherdin is an antagonist of the interaction between the apoptosis protein, survivin, and the molecular chaperone, heat shock protein 90 (Hsp90). The sequence of shepherdin corresponds to the site where Hsp90 binds to survivin. Shepherdin therefore has high affinity for Hsp90 and thus disrupts survivin binding and acts as an inhibitor of Hsp90 ATPase function by competing with ATP.The survivin-Hsp90 complex is a regulator of cell proliferation and cell viability in cancer tissue. Shepherdin has anti-cancer properties and can significantly suppress the growth of lung cancer cell lines and acute myeloid leukaemia (AML) by inducing apoptosis.Color and Shape:PowderMolecular weight:948.4 g/molTAT-AKAP79 (326-336) scrambled amide
The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons and the neurotransmitter anandamide.- The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. The scrambled peptide was shown in vivo to have no effect on TRPV1 algesia and thus is a vital control for research work. This product is a vital tool for research into suitable TRPV1 antagonists. The scrambled-TAT peptide is available for purchase in both an acid and amide form, this is the C-terminal amide form.
Molecular weight:2,877.6 g/molTAT-CN21
TatCN21 is an inhibitor peptide for the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. TatCN21 blocks both autonomous and stimulated CaMKII activity with high selectivity. CaMKII is highly expressed in brain tissue where it regulates several processes including: neurotransmitter synthesis/release, neuronal plasticity- excitability and calcium homeostasis. Glutamate clearance by astrocytes is an essential part of normal excitatory neurotransmission, and accumulation of glutamate in the central nervous system is associated with many neurodegenerative disorders. CaMKII regulates glutamate homeostasis: CaMKII inhibition results in diminished glutamate uptake, dysregulated calcium homeostasis, release of the gliotransmitter ATP and compromise neuronal survival. Loss of CaMKII signalling may be an important factor in excitotoxicity. Peptide was obtained by linking the 11 amino acid human HIV Tat transporter to a 21 amino acid sequence corresponding to the CN21.
Color and Shape:PowderMolecular weight:3,986.4 g/molTAT - GluR23Y
TAT-GluR23Y is a cell penetrating peptide that inhibits phosphorylation of AMPA receptor endocytosis.Recent studies have shown that AMPA receptor endocytosis, which is a cellular mechanism underlying the formation of LTD, plays a critical role in facilitating initial extinction of learned fear. Tat-Glur23Y can block regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus.Molecular weight:2,632.4 g/molC5aR2 agonist
C5a receptor 2 (C5aR2, or C5L2) is a seven transmembrane non-G-protein-signalling receptor which binds the complement activation peptide C5a ligand. The complement cascade is a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. C5aR2 regulates the release of certain cytokines and is involved in a number of inflammatory conditions. C5aR2 can recruit and form a complex with β-arrestins, which can modulate ERK1/2 signalling in macrophages and neutrophils. C5aR2 has both pro- and anti-inflammatory actions. P32 is a functionally selective C5aR2 ligand which is able to recruit β-arrestin 2 with high efficacy, inhibit C5a-induced ERK1/2 activation and can selectively inhibit LPS-induced IL-6 release from human monocyte-derived macrophages (HMDMs). Functionally selective ligands for C5aR2 such as this are novel tools that can selectively modulate C5a activity and are therefore valuable tools in investigating C5aR2 function.Molecular weight:1,118.5 g/molIntracellular Sigma Peptide
Intracellular Sigma peptide is a membrane-permeable peptide mimetic of protein tyrosine phosphatase sigma (PTPσ) wedge. PTPσ is a neural receptor that binds with very high affinity to chondroitin sulfate proteoglycans (CSPGs). Inhibition of this interaction has been shown to promote regeneration of damaged nerves and improve nerve function in animal models. ISP has a protein transduction domain from HIV's trans-activating regulatory protein (Tat). This domain allows facilitates membrane-penetration.Molecular weight:4,316.2 g/molP2-Hp-1935
P2-Hp-1935 is an antimicrobial peptide isolated from the skin secretions of the Montevideo tree frog (Hypsiboas pulchellus). P2-Hp-1935 displays activity against Gram positive and negative bacteria.Molecular weight:1,935.32 g/molAD01 N-terminal Q
AD01 is a derivative of the FK506 binding protein-like (FKBPL), and exerts potent anti-angiogenic activity in vitro and in vivo to control tumour growth.Recent studies have shown that AD-01 inhibits Rac-1 activity, and up-regulates RhoA and the actin binding proteins, profilin and vinculin.In this way, the anti-angiogenic proteins, FKBPL, and AD-01, offer a promising and alternative approach for targeting both CD44 positive tumours and vasculature networks. Recent clinical studies have shown that AD01 and other FKBPL-based peptides may offer an alternative for targeting treatment-resistant breast cancer stem cells.Molecular weight:2,702.4 g/mol[5-FAM]-(KFF)3K
(KFF)3K is a cationic cell penetrating peptide which can be conjugated to PNA oligomers to aid in their penetration of the bacterial cell wall to function as anti-microbials. It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Molecular weight:1,769.9 g/molSARS-CoV-2 NSP13 (231-245)
The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication. NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (231-245) is an epitope candidate with various predicted HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.
Molecular weight:1,618.8 g/molFormyl-MLF-[Cys(AF488)]
Formyl-MLF-[Cys(AF488)] is composed of the chemotactic peptide: N-formyl-methionine-leucine-phenylalanine. N-formyl-methionine is the N-terminal amino acid present on bacteria and allows the bacteria to interact with phagocytic cells such as macrophages and monocyte-derived dendritic cells through surface formyl-MLF receptors. As a result Formyl-MLF labelled with the fluorescent dye, Alexa Fluor 488 can be used as a marker of bacterial infections. It has also been demonstrated that the use of multiple formyl-MLF moieties can target polymeric drug delivery molecules to phagocytic cells. In addition to Alexa Fluor 488's application in marking bacterial infections, its properties of being photo-bleaching resistant and having a high quantum yield allow it to carry out its most common use in the visualisation and location of dendritic structures and synapses.Molecular weight:1,237.3 g/molSARS-CoV-2 NSP7 (46-60)
SARS-CoV-2 NSP7 is part of the RNA-dependent RNA polymerase heterotetramer for mediating coronavirus RNA synthesis. NSP7 and NSP8 form a channel to confer processivity on RNA polymerase. NSP7 aids in stabilising NSP12 regions involved in RNA binding and is essential for a highly active NSP12 polymerase complex. These factors make NSP7 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP7 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP7 (46-60) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Molecular weight:1,678.9 g/molLL-37 fragment (30-34)
LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also regulates many aspects of the innate immune system and overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis, making LL-37 the most studied form of the human cathelicidin peptides.More recently, studies have shown that LL-37 binds to SARS-CoV-2 S protein and inhibits binding to its receptor hACE2, which may inhibit viral entry into the cell. LL-37 is upregulated by vitamin D, therefore this may be one mode of action for the positive outcomes seen with vitamin D treatment for Covid-19.Color and Shape:PowderMolecular weight:597.4 g/molDYKDDDDK FLAG peptide
Highly specific protein tag that can be added to a protein using recombinant DNA technology. FLAG is an artificial antigen to which high affinity monoclonal antibodies have been raised, therefore allowing for highly effective protein purification by affinity chromatography as well as accurate localisation of FLAG tagged proteins within living cells, or Western blots. FLAG peptide can be used to effectively purify complexes with multiple proteins as its mild purification procedure tends not to disrupt such complexes. It can be used to obtain proteins of sufficient purity for x-ray crystallography.Molecular weight:1,012.4 g/molTetanus Toxin (1084-1099)
Tetanus Toxin (1084-1099) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.Molecular weight:1,878.1 g/molCSK substrate
Substrate peptide for C-terminal Src kinase (Csk) for use in kinase assays. Csk is a cytosolic tyrosine kinase that is closely related to the kinase Src and is a well-known negative regulator of Src family kinases. Csk has both tumour suppressor and oncogenic properties and has also been implicated in regulating blood pressure, making Csk a novel therapeutic target for hypertension disorders.
Color and Shape:PowderMolecular weight:1,504.8 g/molApolipoprotein KV domain (67 - 77)
Vascular lipid deposition and altered lipid profiles are typical when unregulated angiogenesis is occurring, it is often seen in vascular disorders such as cancer and atherosclerosis. Apolipoprotein a (ApoA) functions as part of the lipid transporter complex high-density lipoproteins (HDL) to ensure lipid homeostasis and therefore the balance of angiogenesis. Within ApoA the Kringle5 (KV) domain (67 - 77), also known as KV11, has been identified as the region of ApoA that exerts anti-angiogenic effect. KV11 was shown in tumour cells to inhibit angiogenesis and consequently inhibits tumour progression. KV11 targets the angiogenesis c-Src/ERK pathway by blocking the activation signals received from vascular endothelial growth factor (VEGF). KV11 provides a new research potential for an anti-angiogenesis and anti-tumour therapeutic agent.Molecular weight:1,447.66 g/molAc-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2
Ac-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2 is a peptide that has antagonist activity against melanin, the hormone receptor. This peptide can be used to treat skin pigmentation disorders such as vitiligo, which is an autoimmune disorder in which the melanocytes are destroyed. Ac-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2 is also an aminovaleric acid derivative, which can inhibit the production of aminovaleric acid and related compounds.Formula:C49H82N16O11S3Purity:Min. 95%Molecular weight:971.22 g/molFmoc-ß-Ala-Wang Resin (100-200 mesh) 1% DVB
Fmoc-ß-Ala-Wang Resin (100-200 mesh) 1% DVB is a high purity reagent for peptide synthesis. It is used in the production of cell biology research tools, such as inhibitors and activators of ion channels, ligands for receptor binding, and antibodies. Fmoc-ß-Ala-Wang Resin (100-200 mesh) 1% DVB is a reagent that is used to synthesize peptides. This resin can be used in the production of various types of research tools, including inhibitors and activators of ion channels, ligands for receptor binding, and antibodies.Purity:Min. 95%Fmoc-Cys(Trt)-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Cys(Trt)-Wang Resin (100-200 mesh) 1% DVB is a research tool that is used as an activator, ligand or receptor for cell biology, antibody production or ion channels. It has been used in the study of protein interactions and pharmacology. Fmoc-Cys(Trt)-Wang Resin (100-200 mesh) 1% DVB is a high purity resin that can be used to synthesize peptides and compounds for life science purposes. It is also an inhibitor that can be used to block enzymatic reactions.Purity:Min. 95%Retatrutide trifluoroacetate
CAS:Retatrutide is a 39 amino acid single peptide with triple agonist activity at the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The backbone is conjugated to a C20 fatty diacid moiety at position 17. Retatrutide has a Glucose-dependent insulinotropic polypeptide (GIP) peptide backbone, which then contains three non-coded amino acids. Aib2 (α-amino isobutyric acid) residues at positions 2 and 20 provide stability against Dipeptidyl Peptidase 4 (DPP4) cleavage and contribute to GIP activity. αMeL13 (α-methyl-L-leucine)at position 20 also contributes to GIP and glucagon activity. Retatrutide can be used for the research of obesity obesity, diabetes, and fatty liver disease. It is a works in three ways: stimulating insulin release, suppressing appetite, and promoting fat breakdown.Formula:C221H342N46O68xC2HF3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:4,731.33 g/molFmoc-Met-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB is a resin that has been synthesized by the Fmoc group. The resin is used to attach peptides, proteins and other organic molecules to a solid support for use in research. The resin is also an activator of ligands and can be used as a receptor for the binding of antibodies. The resin has high purity and is made from methacrylate polymer. It contains no detectable levels of hydroquinone and 4-Vinylpyridine. Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB can be used as a research tool in cell biology, immunology, pharmacology, protein interactions, receptor binding, ion channel activation and more. CAS No.: 58897-27-6Purity:Min. 95%KGF 2 Human
KGF 2 is a recombinant human protein that binds to the KGFR-2 receptor, which regulates cell growth and differentiation. It is a potent inhibitor of cell proliferation and has been shown to inhibit the growth of breast cancer cells in vitro. The KGF 2 peptide is synthesized as a fusion protein with six histidine residues on the N-terminus and two cysteine residues on the C-terminus. This product can be used as a research tool, as well as an antibody for immunodetection of KGFR-2 protein in tissue culture.Purity:Min. 95%H-AEEEA-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2
H-AEEEA-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is a peptide that binds to the integrin αvβ3, which is expressed on many types of cancer cells. This binding causes cell death by apoptosis. H-AEEEA-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 also has the potential to be used as an imaging agent for tumor detection and diagnosis.Formula:C67H102N20O22Purity:Min. 95%Molecular weight:1,539.68 g/mol[Sar1]-Angiotensin II
CAS:Controlled ProductAngiotensin II is a peptide hormone that is secreted by the kidneys. It stimulates the release of aldosterone and causes vasoconstriction, leading to an increase in blood pressure. Angiotensin II is also involved in other physiological functions such as the regulation of fluid balance, electrolyte levels, and blood coagulation. The drug is used to treat congestive heart failure and high blood pressure. Sar1-Angiotensin II has been shown to inhibit transcriptional regulation by binding to the angiotensin receptor type 1 (AT1). This binding disrupts conformational changes in the receptor, preventing signal transduction from occurring and decreasing the activity of enzymes such as protein kinase A, which are needed for activation of transcription factors.Formula:C49H71N13O10•(C2H4O2)2Purity:Min. 95%Molecular weight:1,122.28 g/molPresenilin 1 (349-361)
Presenilin 1 (349-361) is a peptide that is a substrate for glycogen synthase. It is cleaved from the precursor protein presenilin 1 and has a molecular weight of 4.5 kDa. Presenilin 1 (349-361) is an enzyme substrate that can be used in biochemical assays to research glycogen metabolism.Formula:C56H93N21O19Purity:Min. 95%Molecular weight:1,364.49 g/molH-Trp(Boc)-2-ClTrt-Resin (200-400 mesh) 1% DVB
H-Trp(Boc)-2-ClTrt-Resin (200-400 mesh) is a resin that contains amines and thiols. It can be used as a building block of peptides and proteins. H-Trp(Boc)-2-ClTrt-Resin (200-400 mesh) can also be used in the synthesis of alcohols, which are important chemicals for industry.
Purity:Min. 95%
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