Peptides

<p>K-252A is an antimicrobial agent that inhibits the growth of bacteria. It binds to the response element in the promoter region of genes and blocks gene transcription, thereby preventing protein synthesis. K-252A has been shown to inhibit the growth of bacteria that are resistant to many other antibiotics, including ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin and kanamycin. This drug also induces significant up-regulation of cyclic nucleotide phosphodiesterases (PDE) and cytosolic Ca2+ in vitro. K-252A has been shown to cause neuronal death in vitro by inhibiting axonal growth. K-252A also inhibits leukemia inhibitory factor (LIF) from binding to its receptor on mouse lymphocytes.</p>

<p>Fmoc-ß-Ala-OH is a synthetic amino acid that is used in the synthesis of cyclic peptides. It has been shown to have receptor activity, such as the ability to bind to an erythrocyte membrane protein. Fmoc-ß-Ala-OH is also able to stimulate macrophage-like cells and polypeptide synthesis. Fmoc-ß-Ala-OH has been synthesized by chemical ligation, followed by purification on an agarose gel. This synthetic amino acid is used as a building block for affinity ligands, which are compounds that bind to specific receptors or other molecules with high specificity and affinity.</p>

<p>H-Ser-Phe-Asn-Gly-Gly-Pro-NH2 is a peptide that activates Protease Activated Receptor 1 (PAR1) and Protease Activated Receptor 3 (PAR3). It also has been shown to decrease blood pressure in mice, inhibit coagulation, and increase the breakdown of fibrin clots. This product is a ligand for PAR1 and PAR3. It has been shown to activate these receptors by binding to them through its amino acid sequence. HSPNP binds to proteases that cleave the peptide from the receptor, which leads to activation of the receptor. HSPNP can also bind to PAR3 and PAR4.</p>

<p>Boc-D-Ala-OH is a chiral amino acid that can be used in the synthesis of peptides. Boc-D-Ala-OH is a building block for the synthesis of amino acids, and it can also be used as a ligand to form metal complexes. This product has been shown to be effective in reducing optical activity through chemoenzymatic reduction processes. Boc-D-Ala-OH has also been shown to be hydrolyzed by various enzymes, including alcohols and acrylates.</p>

<p>Chloromethylated Polystyrene Resin (200-400 mesh) 1% DVB is a reaction solution that is used in biological studies. It reacts with human serum to form a bicyclic heterocycle. The hydrogen fluoride in the reaction solution reacts with the trifluoroacetic acid to form an intermediate, which then reacts with the chloromethylated polystyrene resin to form the bicyclic heterocycle. The redox potentials of this reaction are measured and can be used as a probe for determining the chemical stability of this product. This product has been shown to have fluorescence properties and can be used as a probe for detecting DNA and RNA samples in vitro.</p>

<p>Leupeptin is an ion channel blocker that belongs to the group of protease inhibitors. It blocks the passage of ions across cell membranes by binding to the active site of a variety of enzymes in the membrane. Leupeptin is used as a research tool for studying protein interactions, and can be used for antibody production. Leupeptin is also useful in cell biology studies, because it inhibits the activation of many proteins involved in signal transduction and cell division.</p>

<p>m-dPEG®8-Azide (Azido-m-dPEG®8) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®8-Azide (Azido-m-dPEG®8) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose is a per-O-acetylated version of 5-alkynyl-L-fucose, an inhibitor of the cellular fucosylation pathway. 1,2,3,4-Tetra-O-acetyl-5-alkynyl-L-fucose can pass through the eukaryotic cell membrane somewhat better than 5-alkynyl-L-fucose can itself, is deacetylated by cellular esterases and interferes with the biosynthesis of the fucosyl-donor and fucosyltransferase substrate GDP-Fuc, thus reducing fucosylation levels during glycoprotein biosynthesis.</p>

<p>Amino-dPEG®4-t-Butyl Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-t-Butyl Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Boc-Asp(OBzl)-Pro-Arg-MCA is a peptide that can activate the receptor GPRC6A. The peptide has been shown to activate the receptor by binding to it and activating the signal transduction pathway. This peptide is also an inhibitor of ion channels, such as voltage-gated potassium channels. Boc-Asp(OBzl)-Pro-Arg-MCA is a high purity product with CAS No. 113866-00-5.</p>

<p>This product is an antiserum targeting amino acids 1-16 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.</p>

<p>Fmoc-Lys(Boc)-Rink-Amide MBHA Resin is a resin that is used in the synthesis of peptides.Crosslinkage (DVB): max 1%Swelling, DCM for 3min: ca 9ml/g</p>

<p>Ac-D-Arg-[Cys-Met-Leu-Asn-Arg-Val-Tyr-Arg-Pro-Cys]-NH2 is a disulfide rich peptide that has been shown to act as a hormone receptor. The peptide binds with high affinity to the Melanin Concentrating Hormone Receptor, which is found in the hypothalamus and regulates metabolism. Ac-D-Arg-[Cys-Met-Leu-Asn-Arg-Val-Tyr-Arg]NH2 has been shown to regulate melanin production through its interaction with Melanin Concentrating Hormone.</p>

<p>H-Val-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is used as a building block for the synthesis of peptides. H-Val-2-ClTrt-Resin (100-200 mesh) 1% DVB is soluble in dichloromethane and ether.</p>

<p>Cytokeratin 8 is a human protein that is encoded by the KRT8 gene. It is a type I transmembrane protein that consists of three alpha-helical domains. Cytokeratin 8 has been shown to be involved in the regulation of keratinocyte migration, differentiation and proliferation. Recombinant human cytokeratin 8 is produced using Escherichia coli as a host cell. The recombinant form of this protein can be used to study cytokeratin 8's role in cellular processes.</p>

<p>Fmoc-Ile-Rink-Amide MBHA Resin is a resin that is used in the synthesis of peptides. It is composed of amino acid building blocks, which are connected to form polymers. The resin is insoluble in water and organic solvents, which makes it suitable for use in peptide synthesis and other applications. Fmoc-Ile-Rink-Amide MBHA Resin can be used as an alternative to polystyrene and polypropylene resins because it has a higher loading capacity and is more stable at high temperatures.</p>

<p>Nesfatin-1 Like Peptide (Mouse) is a peptide that regulates feeding behavior and insulin secretion. It is an insulinotropic peptide, which means it stimulates the release of insulin from pancreatic beta cells. Nesfatin-1 Like Peptide (Mouse) has been shown to be upregulated in the hypothalamus during fasting, thereby regulating feeding behavior. This peptide also has neurologic effects, such as stimulating locomotor activity, and may have antiinflammatory effects.</p>

<p>For preparation of acids, alcohols, thiols, or amines</p>

<p>H-Glu(Edans)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(Dabcyl)-OH is a peptide and biochemical that belongs to the group of enzyme substrates. It is a nonapeptide that contains an amidated lysine residue at the N terminus and the sequence H-Glu(Edans)-Pro-Leu is repeated. The amidated lysine residue facilitates the attachment of H-Glu(Edans)-Pro-Leu to an enzyme substrate, in this case calpain. H-Glu(Edans)-Pro-Leu binds to calpain by forming a covalent bond with a reactive cysteine residue on the enzyme's active site, thereby inhibiting its activity.</p>

<p>As a metabolite of penicillin and a di-methly analog of cysteine, D-Penicillamine (D-Pen) has properties as a heavy metal chelator. In particular, D-Pen forms complexes with thiol groups of copper ions and so can help regulate conditions such as Wilson’s disease, contributing to the renal excretion of copper. Studies have suggested that D-Pen could be used in the treatment of Alzheimer’s disease due to a reduced activity of copper and zinc superoxide dismutases in the blood of Alzheimer’s disease patients. It can further be used to treat copper and lead poisoning cases. Although D-Pen is clinically relevant, it is important to distinguish it from its enantiomer L-Pen which has been found to be toxic and can result in neuritis and marrow damage.</p>

<p>Cyclorasin 9A54 is a peptide that is a potent activator of the G protein-coupled receptor, CXCR4. Cyclorasin 9A54 is a ligand that binds to the CXCR4 receptor and activates its signaling pathway by binding to the receptor and activating it. Cyclorasin 9A54 has been shown to inhibit the activity of ion channels in cells with high purity, as well as to be an antibody for cell biology research.</p>

<p>IL-6 Human is a recombinant peptide, which belongs to the class of activator. It is an inhibitor that binds to the IL-6 receptor and inhibits IL-6 binding. IL-6 Human has been shown to inhibit protein interactions, such as cytokine receptors and ligands. IL-6 Human may also inhibit ion channels. This product is a research tool for use in life science and cell biology experiments.</p>

<p>Myelin PLP (178-191) is a peptide that is immunogenic. It is useful for the study of myelin protein and its role in the human body. It can be used for various purposes, such as studying the effects of myelin protein on the immune system or how it is involved in neural transmission.</p>

<p>Gly-Pro-Pro (Gly-Pro-Pro)7 is a peptide that has been shown to inhibit the activity of various proteases, including collagenase and elastase. It also inhibits the activity of matrix metalloproteinases, which are enzymes that degrade collagen and other extracellular matrix proteins. Gly-Pro-Pro (Gly-Pro-Pro)7 is therefore potentially useful for the treatment of diseases involving excessive degradation of connective tissue.</p>

<p>Fmoc-Thr(tBu)-Wang Resin (100-200 mesh) 1% DVB is a pharmacological research tool that is used to study protein interactions. It is also used as an inhibitor in the synthesis of peptides and has a high purity. This resin can be used for the production of antibodies, which are antibodies that specifically bind to a particular antigen. Fmoc-Thr(tBu)-Wang Resin (100-200 mesh) 1% DVB is an ion channel inhibitor that blocks voltage gated sodium channels, which are involved in pain transmission.</p>

<p>IL-1 beta is a cytokine that plays an important role in the inflammatory response. IL-1 beta is produced by macrophages, monocytes, and fibroblasts in response to stimuli such as lipopolysaccharide (LPS), bacterial endotoxin, and other cytokines. It is also produced by keratinocytes and dendritic cells in response to bacterial products. IL-1 beta binds to the IL-1 receptor on the cell surface membrane, triggering a cascade of reactions inside the cell that lead to changes in gene expression and protein production. IL-1 beta can be used as an indicator of inflammation due to its release by activated lymphocytes, natural killer cells, and neutrophils during acute infections. The presence of this substance indicates that there has been tissue damage or some other form of cell injury.</p>

<p>H-Arg(Pbf)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin used in the synthesis of peptides. This resin contains two amino acid residues that are used to form peptide bonds. These residues can be either H-Arg or H-Lys, but not both. The resin also contains a reagent called 2,4,6-trichlorophenoxyacetic acid (Troc), which reacts with the NH groups on the amino acids to form an ester linkage. The resin is typically used for building blocks and as an intermediate for synthesizing more complex molecules such as peptides and proteins.</p>

<p>S-Trityl-ß-Mercaptopropionyl-p-Methyl-Benzhydrylamine Resin is a resin that is used in the synthesis of peptides. It has a high efficiency and can be used in protein ligation and other peptide syntheses. This resin is available in both small molecule and large molecule formats, with modifications for specific purposes such as building blocks for protein synthesis or ligation.</p>

<p>H-Glu(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB is a resin that is used in peptide synthesis. It can be used as a building block for the synthesis of peptides and amino acids. H-Glu(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB can also be used to synthesize thiols, alcohols, and amines.</p>

<p>H-D-Ala-D-Nal(2')-Ala-Trp-D-Phe-Lys-NH2 is a Growth-Hormone Secretagogue (GHS) receptor agonist which usually associates with the peptide hormone, Ghrelin to stimulates growth hormone release from the anterior pituitary gland and stimulate food intake.</p>

<p>H-Tyr-Ala-Pro-Gly-Lys-Phe-NH2 is a synthetic peptide that can activate the PAR4 receptor. The PAR4 receptor is activated by proteolytic cleavage, which occurs when PAR4 interacts with the enzyme thrombin. Activation of the PAR4 receptor leads to vasodilation and increased blood flow. H-Tyr-Ala-Pro-Gly-Lys-Phe NH2 has shown potential for use in cardiovascular diseases such as hypertension, which is characterized by elevated blood pressure.</p>

<p>Tau Conotoxin CnVA is a peptide toxin derived from the venom of the cone snail. It has been shown to be a receptor agonist and to cause pain. Tau Conotoxin CnVA is a disulfide-rich peptide that has been shown to have neurotoxic effects in mammalian cells.</p>

<p>H-Gly-2-ClTrt-Resin (200-400 mesh) 1% DVB is an amine resin that is used as a building block in the synthesis of peptides. It is composed of 2,4,6-trinitrobenzene sulfonic acid (TNB), glycolic acid and 2,2'-dithio bis(ethane sulfonic acid) (DTES). This resin has a high level of reactivity with thiols and can be used to synthesize peptides. H-Gly-2-ClTrt-Resin (200-400 mesh) 1% DVB is also used for the synthesis of alcohols.</p>

<p>Fmoc-Asn(Trt)-Wang resin is a resin that is used for solid phase peptide synthesis. It is a polystyrene with an amino acid sequence of Asn(Trt) and Wang. This resin can be used as a research tool to study receptor-ligand interactions, protein interactions, and peptide synthesis. It has been shown to be an excellent high-purity reagent for antibody production. Fmoc-Asn(Trt)-Wang resin has also been shown to inhibit the activation of ion channels by binding to the receptor site on the channel protein.</p>

<p>H-Lys(Boc)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that can be used for the synthesis of peptides. It is an amine resin that contains two reactive groups, one thiol and one amine. H-Lys(Boc)-2-ClTrt-Resin (100-200 mesh) 1% DVB is also a building block for alcohols and thiols.</p>

<p>Ac-Lys-N-Me-Leu-Val-N-Me-Phe-Phe-NH2 is a peptide that has been shown to inhibit the formation of amyloid fibrils in Alzheimer's Disease. Ac-Lys-N-Me-Leu-Val-N-Me-Phe (KLVFF) is a biologically active peptide that is membrane permeable, allowing it to cross the blood brain barrier and enter the central nervous system. It inhibits the fibrillogenesis of amyloid beta protein, preventing it from aggregating into plaques.</p>

<p>H-Arg-Ala-Asp-Ser-Lys-OH is a peptide that is used in biochemistry research as a substrate for protease enzymes. It has the sequence H-Arg-Ala-Asp-Ser-Lys and is labeled with a fluorescent dye.</p>

<p>H-Leu-2-ClTrt-Resin (200-400 mesh) 1% DVB is a building block for the synthesis of peptides. It may be used in the synthesis of amines, thiols, alcohols, and resin. This product can also be used as a tool for peptide synthesis.</p>

<p>Marfey's reagent is a mixture of l-tartaric acid, hydrochloric acid and trifluoroacetic acid. It is used to determine the presence of β-amino acids in urine samples by reacting with the amide group on the β-amino acid. The reaction produces a white precipitate that can be filtered and analyzed using a UV spectrophotometer or LC/MS/MS. Marfey's reagent has significant cytotoxicity and should not be used in cell culture experiments.</p>

<p>When 99mTc-labeled, this cyclic RGD dimer is a useful tool for tumor imaging. This novel galacto RGD dimer has enhanced hydrophilic properties that improve biodistribution and tumor-imaging in comparison to 3P-RGD2 tracer. This product is available as a trifluoroacetate salt.</p>

<p>IL 4 is a cytokine that is responsible for the proliferation and activation of B cells, T cells, macrophages and other immune cells. IL 4 binds to the high affinity receptor IL-4Rα. It also activates the membrane bound IL-4Rβ. The IL-4Rα is a heterodimer consisting of an alpha chain, which is shared by all members of the type II cytokine receptor family, and the common beta chain shared by all type I cytokines receptors. IL-4 has been shown to be effective in inhibiting tumor growth in vivo and in vitro.</p>

<p>A Crocodile peptide hormone consisting of the disulfide bonds: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, and Cys14-Cys22. Hepcidin is small peptide hormone that is produced in the liver and acts on the kidney to regulate iron levels. Hepcidin regulates iron uptake by binding to ferroportin, a protein found in cells of the gut lining. The regulation of iron levels by Hepcidin prevents excessive tissue damage. Hepcidin also demonstrates anti-microbial activity through reducing the amount of circulating iron that is available to pathogens.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-YARAAARQARAKALARQLGVAA-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AWW-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Overlaping peptide library of ovalbumin, 15 amino acids per peptide with offset 11. Purity crude. All peptides are pooled in a single tube.</p>

<p>Peptide H-YEINVLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-KQL^ATKAAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Ac-LLM-CHO is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>