Peptides

Azido-dPEG® 11-amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG® 11-amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.

Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.

DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Hydroxy-dPEG®8-t-Butyl Ester is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, hydroxy-dPEG®8-t-Butyl Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Big Endothelin-3 (Rat, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial.

Neurokinin A is a peptide that belongs to the tachykinin family and has been shown to activate receptors, such as NK-1. It is a potent inhibitor of ion channels and has also been shown to inhibit ligand binding to the receptor. Neurokinin A is used in research for studying protein interactions, receptor effects, peptides, and ion channels. It can be used in cell biology for studying life science and research tools for high purity and antibody production. This product is not intended for therapeutic use.

Prosaposin is a human, recombinant secretory protein that is produced by the freeze-drying of a lysosomal extract. It is used to treat cerebrospinal fluid that has been depleted of prosaposin. This protein functions as a linker and interacts with choline, glycosphingolipids, and phospholipids to form the myelin sheath in the central nervous system. Prosaposin can also be reconstituted with deionized water and aliquots containing 1 mg/mL of this protein are available for purchase.

Z-Gly-Gly-Leu-pNA is a peptide that is derived from the amino acid sequence of a basic protein. It can be used as a fluorescent probe to detect hydration and enhance the fluorescence of other proteins. Z-Gly-Gly-Leu-pNA has been shown to bind basic protein subunits with high affinity, forming a stable complex. This peptide has also been shown to hydrolyze in acidic pH, making it useful for detecting proteolytic activity. The optimum pH for this peptide is neutral, at around 7.5. This peptide can be solubilized by adding Triton X or Brij 35 detergent and stored at -20°C.

IL-15 is a cytokine that belongs to the IL-2 family and is produced by activated T cells. IL-15 binds with high affinity to the IL-15 receptor, which then signals through the JAK/STAT pathway. IL-15 has been shown to activate NK cells and stimulate their production of IFNγ. In addition, IL-15 has been shown to cause activation of certain B cells, which leads to increased antibody production. This cytokine also stimulates proliferation of CD4+ and CD8+ T cells and induces differentiation into Th1 or cytotoxic T cell subsets.

Azido-dPEG®4-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.