Peptides

A synthetic peptide for use as a blocking control in assays to test for specificity of MRE11A antibody, catalog no. 70R-9416

Sarafotoxin S6b, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction.
As the most potent Sarafotoxin, sarafotoxin S6b binds to both ETA and ETB receptors with a similar affinity to Endothelin-1. This is evident as when given to mice intravenously, sarafotoxin S6b caused cardiac arrest and death in mice almost immediately. Additional characteristics of S6b is its matrix metalloproteinase inhibitory activity due to it exhibiting a fold which is also found in the core region of tissue inhibitors of metalloproteinases (TIMPs).
Sarafotoxin S6b can be used as a pharmacological reagent to study the interactions of Endothelins and their corresponding receptors. This product is available as a 0.1mg vial.

A synthetic peptide for use as a blocking control in assays to test for specificity of WFDC5 antibody, catalog no. 70R-5376

A synthetic peptide for use as a blocking control in assays to test for specificity of CHCHD1 antibody, catalog no. 70R-3971

A synthetic peptide for use as a blocking control in assays to test for specificity of NCRNA00114 antibody, catalog no. 70R-3296

m-dPEG®36-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®36-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of ECHDC1 antibody, catalog no. 70R-2161

IL-5 is a mouse monoclonal antibody that is used as a research tool. This antibody binds to the IL-5 receptor and is an activator of the receptor. IL-5 has been shown to activate ion channels and inhibit protein interactions, among other things. IL-5 has been shown to inhibit the binding of Ligand to Receptor, which may be due to its ability to bind to both Ligand and Receptor simultaneously.

A synthetic peptide for use as a blocking control in assays to test for specificity of COPA antibody, catalog no. 70R-6204

A synthetic peptide for use as a blocking control in assays to test for specificity of TRNT1 antibody, catalog no. 70R-1345

A synthetic peptide for use as a blocking control in assays to test for specificity of PTGDR antibody, catalog no. 70R-10286

A synthetic peptide for use as a blocking control in assays to test for specificity of NYD-SP21 antibody, catalog no. 70R-6530

A synthetic peptide for use as a blocking control in assays to test for specificity of RTP4 antibody, catalog no. 70R-3383

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF499 antibody, catalog no. 70R-7818

A synthetic peptide for use as a blocking control in assays to test for specificity of Wdr8 antibody, catalog no. 70R-8500

A synthetic peptide for use as a blocking control in assays to test for specificity of MSTO1 antibody, catalog no. 70R-8488

A synthetic peptide for use as a blocking control in assays to test for specificity of OR2H1 antibody, catalog no. 70R-9861

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF428 antibody, catalog no. 70R-7870

Bis-dPEG®4-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®4-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Amino acids 39-68 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.

Beta Amyloid peptides, also called Amyloid beta peptides (Abeta peptides) are the main component of amyloid peptide plaques in the brain of patients with Alzheimer's disease. sb-PEPTIDE provides a broad range of chemically synthesized amyloid beta peptides for Alzheimer's disease research. We supply Abeta peptides of different lengths and point-mutated versions. Do not hesitate to contact us for any information.

A synthetic peptide for use as a blocking control in assays to test for specificity of EIF5 antibody, catalog no. 70R-3190

A synthetic peptide for use as a blocking control in assays to test for specificity of TGM1 antibody, catalog no. 70R-3477

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM108 antibody, catalog no. 70R-1305

Angiotensin converting enzyme (ACE) heavy tryptic peptide standard for use in proteomics studies. ACE is involved in the regulation of blood pressure through converting inactive angiotensin I to active angiotensin II and also degrading active Bradykinin.

Amino-dPEG®2-t-Butyl Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®2-t-Butyl Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF619 antibody, catalog no. 70R-8158

A synthetic peptide for use as a blocking control in assays to test for specificity of CLDN18 antibody, catalog no. 70R-6157

MAL-dPEG®2-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®2-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

MAL-dPEG®4-Lys(TFA-)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

A synthetic peptide for use as a blocking control in assays to test for specificity of ESR1 antibody, catalog no. 70R-5681

Amino-dPEG®8-t-boc-hydrazide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®8-t-boc-hydrazide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of PLTP antibody, catalog no. 70R-10288

A synthetic peptide for use as a blocking control in assays to test for specificity of C2orf25 antibody, catalog no. 70R-4055

A synthetic peptide for use as a blocking control in assays to test for specificity of MYST1 antibody, catalog no. 70R-2166

m-dPEG®24-Lipoamide is a PEG molecule conjugated with a lipid moiety. m-dPEG®24-Lipoamide, conjugated to this lipid constituent, is very important especially in drug delivery and vaccine development as it helps improve the stability and circulation time of lipid nanoparticles (LNPs) and liposomes.

Prolactin-Releasing Peptide (Human) is a peptide that belongs to the class of inhibitors. It is a protein inhibitor that binds to the receptor and inhibits the activation of the receptor by its ligand. The binding of this peptide to the receptor prevents it from transmitting signals to other cells, thereby blocking cell function. Prolactin-Releasing Peptide (Human) has been shown to inhibit ion channels and can be used as a research tool in cell biology and pharmacology studies. This product is high purity and has not been shown to have any side effects on humans or animals when administered at therapeutic doses.

A synthetic peptide for use as a blocking control in assays to test for specificity of TUBG2 antibody, catalog no. 70R-4513

Cysteine peptide (Ac RFAAKAA COOH) is used in combination with Lysinepeptide (Ac RFAACAA COOH) in the Direct Peptide Reactivity Assay (DPRA) test.
Direct Peptide Reactivity Assay is used in cosmetic applications for the characterization of the skin sensitizing potential of a substance, framed by OECD Guideline no 442.
The molecular initiating event (MIE) in skin sensitization is a binding between epidermal proteins and the sensitizing chemical substance. MIE is part of the adverse outcome pathway (AOP) of skin sensitization.
It is thanks to the properties of Lysine peptide and Cysteine peptide that the chemical binding will be able to take place, so these synthetic heptapeptides will mimic the reaction of a skin exposed to a substance.
Binding between nucleophilic proteins and electrophile substance will be measured by High Performance Liquid Chromatography (HPLC). Therefore, the decrease in Lysine peptide and Cysteine peptide levels will be a sign of sensitizing event. Depending on the rate of depletion, the sensitizing character of a molecule will be determined (see table at the bottom of the page).
In chemico DPRA test also has wider applications such as hazard classification in cosmetics, but also for pharmaceuticals and biocides. It is a good alternative to animal experimentation.

Suc-[Glu9,Ala11,15]-Endothelin-1 (8-21) is a peptide that has been used as a research tool in pharmacology and protein interactions. Suc-[Glu9,Ala11,15]-Endothelin-1 (8-21) has been shown to be an agonist of the endothelin receptor. Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure.
Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.

Atrial Natriuretic Peptide (ANP) is a hormone that regulates blood pressure and fluid balance. Research has shown that ANP activates the receptor to inhibit the production of cyclic AMP, which is an intracellular second messenger. This process causes the opening of potassium channels, leading to hyperpolarization of the membrane, which decreases the excitability of cells. The ANP Antiserum is used as a research tool for studying the effects of ANP on ion channels and protein interactions in cell biology experiments.

A synthetic peptide for use as a blocking control in assays to test for specificity of KCNH3 antibody, catalog no. 70R-5167

A synthetic peptide for use as a blocking control in assays to test for specificity of MITD1 antibody, catalog no. 70R-4507

A synthetic peptide for use as a blocking control in assays to test for specificity of Ttbk2 antibody, catalog no. 70R-8045

A synthetic peptide for use as a blocking control in assays to test for specificity of NMRAL1 antibody, catalog no. 70R-3374

A synthetic peptide for use as a blocking control in assays to test for specificity of VEGFA antibody, catalog no. 70R-10216

A synthetic peptide for use as a blocking control in assays to test for specificity of KIAA1324 antibody, catalog no. 70R-6707

A synthetic peptide for use as a blocking control in assays to test for specificity of KIRREL antibody, catalog no. 70R-6888

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC22A2 antibody, catalog no. 70R-1735

A synthetic peptide for use as a blocking control in assays to test for specificity of JPH1 antibody, catalog no. 70R-6898