Peptides

Gly-Gly-His is a peptide that binds to copper and forms a complex. It has been shown to have antimicrobial properties in a model system using human serum. Gly-Gly-His is a diazonium salt that reacts with histidine, leading to the formation of an amide bond. The histidine residue can be replaced by other amino acids, such as lysine, arginine, or asparagine. This peptide also has calcium binding properties and has been shown to have biological properties in the femoral vein of rats.

Cancer antigen 125 (CA 125) light tryptic peptide standard for proteomics studies. CA 125 is an antigenic tumor marker which can be used to diagnose epithelial ovarian cancers. It is expressed by epithelial ovarian neoplasms and cells lining the fallopian tubes, endometrium, pericardium, peritoneum and pleura.

Obestatin is a peptide that was originally isolated from rat and mouse brain. It is a potent inhibitor of Kv1.3 and Kv1.5 potassium channels, with an IC50 of about 1 nM for both channels, but has no effect on other ion channels. Obestatin also inhibits the binding of antibodies to epitopes on the surface of cells, which may be due to its ability to inhibit cell-cell adhesion. The antibody-binding activity of obestatin is also inhibited by peptides corresponding to residues in the N-terminal region of obestatin, but not by peptides corresponding to residues in the C-terminal region. Obestatin has been shown to activate receptor tyrosine kinase (RTK) pathways and induce signaling cascades that lead to the proliferation and differentiation of tumor cells.

m-dPEG®24-Azide (Azido-m-dPEG®24) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Azide (Azido-m-dPEG®24) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

APYTFGQGTK peptide is a sequence from light chain of Adalimumab monoclonal antibody. Due to its universal location in Adalimumab antibody, APYTFGQGTK is used as a specific signature peptide for the quantitation of Adalimumab. Indeed, proteomic studies allows quantification of proteins in blood samples.
What is Adalimumab?
Adalimumab corresponds to a therapeutic monoclonal antibody. It is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor. This drug is frequently known as Humira.

FRETS-25-STD1 is a synthetic peptide that binds to and activates the TRPA1 receptor. It has been shown to inhibit the activity of the TRPA1 receptor in vitro, but has not been tested for in vivo activity. FRETS-25-STD1 competitively inhibits binding of various ligands to the TRPA1 receptor, including allyl isothiocyanate, cinnamaldehyde, and 4-hydroxybenzoic acid. FRETS-25-STD1 also inhibits activation of the TRPA1 receptor by agonists such as AITC or cinnamaldehyde.

Please enquire for more information about Fmoc-N-Lys-(dPEG®12-Biotin)-OH-(Acid) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Centromere protein B (CENP-B) is a protein that belongs to the histone H3 family. It is one of the proteins involved in regulating chromosome segregation during mitosis and meiosis. CENP-B has been shown to be involved in the activation of kinetochores, which are structures on the surface of chromosomes that attach to microtubules and help with mitotic chromosome movement. Centromere protein B can also be used as a ligand or receptor, or a tool for cell biology, immunology, and pharmacology research.

Vasotocin is a peptide hormone that is found in the hypothalamus. It is an activator of the vasopressin receptor and has been shown to activate ion channels and inhibit the release of neurotransmitters. Vasotocin also binds to a specific receptor on the surface of cells, which may be involved in cell biology and may have applications in pharmacology and antibody research. Vasotocin is purified from pig pituitary glands.

Substitution Functional Group:-NH-CO-CH2-CH2-COOHTentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. TentaGel; HL (High Load) (mean particle size 110 μm: capacity 04-06 meq/g)

Human Prorenin ELISA kit is a solid-phase competitive immunoassay for the quantitative measurement of prorenin in human serum. This kit has been designed to provide accurate and reproducible results. The assay employs a monoclonal antibody to the analyte and a polyclonal antiserum that recognizes the analyte. The antibodies are used in an indirect sandwich assay with horseradish peroxidase-conjugated goat anti-mouse IgG as the second antibody.

Z-Pyr-Gly-Arg-AMC is an inhibitor of protein interactions. It binds to the peptide receptor and blocks the activation of the receptor. This product is a research tool in cell biology, pharmacology, and proteomics.

Please enquire for more information about 4-[D10]Leu-M1 including the price, delivery time and more detailed product information at the technical inquiry form on this page

IL 10 rat (IL-10) is a cytokine that belongs to the family of IL-10 cytokines. IL-10 binds to the IL-10 receptor and inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. This cytokine has been shown to inhibit the production of reactive oxygen species by macrophages and neutrophils. The physiological role of this cytokine is not yet fully understood, but it is believed to be important for immune regulation in response to bacterial infections.

DNP-Pro-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ is a peptide that belongs to the class of activator. It facilitates the interaction between antibodies and their corresponding antigens, which is important for the immune system. DNP-Pro-Leu-Gly-Ile-Ala-Gly-Arg possesses high purity and can be used as a research tool in Cell Biology, Immunology, and Pharmacology. This peptide has been shown to inhibit the activity of ion channels by binding to them and preventing ions from passing through.

Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.
Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.

Thrombin Receptor Activator Peptide 6 (TRAP-6), also called Selective Protease-Activated Receptor 1 (PAR-1) Agonist, is an hexapeptide fragment of the thrombin receptor (residues 42-47).

Phosphoramidon is a peptide that is used as a research tool. It has been shown to activate the protein kinase C, which plays a role in the regulation of ion channels and other cellular functions. Phosphoramidon binds to the receptor site of protein A and inhibits the binding of phosphorylated erythropoietin (EPO) to its receptor. EPO is an important hormone for red blood cell production.

Amino-dPEG®11-ONH-t-boc is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®11-ONH-t-boc is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

CCK-33 is a peptide that was originally isolated from porcine brain. It has been shown to be an activator of ion channels, a ligand for receptors, and an inhibitor of protein interactions. CCK-33 is also a pharmacological tool that can be used to study the role of ion channels in cellular processes such as neurotransmission and cell proliferation. CCK-33 is a receptor antagonist, which means it binds to the receptor and blocks the binding site. This prevents other compounds from binding to the receptor and activating it, thereby blocking its effects.