Peptides

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF428 antibody, catalog no. 70R-8460

Uroguanylin is a peptide that is released by cells in the intestine. It binds to the guanylate cyclase receptor, which stimulates the production of cyclic GMP (cGMP). This leads to an increase in intestinal water and electrolyte secretion. Uroguanylin Isomer A (Human) is a high-purity peptide that can be used as a research tool for studying ligand-receptor interactions and as an inhibitor of ion channels.

Suc-Ala-Ala-pNA is a synthetic peptide that has been shown to inhibit the activity of enzymes in the metabolic pathway of cholesterol biosynthesis. It also inhibits the activity of phospholipase A2 and cyclooxygenase, which are involved in arachidonic acid metabolism. Suc-Ala-Ala-pNA is a hydrophobic molecule that can be used as an inhibitor for enzymes such as esterases, aminopeptidases, amidases, carboxypeptidases, and proteases. Suc-Ala-Ala-pNA has been shown to have antiatherosclerotic properties because it inhibits the production of lipid peroxides.

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC43A1 antibody, catalog no. 70R-6331

A synthetic peptide for use as a blocking control in assays to test for specificity of PNMA3 antibody, catalog no. 70R-2050

A synthetic peptide for use as a blocking control in assays to test for specificity of TRPM8 antibody, catalog no. 70R-5149

Crotamine is a bioactive compound that is isolated from Croton tiglium, which is a plant indigenous to Southeast Asia. It is the most active component of the extract, and has been shown to have anti-inflammatory properties in various animal models. Crotamine has been used as an analytical standard for HPLC and can be used as a reference material for screening purposes. CAS No. 58740-15-1

α-Defensin-1, human is a peptide that belongs to the class of defensins. It is an activator of ion channels and a ligand for receptors. α-Defensin-1, human also inhibits protein interactions with the receptor. It is purified to high purity and has CAS number 99287-08-8. This product can be used as a research tool in cell biology and pharmacology.

Amino-dPEG®24-t-Butyl Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®24-t-Butyl Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Omega-Conotoxin MVIIA is a neurotoxin that inhibits voltage-dependent calcium channels and has been shown to be effective against neuropathic pain, chronic pain, and inflammatory pain. The long-term efficacy of this drug is due to its ability to block cytosolic calcium, which leads to the activation of neurotrophic factors. Omega-Conotoxin MVIIA binds to specific protein targets and inhibits ion channel activity in neurons. This toxin can also inhibit the production of proinflammatory cytokines by blocking the activation of NF-κB through intracellular targets. Omega-Conotoxin MVIIA has been shown to have a wide range of therapeutic potentials, including as an analgesic for acute and chronic pain, as an anti-inflammatory agent, and as a neuroprotective agent for treating neuronal degeneration.

AIP-III is a peptide that belongs to the group of activators. It binds to the nicotinic acetylcholine receptor, thereby activating it. AIP-III has been shown to cause significant changes in the activity of ion channels and is used as a research tool for pharmacology and protein interactions. AIP-III has been found to be a potent inhibitor of various types of cancer cells in cell culture experiments, although its effects on humans are unknown.

α7 nAChR selective blocker

Anti Na Channel ll (467-485) (Rat) Serum is an anti-Na channel antibody that can be used for research purposes. It is a monoclonal antibody that has been generated according to the sequence and features of the rat N-type voltage-gated sodium channels. The affinity of this antibody for its target is high, with a Kd of 0.5 nM. This antibody can be used in immunoassays, Western blots and immunoprecipitations to determine the level of Na channel expression in various tissues.

HG1 toxin is a peptide that is found in the venom of the scorpion Heterometrus fulvipes. It is a member of the short-chain scorpion toxins, which are composed of a single chain of amino acids. This protein has been shown to bind to potassium channels and inhibit their function, leading to paralysis of the prey's nervous system. HG1 toxin has been shown to be able to activate or inhibit ion channels and other receptors. It can also bind to ligands such as peptides or antibodies and affect cellular activity. HG1 toxin is produced by recombinant DNA technology and purified by HPLC for use in biochemical research and pharmacological studies.

Cytochrome B5 Reductase 3, human, recombinant is a high-quality protein used in research and scientific studies. Produced using Escherichia Coli, this protein is essential for various biological processes. Cytochrome B5 Reductase 3 plays a crucial role in electron transfer reactions and is involved in the metabolism of drugs and toxins. It has been extensively studied for its ability to catalyze the reduction of cytochrome b5, an important component of the electron transport chain. This recombinant protein provides researchers with a reliable tool to investigate cellular processes and advance scientific knowledge.

4-Formyl-Benzamido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. 4-Formyl-Benzamido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

MAGE-A1 protein:
MAGE-A1 (278-286) is an epitope of Melanoma Antigen Gene A1 expressed by tumors of different histological types such as on the surface of breast carcinoma cell and is a Cancer/Testis Antigens (CTA). MAGE-A1 is a tumor antigen expressed in 40% of melanoma and contains epitope for binding HLA-A*02:01 molecules and that are recognized by cytotoxic T cells.
Applications of MAGE-A1 (278-286):
MAGE-A1 (278-286) is used to stimulate specific cytotoxic T cells in PBMCs and to analyze by ELISPOT peptide epitope specificity and cytokine production like IFN-γ. Immunogenicity of MAGE-A1 (278-286) raised the possibility of developing anticancer immunotherapies or vaccinations. MAGE-A1 is also expressed in lung adenocarcinoma and studies suggest that MAGE-A1 may serve to develop Chimeric Antigen Receptor (CAR) T cell therapy using lentiviral vector and show an encouraging tumor-inhibitory efficacy.

gp100 (280-288) A288V HLA-A*0201 antigen peptide – YLEPGPVTV

Alyerserin-2a is a C-terminally α-amidated 17 residue cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-2a, 2b and -2c show some sequence identity with bombinin H6, a peptide from the skins Bombinatoridae family of frogs.Alyteserin-2a is most potent against the Gram-positive bacteria-Staphylococcus aureus and has weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards them compared to conventional antibiotics. Alyteserin-2a has the tendency to adopt an α-helical conformation between residues 9-14 when in membrane-mimetic solvent.