Transporter/Ionenkanal

Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to …

Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst.

RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist …

Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in …

Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) …

U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.

Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved …

AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and …

β-Pompilidotoxin Acetate is a wasp venom peptide.

Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the …

Phenibut hydrochloride (3-Amino-4-phenylbutyric acid hydrochloride) is a GABA mimetic that acts as an agonist at …

YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in …

DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (-)-menthol and (+)-menthod, which have …

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe …

AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the …

L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a …

AZD3965 (AZD-3965) is a selective inhibitor of monocarboxylate transporter 1 (MCT1).

KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator, details of which are from Compound …

Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.

VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), …

XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 …

TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).

Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive …

1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig …

NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels

Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment …

Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.

ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy

Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.

NFAT Inhibitor-2 is a potent inhibitor of NFAT signaling by calmodulin phosphatase.

A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonist

Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties …

Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a …

Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux …

Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited …

Phe-Met-Arg-Phe amide acetate (ED50=23 nM) triggers K+ current in caudodorsal neurons, co-localizes with neuropeptide Y …

Nateglinide is an oral drug for type 2 diabetes, stimulating insulin release; may cause rare …

M084 (N-Butyl-1H-benzimidazol-2-amine) is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.

CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and …

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and …

Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.

Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent …

Tiagabine (NO050328) is an Anti-epileptic Agent.

Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective …